Detailed information for compound 151735

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 568.062 | Formula: C33H30ClN3O4
  • H donors: 1 H acceptors: 2 LogP: 5.3 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1C[C@H]2COCCN2Cc2c1cccc2)c1ccccc1
  • InChi: 1S/C33H30ClN3O4/c1-40-26-12-14-27(22-7-3-2-4-8-22)29(18-26)32(38)35-24-11-13-28(30(34)17-24)33(39)37-20-25-21-41-16-15-36(25)19-23-9-5-6-10-31(23)37/h2-14,17-18,25H,15-16,19-21H2,1H3,(H,35,38)/t25-/m0/s1
  • InChiKey: XBABFSDKCCDEJN-VWLOTQADSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens arginine vasopressin receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase seto7 0.0071 0.0334 0.0592
Brugia malayi proprotein convertase 2 0.056 0.3473 0.3471
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.007 0.0085
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0038 0.0126 0.437
Brugia malayi nuclear hormone receptor 0.003 0.0073 0.007
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Trypanosoma brucei RNA helicase, putative 0.0597 0.3708 1
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0038 0.0126 0.6337
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0211 0.1231 0.3664
Onchocerca volvulus 0.0062 0.0278 0.1167
Onchocerca volvulus Putative endochitinase 0.0074 0.0354 0.1593
Schistosoma mansoni biogenic amine receptor 0.0029 0.007 0.0118
Onchocerca volvulus 0.0036 0.0111 0.0233
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.0111
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.007 0.0118
Trichomonas vaginalis cyclin B3, putative 0.0031 0.0079 0.0225
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.0111
Toxoplasma gondii subtilisin SUB6 0.0038 0.0126 0.3704
Toxoplasma gondii subtilisin SUB1 0.0038 0.0126 0.3704
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0073 0.009
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.007 0.0085
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.016 0.0906 0.0903
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.1234 0.7787 1
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0172 0.0987 0.2935
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0079 0.0225
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Brugia malayi sulfakinin receptor protein 0.0029 0.007 0.0066
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0073 0.007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.007 0.0085
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0111 0.0108
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.007 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0073 0.007
Brugia malayi celfurPC protein 0.0719 0.4491 0.4489
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0079 0.0204
Trichomonas vaginalis cyclins, putative 0.0049 0.0197 0.0577
Loa Loa (eye worm) subtilase 0.0038 0.0126 0.0126
Echinococcus granulosus G protein coupled receptor kinase 1 0.0088 0.0446 0.0568
Echinococcus granulosus histone lysine n methyltransferase setd8 0.0071 0.0334 0.0425
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0511 0.0908
Toxoplasma gondii rhoptry neck protein RON9 0.0062 0.0278 0.8283
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.007 0.0085
Loa Loa (eye worm) melatonin receptor type 1A 0.0029 0.007 0.007
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0038 0.0126 0.437
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0029 0.007 0.0085
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0036 0.0111 0.0111
Echinococcus granulosus alpha 1A adrenergic receptor 0.0029 0.007 0.0085
Echinococcus granulosus Furin 1 0.0211 0.1231 0.1578
Giardia lamblia High cysteine membrane protein Group 2 0.0331 0.2005 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0073 0.009
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Echinococcus granulosus cyclin B3 1 0.0031 0.0079 0.0097
Trichomonas vaginalis cyclins, putative 0.0026 0.0048 0.0131
Echinococcus granulosus cyclins 0.0031 0.0079 0.0097
Schistosoma mansoni biogenic amine receptor 0.0029 0.007 0.0118
Echinococcus multilocularis serotonin receptor 0.0029 0.007 0.0085
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.007 0.0118
Loa Loa (eye worm) hypothetical protein 0.003 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.0172 0.0987 0.1759
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.007 0.0085
Brugia malayi G-protein coupled receptor 0.0029 0.007 0.0066
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.007 0.0085
Echinococcus granulosus orexin receptor type 2 0.0029 0.007 0.0085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.007 0.0085
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0142 0.0375
Schistosoma mansoni amine GPCR 0.0029 0.007 0.0118
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.0111
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.007 0.0085
Echinococcus multilocularis membrane bound transcription factor site 1 0.0038 0.0126 0.0157
Echinococcus multilocularis neuropeptide s receptor 0.0029 0.007 0.0085
Echinococcus multilocularis cyclin B3 1 0.0031 0.0079 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0073 0.007
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0029 0.007 0.0085
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0111 0.0108
Entamoeba histolytica cyclin family protein 0.0031 0.0079 0.2152
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Loa Loa (eye worm) cyclin domain-containing protein 0.0031 0.0079 0.0079
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0016 0.0428
Toxoplasma gondii subtilisin SUB7 0.0038 0.0126 0.3704
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0038 0.0126 0.437
Schistosoma mansoni amine GPCR 0.0029 0.007 0.0118
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0038 0.0126 0.437
Brugia malayi hypothetical protein 0.0062 0.0278 0.0274
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.007 0.0118
Brugia malayi ecdysteroid receptor 0.003 0.0073 0.007
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0142 0.0178
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0029 0.007 0.0066
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0038 0.0126 0.0157
Toxoplasma gondii subtilisin SUB12 0.0038 0.0126 0.3704
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0004 0.5
Echinococcus granulosus neuropeptide FF receptor 2 0.0029 0.007 0.0085
Toxoplasma gondii subtilisin SUB9 0.0038 0.0126 0.3704
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0892 0.5596 1
Echinococcus multilocularis fmrfamide receptor 0.0029 0.007 0.0085
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.035 0.2123 0.2123
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0142 0.0375
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0073 0.0073
Echinococcus multilocularis GPCR, family 2 0.016 0.0906 0.116
Echinococcus multilocularis neuropeptide FF receptor 2 0.0029 0.007 0.0085
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.007 0.0085
Loa Loa (eye worm) hypothetical protein 0.1579 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0073 0.0073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.007 0.0118
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0029 0.007 0.0085
Echinococcus multilocularis cyclins 0.0031 0.0079 0.0097
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0211 0.1231 0.3664
Echinococcus multilocularis neuropeptide receptor 0.0029 0.007 0.0085
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0542 0.3355 0.4306
Schistosoma mansoni histamine h1 receptor 0.0029 0.007 0.0118
Plasmodium falciparum subtilisin-like protease 1 0.0038 0.0126 0.3704
Mycobacterium ulcerans chitinase/cellulase 0.0063 0.0284 1
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0038 0.0126 0.0219
Plasmodium vivax thrombospondin-related anonymous protein 0.0036 0.0111 0.3257
Echinococcus granulosus cyclins 0.0031 0.0079 0.0097
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0079 0.0204
Echinococcus multilocularis c4b binding protein beta chain 0.0062 0.0278 0.0352
Brugia malayi neuroendocrine convertase 1 precursor 0.056 0.3473 0.3471
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0803 0.5026 0.6452
Echinococcus granulosus beta-adrenergic receptor kinase 0.0098 0.0511 0.0652
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Onchocerca volvulus Putative endochitinase 0.0074 0.0354 0.1593
Onchocerca volvulus 0.003 0.0073 0.002
Trichomonas vaginalis cyclin A, putative 0.0049 0.0197 0.0577
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.007 0.0118
Schistosoma mansoni hypothetical protein 0.016 0.0906 0.1614
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0142 0.0375
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.0111
Brugia malayi hypothetical protein 0.0029 0.007 0.0066
Echinococcus granulosus membrane bound transcription factor site 1 0.0038 0.0126 0.0157
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0211 0.1231 0.3664
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.0111
Brugia malayi Tachykinin-like peptides receptor 99D 0.0029 0.007 0.0066
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0029 0.007 0.0118
Echinococcus granulosus C type lectin domian containing protein 0.0062 0.0278 0.0352
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0062 0.0278 0.0278
Echinococcus multilocularis cyclins 0.0031 0.0079 0.0097
Toxoplasma gondii histone lysine methyltransferase SET8 0.0071 0.0334 1
Schistosoma mansoni hypothetical protein 0.0307 0.1851 0.3304
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0029 0.007 0.0085
Echinococcus multilocularis cyclins 0.0031 0.0079 0.0097
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Giardia lamblia G2/mitotic-specific cyclin B 0.0049 0.0197 0.0966
Brugia malayi Cyclin, N-terminal domain containing protein 0.0049 0.0197 0.0193
Echinococcus multilocularis G-protein coupled receptor, putative 0.0029 0.007 0.0085
Loa Loa (eye worm) microfilarial chitinase 0.0063 0.0284 0.0284
Schistosoma mansoni hypothetical protein 0.016 0.0906 0.1614
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0211 0.1231 0.3664
Toxoplasma gondii subtilisin SUB8 0.0038 0.0126 0.3704
Mycobacterium leprae Possible secreted protease 0.0038 0.0126 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0987 0.2935
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0111 0.0108
Loa Loa (eye worm) hypothetical protein 0.0062 0.0278 0.0278
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0111 0.3257
Echinococcus granulosus dna polymerase kappa 0.0041 0.0142 0.0178
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0142 0.0375
Echinococcus granulosus peptide allatostatin:somatostatin 0.0029 0.007 0.0085
Trypanosoma cruzi cyclin, putative 0.0049 0.0197 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0126 0.0366
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0126 0.0366
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.007 0.0085
Onchocerca volvulus 0.0062 0.0278 0.1167
Treponema pallidum hypothetical protein 0.0036 0.0111 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Plasmodium vivax SUMO-conjugating enzyme UBC9, putative 0.0025 0.0042 0.1161
Mycobacterium ulcerans chitinase/cellulase 0.0063 0.0284 1
Schistosoma mansoni hypothetical protein 0.0036 0.0111 0.0193
Brugia malayi Dopamine receptor 0.0029 0.007 0.0066
Echinococcus multilocularis thyroid hormone receptor alpha 0.0154 0.0872 0.1116
Trichomonas vaginalis cyclin B, putative 0.0049 0.0197 0.0577
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0029 0.007 0.0118
Plasmodium falciparum SET domain protein, putative 0.0071 0.0334 1
Trypanosoma brucei subtilisin peptidase 0.0038 0.0126 0.0331
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0737 0.4607 0.5915
Plasmodium falciparum thrombospondin-related anonymous protein 0.0036 0.0111 0.3257
Plasmodium falciparum subtilisin-like protease 2 0.0038 0.0126 0.3704
Loa Loa (eye worm) hypothetical protein 0.016 0.0906 0.0906
Giardia lamblia Cyclin A 0.0031 0.0079 0.0376
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0036 0.0111 0.0108
Brugia malayi Latrophilin receptor protein 2 0.016 0.0906 0.0903
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.068 0.087
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0542 0.3355 0.4306
Schistosoma mansoni hypothetical protein 0.0125 0.068 0.121
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0211 0.1231 0.2196
Trichomonas vaginalis cyclin D, putative 0.0031 0.0079 0.0225
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0142 0.0375
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.0111
Plasmodium vivax apical sushi protein, putative 0.0062 0.0278 0.8283
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0036 0.0111 0.0322
Brugia malayi Sushi domain 0.0062 0.0278 0.0274
Plasmodium vivax subtilisin-like serine protease, putative 0.0038 0.0126 0.3704
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0073 0.0125
Trichomonas vaginalis cyclin B, putative 0.0049 0.0197 0.0577
Schistosoma mansoni opsin-like receptor 0.0029 0.007 0.0118
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0098 0.0511 0.0511
Brugia malayi hypothetical protein 0.0062 0.0278 0.0274
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.007 0.0085
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0073 0.0125
Brugia malayi hypothetical protein 0.0029 0.007 0.0066
Trypanosoma brucei mitotic cyclin 6 0.0049 0.0197 0.0522
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0987 0.2935
Loa Loa (eye worm) hypothetical protein 0.0062 0.0278 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0987 0.2935
Echinococcus multilocularis cyclin B 0.0049 0.0197 0.0248
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.007 0.0085
Treponema pallidum 76K protein 0.0036 0.0111 1
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0073 0.007
Brugia malayi putative neuropeptide receptor NPR1 0.0029 0.007 0.0066
Brugia malayi polk-prov protein 0.0031 0.0079 0.0076
Echinococcus granulosus cyclins 0.0031 0.0079 0.0097
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Trichomonas vaginalis cyclins, putative 0.0049 0.0197 0.0577
Echinococcus multilocularis g protein coupled receptor 0.0029 0.007 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0073 0.0073
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0029 0.007 0.007
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0073 0.0125
Echinococcus granulosus cyclin b3 0.0031 0.0079 0.0097
Schistosoma mansoni adenoreceptor 0.0029 0.007 0.0118
Trypanosoma cruzi subtilisin peptidase 0.0038 0.0126 0.6337
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0073 0.009
Schistosoma mansoni thyroid hormone receptor 0.0154 0.0872 0.1553
Brugia malayi endoprotease bli-4 precursor 0.0892 0.5596 0.5595
Echinococcus multilocularis ubiquitin conjugating enzyme e2 i 0.0025 0.0042 0.0049
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0029 0.007 0.007
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0029 0.007 0.007
Brugia malayi Dopamine receptor protein 2 0.0029 0.007 0.0066
Echinococcus granulosus neuropeptide receptor 0.0029 0.007 0.0085
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.007 0.0085
Echinococcus multilocularis 0.0719 0.4491 0.5765
Loa Loa (eye worm) hypothetical protein 0.0062 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0111 0.0108
Onchocerca volvulus Putative endochitinase 0.0074 0.0354 0.1593
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0987 0.2935
Echinococcus multilocularis cyclins 0.0031 0.0079 0.0097
Brugia malayi hypothetical protein 0.0029 0.007 0.0066
Echinococcus multilocularis cyclins 0.0031 0.0079 0.0097
Trypanosoma cruzi cyclin, putative 0.0049 0.0197 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0505 0.3119 0.3116
Schistosoma mansoni amine GPCR 0.0029 0.007 0.0118
Schistosoma mansoni opsin-like receptor 0.0029 0.007 0.0118
Brugia malayi Protein set-1 0.0071 0.0334 0.0331
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0542 0.3355 1
Schistosoma mansoni hypothetical protein 0.0036 0.0111 0.0193
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0073 0.009
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.016 0.0906 0.116
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0036 0.0111 0.0138
Loa Loa (eye worm) hypothetical protein 0.0031 0.0079 0.0079
Echinococcus granulosus 7TM GPCR rhodopsin 0.0029 0.007 0.0085
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0029 0.007 0.0118
Entamoeba histolytica hypothetical protein 0.0036 0.0111 0.308
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0029 0.007 0.0085
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0073 0.009
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0062 0.0278 0.0278
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0025 0.0042 0.1098
Loa Loa (eye worm) TYRA-2 protein 0.0029 0.007 0.007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Loa Loa (eye worm) endoprotease bli-4 0.0892 0.5596 0.5596
Schistosoma mansoni nuclear hormone receptor 0.003 0.0073 0.0125
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0029 0.007 0.0085
Echinococcus granulosus furin 0.0892 0.5596 0.7185
Brugia malayi hypothetical protein 0.0029 0.007 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0073 0.007
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.007 0.0085
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Echinococcus multilocularis protein will die slowly 0.0307 0.1851 0.2374
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0073 0.0125
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0073 0.009
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.007 0.0085
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0111 0.0108
Loa Loa (eye worm) hypothetical protein 0.0063 0.0284 0.0284
Schistosoma mansoni cyclin B3 0.0031 0.0079 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0987 0.2935
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0031 0.0079 0.0097
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0172 0.0987 0.2935
Loa Loa (eye worm) hypothetical protein 0.0345 0.2095 0.2095
Schistosoma mansoni myosin xvIII 0.0029 0.007 0.0118
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0038 0.0126 0.0123
Echinococcus granulosus neuropeptide receptor A26 0.0029 0.007 0.0085
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0073 0.009
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0025 0.0042 0.1098
Schistosoma mansoni hypothetical protein 0.0029 0.007 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0126 0.0366
Onchocerca volvulus 0.0062 0.0278 0.1167
Leishmania major DNA polymerase kappa, putative 0.0021 0.0016 0.0343
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0029 0.007 0.0118
Echinococcus multilocularis allatostatin A receptor 0.0029 0.007 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0142 0.0375
Brugia malayi Zona pellucida-like domain containing protein 0.0036 0.0111 0.0108
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Echinococcus granulosus cyclins 0.0031 0.0079 0.0097
Trichomonas vaginalis cyclin B, putative 0.0049 0.0197 0.0577
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0511 0.0908
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0073 0.0073
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0029 0.007 0.0085
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0029 0.007 0.0066
Brugia malayi AKH receptor 0.0029 0.007 0.0066
Schistosoma mansoni hypothetical protein 0.0597 0.3708 0.6624
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0029 0.007 0.0118
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0029 0.007 0.0066
Echinococcus multilocularis g protein coupled receptor 0.0029 0.007 0.0085
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0111 0.0108
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Echinococcus granulosus collagen alpha 1VII chain 0.0036 0.0111 0.0138
Schistosoma mansoni furin-1 (S08 family) 0.0388 0.2368 0.4227
Loa Loa (eye worm) latrophilin receptor protein 2 0.016 0.0906 0.0906
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0016 0.0032
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.007 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0073 0.007
Echinococcus granulosus g protein coupled receptor 0.0029 0.007 0.0085
Echinococcus multilocularis C type lectin domian containing protein 0.0062 0.0278 0.0352
Brugia malayi hypothetical protein 0.0029 0.007 0.0066
Echinococcus multilocularis G protein coupled receptor 139 0.0029 0.007 0.0085
Giardia lamblia UBC3 0.0025 0.0042 0.0192
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.007 0.0085
Mycobacterium tuberculosis Possible chitinase 0.0063 0.0284 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0142 0.0375
Brugia malayi Melatonin receptor type 1A 0.0029 0.007 0.0066
Trichomonas vaginalis hypothetical protein 0.0172 0.0987 0.2935
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0987 0.2935
Entamoeba histolytica cyclin family protein 0.0031 0.0079 0.2152
Onchocerca volvulus 0.0062 0.0278 0.1167
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.007 0.0085
Entamoeba histolytica hypothetical protein, conserved 0.0036 0.0111 0.308
Loa Loa (eye worm) cuticular endochitinase 0.0074 0.0354 0.0354
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0004 0.0004
Loa Loa (eye worm) ube2i2 protein 0.0025 0.0042 0.0042
Brugia malayi hypothetical protein 0.0062 0.0278 0.0274
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.007 0.0085
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0073 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0987 0.2935
Echinococcus granulosus cyclin B 0.0049 0.0197 0.0248
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0025 0.0042 0.1098
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.007 0.0085
Schistosoma mansoni neuropeptide receptor 0.0029 0.007 0.0118
Echinococcus multilocularis dro:myosuppressin receptor 0.0029 0.007 0.0085
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.007 0.0118
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.007 0.0085
Loa Loa (eye worm) CUTiclin family member 0.0036 0.0111 0.0111
Echinococcus granulosus GPCR family 2 0.016 0.0906 0.116
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0142 0.0375
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0142 0.0414
Brugia malayi hypothetical protein 0.0029 0.007 0.0066
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.007 0.0118
Schistosoma mansoni neuropeptide receptor 0.0029 0.007 0.0118
Onchocerca volvulus 0.0036 0.0111 0.0233
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.007 0.0085
Echinococcus granulosus somatostatin receptor 0.0029 0.007 0.0085
Loa Loa (eye worm) hypothetical protein 0.0892 0.5596 0.5596
Echinococcus multilocularis cyclin b3 0.0031 0.0079 0.0097
Brugia malayi steroid hormone receptor 0.003 0.0073 0.007
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.007 0.0085
Loa Loa (eye worm) chitinase I 0.0074 0.0354 0.0354
Echinococcus granulosus tachykinin peptides receptor 99D 0.0029 0.007 0.0085
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0025 0.0042 0.1987
Echinococcus granulosus g-protein coupled receptor 0.0029 0.007 0.0085
Echinococcus granulosus sex peptide receptor 0.0029 0.007 0.0085
Trichomonas vaginalis cyclins, putative 0.0049 0.0197 0.0577
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0111 0.0108
Brugia malayi hypothetical protein 0.0029 0.007 0.0066
Echinococcus granulosus c4b binding protein beta chain 0.0062 0.0278 0.0352
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.007 0.0085
Brugia malayi G-protein coupled receptor 0.0029 0.007 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0987 0.2935
Loa Loa (eye worm) CUTiclin-Like family member 0.0036 0.0111 0.0111
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0073 0.009
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0737 0.4607 0.8232
Echinococcus granulosus cyclins 0.0031 0.0079 0.0097
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Schistosoma mansoni ubiquitin-conjugating enzyme E2 I 0.0025 0.0042 0.0069
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Onchocerca volvulus Putative endochitinase 0.0074 0.0354 0.1593
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Echinococcus multilocularis g-protein coupled receptor 0.0029 0.007 0.0085
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0073 0.007
Echinococcus multilocularis sex peptide receptor 0.0029 0.007 0.0085
Brugia malayi neuropeptide F receptor 0.0029 0.007 0.0066
Brugia malayi endochitinase 0.0074 0.0354 0.035
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0073 0.009
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.007 0.0085
Echinococcus multilocularis serotonin receptor 0.0029 0.007 0.0085
Echinococcus granulosus serotonin receptor 0.0029 0.007 0.0085
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0036 0.0111 0.0193
Trichomonas vaginalis cyclin B, putative 0.0031 0.0079 0.0225
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0038 0.0126 0.0157
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0088 0.0446 0.0568
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0073 0.007
Echinococcus granulosus fmrfamide receptor 0.0029 0.007 0.0085
Echinococcus multilocularis Furin 1 0.0211 0.1231 0.1578
Plasmodium falciparum subtilisin-like protease 3 0.0038 0.0126 0.3704
Trichomonas vaginalis WD repeat domain, putative 0.0307 0.1851 0.5514
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0038 0.0126 0.0219
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0036 0.0111 0.3257
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Brugia malayi Will die slowly protein 0.0307 0.1851 0.1848
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0126 0.0366
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.1234 0.7787 1
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0038 0.0126 0.0331
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0029 0.007 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0987 0.2935
Echinococcus multilocularis orexin receptor type 2 0.0029 0.007 0.0085
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0101 0.0262
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0029 0.007 0.0085
Echinococcus granulosus neuropeptide receptor 0.0029 0.007 0.0085
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0071 0.0334 0.0334
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0142 0.7177
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Brugia malayi von Willebrand Factor 0.0036 0.0111 0.0108
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0029 0.007 0.007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.007 0.0118
Schistosoma mansoni site-1 peptidase (S08 family) 0.0038 0.0126 0.0219
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0073 0.002
Onchocerca volvulus 0.0036 0.0111 0.0233
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.007 0.007
Echinococcus multilocularis beta adrenergic receptor kinase 0.0098 0.0511 0.0652
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.007 0.0118
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0211 0.1231 0.3664
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0029 0.007 0.0066
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0036 0.0111 0.3257
Brugia malayi GCC2 and GCC3 family protein 0.0062 0.0278 0.0274
Onchocerca volvulus 0.0062 0.0278 0.1167
Loa Loa (eye worm) hypothetical protein 0.003 0.0073 0.0073
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0142 0.4949
Loa Loa (eye worm) hypothetical protein 0.0062 0.0278 0.0278
Echinococcus granulosus dro:myosuppressin receptor 0.0029 0.007 0.0085
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0049 0.0197 0.5527
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.007 0.0118
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0211 0.1231 0.3664
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.007 0.0118
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.007 0.0085
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0073 0.007
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Echinococcus multilocularis fmrfamide receptor 0.0029 0.007 0.0085
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0038 0.0126 0.6337
Schistosoma mansoni c4b-binding protein beta chain 0.0062 0.0278 0.049
Plasmodium vivax SET domain protein, putative 0.0071 0.0334 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0142 0.7177
Schistosoma mansoni neuropeptide receptor 0.0029 0.007 0.0118
Brugia malayi G protein-coupled receptor F59B2.13 0.0029 0.007 0.0066
Brugia malayi pregnancy-associated plasma protein-A 0.0062 0.0278 0.0274
Echinococcus multilocularis somatostatin receptor 0.0029 0.007 0.0085
Giardia lamblia DINP protein human, muc B family 0.0021 0.0016 0.006
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0038 0.0126 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0126 0.0366
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0029 0.007 0.0066
Echinococcus granulosus allatostatin A receptor 0.0029 0.007 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0142 0.0375
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.007 0.0085
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0073 0.009
Entamoeba histolytica chitinase, putative 0.0074 0.0354 1
Trypanosoma cruzi cyclin 6, putative 0.0049 0.0197 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0073 0.007
Loa Loa (eye worm) hypothetical protein 0.003 0.0073 0.0073
Brugia malayi GnHR receptor homolog 0.0029 0.007 0.0066
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0029 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.0111
Schistosoma mansoni neuropeptide receptor 0.0029 0.007 0.0118
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0142 0.0375
Brugia malayi Cyclin, N-terminal domain containing protein 0.0049 0.0197 0.0193
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0073 0.007
Echinococcus multilocularis cyclins 0.0031 0.0079 0.0097
Brugia malayi Cyclin, N-terminal domain containing protein 0.0031 0.0079 0.0075
Echinococcus granulosus neuroendocrine convertase 2 0.056 0.3473 0.4457
Brugia malayi ORL1-like opioid receptor 0.0029 0.007 0.0066
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Trichomonas vaginalis cyclin B, putative 0.0049 0.0197 0.0577
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.007 0.0085
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0029 0.007 0.0085
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Brugia malayi hypothetical protein 0.0029 0.007 0.0066
Schistosoma mansoni amine GPCR 0.0029 0.007 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0073 0.007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Schistosoma mansoni hypothetical protein 0.016 0.0906 0.1614
Brugia malayi RE15519p 0.0029 0.007 0.0066
Onchocerca volvulus 0.0062 0.0278 0.1167
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0142 0.7177
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0073 0.009
Plasmodium falciparum cyclin 0.0031 0.0079 0.2276
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Trypanosoma cruzi CYC2-like cyclin, putative 0.0049 0.0197 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0542 0.3355 1
Onchocerca volvulus Putative endochitinase 0.0074 0.0354 0.1593
Schistosoma mansoni growth hormone secretagogue receptor 0.0029 0.007 0.0118
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Echinococcus granulosus neuropeptide s receptor 0.0029 0.007 0.0085
Schistosoma mansoni site-1 peptidase (S08 family) 0.0038 0.0126 0.0219
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Onchocerca volvulus 0.0036 0.0111 0.0233
Echinococcus multilocularis g protein coupled receptor 0.0029 0.007 0.0085
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0111 0.0108
Echinococcus granulosus hypothetical protein 0.0029 0.007 0.0085
Echinococcus granulosus G protein coupled receptor 139 0.0029 0.007 0.0085
Schistosoma mansoni cyclins 0.0031 0.0079 0.0135
Loa Loa (eye worm) hypothetical protein 0.003 0.0073 0.0073
Brugia malayi Subtilase family protein 0.0038 0.0126 0.0123
Echinococcus multilocularis neuropeptide receptor 0.0029 0.007 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0073 0.007
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0038 0.0126 0.437
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0036 0.0111 0.3257
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0073 0.009
Schistosoma mansoni hypothetical protein 0.0029 0.007 0.0118
Echinococcus granulosus FTZ F1 alpha 0.003 0.0073 0.009
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0142 0.4949
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.0111
Onchocerca volvulus 0.0049 0.0197 0.0714
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0073 0.009
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0142 0.0414
Loa Loa (eye worm) WD40 repeat protein 0.0307 0.1851 0.1851
Giardia lamblia Furin precursor putative serine protease 0.0172 0.0987 0.4914
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0073 0.0073
Brugia malayi hypothetical protein 0.0062 0.0278 0.0274
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Echinococcus multilocularis neuropeptide receptor A26 0.0029 0.007 0.0085
Toxoplasma gondii subtilisin SUB2 0.0038 0.0126 0.3704
Brugia malayi Dopamine receptor protein 1 0.0029 0.007 0.0066
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.016 0.0906 0.116
Brugia malayi Serotonin receptor 0.0029 0.007 0.0066
Onchocerca volvulus 0.0038 0.0126 0.0317
Toxoplasma gondii rhoptry neck protein RON1 0.0062 0.0278 0.8283
Echinococcus granulosus protein will die slowly 0.0307 0.1851 0.2374
Echinococcus granulosus g protein coupled receptor 0.0029 0.007 0.0085
Leishmania major chitinase 0.0074 0.0354 1
Onchocerca volvulus 0.0062 0.0278 0.1167
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.0111
Brugia malayi Zona pellucida-like domain containing protein 0.0036 0.0111 0.0108
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Toxoplasma gondii microneme protein MIC2 0.0036 0.0111 0.3257
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.068 0.087
Loa Loa (eye worm) hypothetical protein 0.003 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.003 0.0073 0.0073
Trypanosoma brucei ubiquitin-conjugating enzyme E2, putative 0.0025 0.0042 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0987 0.2935
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.007 0.0085
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0036 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0029 0.007 0.0118
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0038 0.0126 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Brugia malayi Serotonin receptor 0.0029 0.007 0.0066
Trichomonas vaginalis cyclin D, putative 0.0031 0.0079 0.0225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0073 0.0073
Brugia malayi nuclear receptor NHR-88 0.003 0.0073 0.007
Echinococcus granulosus voltage dependent calcium channel subunit 0.0036 0.0111 0.0138
Brugia malayi neuropeptide F receptor 0.0029 0.007 0.0066
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0073 0.0073
Brugia malayi Endochitinase 0.0074 0.0354 0.035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0073 0.009
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Toxoplasma gondii hypothetical protein 0.0023 0.0031 0.084
Onchocerca volvulus 0.0036 0.0111 0.0233
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0073 0.009
Onchocerca volvulus 0.0062 0.0278 0.1167
Brugia malayi G protein-coupled receptor 0.0029 0.007 0.0066
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0073 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0142 0.0375
Brugia malayi endochitinase 0.0074 0.0354 0.035
Brugia malayi hypothetical protein 0.0029 0.007 0.0066
Brugia malayi latrophilin 2 splice variant baaae 0.0345 0.2095 0.2092
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.007 0.0118
Loa Loa (eye worm) hypothetical protein 0.0062 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.0036 0.0111 0.0111
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0073 0.0125
Schistosoma mansoni amine GPCR 0.0029 0.007 0.0118
Trichomonas vaginalis cyclins, putative 0.0049 0.0197 0.0577
Echinococcus granulosus 7tm_1 domain containing protein 0.0029 0.007 0.0085
Schistosoma mansoni cyclin B 0.0049 0.0197 0.0346
Entamoeba histolytica cyclin, putative 0.0049 0.0197 0.5527
Plasmodium falciparum SUMO-conjugating enzyme UBC9 0.0025 0.0042 0.1161
Brugia malayi follicle stimulating hormone receptor 0.0029 0.007 0.0066
Schistosoma mansoni hypothetical protein 0.0345 0.2095 0.3739
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0073 0.009
Plasmodium vivax subtilisin-like protease 2, putative 0.0038 0.0126 0.3704
Onchocerca volvulus 0.0062 0.0278 0.1167
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0073 0.007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.007 0.0118
Brugia malayi hypothetical protein 0.0036 0.0111 0.0108
Loa Loa (eye worm) hypothetical protein 0.0049 0.0197 0.0197
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0029 0.007 0.0118
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0036 0.0111 0.3257
Schistosoma mansoni biogenic amine receptor 0.0029 0.007 0.0118
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0142 0.7177
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0073 0.0125
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Onchocerca volvulus 0.0036 0.0111 0.0233
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Entamoeba histolytica elongation factor-2 kinase, putative 0.0036 0.0111 0.308
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.007 0.0118
Schistosoma mansoni opsin-like receptor 0.0029 0.007 0.0118
Echinococcus multilocularis neuroendocrine convertase 2 0.056 0.3473 0.4457
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.007 0.0118
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0038 0.0126 0.437
Loa Loa (eye worm) hypothetical protein 0.0062 0.0278 0.0278
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.007 0.0085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.007 0.0085
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Echinococcus multilocularis histone lysine n methyltransferase setd8 0.0071 0.0334 0.0425
Loa Loa (eye worm) hypothetical protein 0.0038 0.0126 0.0126
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.007 0.0085
Brugia malayi putative neuropeptide receptor 0.0029 0.007 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.007 0.0118
Entamoeba histolytica cyclin, putative 0.0031 0.0079 0.2152
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0036 0.0111 0.0138
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0038 0.0126 0.5
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0111 0.0108
Loa Loa (eye worm) hypothetical protein 0.0062 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.0049 0.0197 0.0197
Echinococcus granulosus ubiquitin conjugating enzyme e2 i 0.0025 0.0042 0.0049
Echinococcus granulosus g protein coupled receptor 0.0029 0.007 0.0085
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.007 0.0085
Entamoeba histolytica hypothetical protein, conserved 0.0036 0.0111 0.308
Onchocerca volvulus 0.0307 0.1851 1
Trypanosoma brucei unspecified product 0.0034 0.0101 0.0262
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0016 0.0343
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0737 0.4607 0.5915
Schistosoma mansoni hypothetical protein 0.0029 0.007 0.0118
Onchocerca volvulus 0.0036 0.0111 0.0233
Giardia lamblia Hypothetical protein 0.0031 0.0079 0.0376
Brugia malayi hypothetical protein 0.0062 0.0278 0.0274
Schistosoma mansoni coup transcription factor 0.003 0.0073 0.0125
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.007 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0073 0.007
Loa Loa (eye worm) hypothetical protein 0.003 0.0073 0.0073
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0029 0.007 0.0085
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0031 0.0079 0.0097
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0038 0.0126 0.0366
Echinococcus multilocularis cyclins 0.0031 0.0079 0.0097
Brugia malayi ube2i2 protein 0.0025 0.0042 0.0038
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0036 0.0111 0.3257
Schistosoma mansoni neuropeptide f receptor 76f 0.0029 0.007 0.0118
Schistosoma mansoni alpha-1 adrenergic receptor 0.0029 0.007 0.0118
Brugia malayi hypothetical protein 0.0062 0.0278 0.0274
Plasmodium vivax subtilisin-like protease 1 0.0038 0.0126 0.3704
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0073 0.002
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0172 0.0987 0.2935
Toxoplasma gondii subtilisin SUB11 0.0038 0.0126 0.3704
Loa Loa (eye worm) hypothetical protein 0.0062 0.0278 0.0278
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0029 0.007 0.0085
Brugia malayi hypothetical protein 0.0062 0.0278 0.0274
Loa Loa (eye worm) proprotein convertase 2 0.0211 0.1231 0.1231
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0036 0.0111 0.3257
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0073 0.0125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.007 0.007
Trichomonas vaginalis ubiquitin-conjugating enzyme rad6, putative 0.0025 0.0042 0.0115
Leishmania major subtilisin-like serine peptidase 0.0038 0.0126 0.3503
Brugia malayi larval opioid receptor 0.0029 0.007 0.0066
Toxoplasma gondii subtilisin SUB4 0.0038 0.0126 0.3704
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0038 0.0126 0.437
Schistosoma mansoni hypothetical protein 0.016 0.0906 0.1614
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.007 0.007
Trichomonas vaginalis cyclins, putative 0.0031 0.0079 0.0225
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0073 0.0125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.007 0.0118
Plasmodium falciparum apical sushi protein 0.0062 0.0278 0.8283
Schistosoma mansoni thyroid hormone receptor 0.0154 0.0872 0.1553
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0025 0.0042 0.1987
Brugia malayi hypothetical protein 0.0029 0.007 0.0066
Leishmania major cyclin 0.0049 0.0197 0.5527
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.007 0.007
Toxoplasma gondii subtilisin SUB5 0.0038 0.0126 0.3704
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0505 0.3119 0.3119
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0038 0.0126 0.6337
Toxoplasma gondii subtilisin SUB10 0.0038 0.0126 0.3704
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0025 0.0042 0.1161
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0073 0.002
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.007 0.0085
Onchocerca volvulus 0.0062 0.0278 0.1167
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0073 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0987 0.2935

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) nM Inhibition of [3H]-AVP binding to recombinant human vasopressin V1a receptor ChEMBL. 15125926
Ki (binding) 0 nM Inhibition of [3H]-AVP binding to recombinant human vasopressin V1a receptor ChEMBL. 15125926
Ki (binding) = 17 nM Inhibition of [3H]-AVP binding to recombinant human vasopressin V2 receptor ChEMBL. 15125926
Ki (binding) = 17 nM Inhibition of [3H]-AVP binding to recombinant human vasopressin V2 receptor ChEMBL. 15125926

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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