Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.315 | 0.296 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0841 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0272 | 0.0284 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.027 | 0.0283 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.2976 | 0.3109 |
Echinococcus multilocularis | geminin | 0.0169 | 0.9573 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.6542 | 0.6446 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.6542 | 0.6446 |
Brugia malayi | hypothetical protein | 0.0151 | 0.8462 | 0.842 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.6542 | 0.6446 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0272 | 0.0284 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1378 | 0.144 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.315 | 0.3291 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0272 | 0.0002 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.2976 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.2976 | 0.3109 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.9573 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1378 | 0.1139 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0841 | 0.0587 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.315 | 0.3291 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.2333 | 0.212 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.027 | 0.0283 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.315 | 0.3291 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.315 | 0.3291 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0272 | 0.0284 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.027 | 0.0283 |
Brugia malayi | RNA binding protein | 0.0063 | 0.315 | 0.296 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.315 | 0.296 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.9573 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.2976 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0841 | 0.2106 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.2333 | 0.212 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.027 | 0.0283 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0841 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0272 | 0.0002 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.315 | 0.3291 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.315 | 0.296 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.2976 | 0.3109 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.315 | 0.296 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1378 | 0.1139 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0272 | 0.0284 |
Echinococcus granulosus | geminin | 0.0169 | 0.9573 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0841 | 0.2106 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.027 | 0.0283 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0272 | 0.0284 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.027 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.8462 | 0.842 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.027 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0841 | 0.0587 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.2976 | 0.3109 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0841 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0841 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0272 | 0.0284 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.2976 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2333 | 0.212 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.315 | 0.3291 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.027 | 0.0283 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.315 | 0.3291 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0841 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.2976 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.027 | 0.0283 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.2976 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0272 | 0.0002 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.027 | 0.0283 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.315 | 0.296 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0301 | 0.0031 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.2333 | 0.212 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0841 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.2976 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0272 | 0.0284 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.