Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine deaminase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | adenosine deaminase, putative | 0.0104 | 0.2675 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0104 | 0.2675 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.0104 | 0.2675 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.0104 | 0.2675 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0104 | 0.2675 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0196 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0104 | 0.2675 | 1 |
Loa Loa (eye worm) | IRE protein kinase | 0.0196 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.0104 | 0.2675 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.0104 | 0.2675 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0196 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0104 | 0.2675 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0104 | 0.2675 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.0104 | 0.2675 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2675 | 0.2675 |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.0196 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.0104 | 0.2675 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.0196 | 1 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.0104 | 0.2675 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0104 | 0.2675 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 700 nM | Inhibitory concentration against adenosine deaminase | ChEMBL. | 16033254 |
IC50 (binding) | = 700 nM | Inhibitory concentration against adenosine deaminase | ChEMBL. | 16033254 |
Ki (binding) | = 1.2 uM | In vitro binding affinity of the compound towards huaman adenosine deaminase (ADA) | ChEMBL. | 15139750 |
Ki (binding) | = 1.2 uM | Inhibition of human adenosine deaminase (ADA) | ChEMBL. | 15239652 |
Ki (binding) | = 1.2 uM | In vitro binding affinity of the compound towards huaman adenosine deaminase (ADA) | ChEMBL. | 15139750 |
Ki (binding) | = 1.2 uM | Inhibition of human adenosine deaminase (ADA) | ChEMBL. | 15239652 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.