Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ImpB/MucB/SamB family protein | 0.0054 | 0.615 | 0.8338 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.615 | 0.8338 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 0.615 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 0.615 | 0.615 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.2937 | 0.2937 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 0.615 | 0.615 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 0.615 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3568 | 0.4837 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.7376 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.3568 | 0.3568 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.7376 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.7376 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.7376 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 0.615 | 0.615 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.3568 | 0.4837 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.2937 | 0.4775 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 0.615 | 0.615 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.