Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidase homolog | 0.0207 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0207 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0207 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0207 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0207 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0207 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0207 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0207 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0207 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0207 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0207 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0207 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0207 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0207 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0207 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0207 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0207 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0207 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0207 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0207 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0207 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0207 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0207 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0207 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0207 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 3.12 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 to 24 hrs by serial plate dilution method | ChEMBL. | 21489660 |
MIC (functional) | = 100 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 7 days by resazurin method | ChEMBL. | 21489660 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.