Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/FER protein kinase | 0.0105 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3339 | 0.3339 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0105 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0105 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0105 | 1 | 1 |
Brugia malayi | SRC-1 | 0.0105 | 1 | 1 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0105 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0105 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0105 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0105 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0105 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0105 | 1 | 1 |
Onchocerca volvulus | 0.0105 | 1 | 1 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0105 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0105 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0105 | 1 | 1 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0105 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0105 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3339 | 0.3339 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0105 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0105 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0105 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0105 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0105 | 1 | 1 |
Onchocerca volvulus | 0.0105 | 1 | 1 | |
Brugia malayi | Protein kinase domain containing protein | 0.0105 | 1 | 1 |
Brugia malayi | protein-tyrosine kinase | 0.0105 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0105 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3339 | 0.3339 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3339 | 0.3339 |
Onchocerca volvulus | 0.0105 | 1 | 1 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3339 | 0.3339 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0105 | 1 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.0105 | 1 | 1 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0105 | 1 | 1 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0105 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0105 | 1 | 1 |
Onchocerca volvulus | 0.0105 | 1 | 1 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0105 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0105 | 1 | 1 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0105 | 1 | 1 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0105 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0105 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0105 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0105 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0105 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.0105 | 1 | 1 |
Brugia malayi | SH2 domain containing protein | 0.0105 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0105 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0105 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0105 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3339 | 0.3339 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0105 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0105 | 1 | 1 |
Loa Loa (eye worm) | SRC-1 | 0.0105 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0105 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0105 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0105 | 1 | 1 |
Onchocerca volvulus | 0.0105 | 1 | 1 | |
Echinococcus granulosus | tyrosine kinase | 0.0105 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3339 | 0.3339 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3339 | 0.3339 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0105 | 1 | 1 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0105 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0105 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3339 | 0.3339 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0105 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0105 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0105 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0105 | 1 | 1 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0105 | 1 | 1 |
Onchocerca volvulus | 0.0105 | 1 | 1 | |
Echinococcus granulosus | c src tyrosine kinase | 0.0105 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3339 | 0.3339 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3339 | 0.3339 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0105 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0105 | 1 | 1 |
Brugia malayi | SH2 domain containing protein | 0.0105 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0105 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0105 | 1 | 1 |
Echinococcus multilocularis | tyrosine kinase | 0.0105 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0105 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3339 | 0.3339 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0105 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0105 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0105 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3339 | 0.3339 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.