Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0691 | 0.5 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0691 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0691 | 0.5 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0691 | 0.5 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0691 | 0.5 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0691 | 0.5 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0691 | 0.5 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0691 | 0.5 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0691 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Agonist activity at human PXR expressed in human HepG2 cells assessed as induction of transactivation at 10 uM after 18 hrs by luciferase reporter gene assay | ChEMBL. | 21428459 | |
Activity (functional) | Partial agonist activity at human FXR expressed in human HepG2 cells assessed as induction of transactivation at 10 uM after 18 hrs by luciferase reporter gene assay | ChEMBL. | 21428459 | |
Inhibition (functional) | Antagonist activity at human FXR expressed in HepG2 cells assessed as inhibition of CDCA-induced transactivation at 10 uM after 18 hrs by luciferase reporter gene assay | ChEMBL. | 21428459 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.