Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cytochrome P450, putative | 0.011 | 0.3428 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.011 | 0.3428 | 1 |
Leishmania major | cytochrome p450-like protein | 0.011 | 0.3428 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.001 | 0.0013 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.001 | 0.0013 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.001 | 0.0013 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.011 | 0.3428 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0168 | 0.7466 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.011 | 0.3428 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.011 | 0.3428 | 0.4592 |
Brugia malayi | Cytochrome P450 family protein | 0.011 | 0.3428 | 0.4592 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.011 | 0.3428 | 0.4592 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.001 | 0.0013 |
Brugia malayi | Cytochrome P450 family protein | 0.011 | 0.3428 | 0.4592 |
Brugia malayi | Cytochrome P450 family protein | 0.0168 | 0.7466 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.011 | 0.3428 | 0.4592 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.8048 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.2 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.