Detailed information for compound 1518743

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 524.624 | Formula: C30H37FN2O5
  • H donors: 2 H acceptors: 4 LogP: 3.61 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: OCCN(C(=O)C[C@@H]1C/C=C/CC[C@@H](C(=O)OC[C@@H](NC1=O)C)Cc1ccc(cc1)F)Cc1ccccc1
  • InChi: 1S/C30H37FN2O5/c1-22-21-38-30(37)26(18-23-12-14-27(31)15-13-23)11-7-3-6-10-25(29(36)32-22)19-28(35)33(16-17-34)20-24-8-4-2-5-9-24/h2-6,8-9,12-15,22,25-26,34H,7,10-11,16-21H2,1H3,(H,32,36)/b6-3+/t22-,25-,26+/m0/s1
  • InChiKey: SNXITGWIQXQFRI-UVXQVQNASA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0023 0.0006 0.0045
Schistosoma mansoni hypothetical protein 0.0032 0.0025 0.0042
Brugia malayi Serotonin receptor 0.0026 0.0012 0.0035
Brugia malayi G-protein coupled receptor 0.0026 0.0012 0.0035
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0305 0.0574 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0101 0.0164 0.0574
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0006 0.0244
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.0164 0.0163
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0026 0.0012 0.0011
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0039 0.3417
Loa Loa (eye worm) oxidoreductase 0.0023 0.0006 0.002
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0038 0.0037 0.0036
Schistosoma mansoni hypothetical protein 0.0032 0.0025 0.0042
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0116 0.0401
Schistosoma mansoni hypothetical protein 0.0032 0.0025 0.0042
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0058 0.0077 1
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0023 0.0077
Entamoeba histolytica hypothetical protein 0.0038 0.0037 0.194
Trypanosoma brucei glycosyl hydrolase-like protein 0.0027 0.0016 0.0901
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0026 0.0012 0.0011
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0026 0.0012 0.0011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.0164 0.0163
Echinococcus multilocularis neuropeptide receptor A26 0.4993 1 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0059 0.0058
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0016 0.0207
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0039 0.0039
Schistosoma mansoni amine GPCR 0.0026 0.0012 0.002
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0036 0.0035
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0026 0.0012 0.0011
Echinococcus granulosus lysosomal alpha glucosidase 0.033 0.0625 0.0624
Onchocerca volvulus 0.0026 0.0012 0.0189
Brugia malayi putative neuropeptide receptor 0.0026 0.0012 0.0035
Loa Loa (eye worm) hypothetical protein 0.006 0.0081 0.0281
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.003 0.0545
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0139
Loa Loa (eye worm) hypothetical protein 0.0069 0.01 0.0347
Schistosoma mansoni alpha-glucosidase 0.0284 0.0532 0.0922
Brugia malayi hypothetical protein 0.0026 0.0012 0.0035
Schistosoma mansoni opsin-like receptor 0.0026 0.0012 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.0164 0.0283
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0011
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0012 0.002
Echinococcus granulosus sex peptide receptor 0.0026 0.0012 0.0011
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0164 0.0567
Onchocerca volvulus 0.0243 0.0449 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0026 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0006 0.002
Loa Loa (eye worm) hypothetical protein 0.0077 0.0116 0.0406
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.0006 0.0014
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0012 0.0011
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0047 0.0056 0.0055
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Echinococcus granulosus geminin 0.0168 0.0298 0.0297
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.003 0.0545
Schistosoma mansoni hypothetical protein 0.0168 0.0298 0.0515
Mycobacterium tuberculosis Carboxylesterase LipT 0.0243 0.0449 0.846
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0077 0.0116 0.1974
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0026 0.0012 0.0035
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0025 0.0024
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0089 0.0309
Echinococcus multilocularis neuropeptide s receptor 0.4993 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.01 0.0342
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0016 0.0207
Brugia malayi Dopamine receptor protein 1 0.0026 0.0012 0.0035
Brugia malayi Dopamine receptor 0.0026 0.0012 0.0035
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0108 0.2296
Onchocerca volvulus 0.0026 0.0012 0.0189
Loa Loa (eye worm) hypothetical protein 0.0119 0.0201 0.0701
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0012 0.0011
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.0006 0.012
Loa Loa (eye worm) carboxylesterase 0.1437 0.285 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0012 0.002
Onchocerca volvulus 0.0243 0.0449 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0073 0.0108 0.2296
Onchocerca volvulus 0.0026 0.0012 0.0189
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0073 0.0108 0.2296
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.193 0.1929
Brugia malayi neuropeptide F receptor 0.0026 0.0012 0.0035
Loa Loa (eye worm) hypothetical protein 0.0243 0.0449 0.1573
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0071 0.1331
Schistosoma mansoni microtubule-associated protein tau 0.2887 0.5766 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0243 0.0449 0.0448
Loa Loa (eye worm) hypothetical protein 0.0058 0.0077 0.0267
Echinococcus multilocularis carboxylesterase 5A 0.1437 0.285 0.285
Brugia malayi Melatonin receptor type 1A 0.0026 0.0012 0.0035
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0023 0.0006 0.0045
Onchocerca volvulus Huntingtin homolog 0.0119 0.0201 0.4419
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0006 0.0045
Trypanosoma brucei glucosidase, putative 0.0073 0.0108 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0026 0.0012 0.002
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0243 0.0449 0.846
Plasmodium falciparum protoporphyrinogen oxidase 0.0021 0.0004 0.0403
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Brugia malayi hypothetical protein 0.0026 0.0012 0.0035
Brugia malayi MH2 domain containing protein 0.0243 0.0449 0.1567
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0016 0.0207
Brugia malayi Bromodomain containing protein 0.0033 0.0027 0.0088
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0012 0.0011
Brugia malayi hypothetical protein 0.0119 0.0201 0.0696
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0025 0.0024
Brugia malayi hypothetical protein 0.0026 0.0012 0.0035
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0006 0.012
Brugia malayi CHE-14 protein 0.0049 0.0059 0.0198
Schistosoma mansoni cpg binding protein 0.0164 0.029 0.0502
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0073 0.0108 0.191
Trichomonas vaginalis spcc417.12 protein, putative 0.0243 0.0449 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Echinococcus granulosus BC026374 protein S09 family 0.0243 0.0449 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.003 0.0545
Onchocerca volvulus Huntingtin homolog 0.0119 0.0201 0.4419
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0001 0.0001
Schistosoma mansoni cpg binding protein 0.0164 0.029 0.0502
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.003 0.0545
Echinococcus granulosus Niemann Pick C1 protein 0.0162 0.0287 0.0286
Schistosoma mansoni hypothetical protein 0.0031 0.0023 0.0038
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0039 0.3163
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0006 0.012
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0047 0.0056 0.0055
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0026 0.0012 0.0011
Onchocerca volvulus 0.0026 0.0012 0.0189
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0027 0.0016 0.0784
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0012 0.004
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.0006 0.0347
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.0006 0.012
Schistosoma mansoni jumonji domain containing protein 0.008 0.0122 0.0211
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0016 0.0207
Echinococcus granulosus neuropeptide receptor 0.0026 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0036 0.0123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0012 0.002
Echinococcus granulosus allatostatin A receptor 0.0026 0.0012 0.0011
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0002 0.0001
Echinococcus multilocularis lysosomal alpha glucosidase 0.033 0.0625 0.0624
Schistosoma mansoni hypothetical protein 0.002 0.0001 0.0001
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0026 0.0012 0.0011
Brugia malayi ORL1-like opioid receptor 0.0026 0.0012 0.0035
Echinococcus granulosus lysine specific demethylase 5A 0.0048 0.0057 0.0056
Schistosoma mansoni acetylcholinesterase 0.0243 0.0449 0.0777
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0101 0.0164 0.0569
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.003 0.0545
Echinococcus granulosus g protein coupled receptor 0.0026 0.0012 0.0011
Schistosoma mansoni hypothetical protein 0.0047 0.0055 0.0094
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0073 0.0108 0.5694
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0012 0.002
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0012 0.004
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0006 0.0244
Schistosoma mansoni hypothetical protein 0.0168 0.0298 0.0515
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.0243 0.0449 0.1573
Loa Loa (eye worm) hypothetical protein 0.0058 0.0077 0.0267
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0026 0.0012 0.004
Schistosoma mansoni jumonji/arid domain-containing protein 0.0048 0.0057 0.0098
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Onchocerca volvulus 0.0023 0.0006 0.0057
Onchocerca volvulus 0.0026 0.0012 0.0189
Schistosoma mansoni hypothetical protein 0.2183 0.435 0.7545
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0006 0.0226
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.0006 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.003 0.0545
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0025 0.008
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0073 0.0108 0.2296
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0116 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0243 0.0449 0.7809
Mycobacterium ulcerans acetyl-CoA synthetase 0.0023 0.0006 0.0045
Loa Loa (eye worm) hypothetical protein 0.0049 0.0059 0.0203
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0116 0.6139
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0006 0.0226
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0023 0.0006 0.0045
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0115 0.0193 0.0333
Echinococcus granulosus acetylcholinesterase 0.1437 0.285 0.285
Schistosoma mansoni neuropeptide receptor 0.0026 0.0012 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0012 0.0011
Brugia malayi RE15519p 0.0026 0.0012 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.003 0.0545
Schistosoma mansoni biogenic amine receptor 0.0026 0.0012 0.002
Echinococcus multilocularis g-protein coupled receptor 0.0026 0.0012 0.0011
Schistosoma mansoni cpg binding protein 0.0153 0.0269 0.0465
Loa Loa (eye worm) jmjC domain-containing protein 0.0048 0.0057 0.0198
Echinococcus multilocularis BC026374 protein (S09 family) 0.0243 0.0449 0.0448
Brugia malayi F/Y-rich N-terminus family protein 0.0059 0.0079 0.0269
Echinococcus granulosus g-protein coupled receptor 0.0026 0.0012 0.0011
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0039 0.0067
Brugia malayi follicle stimulating hormone receptor 0.0026 0.0012 0.0035
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.0006 0.0006
Onchocerca volvulus 0.0026 0.0012 0.0189
Schistosoma mansoni zinc finger protein 0.0028 0.0017 0.0027
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0016 0.1123
Loa Loa (eye worm) hypothetical protein 0.0101 0.0164 0.0572
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0012 0.002
Echinococcus granulosus para nitrobenzyl esterase 0.0243 0.0449 0.0448
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Brugia malayi G protein-coupled receptor F59B2.13 0.0026 0.0012 0.0035
Loa Loa (eye worm) hypothetical protein 0.0031 0.0023 0.0077
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0012 0.0011
Echinococcus multilocularis Niemann Pick C1 protein 0.0162 0.0287 0.0286
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0012 0.0011
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0243 0.0449 1
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Brugia malayi hypothetical protein 0.0026 0.0012 0.0035
Echinococcus granulosus fetal alzheimer antigen falz 0.0031 0.0022 0.0022
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0116 0.1974
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0164 0.0572
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0071 0.1331
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0012 0.0011
Echinococcus multilocularis neuropeptide FF receptor 2 0.0026 0.0012 0.0011
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0243 0.0449 0.0777
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0011
Schistosoma mansoni jumonji/arid domain-containing protein 0.0048 0.0057 0.0098
Echinococcus granulosus serotonin receptor 0.0026 0.0012 0.0011
Schistosoma mansoni alpha-1 adrenergic receptor 0.0026 0.0012 0.002
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0039 0.3417
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Brugia malayi Serotonin receptor 0.0026 0.0012 0.0035
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0059 0.0058
Echinococcus granulosus acetylcholinesterase 0.1437 0.285 0.285
Echinococcus granulosus carboxylesterase 5A 0.1437 0.285 0.285
Echinococcus granulosus G protein coupled receptor 139 0.0026 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0077 0.0116 0.0406
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0023 0.0006 0.0045
Schistosoma mansoni hypothetical protein 0.0026 0.0012 0.002
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0073 0.0108 0.5694
Loa Loa (eye worm) hypothetical protein 0.1437 0.285 1
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0023 0.0006 0.0045
Loa Loa (eye worm) hypothetical protein 0.0243 0.0449 0.1573
Schistosoma mansoni amine GPCR 0.0026 0.0012 0.002
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0243 0.0449 0.1573
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.0006 0.0736
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0038 0.0037 0.0036
Echinococcus multilocularis neutral alpha glucosidase AB 0.0073 0.0108 0.0107
Schistosoma mansoni amine GPCR 0.0026 0.0012 0.002
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0006 0.0014
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0114 0.0189 1
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0021 0.0004 0.0005
Brugia malayi hypothetical protein 0.0026 0.0012 0.0035
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0011
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0016 0.0207
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0039 0.0039
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.0006 0.0006
Echinococcus multilocularis cpg binding protein 0.0164 0.029 0.0289
Entamoeba histolytica hypothetical protein 0.0038 0.0037 0.194
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0026 0.0012 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0006 0.0045
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0023 0.0022
Echinococcus multilocularis allatostatin A receptor 0.0026 0.0012 0.0011
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0026 0.0012 0.002
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0031 0.003
Echinococcus granulosus mixed lineage leukemia protein mll 0.0038 0.0037 0.0036
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0026 0.0012 0.0011
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0012 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0012 0.002
Schistosoma mansoni hypothetical protein 0.0047 0.0055 0.0094
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0114 0.0189 0.0661
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0012 0.002
Brugia malayi jmjC domain containing protein 0.0048 0.0057 0.0193
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.0006 0.0298
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.0164 0.0163
Echinococcus granulosus cpg binding protein 0.0164 0.029 0.0289
Brugia malayi hypothetical protein 0.0021 0.0004 0.0006
Onchocerca volvulus 0.0026 0.0012 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.003 0.0545
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.0164 0.0163
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0012 0.002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0025 0.0024
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0243 0.0449 0.846
Echinococcus granulosus g protein coupled receptor 0.0026 0.0012 0.0011
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0116 0.0401
Echinococcus granulosus peptide allatostatin:somatostatin 0.0026 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0069 0.0099 0.0345
Schistosoma mansoni neuroligin 3 (S09 family) 0.0243 0.0449 0.0777
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0006 0.0045
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0026 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Brugia malayi Carboxylesterase family protein 0.0243 0.0449 0.1568
Schistosoma mansoni amine GPCR 0.0026 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Loa Loa (eye worm) acetylcholinesterase 1 0.1437 0.285 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Schistosoma mansoni neuropeptide f receptor 76f 0.0026 0.0012 0.002
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0059 0.0203
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0006 0.0045
Echinococcus granulosus peregrin 0.0033 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0058 0.0077 0.0267
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0025 0.0024
Onchocerca volvulus 0.0026 0.0012 0.0189
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0021 0.0004 0.0003
Echinococcus granulosus orexin receptor type 2 0.0026 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0026 0.0012 0.002
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0012 0.0011
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0012 0.0011
Brugia malayi PHD-finger family protein 0.0031 0.0023 0.0072
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0006 0.012
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0039 0.0136
Echinococcus multilocularis serotonin receptor 0.0026 0.0012 0.0011
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0059 0.0058
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0012 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0001 0.0000034634
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.0164 0.0283
Echinococcus multilocularis 0.0021 0.0004 0.0003
Brugia malayi Carboxylesterase family protein 0.1437 0.285 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0023 0.0038
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0012 0.0011
Loa Loa (eye worm) carboxylesterase 0.0243 0.0449 0.1573
Onchocerca volvulus 0.0026 0.0012 0.0189
Schistosoma mansoni opsin-like receptor 0.0026 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0006 0.0014
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0012 0.0011
Schistosoma mansoni hypothetical protein 0.0026 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Onchocerca volvulus 0.0026 0.0012 0.0189
Loa Loa (eye worm) CXXC zinc finger family protein 0.0153 0.0269 0.0941
Echinococcus multilocularis protein patched 0.0049 0.0059 0.0058
Echinococcus granulosus neuropeptide receptor A26 0.4993 1 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0006 0.002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0012 0.0011
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0026 0.0012 0.0011
Onchocerca volvulus 0.0243 0.0449 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0243 0.0449 0.0777
Onchocerca volvulus 0.0191 0.0345 0.7658
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0006 0.0045
Loa Loa (eye worm) hypothetical protein 0.1437 0.285 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0012 0.0011
Brugia malayi Carboxylesterase family protein 0.1437 0.285 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0071 0.1331
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0006 0.012
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0026 0.0012 0.0035
Schistosoma mansoni neuropeptide receptor 0.0026 0.0012 0.002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0012 0.0011
Onchocerca volvulus 0.0023 0.0006 0.0057
Schistosoma mansoni neuropeptide receptor 0.0026 0.0012 0.002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0116 0.6139
Onchocerca volvulus 0.0026 0.0012 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0012 0.0011
Brugia malayi PHD-finger family protein 0.0033 0.0027 0.0087
Schistosoma mansoni hypothetical protein 0.0047 0.0055 0.0094
Schistosoma mansoni neuropeptide receptor 0.0026 0.0012 0.002
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0026 0.0012 0.0189
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0077 0.0116 0.1974
Schistosoma mansoni amine GPCR 0.0026 0.0012 0.002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.0164 0.0163
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.0006 0.012
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1437 0.285 0.4943
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0026 0.0012 0.002
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0037 0.0063
Loa Loa (eye worm) hypothetical protein 0.0058 0.0077 0.0267
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0026 0.0012 0.002
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0031 0.0023 0.0345
Brugia malayi larval opioid receptor 0.0026 0.0012 0.0035
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0023 0.0347
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0108 0.2296
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0012 0.0011
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0026 0.0012 0.002
Schistosoma mansoni biogenic amine receptor 0.0026 0.0012 0.002
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0037 0.0037
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0021 0.0004 0.0005
Onchocerca volvulus 0.0243 0.0449 1
Echinococcus multilocularis GPCR, family 2 0.0032 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Echinococcus granulosus neuropeptide FF receptor 2 0.0026 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.003 0.0545
Echinococcus multilocularis geminin 0.0168 0.0298 0.0297
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0012 0.0011
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0039 0.0039
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0164 0.0567
Schistosoma mansoni alpha-glucosidase 0.0284 0.0532 0.0922
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0116 1
Brugia malayi Carboxylesterase family protein 0.0243 0.0449 0.1568
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0012 0.0011
Mycobacterium tuberculosis Possible oxidoreductase 0.0021 0.0004 0.0072
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.0164 0.0163
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0077 0.0116 0.1974
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0023 0.2586
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0325 0.0614 0.1064
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0026 0.0012 0.004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.003 0.0545
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0095 0.0094
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0073 0.0108 0.0376
Plasmodium falciparum acyl-CoA synthetase 0.0058 0.0077 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0116 0.0406
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0243 0.0449 0.1573
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0095 0.0094
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0012 0.002
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0026 0.0012 0.002
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.0006 0.012
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0006 0.012
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.033 0.0625 0.2189
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0071 0.1331
Echinococcus multilocularis dro:myosuppressin receptor 0.0026 0.0012 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0012 0.002
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0039 0.0747
Schistosoma mansoni patched 1 0.0049 0.0059 0.01
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0116 0.0401
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0039 1
Plasmodium falciparum phd finger protein, putative 0.0031 0.0023 0.2885
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0012 0.0011
Echinococcus granulosus g protein coupled receptor 0.0026 0.0012 0.0011
Echinococcus multilocularis zinc finger protein 0.0028 0.0017 0.0016
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0025 0.008
Brugia malayi putative neuropeptide receptor NPR1 0.0026 0.0012 0.0035
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0026 0.0012 0.002
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.0006 0.001
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0016 0.0207
Brugia malayi jmjC domain containing protein 0.0101 0.0164 0.0568
Brugia malayi CXXC zinc finger family protein 0.0153 0.0269 0.0936
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0031 0.003
Mycobacterium ulcerans hypothetical protein 0.0077 0.0116 0.1974
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0026 0.0012 0.0035
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0023 0.0006 0.0045
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0077 0.0116 0.1974
Schistosoma mansoni hypothetical protein 0.0069 0.01 0.0171
Schistosoma mansoni bromodomain containing protein 0.007 0.0102 0.0176
Brugia malayi neuropeptide F receptor 0.0026 0.0012 0.0035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0012 0.002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0037 0.0037
Echinococcus multilocularis G-protein coupled receptor, putative 0.0026 0.0012 0.0011
Onchocerca volvulus Neuropeptide F receptor homolog 0.0026 0.0012 0.0189
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0021 0.0004 0.0403
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0108 1
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0283 0.0531 1
Echinococcus multilocularis sex peptide receptor 0.0026 0.0012 0.0011
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0116 1
Entamoeba histolytica hypothetical protein 0.0038 0.0037 0.194
Brugia malayi hypothetical protein 0.0243 0.0449 0.1568
Brugia malayi hypothetical protein 0.0026 0.0012 0.0035
Schistosoma mansoni hypothetical protein 0.0038 0.0037 0.0063
Onchocerca volvulus 0.0026 0.0012 0.0189
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0021 0.0004 0.0403
Brugia malayi hypothetical protein 0.0026 0.0012 0.0035
Brugia malayi Niemann-Pick C1 protein precursor 0.0114 0.0189 0.0656
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0016 0.0207
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0012 0.0011
Onchocerca volvulus 0.0023 0.0006 0.0057
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0026 0.0012 0.0011
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0026 0.0012 0.004
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0026 0.0012 0.004
Echinococcus granulosus microtubule associated protein 2 0.2887 0.5766 0.5766
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0006 0.0244
Schistosoma mansoni gliotactin 0.0243 0.0449 0.0777
Echinococcus multilocularis G protein coupled receptor 139 0.0026 0.0012 0.0011
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0025 0.0085
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0305 0.0574 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0012 0.0011
Echinococcus granulosus dro:myosuppressin receptor 0.0026 0.0012 0.0011
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0006 0.0226
Echinococcus multilocularis protoporphyrinogen oxidase 0.0021 0.0004 0.0003
Schistosoma mansoni amine oxidase 0.0021 0.0004 0.0005
Loa Loa (eye worm) TYRA-2 protein 0.0026 0.0012 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.003 0.0545
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0108 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0012 0.0011
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0012 0.0011
Onchocerca volvulus 0.0023 0.0006 0.0057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0012 0.0011
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0243 0.0449 0.0448
Brugia malayi Dopamine receptor protein 2 0.0026 0.0012 0.0035
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0038 0.0037 0.0036
Echinococcus multilocularis dnaJ subfamily B 0.2183 0.435 0.435
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Schistosoma mansoni BC026374 protein (S09 family) 0.0243 0.0449 0.0777
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0012 0.0011
Onchocerca volvulus 0.0026 0.0012 0.0189
Echinococcus multilocularis acetylcholinesterase 0.1437 0.285 0.285
Echinococcus granulosus neuropeptide receptor 0.0026 0.0012 0.0011
Brugia malayi hypothetical protein 0.0026 0.0012 0.0035
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0012 0.002
Brugia malayi Tachykinin-like peptides receptor 99D 0.0026 0.0012 0.0035
Loa Loa (eye worm) hypothetical protein 0.0243 0.0449 0.1573
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0006 0.0014
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.0006 0.0047
Brugia malayi amine oxidase, flavin-containing family protein 0.0021 0.0004 0.0006
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0058 0.0077 0.1451
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0023 0.0006 0.0226
Echinococcus multilocularis orexin receptor type 2 0.0026 0.0012 0.0011
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0039 0.3252
Onchocerca volvulus 0.0077 0.0116 0.2528
Echinococcus granulosus somatostatin receptor 0.0026 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Leishmania major alpha glucosidase II subunit, putative 0.0073 0.0108 0.9256
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Schistosoma mansoni hypothetical protein 0.0026 0.0012 0.002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0012 0.002
Echinococcus granulosus 7TM GPCR rhodopsin 0.0026 0.0012 0.0011
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0108 0.2296
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0023 0.0006 0.0226
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0027 0.0016 0.0263
Echinococcus granulosus alpha 1A adrenergic receptor 0.0026 0.0012 0.0011
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0035 0.003 0.0545
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.0164 0.0283
Echinococcus multilocularis serotonin receptor 0.0026 0.0012 0.0011
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0006 0.0014
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0039 0.2053
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.0449 0.1572
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0039 0.0039
Brugia malayi Bromodomain containing protein 0.0082 0.0125 0.0431
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0006 0.0045
Echinococcus granulosus GPCR family 2 0.0032 0.0025 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0039 0.0747
Echinococcus granulosus Niemann Pick C1 protein 0.0114 0.0189 0.0188
Onchocerca volvulus Alhambra homolog 0.0031 0.0023 0.0425
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.002
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0012 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0039 0.0747
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0052
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0077 0.0116 0.2193
Onchocerca volvulus 0.0026 0.0012 0.0189
Entamoeba histolytica acyl-coA synthetase, putative 0.0077 0.0116 0.6139
Loa Loa (eye worm) histone methyltransferase 0.0047 0.0056 0.0194
Echinococcus multilocularis somatostatin receptor 0.0026 0.0012 0.0011
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0012 0.002
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0023 0.0022
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0012 0.0011
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.0006 0.012
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0108 0.2296
Loa Loa (eye worm) hypothetical protein 0.005 0.0062 0.0214
Echinococcus multilocularis para nitrobenzyl esterase 0.0243 0.0449 0.0448
Echinococcus multilocularis microtubule associated protein 2 0.2887 0.5766 0.5766
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0116 0.1974
Echinococcus granulosus 7tm_1 domain containing protein 0.0026 0.0012 0.0011
Brugia malayi G protein-coupled receptor 0.0026 0.0012 0.0035
Loa Loa (eye worm) carboxylesterase 0.0243 0.0449 0.1573
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.003 0.0545
Toxoplasma gondii propionate-CoA ligase 0.0023 0.0006 0.0047
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0035 0.003 0.0545
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0012 0.002
Echinococcus multilocularis peregrin 0.0033 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Echinococcus granulosus tachykinin peptides receptor 99D 0.0026 0.0012 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0001 0.0000034634
Schistosoma mansoni histamine h1 receptor 0.0026 0.0012 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0006 0.0045
Loa Loa (eye worm) hypothetical protein 0.0032 0.0025 0.0085
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.0449 0.1572
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Schistosoma mansoni biogenic amine receptor 0.0026 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Echinococcus multilocularis expressed conserved protein 0.0107 0.0175 0.0174
Brugia malayi hypothetical protein 0.0026 0.0012 0.0035
Loa Loa (eye worm) hypothetical protein 0.0053 0.0067 0.0233
Echinococcus multilocularis lysosomal alpha glucosidase 0.033 0.0625 0.0624
Brugia malayi SWIRM domain containing protein 0.0021 0.0004 0.0006
Echinococcus multilocularis neuroligin 0.0243 0.0449 0.0448
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0012 0.0011
Schistosoma mansoni opsin-like receptor 0.0026 0.0012 0.002
Schistosoma mansoni hypothetical protein 0.0047 0.0055 0.0094
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0006 0.0045
Trichomonas vaginalis maltase-glucoamylase, putative 0.0073 0.0108 0.2296
Trichomonas vaginalis helicase, putative 0.0035 0.003 0.0545
Echinococcus granulosus neutral alpha glucosidase AB 0.0073 0.0108 0.0107
Brugia malayi G-protein coupled receptor 0.0026 0.0012 0.0035
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Toxoplasma gondii histone lysine methyltransferase SET1 0.0293 0.0549 1
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0006 0.0226
Plasmodium vivax acyl-CoA synthetase, putative 0.0058 0.0077 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0006 0.0244
Echinococcus multilocularis protein dispatched 1 0.0056 0.0073 0.0072
Echinococcus multilocularis Niemann Pick C1 protein 0.0114 0.0189 0.0188
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0016 0.1123
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0116 0.1974
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0006 0.0045
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0012 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0012 0.002
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0006 0.0014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Schistosoma mansoni growth hormone secretagogue receptor 0.0026 0.0012 0.002
Brugia malayi hypothetical protein 0.0038 0.0037 0.0123
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0004 0.0072
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0012 0.002
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0012 0.002
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0243 0.0449 0.0777
Echinococcus granulosus hypothetical protein 0.0026 0.0012 0.0011
Onchocerca volvulus 0.0026 0.0012 0.0189
Loa Loa (eye worm) melatonin receptor type 1A 0.0026 0.0012 0.004
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0039 0.013
Entamoeba histolytica hypothetical protein 0.0038 0.0037 0.194
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0012 0.004
Brugia malayi Carboxylesterase family protein 0.0243 0.0449 0.1568
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0039 0.0039
Onchocerca volvulus 0.0243 0.0449 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0201 0.0701
Loa Loa (eye worm) hypothetical protein 0.0243 0.0449 0.1573
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0005 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.003 0.0545
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.003 0.0545
Brugia malayi hypothetical protein 0.0026 0.0012 0.0035
Echinococcus granulosus zinc finger protein 0.0028 0.0017 0.0016
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0012 0.0011
Leishmania major glycosyl hydrolase-like protein 0.0027 0.0016 0.104
Brugia malayi Glycosyl hydrolases family 31 protein 0.0073 0.0108 0.0371
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0108 0.2296
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Echinococcus granulosus dnaJ subfamily B 0.2183 0.435 0.435
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0023 0.0006 0.0045
Onchocerca volvulus 0.0153 0.0269 0.5955
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0116 1
Onchocerca volvulus 0.0026 0.0012 0.0189
Loa Loa (eye worm) hypothetical protein 0.0058 0.0077 0.0267
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0023 0.0347
Brugia malayi sulfakinin receptor protein 0.0026 0.0012 0.0035
Brugia malayi Glycosyl hydrolases family 31 protein 0.033 0.0625 0.2185
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0039 0.0039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0012 0.0011
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0012 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0048 0.0058 0.0098
Brugia malayi Glycosyl hydrolases family 31 protein 0.0027 0.0016 0.0047
Brugia malayi Bromodomain containing protein 0.0037 0.0036 0.0117
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.003 0.0545
Schistosoma mansoni alpha glucosidase 0.0073 0.0108 0.0186
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0004 0.0003
Brugia malayi AKH receptor 0.0026 0.0012 0.0035
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0077 0.0116 0.2193
Echinococcus multilocularis acetylcholinesterase 0.1437 0.285 0.285
Echinococcus granulosus expressed conserved protein 0.0107 0.0175 0.0174
Schistosoma mansoni hypothetical protein 0.0032 0.0025 0.0042
Schistosoma mansoni hypothetical protein 0.0026 0.0012 0.002
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.0006 0.0047
Schistosoma mansoni myosin xvIII 0.0026 0.0012 0.002
Onchocerca volvulus 0.0026 0.0012 0.0189
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0031 0.0022 0.0022
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0012 0.0011
Trichomonas vaginalis maltase-glucoamylase, putative 0.0027 0.0016 0.0207
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0011
Brugia malayi Carboxylesterase family protein 0.0243 0.0449 0.1568
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0026 0.0012 0.0035
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.004
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0026 0.0012 0.0035
Echinococcus granulosus fmrfamide receptor 0.0026 0.0012 0.0011
Echinococcus granulosus neuroligin 0.0243 0.0449 0.0448
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0047 0.0046
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0116 1
Brugia malayi GnHR receptor homolog 0.0026 0.0012 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0059 0.1182
Schistosoma mansoni amine oxidase 0.0021 0.0004 0.0005
Schistosoma mansoni adenoreceptor 0.0026 0.0012 0.002
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0058 0.0077 0.1284
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0012 0.0011
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0031 0.0022 0.0037
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0039 0.0067

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.