Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | gabp alpha | 0.0072 | 0.1418 | 0.1418 |
Echinococcus granulosus | tar DNA binding protein | 0.0199 | 0.6464 | 0.6464 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.1693 | 0.5 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0072 | 0.1418 | 0.1418 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0079 | 0.1693 | 0.1693 |
Loa Loa (eye worm) | TAR-binding protein | 0.0199 | 0.6464 | 0.6464 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.6464 | 0.6464 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0052 | 0.0599 | 0.3536 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0998 | 0.0998 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0052 | 0.0599 | 0.0749 |
Brugia malayi | Ets-domain containing protein | 0.0072 | 0.1418 | 0.1418 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.6464 | 0.6464 |
Brugia malayi | TAR-binding protein | 0.0199 | 0.6464 | 0.6464 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0052 | 0.0599 | 0.0599 |
Echinococcus multilocularis | tar DNA binding protein | 0.0199 | 0.6464 | 0.6464 |
Echinococcus granulosus | geminin | 0.0205 | 0.6708 | 0.6708 |
Brugia malayi | Fli-1 protein | 0.022 | 0.7327 | 0.7327 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0199 | 0.6464 | 0.6464 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0237 | 0.7995 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.6708 | 0.6708 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.1693 | 0.5 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0079 | 0.1693 | 0.1693 |
Loa Loa (eye worm) | fli-1 protein | 0.022 | 0.7327 | 0.7327 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0079 | 0.1693 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.1693 | 0.5 |
Schistosoma mansoni | ets-related | 0.022 | 0.7327 | 0.7327 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0079 | 0.1693 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.6708 | 0.6708 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0072 | 0.1418 | 0.1418 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.1693 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.1693 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0199 | 0.6464 | 0.6464 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.6464 | 0.6464 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.1693 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0079 | 0.1693 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.6708 | 0.6708 |
Brugia malayi | RNA binding protein | 0.0199 | 0.6464 | 0.6464 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0052 | 0.0599 | 0.0749 |
Brugia malayi | Ets-domain containing protein | 0.0072 | 0.1418 | 0.1418 |
Brugia malayi | Probable ClpP-like protease | 0.0079 | 0.1693 | 0.1693 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0072 | 0.1418 | 0.1418 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.6464 | 0.6464 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1693 | 0.1693 |
Schistosoma mansoni | tar DNA-binding protein | 0.0199 | 0.6464 | 0.6464 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0079 | 0.1693 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.1693 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0079 | 0.1693 | 0.1693 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0052 | 0.0599 | 0.0599 |
Loa Loa (eye worm) | RNA binding protein | 0.0199 | 0.6464 | 0.6464 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.