TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 539.279 | Formula: C22H27Cl4N3O4
H donors: 2 H acceptors: 2 LogP: 5.5 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: CCN(CCNC(=O)c1cc(Cl)c(cc1OC)NC(=O)COc1ccc(c(c1)Cl)Cl)CC.Cl
InChi: 1S/C22H26Cl3N3O4.ClH/c1-4-28(5-2)9-8-26-22(30)15-11-18(25)19(12-20(15)31-3)27-21(29)13-32-14-6-7-16(23)17(24)10-14;/h6-7,10-12H,4-5,8-9,13H2,1-3H3,(H,26,30)(H,27,29);1H
InChiKey: DEXPWLLJXYYEOE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	cysteine protease	0.005	0.1764	0.1275
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.006	0.2631	0.2631
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.1764	0.7801
Brugia malayi	Melatonin receptor type 1A	0.006	0.2631	0.2631
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Giardia lamblia	Cathepsin B precursor	0.0056	0.2262	0.5
Brugia malayi	putative neuropeptide receptor	0.006	0.2631	0.2631
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0056	0.2262	0.2262
Trypanosoma cruzi	cysteine peptidase, putative	0.005	0.1764	0.1764
Toxoplasma gondii	cathepsin B	0.0056	0.2262	1
Schistosoma mansoni	opsin-like receptor	0.006	0.2631	0.2631
Brugia malayi	Serotonin receptor	0.006	0.2631	0.2631
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.005	0.1764	1
Brugia malayi	hypothetical protein	0.006	0.2631	0.2631
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Brugia malayi	ORL1-like opioid receptor	0.006	0.2631	0.2631
Echinococcus granulosus	cathepsin b	0.0152	1	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Brugia malayi	hypothetical protein	0.006	0.2631	0.2631
Onchocerca volvulus		0.005	0.1764	0.5813
Brugia malayi	AKH receptor	0.006	0.2631	0.2631
Brugia malayi	larval opioid receptor	0.006	0.2631	0.2631
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0561	0.0561
Echinococcus granulosus	g protein coupled receptor	0.006	0.2631	0.2631
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Echinococcus granulosus	G protein coupled receptor 139	0.006	0.2631	0.2631
Onchocerca volvulus		0.006	0.2631	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Onchocerca volvulus		0.005	0.1764	0.5813
Schistosoma mansoni	amine GPCR	0.006	0.2631	0.2631
Echinococcus multilocularis	g protein coupled receptor	0.006	0.2631	0.2631
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Brugia malayi	hypothetical protein	0.006	0.2631	0.2631
Echinococcus granulosus	somatostatin receptor	0.006	0.2631	0.2631
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.006	0.2631	0.2631
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.005	0.1764	0.7801
Echinococcus multilocularis	neuropeptide FF receptor 2	0.006	0.2631	0.2631
Onchocerca volvulus		0.006	0.2631	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.005	0.1764	0.1275
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.006	0.2631	0.2631
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.1764	0.7801
Echinococcus granulosus	sex peptide receptor	0.006	0.2631	0.2631
Echinococcus multilocularis	G protein coupled receptor 139	0.006	0.2631	0.2631
Echinococcus granulosus	neuropeptide FF receptor 2	0.006	0.2631	0.2631
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.006	0.2631	0.2193
Schistosoma mansoni	neuropeptide receptor	0.006	0.2631	0.2631
Echinococcus multilocularis	neuropeptide receptor A26	0.006	0.2631	0.2631
Echinococcus multilocularis	g protein coupled receptor	0.006	0.2631	0.2631
Onchocerca volvulus		0.005	0.1764	0.5813
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.1764	0.7801
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.1764	0.7801
Schistosoma mansoni	neuropeptide f receptor 76f	0.006	0.2631	0.2631
Brugia malayi	hypothetical protein	0.006	0.2631	0.2631
Brugia malayi	Cathepsin L-like precursor	0.005	0.1764	0.1764
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.2631	0.2631
Brugia malayi	neuropeptide F receptor	0.006	0.2631	0.2631
Echinococcus multilocularis	allatostatin A receptor	0.006	0.2631	0.2631
Loa Loa (eye worm)	neuropeptide F receptor	0.006	0.2631	0.2193
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.006	0.2631	0.2631
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.005	0.1764	0.7801
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.2631	0.2631
Echinococcus granulosus	allatostatin A receptor	0.006	0.2631	0.2631
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.006	0.2631	0.2631
Brugia malayi	hypothetical protein	0.006	0.2631	0.2631
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.2631	0.2631
Echinococcus multilocularis	g protein coupled receptor	0.006	0.2631	0.2631
Brugia malayi	GnHR receptor homolog	0.006	0.2631	0.2631
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.006	0.2631	0.2193
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Brugia malayi	Dopamine receptor protein 1	0.006	0.2631	0.2631
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.006	0.2631	0.2631
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.2631	0.2631
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.2631	0.2631
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Echinococcus multilocularis	cathepsin L cysteine protease	0.005	0.1764	0.1764
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.006	0.2631	0.2631
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.2631	0.2631
Brugia malayi	Cathepsin L-like precursor	0.005	0.1764	0.1764
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.005	0.1764	0.1764
Schistosoma mansoni	amine GPCR	0.006	0.2631	0.2631
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.1764	0.7801
Echinococcus granulosus	g protein coupled receptor	0.006	0.2631	0.2631
Loa Loa (eye worm)	hypothetical protein	0.005	0.1764	0.1275
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.1764	0.7801
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.2631	0.2631
Loa Loa (eye worm)	melatonin receptor type 1A	0.006	0.2631	0.2193
Plasmodium vivax	vivapain-2	0.005	0.1764	1
Echinococcus multilocularis	somatostatin receptor	0.006	0.2631	0.2631
Schistosoma mansoni	hypothetical protein	0.006	0.2631	0.2631
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0152	1	1
Brugia malayi	hypothetical protein	0.006	0.2631	0.2631
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.005	0.1764	0.7801
Plasmodium falciparum	cysteine proteinase falcipain 3	0.005	0.1764	1
Onchocerca volvulus		0.006	0.2631	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.2631	0.2631
Echinococcus granulosus	fmrfamide receptor	0.006	0.2631	0.2631
Onchocerca volvulus		0.006	0.2631	1
Brugia malayi	Cathepsin L-like precursor	0.005	0.1764	0.1764
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.1764	0.7801
Onchocerca volvulus		0.006	0.2631	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Echinococcus multilocularis	orexin receptor type 2	0.006	0.2631	0.2631
Onchocerca volvulus		0.006	0.2631	1
Echinococcus granulosus	dro:myosuppressin receptor	0.006	0.2631	0.2631
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.1764	0.7801
Onchocerca volvulus	Cathepsin L homolog	0.005	0.1764	0.5813
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.006	0.2631	0.2631
Echinococcus granulosus	tm gpcr rhodopsin	0.006	0.2631	0.2631
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.006	0.2631	0.2193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.1764	0.7801
Schistosoma mansoni	cathepsin F (C01 family)	0.0035	0.0561	0.0561
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.2631	0.2631
Schistosoma mansoni	cathepsin F (C01 family)	0.005	0.1764	0.1764
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0035	0.0561	0.0561
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.1764	0.7801
Echinococcus granulosus	neuropeptide Y receptor	0.006	0.2631	0.2631
Echinococcus granulosus	tachykinin peptides receptor 99D	0.006	0.2631	0.2631
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Echinococcus multilocularis	fmrfamide receptor	0.006	0.2631	0.2631
Schistosoma mansoni	neuropeptide receptor	0.006	0.2631	0.2631
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.006	0.2631	0.2631
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.006	0.2631	0.2631
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.1764	0.7801
Echinococcus multilocularis	G-protein coupled receptor, putative	0.006	0.2631	0.2631
Echinococcus multilocularis	cathepsin b	0.0152	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.005	0.1764	0.1764
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Brugia malayi	putative neuropeptide receptor NPR1	0.006	0.2631	0.2631
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.006	0.2631	0.2631
Brugia malayi	hypothetical protein	0.006	0.2631	0.2631
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.2631	0.2631
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.1764	0.7801
Onchocerca volvulus		0.005	0.1764	0.5813
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.1764	0.7801
Echinococcus granulosus	hypothetical protein	0.006	0.2631	0.2631
Echinococcus multilocularis	neuropeptides capa receptor	0.006	0.2631	0.2631
Loa Loa (eye worm)	ctsf protein	0.005	0.1764	0.1275
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.006	0.2631	0.2631
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Echinococcus granulosus	tm gpcr rhodopsin	0.006	0.2631	0.2631
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0152	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.005	0.1764	0.1764
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.2631	0.2631
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.006	0.2631	0.2631
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0056	0.2262	1
Schistosoma mansoni	histamine h1 receptor	0.006	0.2631	0.2631
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.006	0.2631	0.2631
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0561	0.2482
Echinococcus multilocularis	neuropeptide Y receptor	0.006	0.2631	0.2631
Schistosoma mansoni	opsin-like receptor	0.006	0.2631	0.2631
Onchocerca volvulus		0.006	0.2631	1
Brugia malayi	hypothetical protein	0.006	0.2631	0.2631
Loa Loa (eye worm)	TYRA-2 protein	0.006	0.2631	0.2193
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.2631	0.2631
Schistosoma mansoni	myosin xvIII	0.006	0.2631	0.2631
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.006	0.2631	0.2631
Schistosoma mansoni	neuropeptide F-like receptor	0.006	0.2631	0.2631
Echinococcus granulosus	cathepsin l1	0.005	0.1764	0.1764
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.005	0.1764	0.1275
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.006	0.2631	0.2631
Onchocerca volvulus	Cathepsin L homolog	0.005	0.1764	0.5813
Brugia malayi	hypothetical protein	0.006	0.2631	0.2631
Schistosoma mansoni	hypothetical protein	0.006	0.2631	0.2631
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.005	0.1764	0.7801
Echinococcus granulosus	g-protein coupled receptor	0.006	0.2631	0.2631
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.005	0.1764	0.7801
Onchocerca volvulus		0.006	0.2631	1
Brugia malayi	hypothetical protein	0.006	0.2631	0.2631
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.2631	0.2631
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.005	0.1764	0.7801
Brugia malayi	G-protein coupled receptor	0.006	0.2631	0.2631
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.006	0.2631	0.2631
Echinococcus multilocularis	g-protein coupled receptor	0.006	0.2631	0.2631
Brugia malayi	Cathepsin L-like precursor	0.005	0.1764	0.1764
Plasmodium vivax	vivapain-2	0.005	0.1764	1
Echinococcus granulosus	cathepsin b	0.0152	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0056	0.2262	0.2262
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.006	0.2631	0.2631
Schistosoma mansoni	alpha-1 adrenergic receptor	0.006	0.2631	0.2631
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.2631	0.2631
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0056	0.2262	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.006	0.2631	0.2631
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.005	0.1764	0.1764
Schistosoma mansoni	growth hormone secretagogue receptor	0.006	0.2631	0.2631
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Trypanosoma cruzi	cruzipain precursor, putative	0.005	0.1764	0.1764
Brugia malayi	sulfakinin receptor protein	0.006	0.2631	0.2631
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.005	0.1764	0.7801
Echinococcus granulosus	biogenic amine 5HT receptor	0.006	0.2631	0.2631
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.2631	0.2631
Echinococcus granulosus	cathepsin l1	0.0035	0.0561	0.0561
Loa Loa (eye worm)	G-protein coupled receptor	0.006	0.2631	0.2193
Echinococcus granulosus	7TM GPCR rhodopsin	0.006	0.2631	0.2631
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.1764	0.7801
Onchocerca volvulus		0.006	0.2631	1
Echinococcus multilocularis	neuropeptide receptor	0.006	0.2631	0.2631
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.1764	0.7801
Echinococcus granulosus	neuropeptides capa receptor	0.006	0.2631	0.2631
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.006	0.2631	0.2631
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.006	0.2631	1
Brugia malayi	Cathepsin L-like precursor	0.005	0.1764	0.1764
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.006	0.2631	0.2193
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.2631	0.2631
Entamoeba histolytica	cysteine proteinase, putative	0.0035	0.0561	0.3182
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.005	0.1764	0.7801
Entamoeba histolytica	cysteine proteinase, putative	0.005	0.1764	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.006	0.2631	0.2631
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.1764	0.7801
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.005	0.1764	0.7801
Echinococcus multilocularis	neuropeptide receptor	0.006	0.2631	0.2631
Brugia malayi	G-protein coupled receptor	0.006	0.2631	0.2631
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Entamoeba histolytica	cysteine protease, putative	0.005	0.1764	1
Brugia malayi	Cathepsin L-like precursor	0.005	0.1764	0.1764
Echinococcus granulosus	g protein coupled receptor	0.006	0.2631	0.2631
Onchocerca volvulus		0.006	0.2631	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Echinococcus multilocularis	sex peptide receptor	0.006	0.2631	0.2631
Onchocerca volvulus	Neuropeptide F receptor homolog	0.006	0.2631	1
Schistosoma mansoni	amine GPCR	0.006	0.2631	0.2631
Onchocerca volvulus		0.005	0.1764	0.5813
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.006	0.2631	0.2631
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.1764	0.7801
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.006	0.2631	0.2631
Schistosoma mansoni	biogenic amine (5HT) receptor	0.006	0.2631	0.2631
Echinococcus granulosus	7tm_1 domain containing protein	0.006	0.2631	0.2631
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0035	0.0561	0.0561
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.1764	0.7801
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.1764	0.7801
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.006	0.2631	0.2631
Onchocerca volvulus		0.006	0.2631	1
Echinococcus granulosus	neuropeptides capa receptor	0.006	0.2631	0.2631
Brugia malayi	Dopamine receptor protein 2	0.006	0.2631	0.2631
Echinococcus granulosus	cathepsin l cysteine peptidase	0.005	0.1764	0.1764
Onchocerca volvulus		0.006	0.2631	1
Loa Loa (eye worm)	neuropeptide F receptor	0.006	0.2631	0.2193
Echinococcus multilocularis	dro:myosuppressin receptor	0.006	0.2631	0.2631
Echinococcus granulosus	neuropeptide receptor A26	0.006	0.2631	0.2631
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.006	0.2631	0.2631
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.005	0.1764	0.7801
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.005	0.1764	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Echinococcus multilocularis	neuropeptides capa receptor	0.006	0.2631	0.2631
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Schistosoma mansoni	neuropeptide receptor	0.006	0.2631	0.2631
Brugia malayi	neuropeptide F receptor	0.006	0.2631	0.2631
Brugia malayi	Tachykinin-like peptides receptor 99D	0.006	0.2631	0.2631
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.006	0.2631	0.2631
Echinococcus granulosus	peptide allatostatin:somatostatin	0.006	0.2631	0.2631
Echinococcus granulosus	neuropeptide s receptor	0.006	0.2631	0.2631
Schistosoma mansoni	adenoreceptor	0.006	0.2631	0.2631
Echinococcus granulosus	neuropeptide receptor	0.006	0.2631	0.2631
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.006	0.2631	0.2193
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Onchocerca volvulus		0.006	0.2631	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0152	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.1764	0.7801
Brugia malayi	follicle stimulating hormone receptor	0.006	0.2631	0.2631
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0561	0.0561
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0056	0.2262	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.005	0.1764	0.7801
Onchocerca volvulus		0.006	0.2631	1
Onchocerca volvulus		0.006	0.2631	1
Echinococcus multilocularis	serotonin receptor	0.006	0.2631	0.2631
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.2631	0.2631
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0152	1	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.006	0.2631	0.2631
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.006	0.2631	0.2631
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.006	0.2631	0.2631
Schistosoma mansoni	amine GPCR	0.006	0.2631	0.2631
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.006	0.2631	0.2631
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.2631	0.2631
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.006	0.2631	0.2631
Echinococcus multilocularis	serotonin receptor	0.006	0.2631	0.2631
Echinococcus granulosus	biogenic amine 5HT receptor	0.006	0.2631	0.2631
Schistosoma mansoni	biogenic amine receptor	0.006	0.2631	0.2631
Loa Loa (eye worm)	fibroinase	0.005	0.1764	0.1275
Echinococcus granulosus	neuropeptide Y receptor	0.006	0.2631	0.2631
Echinococcus multilocularis	fmrfamide receptor	0.006	0.2631	0.2631
Echinococcus multilocularis	cysteine protease	0.005	0.1764	0.1764
Echinococcus multilocularis	neuropeptide Y receptor	0.006	0.2631	0.2631
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0152	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.1764	0.7801
Schistosoma mansoni	neuropeptide F-like receptor	0.006	0.2631	0.2631
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Onchocerca volvulus		0.006	0.2631	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.1764	0.7801
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Onchocerca volvulus		0.006	0.2631	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Schistosoma mansoni	opsin-like receptor	0.006	0.2631	0.2631
Schistosoma mansoni	biogenic amine (5HT) receptor	0.006	0.2631	0.2631
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.2631	0.2631
Giardia lamblia	Cathepsin B precursor	0.0056	0.2262	0.5
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.006	0.2631	0.2631
Echinococcus multilocularis	cysteine protease	0.005	0.1764	0.1764
Loa Loa (eye worm)	hypothetical protein	0.0152	1	1
Giardia lamblia	Cathepsin B precursor	0.0056	0.2262	0.5
Schistosoma mansoni	biogenic amine receptor	0.006	0.2631	0.2631
Echinococcus multilocularis	cathepsin b	0.0152	1	1
Schistosoma mansoni	hypothetical protein	0.006	0.2631	0.2631
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.2631	0.2631
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.006	0.2631	0.2631
Loa Loa (eye worm)	G-protein coupled receptor	0.006	0.2631	0.2193
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.006	0.2631	0.2631
Brugia malayi	G protein-coupled receptor	0.006	0.2631	0.2631
Echinococcus granulosus	neuropeptide receptor	0.006	0.2631	0.2631
Trypanosoma cruzi	cysteine peptidase, putative	0.005	0.1764	0.1764
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.006	0.2631	0.2631
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.2631	0.2631
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Echinococcus granulosus	serotonin receptor	0.006	0.2631	0.2631
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.1764	0.7801
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.006	0.2631	0.2631
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.005	0.1764	0.7801
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.005	0.1764	0.7801
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.2631	0.2631
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.2631	0.2631
Onchocerca volvulus		0.005	0.1764	0.5813
Brugia malayi	cathepsin L-like precursor	0.0035	0.0561	0.0561
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Schistosoma mansoni	hypothetical protein	0.006	0.2631	0.2631
Onchocerca volvulus		0.005	0.1764	0.5813
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Echinococcus granulosus	cathepsin L cysteine proteinase	0.005	0.1764	0.1764
Schistosoma mansoni	cathepsin F (C01 family)	0.005	0.1764	0.1764
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0561	0.2482
Brugia malayi	G protein-coupled receptor F59B2.13	0.006	0.2631	0.2631
Brugia malayi	Serotonin receptor	0.006	0.2631	0.2631
Schistosoma mansoni	biogenic amine receptor	0.006	0.2631	0.2631
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.006	0.2631	0.2631
Schistosoma mansoni	neuropeptide receptor	0.006	0.2631	0.2631
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.006	0.2631	0.2631
Loa Loa (eye worm)	cathepsin B	0.0056	0.2262	0.1802
Brugia malayi	RE15519p	0.006	0.2631	0.2631
Schistosoma mansoni	amine GPCR	0.006	0.2631	0.2631
Trypanosoma cruzi	cysteine peptidase, putative	0.005	0.1764	0.1764
Loa Loa (eye worm)	hypothetical protein	0.006	0.2631	0.2193
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.006	0.2631	0.2631
Echinococcus multilocularis	cathepsin L cysteine protease	0.005	0.1764	0.1764
Brugia malayi	Dopamine receptor	0.006	0.2631	0.2631
Onchocerca volvulus	Cathepsin F homolog	0.005	0.1764	0.5813
Echinococcus multilocularis	neuropeptide s receptor	0.006	0.2631	0.2631
Echinococcus granulosus	tm gpcr rhodopsin	0.006	0.2631	0.2631
Entamoeba histolytica	cysteine proteinase, putative	0.005	0.1764	1
Echinococcus granulosus	orexin receptor type 2	0.006	0.2631	0.2631
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.2631	0.2631

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1743901

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1517718