Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0054 | 0.0072 | 0.011 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0812 | 0.183 |
Schistosoma mansoni | nuclear hormone receptor | 0.0054 | 0.0072 | 0.0163 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0054 | 0.0072 | 0.011 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0812 | 0.183 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0072 | 0.011 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0054 | 0.0072 | 0.0163 |
Echinococcus multilocularis | tumor protein p63 | 0.0355 | 1 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0132 | 0.265 | 0.2596 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.0812 | 0.1135 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0129 | 0.2546 | 0.2492 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0054 | 0.0072 | 0.0163 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.0812 | 0.1233 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0054 | 0.0072 | 0.0094 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.0812 | 0.0745 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.0812 | 0.0745 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0054 | 0.0072 | 0.011 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0054 | 0.0072 | 0.011 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0054 | 0.0072 | 0.011 |
Brugia malayi | RNA binding protein | 0.0076 | 0.0812 | 0.1135 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.0812 | 0.1233 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0054 | 0.0072 | 0.0163 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0072 | 0.011 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.0812 | 0.1135 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.3047 | 0.4567 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0054 | 0.0072 | 0.0094 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0812 | 0.183 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0054 | 0.0072 | 0.011 |
Schistosoma mansoni | coup transcription factor | 0.0054 | 0.0072 | 0.0163 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0054 | 0.0072 | 0.0163 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0072 | 0.011 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0054 | 0.0072 | 0.011 |
Onchocerca volvulus | 0.0286 | 0.7733 | 1 | |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0158 | 0.349 | 0.7866 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0072 | 0.011 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.6586 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0072 | 0.011 |
Schistosoma mansoni | thyroid hormone receptor | 0.0186 | 0.4437 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0186 | 0.4437 | 0.4396 |
Schistosoma mansoni | thyroid hormone receptor | 0.0186 | 0.4437 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0054 | 0.0072 | 0.011 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0054 | 0.0072 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0072 | 0.011 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.0812 | 0.1233 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.6586 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0072 | 0.011 |
Onchocerca volvulus | 0.0054 | 0.0072 | 0.0094 | |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0054 | 0.0072 | 0.0163 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0054 | 0.0072 | 0.0163 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0054 | 0.0072 | 0.0163 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.3047 | 0.4626 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0054 | 0.0072 | 0.0163 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.7733 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0812 | 0.183 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0158 | 0.349 | 0.3443 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0132 | 0.265 | 0.2596 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0812 | 0.183 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.3047 | 0.4626 |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.265 | 0.5972 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0072 | 0.011 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.9811 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.