Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0555 | 0.381 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0138 | 0.0758 | 0.3871 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0293 | 0.1888 | 1 |
Echinococcus granulosus | neuropeptide receptor | 0.0112 | 0.0563 | 0.1355 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.0304 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0077 | 0.0311 | 0.0258 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0094 | 0.0432 | 0.1004 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0042 | 0.0054 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.1296 | 0.1296 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0042 | 0.0054 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0067 | 0.0235 | 0.0235 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0212 | 0.1296 | 0.1249 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0138 | 0.0758 | 0.3839 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0235 | 0.048 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0293 | 0.1888 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0077 | 0.0311 | 0.1445 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0094 | 0.0432 | 0.1004 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.0304 | 0.5 |
Brugia malayi | hypothetical protein | 0.0077 | 0.0304 | 0.0251 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0077 | 0.0311 | 0.3137 |
Echinococcus multilocularis | geminin | 0.0555 | 0.381 | 1 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0521 | 0.3564 | 0.3564 |
Echinococcus multilocularis | GPCR, family 2 | 0.0067 | 0.0235 | 0.048 |
Mycobacterium leprae | putative cytochrome p450 | 0.0042 | 0.0054 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0094 | 0.0432 | 0.1004 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0077 | 0.0311 | 0.1445 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.0805 | 0.1998 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0077 | 0.0311 | 0.1445 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0094 | 0.0432 | 0.1004 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0077 | 0.0311 | 0.0311 |
Echinococcus granulosus | GPCR family 2 | 0.0067 | 0.0235 | 0.048 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0112 | 0.0563 | 0.1355 |
Brugia malayi | hypothetical protein | 0.024 | 0.15 | 0.1453 |
Echinococcus multilocularis | neuropeptide receptor | 0.0112 | 0.0563 | 0.1355 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0235 | 0.0235 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0212 | 0.1296 | 0.1249 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0138 | 0.0758 | 0.3871 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0094 | 0.0432 | 0.1004 |
Brugia malayi | Cytochrome P450 family protein | 0.0077 | 0.0311 | 0.0258 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0077 | 0.0311 | 0.0311 |
Toxoplasma gondii | hypothetical protein | 0.0047 | 0.0089 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0077 | 0.0304 | 0.0665 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0094 | 0.0432 | 0.0379 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.0958 | 0.0958 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0119 | 0.0613 | 0.0613 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0077 | 0.0304 | 0.0665 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0042 | 0.0054 | 0.0052 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0067 | 0.0235 | 0.0181 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0145 | 0.0805 | 0.0755 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0067 | 0.0235 | 0.0181 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0077 | 0.0304 | 0.0665 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0067 | 0.0235 | 0.048 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.0111 | 0.0358 |
Leishmania major | cytochrome p450-like protein | 0.0077 | 0.0311 | 0.14 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0077 | 0.0311 | 0.0311 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.0304 | 0.5 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0293 | 0.1888 | 1 |
Schistosoma mansoni | neuropeptide receptor | 0.0112 | 0.0563 | 0.1355 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0042 | 0.0054 | 0.0052 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0293 | 0.1888 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0555 | 0.381 | 1 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0521 | 0.3564 | 0.9343 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0521 | 0.3564 | 0.9343 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0521 | 0.3564 | 0.9343 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.0304 | 0.0665 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0235 | 0.048 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0094 | 0.0432 | 0.1004 |
Onchocerca volvulus | 0.0166 | 0.0958 | 0.5 | |
Loa Loa (eye worm) | cytochrome P450 | 0.0042 | 0.0054 | 0.0054 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0235 | 0.048 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0805 | 0.0805 |
Brugia malayi | Cytochrome P450 family protein | 0.0119 | 0.0613 | 0.0562 |
Echinococcus granulosus | geminin | 0.0555 | 0.381 | 1 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0042 | 0.0054 | 0.0052 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0067 | 0.0235 | 0.048 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0094 | 0.0432 | 0.0432 |
Mycobacterium ulcerans | hypothetical protein | 0.0154 | 0.0873 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0077 | 0.0304 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0094 | 0.0432 | 0.1004 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0154 | 0.0873 | 1 |
Brugia malayi | hypothetical protein | 0.0166 | 0.0958 | 0.0909 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0067 | 0.0235 | 0.048 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0067 | 0.0235 | 0.048 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0212 | 0.1296 | 0.1296 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0235 | 0.048 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 2 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 | ChEMBL. | 21515052 |
MIC (functional) | > 128 ug ml-1 | Antibacterial activity against Extended spectrum beta-lactamase producing Escherichia coli 08-5 | ChEMBL. | 21515052 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.