Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0105 | 0.5648 | 0.5648 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0105 | 0.5648 | 0.5314 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3747 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0711 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3747 | 0.3269 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3747 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.3451 | 0.2949 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0711 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3747 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0711 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.0901 | 0.0205 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.0901 | 0.0901 |
Brugia malayi | hypothetical protein | 0.003 | 0.0711 | 0.0711 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3747 | 0.3747 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3747 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3747 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0711 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0711 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.0901 | 0.0901 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.3451 | 0.3451 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0901 | 0.0205 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0711 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3747 | 0.3269 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3747 | 0.3747 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.5648 | 0.5314 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0711 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3747 | 0.3747 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3747 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0105 | 0.5648 | 0.5648 |
Onchocerca volvulus | 0.0171 | 1 | 0.5 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3747 | 0.3269 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3747 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0711 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.3451 | 0.8958 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 21.3313 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.