Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1679 | 0.2501 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.6715 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0235 | 0.035 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.036 | 0.036 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.6715 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.036 | 0.036 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.036 | 0.036 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1239 | 0.1239 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0166 | 0.0166 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2798 | 0.2798 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1554 | 0.2314 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.3033 | 0.3033 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.3802 | 0.5302 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1239 | 0.1239 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.6715 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0166 | 0.0166 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1399 | 0.2083 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0166 | 0.0166 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2798 | 0.2798 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.3522 | 0.5245 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0235 | 0.0235 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.004 | 0.006 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.1394 | 0.1417 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 6.5131 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.