Detailed information for compound 1517056

Basic information

Technical information
  • TDR Targets ID: 1517056
  • Name: N-(4-chloro-2-methoxy-5-methylphenyl)-2-(3-ox o-2-phenylpyrazolo[5,4-b]pyridin-1-yl)acetami de
  • MW: 422.864 | Formula: C22H19ClN4O3
  • H donors: 1 H acceptors: 3 LogP: 4.16 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(Cl)c(cc1NC(=O)Cn1c2ncccc2c(=O)n1c1ccccc1)C
  • InChi: 1S/C22H19ClN4O3/c1-14-11-18(19(30-2)12-17(14)23)25-20(28)13-26-21-16(9-6-10-24-21)22(29)27(26)15-7-4-3-5-8-15/h3-12H,13H2,1-2H3,(H,25,28)
  • InChiKey: SYNKBABATBSLDV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-chloro-2-methoxy-5-methyl-phenyl)-2-(3-oxo-2-phenyl-pyrazolo[5,4-b]pyridin-1-yl)acetamide
  • N-(4-chloro-2-methoxy-5-methylphenyl)-2-(3-oxo-2-phenyl-1-pyrazolo[5,4-b]pyridinyl)acetamide
  • N-(4-chloro-2-methoxy-5-methyl-phenyl)-2-(3-keto-2-phenyl-pyrazolo[5,4-b]pyridin-1-yl)acetamide
  • N-(4-chloro-2-methoxy-5-methyl-phenyl)-2-(3-oxo-2-phenyl-pyrazolo[5,4-b]pyridin-1-yl)ethanamide
  • G024-1204
  • NCGC00128480-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0604 0.4297 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0295 0.1206 0.1209
Toxoplasma gondii cathepsin CPL 0.0557 0.383 1
Trypanosoma cruzi cysteine peptidase, putative 0.0604 0.4297 0.9187
Brugia malayi Papain family cysteine protease containing protein 0.0295 0.1206 0.1318
Onchocerca volvulus 0.0557 0.383 0.7596
Trypanosoma cruzi cysteine proteinase, putative 0.0295 0.1206 0.2509
Schistosoma mansoni cathepsin s 0.0179 0.0045 0.0045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0557 0.383 1
Leishmania major cathepsin L-like protease 0.0557 0.383 0.8565
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0557 0.383 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0557 0.383 1
Entamoeba histolytica cysteine protease, putative 0.0295 0.1206 0.0279
Entamoeba histolytica cysteine proteinase, putative 0.0557 0.383 1
Trypanosoma brucei antigen, putative 0.0411 0.2367 0.4068
Echinococcus granulosus calpain A 0.0411 0.2367 0.2367
Trypanosoma brucei calpain-like protein, putative 0.0411 0.2367 0.4068
Echinococcus granulosus cysteine protease 0.0295 0.1206 0.1206
Echinococcus multilocularis cysteine protease 0.0557 0.383 0.383
Echinococcus multilocularis calpain 7 (C02 family) 0.0411 0.2367 0.2367
Entamoeba histolytica cysteine proteinase, putative 0.0295 0.1206 0.0279
Leishmania major cathepsin L-like protease 0.0557 0.383 0.8565
Brugia malayi calpain 5 0.0287 0.1131 0.1235
Echinococcus granulosus cathepsin b 0.0641 0.4674 0.4674
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.1206 0.0502
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0411 0.2367 0.4068
Loa Loa (eye worm) hypothetical protein 0.0378 0.2041 0.223
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0604 0.4297 1
Trypanosoma cruzi cysteine proteinase, putative 0.0295 0.1206 0.2509
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0604 0.4297 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0557 0.383 0.383
Brugia malayi cathepsin F-like cysteine proteinase 0.0179 0.0045 0.0049
Echinococcus multilocularis cysteine protease 0.0557 0.383 0.383
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0604 0.4297 1
Loa Loa (eye worm) hypothetical protein 0.0641 0.4674 0.5105
Brugia malayi Cathepsin L-like precursor 0.0557 0.383 0.4185
Entamoeba histolytica cysteine protease, putative 0.0295 0.1206 0.0279
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1171 0.9977 1
Trypanosoma brucei calpain-like protein, putative 0.0411 0.2367 0.4068
Onchocerca volvulus Cathepsin F homolog 0.0557 0.383 0.7596
Schistosoma mansoni calpain C (C02 family) 0.0411 0.2367 0.2372
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0411 0.2367 0.5016
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0557 0.383 0.383
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0557 0.383 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0557 0.383 0.383
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0295 0.1206 0.0587
Brugia malayi Cathepsin L-like precursor 0.0179 0.0045 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0557 0.383 1
Trypanosoma brucei kinesin, putative 0.0287 0.1131 0.0271
Entamoeba histolytica cysteine protease, putative 0.0295 0.1206 0.0279
Schistosoma mansoni cathepsin F (C01 family) 0.0557 0.383 0.3839
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0557 0.383 1
Brugia malayi calpain family protein 1 0.1089 0.9154 1
Loa Loa (eye worm) hypothetical protein 0.0179 0.0045 0.0049
Brugia malayi Cathepsin L-like precursor 0.0557 0.383 0.4185
Schistosoma mansoni calpain-7 (C02 family) 0.0411 0.2367 0.2372
Entamoeba histolytica cysteine protease, putative 0.0295 0.1206 0.0279
Plasmodium vivax vivapain-1 0.0295 0.1206 0.3068
Loa Loa (eye worm) hypothetical protein 0.0678 0.5043 0.5509
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0411 0.2367 0.5016
Trypanosoma cruzi cysteine peptidase, putative 0.0604 0.4297 0.9187
Echinococcus multilocularis calpain family protein 1, d 0.0801 0.6279 0.6279
Loa Loa (eye worm) hypothetical protein 0.0378 0.2041 0.223
Leishmania major cathepsin L-like protease 0.0557 0.383 0.8565
Entamoeba histolytica cysteine protease, putative 0.0295 0.1206 0.0279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0557 0.383 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0641 0.4674 0.4684
Entamoeba histolytica cysteine protease, putative 0.0295 0.1206 0.0279
Brugia malayi cathepsin B-like cysteine proteinase 0.0641 0.4674 0.5105
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0179 0.0045 0.0049
Onchocerca volvulus 0.0378 0.2041 0.4048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0604 0.4297 1
Entamoeba histolytica cysteine proteinase 2 0.0295 0.1206 0.0279
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0411 0.2367 0.5016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0378 0.2041 0.3582
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.1206 0.0502
Brugia malayi Cathepsin L-like precursor 0.0378 0.2041 0.223
Onchocerca volvulus 0.0557 0.383 0.7596
Leishmania major cathepsin L-like protease 0.0557 0.383 0.8565
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0557 0.383 1
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0411 0.2367 0.4068
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0411 0.2367 0.5016
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0411 0.2367 0.5016
Echinococcus multilocularis hypothetical protein 0.0411 0.2367 0.2367
Trypanosoma cruzi cruzipain precursor, putative 0.0604 0.4297 0.9187
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0557 0.383 1
Onchocerca volvulus 0.0557 0.383 0.7596
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0557 0.383 0.4185
Echinococcus granulosus cathepsin l cysteine peptidase 0.0557 0.383 0.383
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0411 0.2367 0.4068
Giardia lamblia Cathepsin B precursor 0.0278 0.1043 0.5
Loa Loa (eye worm) cysteine protease 0.0557 0.383 0.4185
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0557 0.383 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0278 0.1043 0.2156
Entamoeba histolytica cysteine proteinase, putative 0.0295 0.1206 0.0279
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0641 0.4674 0.4684
Leishmania major cathepsin L-like protease 0.0604 0.4297 1
Loa Loa (eye worm) hypothetical protein 0.1089 0.9154 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0604 0.4297 1
Loa Loa (eye worm) hypothetical protein 0.0801 0.6279 0.6859
Loa Loa (eye worm) hypothetical protein 0.0378 0.2041 0.223
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0604 0.4297 1
Trypanosoma brucei calpain-like protein, putative 0.0411 0.2367 0.4068
Entamoeba histolytica cysteine proteinase 1, putative 0.0295 0.1206 0.0279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0557 0.383 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0411 0.2367 0.4068
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.1171 0.9977 0.9977
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0295 0.1206 0.1209
Echinococcus granulosus calpain 5 0.0411 0.2367 0.2367
Echinococcus granulosus cathepsin L 0.0295 0.1206 0.1206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0557 0.383 1
Echinococcus granulosus cathepsin l1 0.0378 0.2041 0.2041
Leishmania major cysteine peptidase A (CPA) 0.0557 0.383 0.8565
Brugia malayi Cathepsin L-like precursor 0.0557 0.383 0.4185
Loa Loa (eye worm) ctsf protein 0.0557 0.383 0.4185
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0641 0.4674 1
Entamoeba histolytica cysteine proteinase, putative 0.0378 0.2041 0.3372
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0295 0.1206 0.1209
Plasmodium vivax vivapain-3 0.0295 0.1206 0.3068
Brugia malayi Cathepsin L-like precursor 0.0378 0.2041 0.223
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0604 0.4297 1
Echinococcus multilocularis cathepsin L 0.0295 0.1206 0.1206
Brugia malayi Cathepsin L-like precursor 0.0557 0.383 0.4185
Leishmania major kinesin, putative 0.0287 0.1131 0.0271
Loa Loa (eye worm) hypothetical protein 0.0965 0.7918 0.865
Echinococcus granulosus cathepsin l1 0.0557 0.383 0.383
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1171 0.9977 1
Leishmania major cathepsin L-like protease 0.0604 0.4297 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0179 0.0045 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0557 0.383 1
Onchocerca volvulus Cathepsin L homolog 0.0557 0.383 0.7596
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0557 0.383 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0604 0.4297 1
Loa Loa (eye worm) hypothetical protein 0.0179 0.0045 0.0049
Onchocerca volvulus 0.0557 0.383 0.7596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0557 0.383 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0557 0.383 1
Echinococcus multilocularis calpain 5 0.0411 0.2367 0.2367
Entamoeba histolytica cysteine protease, putative 0.0295 0.1206 0.0279
Trypanosoma cruzi cysteine peptidase, putative 0.0295 0.1206 0.2509
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0557 0.383 1
Entamoeba histolytica cysteine proteinase, putative 0.0295 0.1206 0.0279
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0411 0.2367 0.5016
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0411 0.2367 0.5016
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0411 0.2367 0.4068
Trypanosoma cruzi cysteine peptidase, putative 0.0604 0.4297 0.9187
Brugia malayi Cathepsin L-like precursor 0.0557 0.383 0.4185
Brugia malayi calpain family protein 1 0.1089 0.9154 1
Plasmodium vivax vivapain-2 0.0557 0.383 1
Entamoeba histolytica cysteine protease, putative 0.0295 0.1206 0.0279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0557 0.383 1
Schistosoma mansoni cathepsin F (C01 family) 0.0378 0.2041 0.2046
Plasmodium vivax vivapain-2 0.0557 0.383 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0557 0.383 0.4185
Plasmodium falciparum cysteine proteinase falcipain 3 0.0557 0.383 1
Giardia lamblia Cathepsin B precursor 0.0278 0.1043 0.5
Schistosoma mansoni Mername-AA248 (C02 family) 0.0411 0.2367 0.2372
Plasmodium vivax calpain, putative 0.0411 0.2367 0.6133
Loa Loa (eye worm) calpain 5 0.0287 0.1131 0.1235
Onchocerca volvulus 0.0557 0.383 0.7596
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0411 0.2367 0.5016
Plasmodium vivax unspecified product 0.0295 0.1206 0.3068
Echinococcus multilocularis cathepsin L cysteine protease 0.0557 0.383 0.383
Echinococcus granulosus cathepsin L cysteine protease 0.0295 0.1206 0.1206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0295 0.1206 0.0587
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0557 0.383 1
Onchocerca volvulus 0.0557 0.383 0.7596
Trypanosoma cruzi cysteine peptidase, putative 0.0557 0.383 0.8179
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0411 0.2367 0.5016
Leishmania major cathepsin L-like protease 0.0604 0.4297 1
Loa Loa (eye worm) cathepsin B 0.0278 0.1043 0.1139
Onchocerca volvulus 0.0557 0.383 0.7596
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0557 0.383 1
Schistosoma mansoni calpain (C02 family) 0.0411 0.2367 0.2372
Trypanosoma brucei calpain-like protein, putative 0.0411 0.2367 0.4068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0604 0.4297 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0378 0.2041 0.3582
Entamoeba histolytica cysteine protease, putative 0.0295 0.1206 0.0279
Loa Loa (eye worm) fibroinase 0.0557 0.383 0.4185
Leishmania major cathepsin L-like protease 0.0557 0.383 0.8565
Echinococcus granulosus calpain 7 C02 family 0.0411 0.2367 0.2367
Entamoeba histolytica cysteine protease, putative 0.0295 0.1206 0.0279
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0278 0.1043 0.1045
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.1171 0.9977 0.9977
Loa Loa (eye worm) hypothetical protein 0.0557 0.383 0.4185
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0641 0.4674 0.4684
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1089 0.9154 0.9176
Schistosoma mansoni cathepsin F (C01 family) 0.0557 0.383 0.3839
Entamoeba histolytica cysteine proteinase, putative 0.0557 0.383 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0557 0.383 1
Entamoeba histolytica cysteine protease, putative 0.0295 0.1206 0.0279
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0641 0.4674 0.4684
Brugia malayi cathepsin L-like precursor 0.0378 0.2041 0.223
Brugia malayi calpain 7 0.0411 0.2367 0.2585
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0295 0.1206 0.2509
Onchocerca volvulus 0.0678 0.5043 1
Onchocerca volvulus Cathepsin L homolog 0.0557 0.383 0.7596
Brugia malayi Papain family cysteine protease containing protein 0.0295 0.1206 0.1318
Entamoeba histolytica cysteine protease, putative 0.0295 0.1206 0.0279
Schistosoma mansoni calpain-7 (C02 family) 0.0411 0.2367 0.2372
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0557 0.383 1
Echinococcus multilocularis calpain 0.0411 0.2367 0.2367
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0557 0.383 1
Entamoeba histolytica cysteine proteinase, putative 0.0295 0.1206 0.0279
Trypanosoma cruzi kinesin, putative 0.0287 0.1131 0.2346
Brugia malayi Papain family cysteine protease containing protein 0.0557 0.383 0.4185
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0557 0.383 1
Loa Loa (eye worm) calpain 0.0411 0.2367 0.2585
Loa Loa (eye worm) hypothetical protein 0.0179 0.0045 0.0049
Giardia lamblia Cathepsin B precursor 0.0278 0.1043 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0557 0.383 1
Echinococcus granulosus cathepsin b 0.0641 0.4674 0.4674
Echinococcus multilocularis cathepsin b 0.0641 0.4674 0.4674
Brugia malayi Cathepsin L-like cysteine proteinase 0.0378 0.2041 0.223
Echinococcus granulosus cathepsin L cysteine proteinase 0.0557 0.383 0.383
Loa Loa (eye worm) calpain family protein 1 0.1089 0.9154 1
Trypanosoma cruzi cysteine protease, putative 0.0295 0.1206 0.2509
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0557 0.383 1
Trypanosoma cruzi kinesin, putative 0.0287 0.1131 0.2346
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0604 0.4297 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0557 0.383 1
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0411 0.2367 0.5016
Entamoeba histolytica cysteine protease, putative 0.0295 0.1206 0.0279
Loa Loa (eye worm) calpain family protein 1 0.0801 0.6279 0.6859
Echinococcus granulosus calpain 0.0411 0.2367 0.2367
Brugia malayi Cathepsin L-like precursor 0.0557 0.383 0.4185
Echinococcus multilocularis cathepsin b 0.0641 0.4674 0.4674
Entamoeba histolytica cysteine protease, putative 0.0557 0.383 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0425 0.2508 0.5322

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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