Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | P2X purinoceptor 7 | Starlite/ChEMBL | References |
Homo sapiens | purinergic receptor P2X, ligand-gated ion channel, 7 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.1653 | 0.527 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0164 | 0.4176 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0378 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0164 | 0.4176 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0104 | 0.2551 | 0.8133 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0036 | 0.0698 | 0.2225 |
Echinococcus multilocularis | caspase 2 | 0.0126 | 0.3137 | 0.751 |
Brugia malayi | hypothetical protein | 0.0126 | 0.3137 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0026 | 0.0409 | 0.1304 |
Leishmania major | oxidoreductase-like protein | 0.0026 | 0.0409 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0026 | 0.0409 | 0.5 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0026 | 0.0409 | 0.0979 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.061 | 0.1946 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0568 | 0.181 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.061 | 0.1946 |
Onchocerca volvulus | 0.0126 | 0.3137 | 1 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0036 | 0.0698 | 0.1671 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.3137 | 1 |
Onchocerca volvulus | 0.0026 | 0.0409 | 0.1304 | |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0164 | 0.4176 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0164 | 0.4176 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0026 | 0.0409 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.061 | 0.1462 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1653 | 0.527 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0026 | 0.0409 | 0.0979 |
Onchocerca volvulus | 0.0026 | 0.0409 | 0.1304 | |
Schistosoma mansoni | dihydropteridine reductase | 0.0026 | 0.0409 | 0.0979 |
Schistosoma mansoni | P2X receptor subunit | 0.0164 | 0.4176 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0378 | 1 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.0026 | 0.0409 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0126 | 0.3137 | 0.751 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.061 | 0.1462 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0126 | 0.3137 | 0.751 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.3137 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0164 | 0.4176 | 1 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0126 | 0.3137 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0378 | 1 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0026 | 0.0409 | 0.1304 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0164 | 0.4176 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0378 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.061 | 0.1462 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.061 | 0.1462 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.061 | 0.1462 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.061 | 0.1946 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0378 | 1 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0026 | 0.0409 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.061 | 0.1462 |
Leishmania major | pteridine reductase 1 | 0.0026 | 0.0409 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0164 | 0.4176 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0164 | 0.4176 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0409 | 0.1304 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0104 | 0.2551 | 0.8133 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2551 | 0.8133 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0788 | 0.1888 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0026 | 0.0409 | 0.0979 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0126 | 0.3137 | 0.751 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0026 | 0.0409 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0026 | 0.0409 | 0.1304 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.061 | 0.1462 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0788 | 0.1888 |
Schistosoma mansoni | hypothetical protein | 0.0099 | 0.2419 | 0.5791 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0378 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.1653 | 0.3958 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.061 | 0.1946 |
Echinococcus granulosus | caspase 2 | 0.0126 | 0.3137 | 0.751 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.061 | 0.1462 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0026 | 0.0409 | 0.5 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0026 | 0.0409 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0036 | 0.0698 | 0.2225 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0026 | 0.0409 | 0.1304 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0036 | 0.0698 | 0.1671 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0126 | 0.3137 | 0.751 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0026 | 0.0409 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0104 | 0.2551 | 0.8133 |
Schistosoma mansoni | P2X receptor subunit | 0.0164 | 0.4176 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.061 | 0.1462 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0378 | 1 | 1 |
Brugia malayi | Cell death protein 3 precursor | 0.0126 | 0.3137 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0378 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.061 | 0.1462 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0026 | 0.0409 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0026 | 0.0409 | 0.1304 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0026 | 0.0409 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 6.54 | Antagonist activity at rat recombinant P2X7 receptor expressed in HEK293 cells assessed as inhibition of benzoylbenzoic ATP-induced calcium production by FLIPR assay | ChEMBL. | 21536435 |
IC50 (functional) | = 7.53 | Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells assessed as inhibition of benzoylbenzoic ATP-induced calcium production by FLIPR assay | ChEMBL. | 21536435 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.