Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Bromodomain containing protein | 0.0076 | 0.3811 | 0.3629 |
Schistosoma mansoni | polycystin 1-related | 0.0061 | 0.285 | 0.285 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0051 | 0.2229 | 0.2324 |
Schistosoma mansoni | lipoxygenase | 0.0061 | 0.285 | 0.285 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0061 | 0.285 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0164 | 0.9593 | 0.9593 |
Onchocerca volvulus | 0.0061 | 0.285 | 0.497 | |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.112 | 0.1167 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0061 | 0.285 | 0.285 |
Schistosoma mansoni | lamin | 0.0027 | 0.0652 | 0.0652 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.112 | 0.112 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.2157 | 0.2248 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0051 | 0.2229 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0051 | 0.2229 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.2229 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.285 | 0.2972 |
Brugia malayi | MAP kinase sur-1 | 0.0051 | 0.2229 | 0.1887 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0652 | 0.0652 |
Echinococcus granulosus | RUN | 0.0061 | 0.285 | 0.285 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0061 | 0.285 | 0.285 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3529 | 0.3679 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0051 | 0.2229 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0652 | 0.068 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.1241 | 0.1241 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0166 | 0.0166 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0051 | 0.2229 | 1 |
Brugia malayi | hypothetical protein | 0.0061 | 0.285 | 0.2571 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.673 | 0.7015 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0164 | 0.9593 | 0.9593 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1402 | 0.1461 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0036 | 0.1256 | 0.1256 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.1397 | 0.097 |
Echinococcus multilocularis | RUN | 0.0061 | 0.285 | 0.285 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0051 | 0.2229 | 0.2229 |
Brugia malayi | Doublecortin family protein | 0.0061 | 0.285 | 0.2571 |
Onchocerca volvulus | 0.0095 | 0.5075 | 1 | |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0061 | 0.285 | 0.285 |
Schistosoma mansoni | alpha-glucosidase | 0.0141 | 0.8101 | 0.8101 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0036 | 0.1256 | 0.0815 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.004 | 0.0042 |
Schistosoma mansoni | loxhd1 | 0.0061 | 0.285 | 0.285 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0051 | 0.2229 | 0.2229 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0164 | 0.9593 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0064 | 0.304 | 0.304 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0051 | 0.2229 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0051 | 0.2229 | 0.2229 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0051 | 0.2229 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0652 | 0.0149 |
Schistosoma mansoni | alpha-glucosidase | 0.0141 | 0.8101 | 0.8101 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0652 | 0.0652 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.1241 | 0.1241 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0652 | 0.068 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1683 | 0.1755 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0361 | 0.0361 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.2229 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0361 | 0.0361 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0061 | 0.285 | 0.285 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.285 | 0.285 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.112 | 0.0664 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0061 | 0.285 | 0.285 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0652 | 0.0149 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.006 | 0.2805 | 0.2805 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0166 | 0.0166 |
Loa Loa (eye worm) | doublecortin family protein | 0.0061 | 0.285 | 0.2972 |
Schistosoma mansoni | rab6-interacting | 0.0061 | 0.285 | 0.285 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0235 | 0.0235 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.1256 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0652 | 0.0652 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2157 | 0.2248 |
Schistosoma mansoni | alpha glucosidase | 0.0036 | 0.1256 | 0.1256 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.006 | 0.2805 | 0.2805 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0051 | 0.2229 | 0.2229 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0061 | 0.285 | 0.5 |
Echinococcus granulosus | lamin | 0.0027 | 0.0652 | 0.0652 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0166 | 0.0166 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0652 | 0.0652 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0164 | 0.9593 | 0.9593 |
Schistosoma mansoni | rab6-interacting | 0.0061 | 0.285 | 0.285 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0051 | 0.2229 | 0.2229 |
Trypanosoma brucei | protein kinase, putative | 0.0051 | 0.2229 | 1 |
Onchocerca volvulus | 0.0061 | 0.285 | 0.497 | |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.062 | 0.0646 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0036 | 0.1256 | 0.1309 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1557 | 0.1624 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.2229 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.1256 | 0.5 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0652 | 0.0652 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0361 | 0.0361 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.2157 | 0.1807 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0061 | 0.285 | 0.285 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0051 | 0.2229 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0652 | 0.0652 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0235 | 0.0245 |
Schistosoma mansoni | lamin | 0.0027 | 0.0652 | 0.0652 |
Brugia malayi | hypothetical protein | 0.0061 | 0.285 | 0.2571 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0051 | 0.2229 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0164 | 0.9593 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.673 | 0.7015 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.285 | 0.2972 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.673 | 0.6845 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0652 | 0.068 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0051 | 0.2229 | 1 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0036 | 0.1256 | 0.1256 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.2229 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.2157 | 0.1807 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.