Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 1 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0044 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0137 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0137 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0137 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1204 | 0.1204 |
Giardia lamblia | High cysteine protein | 0.0044 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1204 | 0.1204 |
Brugia malayi | Animal haem peroxidase family protein | 0.0137 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0137 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0137 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0137 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1204 | 0.1204 |
Onchocerca volvulus | Peroxidasin homolog | 0.0137 | 1 | 1 |
Onchocerca volvulus | 0.0137 | 1 | 1 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0137 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1204 | 0.1204 |
Echinococcus multilocularis | peroxidasin | 0.0137 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0137 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0137 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0137 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0137 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1204 | 0.1204 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1204 | 0.1204 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1204 | 0.1204 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0137 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0137 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0137 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0137 | 1 | 1 |
Onchocerca volvulus | 0.0137 | 1 | 1 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1204 | 0.1204 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0137 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0137 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1204 | 0.1204 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0137 | 1 | 1 |
Onchocerca volvulus | 0.0137 | 1 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0137 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.7865 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.