Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | DNA gyrase subunit B, putative | 0.005 | 0.0204 | 0.0626 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0148 | 0.1666 | 0.1785 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0137 | 0.1512 | 0.5227 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0137 | 0.1512 | 0.5227 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0153 | 0.1749 | 0.4463 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.3918 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0153 | 0.1743 | 0.43 |
Brugia malayi | nuclear hormone receptor | 0.0658 | 0.933 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0153 | 0.1743 | 0.1868 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0145 | 0.1633 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.3918 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0153 | 0.1743 | 0.1443 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.005 | 0.0204 | 0.0624 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0153 | 0.1743 | 0.1868 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0145 | 0.1633 | 0.5 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0153 | 0.1749 | 1 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0153 | 0.1749 | 0.1874 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0153 | 0.1743 | 0.9965 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.3918 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.3918 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0658 | 0.933 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0083 | 0.0694 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.3918 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0148 | 0.1666 | 0.1666 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0145 | 0.1633 | 0.925 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0298 | 0.3918 | 1 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.004 | 0.0047 | 0.0121 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0988 | 0.0592 |
Giardia lamblia | DNA topoisomerase II | 0.0146 | 0.1642 | 0.4118 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0298 | 0.3918 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0153 | 0.1749 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0153 | 0.1743 | 0.1743 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0153 | 0.1749 | 0.4315 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0153 | 0.1749 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0153 | 0.1743 | 0.1868 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.3918 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0153 | 0.1743 | 0.1743 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.3918 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0137 | 0.1512 | 0.5227 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0137 | 0.1512 | 0.5227 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0153 | 0.1743 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0043 | 0.0102 | 0.0102 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0153 | 0.1749 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0153 | 0.1749 | 0.4315 |
Mycobacterium ulcerans | hypothetical protein | 0.0153 | 0.1749 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0298 | 0.3918 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0143 | 0.1604 | 0.1604 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0153 | 0.1749 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0153 | 0.1749 | 0.4315 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.005 | 0.0204 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0703 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1749 | 0.1449 |
Leishmania major | DNA topoisomerase ii | 0.0137 | 0.1512 | 0.5227 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0674 | 0.9573 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0703 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0644 | 0.9113 | 0.9755 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0153 | 0.1743 | 0.4448 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0148 | 0.1666 | 0.1666 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0153 | 0.1743 | 0.1743 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0988 | 0.0592 |
Plasmodium falciparum | DNA gyrase subunit B | 0.005 | 0.0204 | 0.0927 |
Loa Loa (eye worm) | acetyltransferase | 0.0148 | 0.1666 | 0.1356 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0153 | 0.1743 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0298 | 0.3918 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0298 | 0.3918 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.