Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3445 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3445 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3445 | 0.3445 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3445 | 0.3445 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3445 | 0.3445 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3445 | 0.3445 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0009 | 0 | 0.5 |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3445 | 0.3445 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0009 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3445 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3445 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3445 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3445 | 0.3445 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3445 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3445 | 0.3445 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: Inhibitors of USP1/UAF1: Pilot qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504878] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.