Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0025 | 0.0153 | 0.0246 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0162 | 0.2364 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0025 | 0.0153 | 0.0246 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0054 | 0.0613 | 0.0613 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0025 | 0.0153 | 0.0538 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0028 | 0.0202 | 0.0424 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0381 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0153 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0202 | 0.0202 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0054 | 0.0613 | 0.0613 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0381 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0085 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0054 | 0.0613 | 0.2593 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0025 | 0.0153 | 0.0648 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0153 | 0.0153 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0054 | 0.0613 | 0.0613 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0085 | 0.5 |
Brugia malayi | tailless protein | 0.0025 | 0.0153 | 0.0068 |
Brugia malayi | steroid hormone receptor | 0.0054 | 0.0613 | 0.0532 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0054 | 0.0613 | 0.2593 |
Echinococcus multilocularis | dna polymerase kappa | 0.0021 | 0.0085 | 0.0299 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0054 | 0.0613 | 0.6047 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0202 | 0.0202 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.1193 | 0.1193 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0153 | 0.0153 |
Brugia malayi | bZIP transcription factor family protein | 0.0092 | 0.1234 | 0.1158 |
Schistosoma mansoni | nuclear hormone receptor | 0.0054 | 0.0613 | 0.191 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0153 | 0.0153 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0025 | 0.0153 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0085 | 0.0085 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0054 | 0.0613 | 0.191 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0613 | 0.0613 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0613 | 0.0613 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0153 | 0.0153 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0138 | 0.1978 | 0.8369 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0054 | 0.0613 | 0.191 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0054 | 0.0613 | 0.2152 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0085 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0153 | 0.0153 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0054 | 0.0613 | 0.191 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0054 | 0.0613 | 0.0532 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0028 | 0.0202 | 0.071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0054 | 0.0613 | 0.0613 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0.0085 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0138 | 0.1978 | 0.6944 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0085 | 0.5 |
Brugia malayi | nuclear receptor RXR | 0.0025 | 0.0153 | 0.0068 |
Schistosoma mansoni | nuclear hormone receptor | 0.0025 | 0.0153 | 0.0246 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0.0085 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0192 | 0.2849 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0054 | 0.0613 | 0.0532 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0054 | 0.0613 | 0.0532 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0025 | 0.0153 | 0.0068 |
Brugia malayi | ecdysteroid receptor | 0.0054 | 0.0613 | 0.0532 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0085 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0054 | 0.0613 | 0.0532 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.0954 | 0.3145 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0025 | 0.0153 | 0.0538 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0054 | 0.0613 | 0.191 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0054 | 0.0613 | 0.0532 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0085 | 0.5 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0025 | 0.0153 | 0.0068 |
Echinococcus granulosus | FTZ F1 alpha | 0.0054 | 0.0613 | 0.2593 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0054 | 0.0613 | 0.2152 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.0381 | 0.1614 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0153 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0153 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0613 | 0.0613 |
Brugia malayi | nuclear receptor NHR-67 | 0.0025 | 0.0153 | 0.0068 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.1863 | 0.1793 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0021 | 0.0085 | 0.0085 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0085 | 0.5 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0025 | 0.0153 | 0.0648 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0054 | 0.0613 | 0.0532 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0054 | 0.0613 | 0.0613 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0054 | 0.0613 | 0.2593 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0054 | 0.0613 | 0.2152 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0153 | 0.0153 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0028 | 0.0202 | 0.0202 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0054 | 0.0613 | 0.191 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0054 | 0.0613 | 0.2152 |
Onchocerca volvulus | 0.0054 | 0.0613 | 0.6047 | |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0025 | 0.0153 | 0.0068 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0054 | 0.0613 | 0.0613 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0054 | 0.0613 | 0.2593 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0054 | 0.0613 | 0.0532 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0025 | 0.0153 | 0.0538 |
Loa Loa (eye worm) | DR-78 | 0.0025 | 0.0153 | 0.0153 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0054 | 0.0613 | 0.2593 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0085 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0381 | 0.1072 |
Brugia malayi | nuclear hormone receptor | 0.0054 | 0.0613 | 0.0532 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0028 | 0.0202 | 0.0424 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0021 | 0.0085 | 0.5 |
Brugia malayi | hypothetical protein | 0.0072 | 0.0914 | 0.0835 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0085 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0025 | 0.0153 | 0.0246 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0202 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0613 | 0.0613 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0025 | 0.0153 | 0.0068 |
Echinococcus granulosus | jun protein | 0.0092 | 0.1234 | 0.522 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0021 | 0.0085 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0632 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0153 | 0.0153 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0381 | 0.0299 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0381 | 1 |
Trypanosoma brucei | unspecified product | 0.0021 | 0.0085 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0192 | 0.2849 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0153 | 0.0153 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0054 | 0.0613 | 0.6047 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0153 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0153 | 0.0153 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0025 | 0.0153 | 0.0648 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0054 | 0.0613 | 0.0532 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0613 | 0.0613 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0.0085 | 0.5 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0025 | 0.0153 | 0.0538 |
Schistosoma mansoni | hypothetical protein | 0.0138 | 0.1978 | 0.685 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0092 | 0.1234 | 0.4331 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0054 | 0.0613 | 0.2152 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0054 | 0.0613 | 0.191 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0081 | 0.105 | 0.4443 |
Brugia malayi | nuclear receptor RXR | 0.0028 | 0.0202 | 0.0118 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0054 | 0.0613 | 0.2593 |
Schistosoma mansoni | nuclear receptor | 0.0025 | 0.0153 | 0.0246 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0025 | 0.0153 | 0.0538 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0.0085 | 0.5 |
Echinococcus granulosus | dna polymerase kappa | 0.0021 | 0.0085 | 0.0361 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0085 | 0.5 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0021 | 0.0085 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0054 | 0.0613 | 0.2593 |
Brugia malayi | nuclear receptor NHR-88 | 0.0025 | 0.0153 | 0.0068 |
Onchocerca volvulus | 0.0072 | 0.0914 | 1 | |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0054 | 0.0613 | 0.0532 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0085 | 0.5 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0085 | 0.0299 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.1863 | 0.1863 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0202 | 0.0202 |
Brugia malayi | ecdysone receptor | 0.0025 | 0.0153 | 0.0068 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0054 | 0.0613 | 0.0613 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0085 | 0.5 |
Schistosoma mansoni | jun-related protein | 0.0075 | 0.0954 | 0.3145 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0085 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0025 | 0.0153 | 0.0246 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0054 | 0.0613 | 0.0532 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0054 | 0.0613 | 0.2152 |
Schistosoma mansoni | thyroid hormone receptor | 0.0192 | 0.2849 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0202 | 0.0118 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.0085 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0054 | 0.0613 | 0.0532 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0025 | 0.0153 | 0.0648 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0381 | 0.1072 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0085 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0202 | 0.0202 |
Schistosoma mansoni | nuclear receptor | 0.0025 | 0.0153 | 0.0246 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0081 | 0.105 | 0.3687 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0025 | 0.0153 | 0.0153 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.0085 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0054 | 0.0613 | 0.0532 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0613 | 0.0613 |
Echinococcus multilocularis | jun protein | 0.0092 | 0.1234 | 0.4331 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0.0085 | 0.5 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0025 | 0.0153 | 0.0648 |
Brugia malayi | conserved hypotetical protein | 0.0025 | 0.0153 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0153 | 0.0153 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0054 | 0.0613 | 0.6047 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0028 | 0.0202 | 0.0118 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0054 | 0.0613 | 0.0532 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0028 | 0.0202 | 0.0856 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0054 | 0.0613 | 0.2152 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0054 | 0.0613 | 0.0613 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0085 | 0.0361 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0025 | 0.0153 | 0.0153 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0025 | 0.0153 | 0.0648 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0054 | 0.0613 | 0.191 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0381 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0202 | 0.0202 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0054 | 0.0613 | 0.0532 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0054 | 0.0613 | 0.2152 |
Echinococcus granulosus | dna polymerase eta | 0.0021 | 0.0085 | 0.0361 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0092 | 0.1234 | 0.522 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0133 | 0.1904 | 0.6683 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0028 | 0.0202 | 0.0118 |
Leishmania major | DNA polymerase kappa, putative | 0.0021 | 0.0085 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0162 | 0.2364 | 0.8245 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0085 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0613 | 0.0613 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0025 | 0.0153 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0153 | 0.0153 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.1863 | 0.1863 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0054 | 0.0613 | 0.0532 |
Schistosoma mansoni | coup transcription factor | 0.0054 | 0.0613 | 0.191 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0054 | 0.0613 | 0.191 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0054 | 0.0613 | 0.0532 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0025 | 0.0153 | 0.0068 |
Leishmania major | DNA polymerase eta, putative | 0.0021 | 0.0085 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0054 | 0.0613 | 0.0532 |
Brugia malayi | nuclear hormone receptor | 0.0025 | 0.0153 | 0.0068 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0085 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0021 | 0.0085 | 0.0299 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.0381 | 0.1339 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0613 | 0.0613 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0025 | 0.0153 | 0.0246 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0085 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 25.1 uM | Antiinflammatory activity against LPS-induced NO production in mouse RAW264.7 cells assessed as reduction in nitrite level preincubated for 15 mins prior to LPS treatment by Griess method | ChEMBL. | 22850207 |
IC50 (ADMET) | = 25.1 uM | Cytotoxicity against mouse RAW264.7 cells assessed as cell survival by SRB assay | ChEMBL. | 23316950 |
IC50 (functional) | = 25.49 uM | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated 30 mins prior to LPS challenge | ChEMBL. | 20685125 |
IC50 (binding) | = 32 uM | Inhibition of iNOS-mediated NO production in mouse RAW264.7 cells by Griess assay | ChEMBL. | 23994869 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.