Detailed information for compound 1515546

Basic information

Technical information
  • TDR Targets ID: 1515546
  • Name: 4-[[2-[(4-bromophenyl)amino]-1,3-benzothiazol -5-yl]oxy]-N-methylpyridine-2-carboxamide
  • MW: 455.328 | Formula: C20H15BrN4O2S
  • H donors: 2 H acceptors: 3 LogP: 5.02 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)c1nccc(c1)Oc1ccc2c(c1)nc(s2)Nc1ccc(cc1)Br
  • InChi: 1S/C20H15BrN4O2S/c1-22-19(26)17-11-15(8-9-23-17)27-14-6-7-18-16(10-14)25-20(28-18)24-13-4-2-12(21)3-5-13/h2-11H,1H3,(H,22,26)(H,24,25)
  • InChiKey: ZRRFUDDSSHZCBP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[[2-[(4-bromophenyl)amino]-1,3-benzothiazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide
  • 4-[[2-[(4-bromophenyl)amino]-1,3-benzothiazol-5-yl]oxy]-N-methyl-2-pyridinecarboxamide
  • 4-[[2-[(4-bromophenyl)amino]-1,3-benzothiazol-5-yl]oxy]-N-methyl-picolinamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Raf-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Raf kinase Get druggable targets OG5_130459 All targets in OG5_130459
Echinococcus granulosus raf serine:threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Loa Loa (eye worm) raf kinase Get druggable targets OG5_130459 All targets in OG5_130459
Echinococcus multilocularis raf serine:threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Loa Loa (eye worm) TKL/RAF/RAF protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Schistosoma japonicum ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative Get druggable targets OG5_130459 All targets in OG5_130459
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0058 0.0492 0.0598
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0377 0.3897 0.474
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0377 0.3897 0.474
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0099 0.0365
Echinococcus granulosus ryanodine receptor 44f 0.0059 0.0506 0.0615
Trypanosoma brucei ingi protein (ORF1) 0.0054 0.0452 0.0967
Brugia malayi AKH receptor 0.0377 0.3897 0.5976
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0099 0.1463
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0103 0.0125
Echinococcus multilocularis microtubule associated protein 2 0.0781 0.8222 0.8222
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0306 0.0469
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0377 0.3897 0.474
Onchocerca volvulus 0.0377 0.3897 1
Schistosoma mansoni lamin 0.0029 0.018 0.0219
Leishmania major hypothetical protein, conserved 0.0058 0.0491 0.1816
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0306 0.1157
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0106 0.0942
Echinococcus multilocularis musashi 0.0029 0.018 0.018
Brugia malayi RNase H family protein 0.0044 0.0343 0.0527
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0324 0.1191
Echinococcus granulosus stromal cell derived factor 2 0.0017 0.0051 0.0062
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0324 0.1191
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.1249 0.4724
Trypanosoma brucei ribonuclease H1 0.0044 0.0343 0.0735
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.006 0.0223
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.006 0.0223
Schistosoma mansoni lamin 0.0029 0.018 0.0219
Onchocerca volvulus 0.0377 0.3897 1
Onchocerca volvulus 0.0377 0.3897 1
Treponema pallidum ribonuclease H (rnhA) 0.0044 0.0343 0.2696
Trypanosoma cruzi ribonuclease H1, putative 0.0044 0.0343 0.1271
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.006 0.0073
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.006 0.0223
Schistosoma mansoni intermediate filament proteins 0.0029 0.018 0.0219
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0103 0.0158
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.112 0.414
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.004 0.0149
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.0149 0.0149
Brugia malayi MIR domain containing protein 0.0017 0.0051 0.0078
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.0491 1
Echinococcus granulosus intermediate filament protein 0.0029 0.018 0.0219
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.004 0.0141
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0116 0.0116
Plasmodium vivax DNA polymerase alpha, putative 0.0047 0.0375 0.7451
Schistosoma mansoni alpha glucosidase 0.0042 0.0324 0.0394
Onchocerca volvulus 0.0017 0.0051 0.0028
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0099 0.0357
Schistosoma mansoni alpha-glucosidase 0.0164 0.1624 0.1975
Loa Loa (eye worm) raf kinase 0.026 0.2654 0.407
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0377 0.3897 0.5976
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0016 0.0043 0.0008
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0099 0.0208
Echinococcus multilocularis neuropeptides capa receptor 0.0377 0.3897 0.3897
Mycobacterium ulcerans hypothetical protein 0.0041 0.0306 0.2731
Toxoplasma gondii O-linked N-acetylglucosamine transferase 0.0044 0.0339 0.6909
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0016 0.0043 0.0153
Echinococcus multilocularis tumor protein p63 0.0395 0.4092 0.4092
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0027 0.0162 0.0601
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0106 0.0162
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0058 0.0492 0.0598
Brugia malayi Melatonin receptor type 1A 0.0377 0.3897 0.5976
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0415 0.8333
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0016 0.0043 0.0161
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0377 0.3897 0.5976
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0099 0.0394
Echinococcus granulosus rhodopsin orphan GPCR 0.0377 0.3897 0.474
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Onchocerca volvulus 0.0029 0.018 0.0362
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0324 0.0324
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0209 0.0767
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0377 0.3897 0.474
Brugia malayi Glycosyl hydrolases family 31 protein 0.019 0.1907 0.2924
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0002 0.0008
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.006 0.0129
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0324 0.1198
Echinococcus granulosus raf serine:threonine protein kinase 0.0262 0.2668 0.3245
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.006 0.0223
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0062
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0158
Echinococcus granulosus rhodopsin orphan GPCR 0.0377 0.3897 0.474
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0158
Echinococcus multilocularis neuropeptide receptor 0.0377 0.3897 0.3897
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0103 0.0158
Brugia malayi hypothetical protein 0.0377 0.3897 0.5976
Loa Loa (eye worm) hypothetical protein 0.0058 0.049 0.0751
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0116 0.042
Echinococcus multilocularis lamin dm0 0.0029 0.018 0.018
Echinococcus multilocularis neuropeptides capa receptor 0.0377 0.3897 0.3897
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.006 0.0223
Trichomonas vaginalis DNA polymerase II, putative 0.0025 0.0143 0.0521
Echinococcus multilocularis g-protein coupled receptor 0.0377 0.3897 0.3897
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0016 0.0043 0.0146
Echinococcus multilocularis ryanodine receptor 44f 0.0059 0.0506 0.0506
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.006 0.006
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.004 0.0141
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.112 0.414
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0022 0.0104 0.0127
Giardia lamblia Ribonuclease H 0.0044 0.0343 0.1128
Loa Loa (eye worm) TYRA-2 protein 0.0377 0.3897 0.5976
Onchocerca volvulus 0.0377 0.3897 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0099 0.0357
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0117 0.112 1
Echinococcus multilocularis neuropeptide receptor A26 0.0377 0.3897 0.3897
Treponema pallidum NADH oxidase 0.0018 0.006 0.0033
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0099 0.0881
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0209 0.0767
Onchocerca volvulus Ribonuclease H1 homolog 0.0044 0.0343 0.0786
Brugia malayi hypothetical protein 0.0022 0.0103 0.0158
Echinococcus granulosus orexin receptor type 2 0.0377 0.3897 0.474
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0103 0.0373
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0377 0.3897 0.3897
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0377 0.3897 0.474
Loa Loa (eye worm) G-protein coupled receptor 0.0377 0.3897 0.5976
Schistosoma mansoni phosphoglucomutase 0.0044 0.0343 0.0418
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0106 0.0391
Schistosoma mansoni neuropeptide receptor 0.0377 0.3897 0.474
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0103 0.0373
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.004 0.0149
Schistosoma mansoni biogenic amine receptor 0.0377 0.3897 0.474
Toxoplasma gondii DNA polymerase family B protein 0.0016 0.0043 0.0884
Loa Loa (eye worm) hypothetical protein 0.0041 0.0306 0.0469
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0103 0.0125
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0377 0.3897 0.474
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0162 0.0594
Schistosoma mansoni hypothetical protein 0.0377 0.3897 0.474
Echinococcus multilocularis rhodopsin orphan GPCR 0.0377 0.3897 0.3897
Echinococcus granulosus ryanodine receptor 44f 0.0076 0.0689 0.0838
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0324 0.0394
Onchocerca volvulus 0.0377 0.3897 1
Trypanosoma brucei unspecified product 0.0054 0.0452 0.0967
Mycobacterium tuberculosis Conserved protein 0.0041 0.0306 0.1157
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0016 0.0043 0.0043
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0099 0.0151
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0377 0.3897 0.5976
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0103 0.0103
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0027 0.0162 0.0601
Brugia malayi GnHR receptor homolog 0.0377 0.3897 0.5976
Echinococcus granulosus lamin 0.0029 0.018 0.0219
Brugia malayi G protein-coupled receptor F59B2.13 0.0377 0.3897 0.5976
Schistosoma mansoni biogenic amine (5HT) receptor 0.0377 0.3897 0.474
Onchocerca volvulus DNA polymerase homolog 0.0016 0.0043 0.0008
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.1249 0.4724
Onchocerca volvulus 0.0058 0.049 0.1165
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.006 0.0538
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0306 0.2731
Loa Loa (eye worm) hypothetical protein 0.0102 0.0964 0.1477
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0377 0.3897 0.474
Echinococcus multilocularis lamin 0.0029 0.018 0.018
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0209 0.0767
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.112 0.4145
Toxoplasma gondii LsmAD domain-containing protein 0.0058 0.0491 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0209 0.3801
Leishmania major hypothetical protein, conserved 0.0061 0.0527 0.1951
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0377 0.3897 0.474
Plasmodium falciparum thioredoxin reductase 0.0018 0.006 0.0376
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0025 0.0143 0.0521
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.111 0.4201
Brugia malayi glutathione reductase 0.0051 0.0415 0.0636
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0016 0.0043 0.0161
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.001 0.0016
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0117 0.112 0.4237
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0021 0.0025
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0209 1
Brugia malayi beta-lactamase 0.0041 0.0306 0.0469
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0103 0.0125
Brugia malayi PXA domain containing protein 0.0022 0.0103 0.0158
Echinococcus multilocularis sex peptide receptor 0.0377 0.3897 0.3897
Onchocerca volvulus 0.0377 0.3897 1
Schistosoma mansoni hypothetical protein 0.0377 0.3897 0.474
Brugia malayi G-protein coupled receptor 0.0377 0.3897 0.5976
Trypanosoma cruzi thymidine kinase, putative 0.0265 0.2702 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0324 0.6597
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Schistosoma mansoni o-linked n-acetylglucosamine transferase ogt 0.0044 0.0344 0.0419
Brugia malayi Cytochrome P450 family protein 0.0055 0.046 0.0705
Mycobacterium leprae Probable lipase LipE 0.0041 0.0306 0.245
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0306 0.1157
Schistosoma mansoni neuropeptide F-like receptor 0.0377 0.3897 0.474
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0377 0.3897 0.5976
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0103 0.0125
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0103 0.0125
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0099 0.012
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0377 0.3897 0.3897
Schistosoma mansoni adenoreceptor 0.0377 0.3897 0.474
Brugia malayi putative neuropeptide receptor NPR1 0.0377 0.3897 0.5976
Echinococcus multilocularis lysosomal alpha glucosidase 0.019 0.1907 0.1907
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0377 0.3897 0.474
Giardia lamblia Thymidine kinase 0.0265 0.2702 1
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0103 0.0125
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0158
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0324 0.1191
Schistosoma mansoni hypothetical protein 0.0449 0.4675 0.5686
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0103 0.0103
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0415 0.0505
Brugia malayi hypothetical protein 0.0377 0.3897 0.5976
Brugia malayi putative neuropeptide receptor 0.0377 0.3897 0.5976
Entamoeba histolytica DNA repair and recombination protein, putative 0.0027 0.0162 0.0594
Schistosoma mansoni growth hormone secretagogue receptor 0.0377 0.3897 0.474
Loa Loa (eye worm) ryanodine receptor 0.0029 0.0181 0.0277
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0106 0.0162
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0107 0.1014 0.1555
Echinococcus granulosus 7tm_1 domain containing protein 0.0377 0.3897 0.474
Loa Loa (eye worm) RecQ helicase 0.0023 0.0116 0.0177
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0103 0.0125
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0377 0.3897 0.5976
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0377 0.3897 0.474
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0377 0.3897 0.5976
Brugia malayi hypothetical protein 0.0377 0.3897 0.5976
Trichomonas vaginalis esterase, putative 0.0041 0.0306 0.1125
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0377 0.3897 0.5976
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0087 0.0802 0.0975
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.006 0.0228
Schistosoma mansoni myosin xvIII 0.0377 0.3897 0.474
Schistosoma mansoni ap endonuclease 0.0021 0.0099 0.012
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.006 0.0376
Onchocerca volvulus 0.0029 0.018 0.0362
Brugia malayi Cytochrome P450 family protein 0.0022 0.0106 0.0162
Echinococcus multilocularis rhodopsin orphan GPCR 0.0377 0.3897 0.3897
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0324 0.0496
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.111 0.4201
Loa Loa (eye worm) hypothetical protein 0.0058 0.0491 0.0752
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0103 0.0125
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0103 0.0125
Echinococcus granulosus G protein coupled receptor 139 0.0377 0.3897 0.474
Giardia lamblia O-linked GlcNAc transferase 0.0044 0.0339 0.1112
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.112 0.1362
Echinococcus granulosus O glycosyltransferase 0.0044 0.0344 0.0419
Schistosoma mansoni phosphoglucomutase 0.0044 0.0343 0.0418
Brugia malayi hypothetical protein 0.0377 0.3897 0.5976
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0037 0.0057
Leishmania major ATP-dependent phosphofructokinase 0.0117 0.112 0.4145
Schistosoma mansoni amine GPCR 0.0377 0.3897 0.474
Echinococcus multilocularis neuropeptide receptor 0.0377 0.3897 0.3897
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0103 0.0125
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.004 0.0141
Echinococcus multilocularis fmrfamide receptor 0.0377 0.3897 0.3897
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.006 0.0223
Onchocerca volvulus 0.0377 0.3897 1
Echinococcus granulosus neuropeptides capa receptor 0.0377 0.3897 0.474
Brugia malayi hypothetical protein 0.0377 0.3897 0.5976
Schistosoma mansoni biogenic amine receptor 0.0377 0.3897 0.474
Trypanosoma brucei ingi protein (ORF1) 0.0054 0.0452 0.0967
Schistosoma mansoni opsin-like receptor 0.0377 0.3897 0.474
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Echinococcus multilocularis rhodopsin orphan GPCR 0.0377 0.3897 0.3897
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0103 0.0158
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0209 0.4265
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.1317 0.2019
Echinococcus granulosus neuropeptide receptor 0.0377 0.3897 0.474
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.004 0.0141
Loa Loa (eye worm) UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 0.0044 0.0343 0.0525
Echinococcus multilocularis orexin receptor type 2 0.0377 0.3897 0.3897
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0209 0.4265
Schistosoma mansoni serine/threonine protein kinase 0.0262 0.2668 0.3245
Brugia malayi Dopamine receptor protein 1 0.0377 0.3897 0.5976
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0117 0.112 0.897
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0209 1
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.006 0.0215
Giardia lamblia Rrm3p helicase 0.0027 0.0162 0.0448
Brugia malayi Thioredoxin reductase 0.0051 0.0415 0.0636
Schistosoma mansoni neuropeptide receptor 0.0377 0.3897 0.474
Echinococcus granulosus rhodopsin orphan GPCR 0.0377 0.3897 0.474
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0306 0.1125
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0103 0.0125
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0016 0.0043 0.0053
Leishmania major glycosyl hydrolase-like protein 0.0016 0.004 0.0149
Echinococcus granulosus tm gpcr rhodopsin 0.0377 0.3897 0.474
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0103 0.0373
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0016 0.0043 0.0067
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0324 0.1191
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.006 0.0517
Toxoplasma gondii DNA polymerase 0.0016 0.0043 0.0884
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0377 0.3897 0.474
Echinococcus multilocularis G-protein coupled receptor, putative 0.0377 0.3897 0.3897
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.004 0.0062
Brugia malayi sulfakinin receptor protein 0.0377 0.3897 0.5976
Loa Loa (eye worm) hypothetical protein 0.0013 0.0015 0.0023
Schistosoma mansoni neuropeptide F-like receptor 0.0377 0.3897 0.474
Trypanosoma brucei RNA helicase, putative 0.0449 0.4675 1
Loa Loa (eye worm) neuropeptide F receptor 0.0377 0.3897 0.5976
Echinococcus granulosus tm gpcr rhodopsin 0.0377 0.3897 0.474
Brugia malayi hypothetical protein 0.0037 0.0271 0.0416
Schistosoma mansoni neuropeptide f receptor 76f 0.0377 0.3897 0.474
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0306 0.0372
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0377 0.3897 0.474
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0016 0.0043 0.0153
Echinococcus granulosus serotonin receptor 0.0377 0.3897 0.474
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0306 0.1125
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0064 0.0078
Echinococcus granulosus tumor protein p63 0.0395 0.4092 0.4977
Brugia malayi UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 0.0044 0.0343 0.0525
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0103 0.0125
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Echinococcus granulosus neuropeptide s receptor 0.0377 0.3897 0.474
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0306 0.1157
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0035 0.0709
Toxoplasma gondii ABC1 family protein 0.0041 0.0306 0.6234
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0377 0.3897 0.474
Schistosoma mansoni microtubule-associated protein tau 0.0781 0.8222 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0116 0.111 0.8893
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0306 0.1157
Loa Loa (eye worm) hypothetical protein 0.0029 0.018 0.0276
Echinococcus granulosus lysosomal alpha glucosidase 0.019 0.1907 0.2319
Brugia malayi RE15519p 0.0377 0.3897 0.5976
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0047 0.0375 0.7642
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0377 0.3897 0.474
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.006 0.0538
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0377 0.3897 0.3897
Trichomonas vaginalis thymidine kinase, putative 0.0265 0.2702 1
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0027 0.0162 0.0198
Trypanosoma cruzi ribonuclease H1, putative 0.0044 0.0343 0.1271
Brugia malayi G-protein coupled receptor 0.0377 0.3897 0.5976
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0103 0.0103
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0099 0.0357
Schistosoma mansoni amine GPCR 0.0377 0.3897 0.474
Schistosoma mansoni survival motor neuron protein 0.0056 0.0475 0.0577
Schistosoma mansoni opsin-like receptor 0.0377 0.3897 0.474
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0415 0.0415
Echinococcus granulosus allatostatin A receptor 0.0377 0.3897 0.474
Brugia malayi Cytochrome P450 family protein 0.0022 0.0106 0.0162
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0324 0.1198
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0027 0.0162 0.0601
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0099 0.1236
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0016 0.0043 0.0067
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Schistosoma mansoni hypothetical protein 0.0377 0.3897 0.474
Loa Loa (eye worm) beta-lactamase 0.0041 0.0306 0.0469
Brugia malayi hypothetical protein 0.0276 0.2826 0.4332
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0377 0.3897 0.3897
Onchocerca volvulus 0.0377 0.3897 1
Onchocerca volvulus 0.0377 0.3897 1
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Leishmania major trypanothione reductase 0.0051 0.0415 0.1536
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0306 0.593
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0306 0.245
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Echinococcus multilocularis g protein coupled receptor 0.0377 0.3897 0.3897
Echinococcus granulosus microtubule associated protein 2 0.0781 0.8222 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0377 0.3897 0.3897
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.0149 0.0182
Mycobacterium tuberculosis Probable reductase 0.0116 0.111 0.4201
Trichomonas vaginalis ribonuclease H1, putative 0.0044 0.0343 0.1264
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0103 0.0125
Brugia malayi hypothetical protein 0.0377 0.3897 0.5976
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.004 0.0141
Brugia malayi 6-phosphofructokinase 0.0117 0.112 0.1717
Echinococcus multilocularis rhodopsin orphan GPCR 0.0377 0.3897 0.3897
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0016 0.0043 0.0146
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.112 0.414
Echinococcus multilocularis lysosomal alpha glucosidase 0.019 0.1907 0.1907
Echinococcus multilocularis stromal cell derived factor 2 0.0017 0.0051 0.0051
Echinococcus granulosus neuropeptides capa receptor 0.0377 0.3897 0.474
Echinococcus multilocularis serotonin receptor 0.0377 0.3897 0.3897
Trichomonas vaginalis mannosyltransferase 1, putative 0.0017 0.0051 0.0181
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0148 0.1457 0.2234
Entamoeba histolytica hypothetical protein 0.0022 0.0103 0.0373
Brugia malayi hypothetical protein 0.0377 0.3897 0.5976
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.009 0.0836 0.3092
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0103 0.0125
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0016 0.0043 0.0161
Echinococcus granulosus neuropeptide Y receptor 0.0377 0.3897 0.474
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0306 0.0372
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0324 0.1191
Onchocerca volvulus Neuropeptide F receptor homolog 0.0377 0.3897 1
Brugia malayi MH2 domain containing protein 0.0135 0.1317 0.2019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0158
Echinococcus multilocularis serotonin receptor 0.0377 0.3897 0.3897
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0016 0.0043 0.0053
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0016 0.0048 0.0168
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.112 0.414
Toxoplasma gondii ribonuclease HI protein 0.0044 0.0343 0.7
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0377 0.3897 0.474
Echinococcus multilocularis g protein coupled receptor 0.0377 0.3897 0.3897
Mycobacterium tuberculosis Conserved protein 0.0041 0.0306 0.1157
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.006 0.0223
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0025 0.0143 0.0528
Brugia malayi hypothetical protein 0.0377 0.3897 0.5976
Brugia malayi hypothetical protein 0.0377 0.3897 0.5976
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0377 0.3897 0.3897
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0041 0.0306 0.0469
Schistosoma mansoni hypothetical protein 0.0056 0.0475 0.0577
Schistosoma mansoni amine GPCR 0.0377 0.3897 0.474
Onchocerca volvulus 0.0041 0.0306 0.0689
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.006 0.0228
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.112 0.1717
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0099 0.1365
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.1249 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0103 0.0103
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.004 0.0141
Brugia malayi cation channel family protein 0.0163 0.1619 0.2482
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0103 0.0103
Entamoeba histolytica hypothetical protein 0.0022 0.0103 0.0373
Brugia malayi beta-lactamase family protein 0.0041 0.0306 0.0469
Mycobacterium ulcerans beta-lactamase 0.0041 0.0306 0.2731
Echinococcus granulosus dro:myosuppressin receptor 0.0377 0.3897 0.474
Schistosoma mansoni phosphoglucomutase 0.0044 0.0343 0.0418
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0377 0.3897 0.474
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0099 0.0373
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.111 0.4201
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Trypanosoma cruzi thymidine kinase, putative 0.0265 0.2702 1
Onchocerca volvulus 0.0377 0.3897 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0377 0.3897 0.3897
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0415 0.0636
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.009 0.0836 0.1787
Brugia malayi Dopamine receptor protein 2 0.0377 0.3897 0.5976
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0209 0.3709
Schistosoma mansoni alpha-1 adrenergic receptor 0.0377 0.3897 0.474
Echinococcus granulosus ribonuclease H1 0.0044 0.0343 0.0418
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0377 0.3897 1
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.112 0.414
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0016 0.0043 0.0153
Schistosoma mansoni hypothetical protein 0.0377 0.3897 0.474
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0027 0.0162 0.0162
Echinococcus multilocularis expressed protein 0.042 0.4364 0.4364
Echinococcus multilocularis ryanodine receptor 44f 0.0076 0.0689 0.0689
Echinococcus granulosus neuropeptide FF receptor 2 0.0377 0.3897 0.474
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0099 0.0365
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.111 0.4201
Echinococcus granulosus sex peptide receptor 0.0377 0.3897 0.474
Schistosoma mansoni amine GPCR 0.0377 0.3897 0.474
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0209 0.0767
Mycobacterium ulcerans lipase LipD 0.0041 0.0306 0.2731
Mycobacterium ulcerans 6-phosphofructokinase 0.0117 0.112 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0276 0.2826 0.4332
Trichomonas vaginalis thymidine kinase, putative 0.0265 0.2702 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0377 0.3897 0.474
Toxoplasma gondii exonuclease III APE 0.0021 0.0099 0.2011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0377 0.3897 0.474
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0377 0.3897 0.474
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0058 0.0492 0.0492
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0377 0.3897 0.3897
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0377 0.3897 0.474
Echinococcus multilocularis rhodopsin orphan GPCR 0.0377 0.3897 0.3897
Brugia malayi larval opioid receptor 0.0377 0.3897 0.5976
Loa Loa (eye worm) hypothetical protein 0.0028 0.0174 0.0267
Leishmania major hypothetical protein, conserved 0.0041 0.0306 0.1132
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0209 0.0767
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0324 0.1191
Echinococcus multilocularis fmrfamide receptor 0.0377 0.3897 0.3897
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0324 0.1191
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.006 0.0223
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0324 0.1191
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0377 0.3897 0.3897
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0103 0.0103
Plasmodium vivax ataxin-2 like protein, putative 0.0058 0.0491 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0021 0.0032
Loa Loa (eye worm) glutathione reductase 0.0051 0.0415 0.0636
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0103 0.0125
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.112 0.2396
Echinococcus granulosus somatostatin receptor 0.0377 0.3897 0.474
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0103 0.0125
Onchocerca volvulus 0.0377 0.3897 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0002 0.0008
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.0103 0.0373
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0377 0.3897 0.474
Loa Loa (eye worm) hypothetical protein 0.0087 0.0802 0.1229
Echinococcus granulosus g protein coupled receptor 0.0377 0.3897 0.474
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0306 0.1157
Echinococcus granulosus survival motor neuron protein 1 0.0276 0.2826 0.3437
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0377 0.3897 0.474
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0099 0.0365
Trypanosoma brucei PAB1-binding protein , putative 0.0058 0.0491 0.1049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0066 0.0102
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Brugia malayi hypothetical protein 0.0377 0.3897 0.5976
Schistosoma mansoni hypothetical protein 0.0027 0.0162 0.0198
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0025 0.0143 0.0305
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0324 0.1191
Onchocerca volvulus 0.0377 0.3897 1
Schistosoma mansoni amine GPCR 0.0377 0.3897 0.474
Echinococcus granulosus biogenic amine 5HT receptor 0.0377 0.3897 0.474
Schistosoma mansoni hypothetical protein 0.0026 0.0149 0.0182
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.0491 1
Wolbachia endosymbiont of Brugia malayi hypothetical protein 0.0017 0.0057 0.0001
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.006 0.0092
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Schistosoma mansoni cellular tumor antigen P53 0.0058 0.049 0.0596
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0133 0.1293 0.1573
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0016 0.0043 0.0146
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0158
Leishmania major cytochrome p450-like protein 0.0022 0.0106 0.0391
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.006 0.0223
Echinococcus multilocularis raf serine:threonine protein kinase 0.0262 0.2668 0.2668
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0027 0.0162 0.0347
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0106 0.0226
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0103 0.0125
Leishmania major thymidine kinase, putative 0.0265 0.2702 1
Giardia lamblia O-linked GlcNAc transferase 0.0026 0.0145 0.0384
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0377 0.3897 0.3897
Echinococcus multilocularis rhodopsin orphan GPCR 0.0377 0.3897 0.3897
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.006 0.0129
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0103 0.0158
Loa Loa (eye worm) hypothetical protein 0.0041 0.0306 0.0469
Echinococcus granulosus neuropeptide receptor A26 0.0377 0.3897 0.474
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0103 0.0373
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Echinococcus multilocularis G protein coupled receptor 139 0.0377 0.3897 0.3897
Schistosoma mansoni neuropeptide receptor 0.0377 0.3897 0.474
Brugia malayi follicle stimulating hormone receptor 0.0622 0.6522 1
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0209 0.0624
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0025 0.0143 0.0528
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.112 0.414
Onchocerca volvulus 0.0377 0.3897 1
Plasmodium falciparum glutathione reductase 0.0051 0.0415 0.8309
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0324 0.1198
Loa Loa (eye worm) G-protein coupled receptor 0.0377 0.3897 0.5976
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0103 0.0373
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0103 0.0158
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.001 0.0016
Echinococcus multilocularis 6 phosphofructokinase 0.0117 0.112 0.112
Trypanosoma brucei trypanothione reductase 0.0051 0.0415 0.0888
Brugia malayi Tachykinin-like peptides receptor 99D 0.0377 0.3897 0.5976
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.0491 0.1816
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0099 0.0151
Loa Loa (eye worm) hypothetical protein 0.0104 0.0985 0.151
Brugia malayi 6-phosphofructokinase 0.0117 0.112 0.1717
Echinococcus granulosus neuropeptide receptor 0.0377 0.3897 0.474
Echinococcus granulosus g protein coupled receptor 0.0377 0.3897 0.474
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0103 0.0125
Schistosoma mansoni alpha-glucosidase 0.0164 0.1624 0.1975
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.006 0.1227
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Echinococcus multilocularis neuropeptide Y receptor 0.0377 0.3897 0.3897
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0016 0.0043 0.0153
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0037 0.0057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0377 0.3897 0.3897
Echinococcus multilocularis allatostatin A receptor 0.0377 0.3897 0.3897
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0106 0.0162
Echinococcus multilocularis ribonuclease H1 0.0044 0.0343 0.0343
Echinococcus granulosus rhodopsin orphan GPCR 0.0377 0.3897 0.474
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0027 0.0162 0.0601
Echinococcus multilocularis survival motor neuron protein 1 0.0276 0.2826 0.2826
Brugia malayi phosphofructokinase 0.0117 0.112 0.1717
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.006 0.0223
Mycobacterium ulcerans hypothetical protein 0.0017 0.0057 0.0507
Echinococcus granulosus tachykinin peptides receptor 99D 0.0377 0.3897 0.474
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0103 0.0158
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0103 0.0158
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0103 0.0158
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0016 0.0043 0.0093
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0415 0.157
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0209 0.0767
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0027 0.0162 0.0347
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0377 0.3897 0.474
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0054 0.0452 0.0967
Echinococcus multilocularis neuropeptide FF receptor 2 0.0377 0.3897 0.3897
Echinococcus multilocularis neuropeptide s receptor 0.0377 0.3897 0.3897
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0103 0.0125
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0016 0.0043 0.0161
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0103 0.0158
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.006 0.0121
Schistosoma mansoni ap endonuclease 0.0021 0.0099 0.012
Onchocerca volvulus 0.011 0.1049 0.2615
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0306 0.1132
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0209 0.0767
Echinococcus granulosus bloom syndrome protein 0.0023 0.0116 0.0141
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0306 0.0654
Brugia malayi beta-lactamase family protein 0.0041 0.0306 0.0469
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0377 0.3897 0.474
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0027 0.0162 0.0601
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0415 0.1536
Brugia malayi Dopamine receptor 0.0377 0.3897 0.5976
Leishmania major ribonuclease H1, putative 0.0044 0.0343 0.1271
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.006 0.0215
Echinococcus granulosus expressed protein 0.042 0.4364 0.5308
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.006 0.0223
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0377 0.3897 0.3897
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0016 0.0048 0.0096
Echinococcus multilocularis O glycosyltransferase 0.0044 0.0344 0.0344
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0306 0.1157
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0106 0.0391
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.0491 0.1816
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.004 0.0141
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0103 0.0125
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.008 0.0724 0.1773
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.006 0.0073
Echinococcus granulosus g protein coupled receptor 0.0377 0.3897 0.474
Brugia malayi intermediate filament protein 0.0029 0.018 0.0276
Echinococcus granulosus lamin dm0 0.0029 0.018 0.0219
Brugia malayi hypothetical protein 0.0058 0.0491 0.0752
Trypanosoma brucei thymidine kinase 0.0265 0.2702 0.578
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.006 0.0223
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.006 0.0063
Entamoeba histolytica hypothetical protein 0.0022 0.0103 0.0373
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.018 0.0276
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0016 0.0043 0.0053
Plasmodium falciparum thioredoxin reductase 0.0051 0.0415 0.8309
Entamoeba histolytica MIR domain protein 0.0017 0.0051 0.0181
Brugia malayi Raf kinase 0.0253 0.2571 0.3941
Brugia malayi Serotonin receptor 0.0377 0.3897 0.5976
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.006 0.1227
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0306 0.0469
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.006 0.0223
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0103 0.0125
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0622 0.6522 1
Trypanosoma brucei hypothetical protein, conserved 0.0054 0.0452 0.0967
Schistosoma mansoni ryanodine receptor 1 skeletal muscle 0.0029 0.0181 0.022
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0209 0.0767
Brugia malayi PXA domain containing protein 0.0022 0.0103 0.0158
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0044 0.0343 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0209 0.3709
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0078 0.0095
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.111 0.4201
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0016 0.0043 0.0043
Echinococcus multilocularis g protein coupled receptor 0.0377 0.3897 0.3897
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0324 0.1191
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0306 0.0372
Schistosoma mansoni neuropeptide receptor 0.0377 0.3897 0.474
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0377 0.3897 0.3897
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Onchocerca volvulus 0.0056 0.0475 0.1126
Schistosoma mansoni opsin-like receptor 0.0377 0.3897 0.474
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.006 0.0376
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0086 0.0953
Toxoplasma gondii thioredoxin reductase 0.0051 0.0415 0.8458
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0306 0.1132
Echinococcus granulosus peptide allatostatin:somatostatin 0.0377 0.3897 0.474
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0377 0.3897 0.3897
Echinococcus granulosus rhodopsin orphan GPCR 0.0377 0.3897 0.474
Schistosoma mansoni stromal cell-derived factor 2 precursor-like protein 0.0017 0.0051 0.0062
Onchocerca volvulus 0.0041 0.0306 0.0689
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0306 0.0306
Echinococcus granulosus tm gpcr rhodopsin 0.0377 0.3897 0.474
Schistosoma mansoni histamine h1 receptor 0.0377 0.3897 0.474
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0209 0.3801
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0016 0.0043 0.0053
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0099 0.0099
Brugia malayi Serotonin receptor 0.0377 0.3897 0.5976
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0377 0.3897 0.474
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0016 0.0043 0.0008
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0002 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0377 0.3897 0.474
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Loa Loa (eye worm) phosphofructokinase 0.0117 0.112 0.1717
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0016 0.0043 0.0161
Loa Loa (eye worm) hypothetical protein 0.0041 0.0306 0.0469
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0158
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.019 0.1907 0.2924
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0324 0.1191
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.112 0.1362
Brugia malayi hypothetical protein 0.0022 0.0103 0.0158
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.112 0.1717
Giardia lamblia DNA polymerase alpha subunit A 0.0049 0.0397 0.133
Echinococcus granulosus g-protein coupled receptor 0.0377 0.3897 0.474
Brugia malayi neuropeptide F receptor 0.0377 0.3897 0.5976
Brugia malayi ORL1-like opioid receptor 0.0377 0.3897 0.5976
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0016 0.0043 0.0053
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0016 0.0043 0.0053
Brugia malayi RNase H family protein 0.0044 0.0343 0.0527
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0377 0.3897 0.3897
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.004 0.0141
Brugia malayi DNA polymerase alpha catalytic subunit 0.0047 0.0375 0.0575
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0377 0.3897 0.5976
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0103 0.0103
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0103 0.0125
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.006 0.0538
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0306 0.1125
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0324 0.0496
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0475 0.0728
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Loa Loa (eye worm) MIR domain-containing protein 0.0017 0.0051 0.0078
Onchocerca volvulus 0.0377 0.3897 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0377 0.3897 0.5976
Onchocerca volvulus 0.0377 0.3897 1
Echinococcus granulosus fmrfamide receptor 0.0377 0.3897 0.474
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0377 0.3897 0.3897
Entamoeba histolytica thymidine kinase, putative 0.0265 0.2702 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.1249 0.4724
Loa Loa (eye worm) neuropeptide F receptor 0.0377 0.3897 0.5976
Brugia malayi DNA polymerase delta catalytic subunit 0.0016 0.0043 0.0067
Loa Loa (eye worm) hypothetical protein 0.008 0.0724 0.111
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0103 0.0125
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0099 0.0211
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0377 0.3897 0.5976
Echinococcus granulosus neuropeptide Y receptor 0.0377 0.3897 0.474
Echinococcus granulosus hypothetical protein 0.0377 0.3897 0.474
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0377 0.3897 0.474
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0377 0.3897 0.474
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0377 0.3897 0.3897
Echinococcus granulosus biogenic amine 5HT receptor 0.0377 0.3897 0.474
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0377 0.3897 0.474
Schistosoma mansoni ryanodine receptor related 0.0107 0.1014 0.1234
Loa Loa (eye worm) hypothetical protein 0.0076 0.0689 0.1056
Trichomonas vaginalis thymidine kinase, putative 0.0265 0.2702 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.018 0.0276
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.006 0.0129
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0209 0.1434
Brugia malayi G protein-coupled receptor 0.0377 0.3897 0.5976
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.1317 0.2019
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.006 0.0517
Brugia malayi DNA polymerase family B containing protein 0.0016 0.0043 0.0067
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.004 0.0141
Trypanosoma brucei glucosidase, putative 0.0042 0.0324 0.0692
Onchocerca volvulus 0.0377 0.3897 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0306 0.2731
Echinococcus granulosus 6 phosphofructokinase 0.0117 0.112 0.1362
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.018 0.0276
Echinococcus granulosus 7TM GPCR rhodopsin 0.0377 0.3897 0.474
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0016 0.0043 0.0093
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.112 0.414
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0209 0.4265
Loa Loa (eye worm) hypothetical protein 0.0041 0.0306 0.0469
Brugia malayi neuropeptide F receptor 0.0377 0.3897 0.5976
Loa Loa (eye worm) hypothetical protein 0.0013 0.0015 0.0023
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0116 0.0177
Echinococcus multilocularis somatostatin receptor 0.0377 0.3897 0.3897
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0016 0.0043 0.0043
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.046 0.0705
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0377 0.3897 0.474
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.006 0.0129
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0103 0.0158
Loa Loa (eye worm) hypothetical protein 0.0377 0.3897 0.5976
Echinococcus granulosus alpha 1A adrenergic receptor 0.0377 0.3897 0.474
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0306 0.1125
Mycobacterium tuberculosis Conserved protein 0.0041 0.0306 0.1157
Loa Loa (eye worm) hypothetical protein 0.0041 0.0306 0.0469
Onchocerca volvulus 0.0377 0.3897 1
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.004 0.0086
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0259 0.2643 1
Plasmodium falciparum glutathione reductase 0.0018 0.006 0.0376
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0306 0.1157
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0016 0.0043 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0162 0.0594
Echinococcus granulosus rhodopsin orphan GPCR 0.0377 0.3897 0.474
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0116 0.042
Brugia malayi RNase H family protein 0.0044 0.0343 0.0527
Plasmodium vivax glutathione reductase, putative 0.0051 0.0415 0.8333
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0103 0.0158
Onchocerca volvulus 0.0041 0.0306 0.0689
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0306 0.1125
Echinococcus multilocularis neuropeptide Y receptor 0.0377 0.3897 0.3897
Schistosoma mansoni biogenic amine receptor 0.0377 0.3897 0.474
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.006 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0103 0.0373

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.002 uM Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA ChEMBL. 21543226
Papp (ADMET) = 10 10'-6 cm/s Apparent permeability from apical to basolateral side of human Caco2 cells ChEMBL. 21543226

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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