Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mannose phosphate isomerase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.009 | 0.7478 | 0.7475 |
Schistosoma mansoni | tyrosinase precursor | 0.009 | 0.7478 | 0.7478 |
Trypanosoma cruzi | phosphomannose isomerase, putative | 0.0117 | 1 | 1 |
Mycobacterium leprae | probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO | 0.0064 | 0.5018 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.7478 | 0.7475 |
Onchocerca volvulus | 0.009 | 0.7478 | 0.5 | |
Onchocerca volvulus | 0.009 | 0.7478 | 0.5 | |
Mycobacterium tuberculosis | Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho | 0.0064 | 0.5018 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.7478 | 0.7475 |
Onchocerca volvulus | 0.009 | 0.7478 | 0.5 | |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.009 | 0.7478 | 0.7475 |
Loa Loa (eye worm) | tyrosinase 1 | 0.009 | 0.7478 | 0.7475 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.009 | 0.7478 | 0.7475 |
Trypanosoma cruzi | phosphomannose isomerase, putative | 0.0117 | 1 | 1 |
Plasmodium falciparum | mannose-6-phosphate isomerase, putative | 0.0117 | 1 | 1 |
Onchocerca volvulus | 0.009 | 0.7478 | 0.5 | |
Schistosoma mansoni | ABC transporter | 0.001 | 0.0012 | 0.0012 |
Entamoeba histolytica | mannose-6-phosphate isomerase, putative | 0.0054 | 0.4101 | 0.3997 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.009 | 0.7478 | 0.7475 |
Trypanosoma brucei | phosphomannose isomerase | 0.0117 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.009 | 0.7478 | 0.7475 |
Leishmania major | phosphomannose isomerase | 0.0117 | 1 | 1 |
Brugia malayi | mannose-6-phosphate isomerase, class I family protein | 0.0117 | 1 | 1 |
Brugia malayi | ShTK domain containing protein | 0.009 | 0.7478 | 0.7475 |
Echinococcus multilocularis | mannose 6 phosphate isomerase | 0.0117 | 1 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.009 | 0.7478 | 0.7478 |
Schistosoma mansoni | mannose-6-phosphate isomerase | 0.0117 | 1 | 1 |
Toxoplasma gondii | phosphomannose isomerase type I protein | 0.0117 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.009 | 0.7478 | 0.7475 |
Entamoeba histolytica | phosphomannose isomerase, putative | 0.0117 | 1 | 1 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.009 | 0.7478 | 0.7475 |
Giardia lamblia | ABC transporter | 0.0011 | 0.016 | 0.5 |
Loa Loa (eye worm) | mannose-6-phosphate isomerase | 0.0117 | 1 | 1 |
Trichomonas vaginalis | mannose-6-phosphate isomerase, putative | 0.0117 | 1 | 0.5 |
Loa Loa (eye worm) | mannose-6-phosphate isomerase | 0.0117 | 1 | 1 |
Echinococcus granulosus | mannose 6 phosphate isomerase | 0.0117 | 1 | 1 |
Schistosoma mansoni | ATP-binding cassette sub-family g2 (white protein) (abcg2) | 0.0011 | 0.0173 | 0.0173 |
Mycobacterium ulcerans | mannose-6-phosphate isomerase ManA | 0.0117 | 1 | 1 |
Plasmodium vivax | mannose-6-phosphate isomerase, putative | 0.0117 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.3 uM | Inhibition of human purified phosphomannose isomerase | ChEMBL. | 21539312 |
IC50 (binding) | = 6.53 uM | PUBCHEM_BIOASSAY: Confirmation of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1209, AID1220, AID1545, AID1553, AID1574, AID1620] | ChEMBL. | No reference |
IC50 (binding) | > 20 uM | Inhibition of human purified PMM2 | ChEMBL. | 21539312 |
IC50 (binding) | > 100 uM | PUBCHEM_BIOASSAY: Counter screen SAR assay for PMM2 inhibitors via a fluorescence intensity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1545, AID1574] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.