Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | RNA polymerase A, putative | 0.0068 | 0.1596 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0148 | 0.4343 | 0.4343 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0021 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0166 | 0.4949 | 0.4949 |
Loa Loa (eye worm) | DNA-directed RNA polymerase II largest subunit | 0.0038 | 0.0601 | 0.0601 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0148 | 0.4343 | 0.4343 |
Schistosoma mansoni | thyroid hormone receptor | 0.0314 | 1 | 1 |
Echinococcus multilocularis | DNA directed RNA polymerase II subunit | 0.0038 | 0.0601 | 0.0601 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0314 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0021 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0314 | 1 | 1 |
Trypanosoma cruzi | DNA-directed RNA polymerase III subunit C1, putative | 0.0038 | 0.0601 | 0.3766 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0021 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0314 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0314 | 1 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0314 | 1 | 1 |
Echinococcus multilocularis | DNA directed RNA polymerase I subunit RPA1 | 0.0068 | 0.1596 | 0.1596 |
Schistosoma mansoni | zinc finger protein | 0.0148 | 0.4343 | 0.4343 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0314 | 1 | 1 |
Brugia malayi | RNA polymerase Rpb1, domain 2 family protein | 0.0076 | 0.1891 | 0.1891 |
Mycobacterium leprae | DNA-DIRECTED RNA POLYMERASE (BETA' CHAIN) RPOC (TRANSCRIPTASE BETA' CHAIN) (RNA POLYMERASE BETA' SUBUNIT). | 0.0038 | 0.0601 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.4949 | 0.4949 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.4949 | 0.4949 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Schistosoma mansoni | RNA polymerase Rpb1 | 0.0038 | 0.0601 | 0.0601 |
Brugia malayi | nuclear receptor RXR | 0.0166 | 0.4949 | 0.4949 |
Brugia malayi | plexin A | 0.0045 | 0.0831 | 0.0831 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0148 | 0.4343 | 0.4343 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0021 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0314 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0314 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0314 | 1 | 1 |
Schistosoma mansoni | DNA-directed RNA polymerase II largest subunit | 0.0038 | 0.0601 | 0.0601 |
Brugia malayi | tailless protein | 0.0148 | 0.4343 | 0.4343 |
Brugia malayi | nuclear receptor RXR | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.4949 | 0.4949 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0314 | 1 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.005 | 0.005 |
Trypanosoma brucei | RNA polymerase IIA largest subunit | 0.0038 | 0.0601 | 0.3766 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | plexin A | 0.0045 | 0.0831 | 0.0831 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0148 | 0.4343 | 0.4343 |
Mycobacterium ulcerans | DNA-directed RNA polymerase subunit beta' | 0.0038 | 0.0601 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0314 | 1 | 1 |
Echinococcus granulosus | plexin a4 | 0.0045 | 0.0831 | 0.0831 |
Plasmodium vivax | DNA-directed RNA polymerase I 190 kDa polypeptide, putative | 0.0076 | 0.1891 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0148 | 0.4343 | 0.4343 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0166 | 0.4949 | 0.4949 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0314 | 1 | 1 |
Brugia malayi | RNA polymerase Rpb1, domain 1 family protein | 0.0038 | 0.0601 | 0.0601 |
Trypanosoma brucei | DNA-directed RNA polymerase I largest subunit | 0.0068 | 0.1596 | 1 |
Onchocerca volvulus | 0.0314 | 1 | 1 | |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0314 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0166 | 0.4949 | 0.4949 |
Toxoplasma gondii | DNA-directed RNA polymerase III RPC1 | 0.0038 | 0.0601 | 0.3179 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0314 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0166 | 0.4949 | 0.4949 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.4949 | 0.4949 |
Schistosoma mansoni | plexin | 0.0038 | 0.0593 | 0.0593 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0314 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0166 | 0.4949 | 0.4949 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0314 | 1 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0148 | 0.4343 | 0.4343 |
Trypanosoma brucei | DNA-directed rna polymerase I largest subunit, putative | 0.0068 | 0.1596 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0314 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0314 | 1 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0148 | 0.4343 | 0.4343 |
Schistosoma mansoni | nuclear hormone receptor | 0.0148 | 0.4343 | 0.4343 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0314 | 1 | 1 |
Schistosoma mansoni | DNA-directed RNA polymerase I | 0.0076 | 0.1891 | 0.1891 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0314 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0314 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0314 | 1 | 1 |
Echinococcus multilocularis | plexin a4 | 0.0045 | 0.0831 | 0.0831 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | DR-78 | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0593 | 0.0593 |
Toxoplasma gondii | DNA-directed RNA polymerase I RPA1 | 0.0076 | 0.1891 | 1 |
Leishmania major | DNA-directed rna polymerase I largest subunit, putative | 0.0068 | 0.1596 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0148 | 0.4343 | 0.4343 |
Entamoeba histolytica | DNA-directed RNA polymerase I largest subunit, putative | 0.0076 | 0.1891 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0314 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0148 | 0.4343 | 0.4343 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0314 | 1 | 1 |
Schistosoma mansoni | plexin | 0.0022 | 0.005 | 0.005 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0166 | 0.4949 | 0.4949 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0148 | 0.4343 | 0.4343 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0166 | 0.4949 | 0.4949 |
Echinococcus granulosus | DNA directed RNA polymerase II subunit | 0.0038 | 0.0601 | 0.0601 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0314 | 1 | 1 |
Echinococcus multilocularis | DNA directed RNA polymerase III subunit RPC1 | 0.0038 | 0.0601 | 0.0601 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0314 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.1891 | 0.1891 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0314 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0314 | 1 | 1 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0148 | 0.4343 | 0.3987 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0148 | 0.4343 | 0.4343 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0148 | 0.4343 | 0.4343 |
Schistosoma mansoni | nuclear hormone receptor | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0314 | 1 | 1 |
Leishmania major | RNA polymerase ii largest subunit | 0.0038 | 0.0601 | 0.3766 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0148 | 0.4343 | 0.4343 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0314 | 1 | 1 |
Leishmania major | DNA-directed RNA polymerase III largest subunit , putative | 0.0038 | 0.0601 | 0.3766 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0314 | 1 | 1 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0148 | 0.4343 | 0.3987 |
Trypanosoma cruzi | RNA polymerase IIA largest subunit, putative | 0.0038 | 0.0601 | 0.3766 |
Brugia malayi | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Wolbachia endosymbiont of Brugia malayi | DNA-directed RNA polymerase subunit beta/beta' | 0.0038 | 0.0601 | 0.5 |
Brugia malayi | Plexin repeat family protein | 0.0038 | 0.0593 | 0.0593 |
Echinococcus granulosus | DNA directed RNA polymerase I subunit RPA1 | 0.0068 | 0.1596 | 0.1596 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0021 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Trypanosoma brucei | DNA-directed RNA polymerase III largest subunit, putative | 0.0024 | 0.0097 | 0.0611 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0314 | 1 | 1 |
Giardia lamblia | RNA polymerase AI large subunit | 0.0076 | 0.1891 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0148 | 0.4343 | 0.4343 |
Trypanosoma brucei | DNA-directed RNA polymerase III subunit C1 | 0.0038 | 0.0601 | 0.3766 |
Plasmodium falciparum | RNA polymerase I | 0.0076 | 0.1891 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0314 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0314 | 1 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0148 | 0.4343 | 0.4343 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0314 | 1 | 1 |
Trypanosoma brucei | DNA-directed RNA polymerase II subunit RPB1 | 0.0038 | 0.0601 | 0.3766 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0148 | 0.4343 | 0.4343 |
Brugia malayi | nuclear receptor NHR-88 | 0.0314 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0148 | 0.4343 | 0.4343 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0148 | 0.4343 | 0.4343 |
Brugia malayi | nuclear receptor NHR-88 | 0.0148 | 0.4343 | 0.4343 |
Trypanosoma cruzi | DNA-directed rna polymerase I largest subunit, putative | 0.0068 | 0.1596 | 1 |
Brugia malayi | ecdysone receptor | 0.0148 | 0.4343 | 0.4343 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.005 | 0.005 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor | 0.0148 | 0.4343 | 0.4343 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0314 | 1 | 1 |
Onchocerca volvulus | 0.0148 | 0.4343 | 0.3987 | |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0314 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0314 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0314 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.4343 | 0.4343 |
Brugia malayi | conserved hypotetical protein | 0.0148 | 0.4343 | 0.4343 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0166 | 0.4949 | 0.4949 |
Schistosoma mansoni | coup transcription factor | 0.0314 | 1 | 1 |
Treponema pallidum | DNA-directed RNA polymerase subunit beta' | 0.0038 | 0.0601 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.4949 | 0.4949 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0148 | 0.4343 | 0.4343 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0148 | 0.4343 | 0.4343 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0314 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0314 | 1 | 1 |
Brugia malayi | DNA-directed RNA polymerase II largest subunit, putative | 0.0038 | 0.0601 | 0.0601 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0314 | 1 | 1 |
Onchocerca volvulus | 0.0148 | 0.4343 | 0.3987 | |
Toxoplasma gondii | DNA-directed RNA polymerase II RPB1 | 0.0038 | 0.0601 | 0.3179 |
Loa Loa (eye worm) | RNA polymerase Rpb1 | 0.0038 | 0.0601 | 0.0601 |
Chlamydia trachomatis | DNA-directed RNA polymerase subunit beta' | 0.0038 | 0.0601 | 0.5 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0148 | 0.4343 | 0.4343 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | DNA directed RNA polymerase III subunit RPC1 | 0.0038 | 0.0601 | 0.0601 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0166 | 0.4949 | 0.4949 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0314 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Compound was tested for the inhibition of human DNA topoisomerase I at a compound concentration of 10 occurred | ChEMBL. | 14971893 | |
Activity (binding) | 0 | Compound was tested for the inhibition of human DNA topoisomerase I at a compound concentration of 10 occurred | ChEMBL. | 14971893 |
GI50 (functional) | = 0.1 uM | In vitro antiproliferative activity of the compound against human HeLa-APL cervix cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 0.1 uM | In vitro antiproliferative activity of the compound against human HeLa-APL cervix cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 0.3 uM | In vitro antiproliferative activity of the compound against human LN-caP prostrate cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 0.3 uM | In vitro antiproliferative activity of the compound against human LN-caP prostrate cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 0.4 uM | In vitro antiproliferative activity of the compound against human HT-29 colon cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 0.4 uM | In vitro antiproliferative activity of the compound against human K-562 cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 0.4 uM | In vitro antiproliferative activity of the compound against human HT-29 colon cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 0.4 uM | In vitro antiproliferative activity of the compound against human K-562 cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 0.5 uM | In vitro antiproliferative activity of the compound against human IGROV ovarian cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 0.5 uM | In vitro antiproliferative activity of the compound against human SK-BR-3 breast cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 0.5 uM | In vitro antiproliferative activity of the compound against human IGROV ovarian cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 0.5 uM | In vitro antiproliferative activity of the compound against human SK-BR-3 breast cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 0.6 uM | In vitro antiproliferative activity of the compound against human LOVO colon cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 0.6 uM | In vitro antiproliferative activity of the compound against human LOVO colon cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 0.7 uM | In vitro antiproliferative activity of the compound against human HeLa cervix cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 0.7 uM | In vitro antiproliferative activity of the compound against human HeLa cervix cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 0.8 uM | In vitro antiproliferative activity of the compound against human A-549 NSCL cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 0.8 uM | In vitro antiproliferative activity of the compound against human A-549 NSCL cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 1 uM | In vitro antiproliferative activity of the compound against human DU-145 prostrate cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 1 uM | In vitro antiproliferative activity of the compound against human MEL-28 melanoma cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 1 uM | In vitro antiproliferative activity of the compound against human DU-145 prostrate cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 1 uM | In vitro antiproliferative activity of the compound against human MEL-28 melanoma cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 1.3 uM | In vitro antiproliferative activity of the compound against human PANC-1 pancreas cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 1.3 uM | In vitro antiproliferative activity of the compound against human PANC-1 pancreas cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 2 uM | In vitro antiproliferative activity of the compound against human IGROV-ET ovarian cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 2 uM | In vitro antiproliferative activity of the compound against human IGROV-ET ovarian cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 3.5 uM | In vitro antiproliferative activity of the compound against human LOVO-DOX colon cell line | ChEMBL. | 14971893 |
GI50 (functional) | = 3.5 uM | In vitro antiproliferative activity of the compound against human LOVO-DOX colon cell line | ChEMBL. | 14971893 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.