Detailed information for compound 1518821

Basic information

Technical information
  • TDR Targets ID: 1518821
  • Name: (3,4-dimethoxyphenyl)-[4-[2-(4-methoxyphenoxy )ethyl]piperazin-1-yl]methanone
  • MW: 400.468 | Formula: C22H28N2O5
  • H donors: 0 H acceptors: 1 LogP: 2.77 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)OCCN1CCN(CC1)C(=O)c1ccc(c(c1)OC)OC
  • InChi: 1S/C22H28N2O5/c1-26-18-5-7-19(8-6-18)29-15-14-23-10-12-24(13-11-23)22(25)17-4-9-20(27-2)21(16-17)28-3/h4-9,16H,10-15H2,1-3H3
  • InChiKey: WDCZCXOQODFNBN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (3,4-dimethoxyphenyl)-[4-[2-(4-methoxyphenoxy)ethyl]-1-piperazinyl]methanone
  • T5595518

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Dopamine receptor protein 1 0.0186 0.1828 0.2469
Entamoeba histolytica hypothetical protein 0.0038 0.0296 0.0645
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1042 0.243
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0417 0.4204 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.05 0.0675
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0267 0.0267
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0057 0.05 0.1132
Echinococcus multilocularis snurportin 1 0.0372 0.3739 0.3739
Leishmania major nucleoside transporter 1, putative 0.0057 0.05 0.0641
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0613 0.0828
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0296 0.0296
Trypanosoma brucei adenosine transporter 2 0.0057 0.05 0.0641
Leishmania major ATP-dependent phosphofructokinase 0.011 0.1042 0.1376
Echinococcus granulosus neuropeptides capa receptor 0.0186 0.1828 0.2469
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0214 0.051
Schistosoma mansoni hypothetical protein 0.0012 0.003 0.0041
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0079 0.0187
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0131 0.0131
Echinococcus granulosus neuropeptide Y receptor 0.0186 0.1828 0.2469
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0112 0.1066 0.144
Echinococcus multilocularis fmrfamide receptor 0.0186 0.1828 0.1828
Schistosoma mansoni neuropeptide receptor 0.0186 0.1828 0.2469
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0214 0.0449
Brugia malayi hypothetical protein 0.0186 0.1828 0.2469
Leishmania major hypothetical protein, conserved 0.0026 0.018 0.0207
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0144 0.1392 1
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0417 0.4204 0.5677
Echinococcus multilocularis neuropeptide receptor 0.0186 0.1828 0.1828
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0186 0.1828 0.2469
Trypanosoma cruzi nucleoside transporter-like, putative 0.0057 0.05 0.0641
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0057 0.05 0.0641
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0186 0.1828 0.2469
Echinococcus multilocularis adenosine kinase 0.0727 0.7405 0.7405
Schistosoma mansoni ribokinase 0.0083 0.0762 0.103
Echinococcus multilocularis geminin 0.0349 0.3504 0.3504
Brugia malayi hypothetical protein 0.0057 0.05 0.0675
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1042 0.1407
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0186 0.1828 0.2469
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0436 0.0589
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.1066 0.144
Toxoplasma gondii kinase, pfkB family protein 0.0727 0.7405 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0079 0.007
Loa Loa (eye worm) hypothetical protein 0.0026 0.018 0.0243
Trypanosoma brucei adenosine transporter, putative 0.0057 0.05 0.0641
Trypanosoma cruzi nucleobase transporter, putative 0.0057 0.05 0.0641
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0079 0.0106
Loa Loa (eye worm) hypothetical protein 0.0077 0.07 0.0945
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0417 0.4204 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0186 0.1828 0.1828
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1042 0.1376
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0417 0.4204 0.5661
Brugia malayi Adenylyl cyclase protein 0.0078 0.0709 0.0957
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0613 0.1403
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Onchocerca volvulus 0.0186 0.1828 0.2726
Echinococcus granulosus biogenic amine 5HT receptor 0.0186 0.1828 0.2469
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0613 0.0794
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1042 0.1407
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0058 0.0078
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0057 0.05 0.0641
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0186 0.1828 0.2469
Echinococcus granulosus G protein coupled receptor 139 0.0186 0.1828 0.2469
Trypanosoma brucei adenosine transporter 2, putative 0.0057 0.05 0.0641
Onchocerca volvulus 0.0083 0.0762 0.1085
Echinococcus multilocularis neuropeptide Y receptor 0.0186 0.1828 0.1828
Brugia malayi larval opioid receptor 0.0186 0.1828 0.2469
Trypanosoma brucei purine nucleoside transporter 0.0057 0.05 0.0641
Schistosoma mansoni adenoreceptor 0.0186 0.1828 0.2469
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.0083 0.0762 0.103
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0417 0.4204 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.1196 0.1616
Brugia malayi hypothetical protein 0.0186 0.1828 0.2469
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0417 0.4204 0.5677
Schistosoma mansoni hypothetical protein 0.0186 0.1828 0.2469
Echinococcus granulosus biogenic amine 5HT receptor 0.0186 0.1828 0.2469
Echinococcus multilocularis neuropeptides capa receptor 0.0186 0.1828 0.1828
Loa Loa (eye worm) G-protein coupled receptor 0.0186 0.1828 0.2469
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.1042 0.7253
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0186 0.1828 0.2469
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.018 0.0243
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0417 0.4204 0.5661
Brugia malayi hypothetical protein 0.0026 0.018 0.0243
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0079 0.0106
Echinococcus granulosus g-protein coupled receptor 0.0186 0.1828 0.2469
Brugia malayi phosphofructokinase 0.011 0.1042 0.1407
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0186 0.1828 0.1828
Trypanosoma brucei ribokinase, putative 0.0083 0.0762 0.0997
Echinococcus granulosus rhodopsin orphan GPCR 0.0186 0.1828 0.2469
Onchocerca volvulus 0.0186 0.1828 0.2726
Mycobacterium ulcerans fructokinase, PfkB 0.0083 0.0762 0.1576
Echinococcus multilocularis orexin receptor type 2 0.0186 0.1828 0.1828
Chlamydia trachomatis endonuclease IV 0.0078 0.0708 0.1236
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0118 0.016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0186 0.1828 0.2469
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0273 0.2723 0.3677
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Schistosoma mansoni biogenic amine receptor 0.0186 0.1828 0.2469
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.003 0.0041
Schistosoma mansoni amine GPCR 0.0186 0.1828 0.2469
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0214 0.0449
Brugia malayi Dopamine receptor protein 2 0.0186 0.1828 0.2469
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0417 0.4204 0.5677
Echinococcus multilocularis neuropeptides capa receptor 0.0186 0.1828 0.1828
Echinococcus multilocularis rhodopsin orphan GPCR 0.0186 0.1828 0.1828
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0186 0.1828 0.2469
Brugia malayi GnHR receptor homolog 0.0186 0.1828 0.2469
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0331 0.3316 0.7873
Schistosoma mansoni histamine h1 receptor 0.0186 0.1828 0.2469
Brugia malayi hypothetical protein 0.0186 0.1828 0.2469
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0417 0.4204 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0186 0.1828 0.2469
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0417 0.4204 0.5677
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0186 0.1828 0.2469
Echinococcus granulosus alpha 1A adrenergic receptor 0.0186 0.1828 0.2469
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0331 0.3316 0.3316
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0129 0.1239 0.1643
Onchocerca volvulus Putative pyridoxal kinase 0.0083 0.0762 0.1085
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0078 0.0708 0.479
Echinococcus granulosus rhodopsin orphan GPCR 0.0186 0.1828 0.2469
Echinococcus multilocularis rhodopsin orphan GPCR 0.0186 0.1828 0.1828
Echinococcus granulosus neuropeptide s receptor 0.0186 0.1828 0.2469
Echinococcus granulosus rhodopsin orphan GPCR 0.0186 0.1828 0.2469
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0078 0.0708 0.1683
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0186 0.1828 0.2469
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0057 0.05 0.0641
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0331 0.3316 0.7873
Trypanosoma cruzi nucleoside transporter 1, putative 0.0057 0.05 0.0641
Entamoeba histolytica hypothetical protein 0.0038 0.0296 0.0645
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0057 0.05 0.1132
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0078 0.0708 0.0956
Mycobacterium ulcerans endonuclease IV 0.0078 0.0708 0.1442
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0186 0.1828 0.1828
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0186 0.1828 0.1828
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0079 0.0079
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0186 0.1828 0.2469
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0417 0.4204 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.1042 0.7336
Loa Loa (eye worm) hypothetical protein 0.0078 0.0708 0.0956
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.018 0.0428
Leishmania major putative PfkB family sugar kinase 0.0083 0.0762 0.0997
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0613 0.0794
Schistosoma mansoni neuropeptide F-like receptor 0.0186 0.1828 0.2469
Brugia malayi Importin beta-1 subunit 0.0035 0.0267 0.0361
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0275 0.0371
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0057 0.05 0.0641
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0079 0.0106
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0417 0.4204 0.5661
Brugia malayi MH2 domain containing protein 0.0125 0.1196 0.1616
Echinococcus multilocularis somatostatin receptor 0.0186 0.1828 0.1828
Schistosoma mansoni importin beta-1 0.0035 0.0267 0.0361
Echinococcus granulosus adenylate cyclase 9 0.0078 0.0709 0.0957
Trypanosoma brucei adenosine transporter 2, putative 0.0057 0.05 0.0641
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0078 0.0709 0.1003
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0186 0.1828 0.2469
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0214 0.0449
Echinococcus multilocularis dro:myosuppressin receptor 0.0186 0.1828 0.1828
Echinococcus multilocularis tumor protein p63 0.035 0.3516 0.3516
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0129 0.1239 0.1643
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0613 0.0613
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0186 0.1828 0.1828
Echinococcus granulosus 7TM GPCR rhodopsin 0.0186 0.1828 0.2469
Echinococcus multilocularis GPCR, family 2 0.0036 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Trypanosoma brucei adenosine transporter, putative 0.0057 0.05 0.0641
Echinococcus granulosus peptide allatostatin:somatostatin 0.0186 0.1828 0.2469
Trypanosoma brucei ribokinase, putative 0.0083 0.0762 0.0997
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0186 0.1828 0.2469
Onchocerca volvulus 0.0186 0.1828 0.2726
Onchocerca volvulus 0.0186 0.1828 0.2726
Loa Loa (eye worm) melatonin receptor type 1A 0.0186 0.1828 0.2469
Brugia malayi G protein-coupled receptor 0.0186 0.1828 0.2469
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0417 0.4204 0.5677
Leishmania major nucleoside transporter 1, putative 0.0057 0.05 0.0641
Echinococcus multilocularis neuropeptide s receptor 0.0186 0.1828 0.1828
Echinococcus multilocularis fmrfamide receptor 0.0186 0.1828 0.1828
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.1042 0.2261
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0199 0.0412
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Schistosoma mansoni neuropeptide F-like receptor 0.0186 0.1828 0.2469
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0417 0.4204 0.5661
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0075 0.0676 0.0676
Onchocerca volvulus 0.0645 0.655 1
Entamoeba histolytica kinase, PfkB family 0.0083 0.0762 0.176
Schistosoma mansoni opsin-like receptor 0.0186 0.1828 0.2469
Schistosoma mansoni biogenic amine (5HT) receptor 0.0186 0.1828 0.2469
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0078 0.0708 0.4628
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0057 0.05 0.0641
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0214 0.0449
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0131 0.0248
Schistosoma mansoni alpha-1 adrenergic receptor 0.0186 0.1828 0.2469
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.003 0.003
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0417 0.4204 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0186 0.1828 0.1828
Onchocerca volvulus 0.0186 0.1828 0.2726
Echinococcus multilocularis rhodopsin orphan GPCR 0.0186 0.1828 0.1828
Brugia malayi hypothetical protein 0.0186 0.1828 0.2469
Echinococcus multilocularis g protein coupled receptor 0.0186 0.1828 0.1828
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0417 0.4204 1
Loa Loa (eye worm) STAT protein 0.0133 0.128 0.1729
Onchocerca volvulus 0.0252 0.2505 0.3769
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0331 0.3316 0.5017
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Echinococcus granulosus dro:myosuppressin receptor 0.0186 0.1828 0.2469
Schistosoma mansoni amine GPCR 0.0186 0.1828 0.2469
Loa Loa (eye worm) hypothetical protein 0.0083 0.0762 0.103
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0613 0.0828
Trypanosoma brucei adenosine transporter 2, putative 0.0057 0.05 0.0641
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0186 0.1828 0.2469
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Brugia malayi hypothetical protein 0.0186 0.1828 0.2469
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0058 0.0078
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0273 0.2723 0.3677
Brugia malayi sulfakinin receptor protein 0.0186 0.1828 0.2469
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0296 0.04
Leishmania major adenosine kinase, putative 0.0727 0.7405 1
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0144 0.1392 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.018 0.0428
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0186 0.1828 0.2469
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.0083 0.0762 0.176
Schistosoma mansoni growth hormone secretagogue receptor 0.0186 0.1828 0.2469
Loa Loa (eye worm) hypothetical protein 0.0212 0.2093 0.2827
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0079 0.0106
Schistosoma mansoni biogenic amine receptor 0.0186 0.1828 0.2469
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0267 0.0325
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1042 0.243
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3739 0.505
Echinococcus multilocularis ribokinase 0.0083 0.0762 0.0762
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0613 0.0828
Trypanosoma cruzi nucleobase transporter, putative 0.0057 0.05 0.0641
Entamoeba histolytica hypothetical protein 0.0038 0.0296 0.0645
Leishmania major adenosine kinase-like protein 0.0083 0.0762 0.0997
Schistosoma mansoni hypothetical protein 0.0038 0.0296 0.04
Plasmodium falciparum importin beta, putative 0.0035 0.0267 0.0635
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0186 0.1828 0.2469
Echinococcus granulosus snurportin 1 0.0372 0.3739 0.505
Brugia malayi AKH receptor 0.0186 0.1828 0.2469
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0058 0.0058
Echinococcus granulosus g protein coupled receptor 0.0186 0.1828 0.2469
Echinococcus multilocularis allatostatin A receptor 0.0186 0.1828 0.1828
Schistosoma mansoni hypothetical protein 0.0036 0.0275 0.0371
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0186 0.1828 0.2469
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0417 0.4204 0.5
Onchocerca volvulus Ribokinase homolog 0.0083 0.0762 0.1085
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0417 0.4204 0.5661
Echinococcus granulosus bloom syndrome protein 0.0022 0.0131 0.0177
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Echinococcus granulosus 7tm_1 domain containing protein 0.0186 0.1828 0.2469
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0079 0.007
Onchocerca volvulus 0.0186 0.1828 0.2726
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Echinococcus granulosus nuclear factor of activated T cells 5 0.0075 0.0676 0.0913
Brugia malayi hypothetical protein 0.0186 0.1828 0.2469
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0199 0.0233
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0057 0.05 0.0641
Onchocerca volvulus 0.0186 0.1828 0.2726
Echinococcus granulosus tumor protein p63 0.035 0.3516 0.4749
Brugia malayi 6-phosphofructokinase 0.011 0.1042 0.1407
Schistosoma mansoni neuropeptide f receptor 76f 0.0186 0.1828 0.2469
Loa Loa (eye worm) G-protein coupled receptor 0.0186 0.1828 0.2469
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0275 0.0371
Leishmania major inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040 0.0057 0.05 0.0641
Trypanosoma brucei adenosine kinase, putative 0.0727 0.7405 1
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0417 0.4204 1
Echinococcus granulosus somatostatin receptor 0.0186 0.1828 0.2469
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Brugia malayi isocitrate dehydrogenase 0.0017 0.0079 0.0106
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0058 0.0058
Loa Loa (eye worm) TYRA-2 protein 0.0186 0.1828 0.2469
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0144 0.1389 0.1876
Schistosoma mansoni hypothetical protein 0.0372 0.3739 0.505
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.002 0.0118 0.016
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0186 0.1828 0.1828
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0214 0.0449
Echinococcus multilocularis g-protein coupled receptor 0.0186 0.1828 0.1828
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0296 0.04
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0214 0.0449
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0186 0.1828 0.1828
Onchocerca volvulus 0.0186 0.1828 0.2726
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0059 0.008
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0215 0.2127 0.3187
Echinococcus multilocularis G-protein coupled receptor, putative 0.0186 0.1828 0.1828
Schistosoma mansoni hypothetical protein 0.0186 0.1828 0.2469
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0079 0.007
Schistosoma mansoni myosin xvIII 0.0186 0.1828 0.2469
Trichomonas vaginalis ribokinase, putative 0.0083 0.0762 0.176
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0186 0.1828 0.2469
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0057 0.0077
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0144 0.1389 0.3262
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0186 0.1828 0.1828
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1042 0.243
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0186 0.1828 0.2469
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0214 0.029
Onchocerca volvulus 0.0186 0.1828 0.2726
Brugia malayi hypothetical protein 0.0038 0.0296 0.04
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0214 0.0376
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0199 0.0412
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0131 0.0177
Echinococcus granulosus neuropeptide receptor 0.0186 0.1828 0.2469
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0186 0.1828 0.2469
Echinococcus multilocularis rhodopsin orphan GPCR 0.0186 0.1828 0.1828
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0186 0.1828 0.2469
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Mycobacterium tuberculosis Ribokinase RbsK 0.0083 0.0762 0.5207
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0131 0.0248
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0417 0.4204 0.5677
Echinococcus multilocularis G protein coupled receptor 139 0.0186 0.1828 0.1828
Echinococcus granulosus allatostatin A receptor 0.0186 0.1828 0.2469
Echinococcus multilocularis neuropeptide Y receptor 0.0186 0.1828 0.1828
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0417 0.4204 0.4204
Echinococcus granulosus hypothetical protein 0.0186 0.1828 0.2469
Echinococcus granulosus rhodopsin orphan GPCR 0.0186 0.1828 0.2469
Echinococcus granulosus Ankyrin 0.0015 0.0059 0.008
Trichomonas vaginalis ribokinase, putative 0.0083 0.0762 0.176
Loa Loa (eye worm) hypothetical protein 0.0727 0.7405 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0079 0.0106
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0079 0.0079
Onchocerca volvulus 0.0186 0.1828 0.2726
Leishmania major tagatose-6-phosphate kinase-like protein 0.0083 0.0762 0.0997
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0273 0.272 0.365
Echinococcus multilocularis serotonin receptor 0.0186 0.1828 0.1828
Brugia malayi Ribokinase 0.0083 0.0762 0.103
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Schistosoma mansoni hypothetical protein 0.0015 0.0058 0.0078
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0079 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0186 0.1828 0.2469
Loa Loa (eye worm) pax transcription factor protein 2 0.0252 0.2505 0.3383
Schistosoma mansoni hypothetical protein 0.0077 0.07 0.0945
Brugia malayi follicle stimulating hormone receptor 0.0419 0.4227 0.5709
Trypanosoma brucei nucleoside transporter 1, putative 0.0057 0.05 0.0641
Brugia malayi hypothetical protein 0.0123 0.1178 0.1591
Echinococcus granulosus serotonin receptor 0.0186 0.1828 0.2469
Brugia malayi latrophilin 2 splice variant baaae 0.0077 0.07 0.0945
Onchocerca volvulus 0.0186 0.1828 0.2726
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0417 0.4204 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0186 0.1828 0.2469
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0214 0.0449
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0417 0.4204 0.5661
Brugia malayi Tachykinin-like peptides receptor 99D 0.0186 0.1828 0.2469
Loa Loa (eye worm) hypothetical protein 0.0331 0.3316 0.4478
Loa Loa (eye worm) hypothetical protein 0.0051 0.0436 0.0589
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0186 0.1828 0.2469
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0275 0.0371
Echinococcus granulosus tachykinin peptides receptor 99D 0.0186 0.1828 0.2469
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1042 0.243
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.018 0.0207
Plasmodium vivax importin-beta 2, putative 0.0035 0.0267 0.0503
Echinococcus granulosus tm gpcr rhodopsin 0.0186 0.1828 0.2469
Brugia malayi Dopamine receptor 0.0186 0.1828 0.2469
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0084 0.0113
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0288 0.2873 0.388
Brugia malayi ORL1-like opioid receptor 0.0186 0.1828 0.2469
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0273 0.2723 0.3677
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0186 0.1828 0.2469
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Mycobacterium tuberculosis Adenosine kinase 0.0083 0.0762 0.5207
Echinococcus granulosus ribokinase 0.0083 0.0762 0.103
Loa Loa (eye worm) hypothetical protein 0.0112 0.1066 0.144
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0417 0.4204 1
Brugia malayi hypothetical protein 0.0331 0.3316 0.4478
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0273 0.2724 0.2724
Onchocerca volvulus 0.0186 0.1828 0.2726
Onchocerca volvulus 0.0186 0.1828 0.2726
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0273 0.2723 0.3677
Trichomonas vaginalis ribokinase, putative 0.0083 0.0762 0.176
Onchocerca volvulus 0.0186 0.1828 0.2726
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0214 0.029
Schistosoma mansoni protein kinase 0.0057 0.05 0.0675
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0186 0.1828 0.2469
Trypanosoma cruzi adenosine kinase, putative 0.0083 0.0762 0.0997
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0118 0.0303
Schistosoma mansoni hypothetical protein 0.0186 0.1828 0.2469
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0079 0.0106
Brugia malayi Serotonin receptor 0.0186 0.1828 0.2469
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0129 0.1239 0.1673
Trypanosoma cruzi nucleoside transporter 1, putative 0.0057 0.05 0.0641
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Schistosoma mansoni hypothetical protein 0.0349 0.3504 0.4732
Echinococcus multilocularis rhodopsin orphan GPCR 0.0186 0.1828 0.1828
Entamoeba histolytica nucleoside transporter, putative 0.0331 0.3316 0.7873
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1042 0.243
Schistosoma mansoni hypothetical protein 0.0036 0.0275 0.0371
Echinococcus granulosus rhodopsin orphan GPCR 0.0186 0.1828 0.2469
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0273 0.272 0.6471
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Trypanosoma cruzi nucleoside transporter 1, putative 0.0057 0.05 0.0641
Loa Loa (eye worm) hypothetical protein 0.0083 0.0762 0.103
Brugia malayi hypothetical protein 0.0186 0.1828 0.2469
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0273 0.2723 0.6454
Toxoplasma gondii nucleoside transporter protein 0.0057 0.05 0.0675
Loa Loa (eye worm) hypothetical protein 0.0017 0.0086 0.0116
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0417 0.4204 1
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0331 0.3316 0.7873
Trypanosoma brucei adenosine kinase, putative 0.0727 0.7405 1
Echinococcus granulosus sex peptide receptor 0.0186 0.1828 0.2469
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0419 0.4227 0.5709
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0078 0.0708 0.1566
Schistosoma mansoni adenosine kinase 0.0727 0.7405 1
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Giardia lamblia Hypothetical protein 0.0331 0.3316 0.7887
Trypanosoma brucei adenosine transporter 2, putative 0.0057 0.05 0.0641
Echinococcus granulosus neuropeptide FF receptor 2 0.0186 0.1828 0.2469
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0417 0.4204 0.5661
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0057 0.05 0.1132
Schistosoma mansoni netrin receptor unc5 0.0015 0.0058 0.0078
Echinococcus granulosus rhodopsin orphan GPCR 0.0186 0.1828 0.2469
Loa Loa (eye worm) adenylyl cyclase 3 0.0078 0.0709 0.0957
Brugia malayi hypothetical protein 0.0083 0.0762 0.103
Loa Loa (eye worm) hypothetical protein 0.0015 0.0058 0.0078
Brugia malayi Pax transcription factor protein 2 0.0252 0.2505 0.3383
Onchocerca volvulus 0.0186 0.1828 0.2726
Schistosoma mansoni hypothetical protein 0.0349 0.3504 0.4732
Loa Loa (eye worm) hypothetical protein 0.0321 0.3217 0.4345
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0288 0.2873 0.388
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0186 0.1828 0.2469
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.018 0.0207
Brugia malayi G-protein coupled receptor 0.0186 0.1828 0.2469
Leishmania major adenosine kinase-like protein 0.0083 0.0762 0.0997
Loa Loa (eye worm) hypothetical protein 0.0036 0.0275 0.0371
Toxoplasma gondii nucleoside transporter protein 0.0057 0.05 0.0675
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0186 0.1828 0.2469
Schistosoma mansoni adenosine kinase 0.0727 0.7405 1
Trypanosoma brucei adenosine transporter 2, putative 0.0057 0.05 0.0641
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0057 0.05 0.1132
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0273 0.272 0.365
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0118 0.0093
Brugia malayi 6-phosphofructokinase 0.011 0.1042 0.1407
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1042 0.1407
Echinococcus multilocularis neuropeptide FF receptor 2 0.0186 0.1828 0.1828
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0316 0.0316
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0417 0.4204 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0613 0.0828
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Schistosoma mansoni neuropeptide receptor 0.0186 0.1828 0.2469
Echinococcus granulosus GPCR family 2 0.0036 0.0275 0.0371
Trypanosoma brucei adenosine transporter 2 0.0057 0.05 0.0641
Toxoplasma gondii nucleoside transporter protein 0.0057 0.05 0.0675
Onchocerca volvulus 0.0186 0.1828 0.2726
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0417 0.4204 0.5661
Echinococcus granulosus 6 phosphofructokinase 0.011 0.1042 0.1407
Echinococcus granulosus neuropeptide Y receptor 0.0186 0.1828 0.2469
Echinococcus multilocularis neuropeptide receptor 0.0186 0.1828 0.1828
Onchocerca volvulus 0.0186 0.1828 0.2726
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.1042 0.2074
Loa Loa (eye worm) hypothetical protein 0.0331 0.3316 0.4478
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.1196 0.1616
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0058 0.0078
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0186 0.1828 0.2469
Mycobacterium ulcerans carbohydrate kinase CbhK 0.0083 0.0762 0.1576
Leishmania major importin beta-1 subunit, putative 0.0028 0.0199 0.0233
Schistosoma mansoni amine GPCR 0.0186 0.1828 0.2469
Echinococcus multilocularis rhodopsin orphan GPCR 0.0186 0.1828 0.1828
Brugia malayi RE15519p 0.0186 0.1828 0.2469
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0079 0.007
Echinococcus multilocularis Ankyrin 0.0015 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0417 0.4204 0.5677
Toxoplasma gondii kinase, pfkB family protein 0.0083 0.0762 0.103
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0613 0.0794
Schistosoma mansoni biogenic amine receptor 0.0186 0.1828 0.2469
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0079 0.0048
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0186 0.1828 0.1828
Schistosoma mansoni neuropeptide receptor 0.0186 0.1828 0.2469
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0214 0.029
Trypanosoma cruzi ribokinase, putative 0.0083 0.0762 0.0997
Brugia malayi Serotonin receptor 0.0186 0.1828 0.2469
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0186 0.1828 0.1828
Schistosoma mansoni hypothetical protein 0.0036 0.0275 0.0371
Trypanosoma cruzi adenosine kinase, putative 0.0727 0.7405 1
Schistosoma mansoni amine GPCR 0.0186 0.1828 0.2469
Echinococcus granulosus orexin receptor type 2 0.0186 0.1828 0.2469
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Brugia malayi hypothetical protein 0.0186 0.1828 0.2469
Schistosoma mansoni neuropeptide receptor 0.0186 0.1828 0.2469
Echinococcus multilocularis neuropeptide receptor A26 0.0186 0.1828 0.1828
Schistosoma mansoni amine GPCR 0.0186 0.1828 0.2469
Echinococcus granulosus neuropeptide receptor 0.0186 0.1828 0.2469
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0186 0.1828 0.2469
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0273 0.272 0.365
Leishmania major nucleobase transporter 0.0057 0.05 0.0641
Trypanosoma cruzi adenosine kinase, putative 0.0727 0.7405 1
Entamoeba histolytica fructokinase, putative 0.0083 0.0762 0.176
Giardia lamblia Ribokinase 0.0083 0.0762 0.1813
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1042 0.1376
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.018 0.0207
Echinococcus granulosus transcription factor Dp 1 0.004 0.0316 0.0427
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0129 0.1239 0.1643
Onchocerca volvulus 0.0078 0.0709 0.1003
Entamoeba histolytica nucleoside transporter, putative 0.0057 0.05 0.1132
Brugia malayi Melatonin receptor type 1A 0.0186 0.1828 0.2469
Brugia malayi Uncoordinated protein 44 0.0015 0.0058 0.0078
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.0331 0.3316 0.3316
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0417 0.4204 0.5677
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0129 0.1239 0.1643
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0214 0.051
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0058 0.0078
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0417 0.4204 0.5677
Echinococcus granulosus equilibrative nucleoside transporter 0.0331 0.3316 0.4478
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.1066 0.144
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.018 0.0293
Onchocerca volvulus 0.0051 0.0436 0.0582
Brugia malayi RNA, U transporter 1 0.0099 0.0929 0.1254
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.0083 0.0762 0.176
Echinococcus multilocularis g protein coupled receptor 0.0186 0.1828 0.1828
Loa Loa (eye worm) hypothetical protein 0.0035 0.0267 0.0361
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1042 0.243
Trypanosoma cruzi nucleoside transporter-like, putative 0.0057 0.05 0.0641
Echinococcus multilocularis serotonin receptor 0.0186 0.1828 0.1828
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0275 0.0275
Mycobacterium leprae Probable adenosine kinase adk 0.0083 0.0762 0.5057
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Brugia malayi Nucleoside transporter family protein 0.0331 0.3316 0.4478
Echinococcus granulosus g protein coupled receptor 0.0186 0.1828 0.2469
Trypanosoma brucei unspecified product 0.0057 0.05 0.0641
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0417 0.4204 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0186 0.1828 0.2469
Schistosoma mansoni hypothetical protein 0.0036 0.0275 0.0371
Brugia malayi Adenosine kinase-like 0.0727 0.7405 1
Leishmania major tagatose-6-phosphate kinase-like protein 0.0083 0.0762 0.0997
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.1042 0.1042
Echinococcus granulosus equilibrative nucleoside transporter 3 0.0331 0.3316 0.4478
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0129 0.1239 0.1643
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0267 0.0325
Echinococcus multilocularis sex peptide receptor 0.0186 0.1828 0.1828
Echinococcus granulosus g protein coupled receptor 0.0186 0.1828 0.2469
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0186 0.1828 0.2469
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0762 0.176
Toxoplasma gondii endonuclease IV APN 0.0078 0.0708 0.0956
Echinococcus granulosus tm gpcr rhodopsin 0.0186 0.1828 0.2469
Brugia malayi Death domain containing protein 0.0015 0.0058 0.0078
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0273 0.2723 0.2723
Onchocerca volvulus Neuropeptide F receptor homolog 0.0186 0.1828 0.2726
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.0083 0.0762 0.5207
Schistosoma mansoni opsin-like receptor 0.0186 0.1828 0.2469
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0186 0.1828 0.2469
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0199 0.0412
Echinococcus granulosus fmrfamide receptor 0.0186 0.1828 0.2469
Loa Loa (eye worm) neuropeptide F receptor 0.0186 0.1828 0.2469
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0214 0.0376
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0186 0.1828 0.2469
Brugia malayi hypothetical protein 0.0017 0.0084 0.0113
Echinococcus granulosus rhodopsin orphan GPCR 0.0186 0.1828 0.2469
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0058 0.0078
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0417 0.4204 0.4204
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0331 0.3316 0.5017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0186 0.1828 0.1828
Trypanosoma brucei purine nucleoside transporter 0.0057 0.05 0.0641
Trypanosoma cruzi adenosine kinase, putative 0.0083 0.0762 0.0997
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0186 0.1828 0.2469
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0057 0.05 0.0641
Echinococcus granulosus death domain containing protein 0.0015 0.0058 0.0078
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0186 0.1828 0.1828
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0273 0.2723 0.6454
Leishmania major ribokinase, putative 0.0083 0.0762 0.0997
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Brugia malayi hypothetical protein 0.0186 0.1828 0.2469
Brugia malayi G-protein coupled receptor 0.0186 0.1828 0.2469
Schistosoma mansoni opsin-like receptor 0.0186 0.1828 0.2469
Trypanosoma brucei unspecified product 0.0057 0.05 0.0641
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0267 0.0361
Loa Loa (eye worm) neuropeptide F receptor 0.0186 0.1828 0.2469
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0186 0.1828 0.2726
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0275 0.0371
Echinococcus multilocularis g protein coupled receptor 0.0186 0.1828 0.1828
Loa Loa (eye worm) hypothetical protein 0.0015 0.0059 0.008
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Echinococcus multilocularis adenylate cyclase 9 0.0078 0.0709 0.0709
Entamoeba histolytica ribokinase, putative 0.0083 0.0762 0.176
Brugia malayi putative neuropeptide receptor NPR1 0.0186 0.1828 0.2469
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0417 0.4204 0.5661
Entamoeba histolytica hypothetical protein 0.0038 0.0296 0.0645
Echinococcus granulosus adenosine kinase 0.0727 0.7405 1
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0331 0.3316 0.7873
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0079 0.007
Brugia malayi neuropeptide F receptor 0.0186 0.1828 0.2469
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.0083 0.0762 0.0762
Loa Loa (eye worm) RecQ helicase 0.0022 0.0131 0.0177
Trypanosoma cruzi nucleobase transporter, putative 0.0057 0.05 0.0641
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0417 0.4204 0.5661
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0186 0.1828 0.2469
Brugia malayi Protein kinase domain containing protein 0.0015 0.0058 0.0078
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0417 0.4204 0.5661
Loa Loa (eye worm) phosphofructokinase 0.011 0.1042 0.1407
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0214 0.0449
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0186 0.1828 0.1828
Onchocerca volvulus 0.0074 0.0675 0.095
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Leishmania major nucleobase transporter 0.0057 0.05 0.0641
Loa Loa (eye worm) hypothetical protein 0.0331 0.3316 0.4478
Schistosoma mansoni equilibrative nucleoside transporter 0.0057 0.05 0.0675
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0273 0.272 0.365
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0186 0.1828 0.1828
Echinococcus granulosus geminin 0.0349 0.3504 0.4732
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0275 0.0371
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0214 0.051
Echinococcus granulosus tm gpcr rhodopsin 0.0186 0.1828 0.2469
Loa Loa (eye worm) hypothetical protein 0.0078 0.0709 0.0957
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1042 0.1407
Brugia malayi putative neuropeptide receptor 0.0186 0.1828 0.2469
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0186 0.1828 0.2469
Schistosoma mansoni hypothetical protein 0.0186 0.1828 0.2469
Echinococcus granulosus neuropeptides capa receptor 0.0186 0.1828 0.2469
Trypanosoma brucei nucleoside transporter 1, putative 0.0057 0.05 0.0641
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0104 0.0247
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0613 0.0794
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0057 0.05 0.1132
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0186 0.1828 0.2469
Echinococcus granulosus neuropeptide receptor A26 0.0186 0.1828 0.2469
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0417 0.4204 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0186 0.1828 0.1828
Entamoeba histolytica hypothetical protein 0.0028 0.0199 0.0412
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0417 0.4204 0.5661
Entamoeba histolytica nucleoside transporter, putative 0.0057 0.05 0.1132
Brugia malayi STAT protein, DNA binding domain containing protein 0.0133 0.128 0.1729
Brugia malayi hypothetical protein 0.0186 0.1828 0.2469
Loa Loa (eye worm) hypothetical protein 0.0186 0.1828 0.2469
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1042 0.243
Brugia malayi neuropeptide F receptor 0.0186 0.1828 0.2469
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0186 0.1828 0.2469
Echinococcus granulosus importin subunit beta 1 0.0035 0.0267 0.0361

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.1714 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.