TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 467.92 | Formula: C21H22ClNO7S
H donors: 4 H acceptors: 5 LogP: 1.78 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H]1O[C@H]([C@@H]([C@H]([C@@H]1O)O)O)c1cc(Cc2ncc(s2)c2cocc2)c(cc1OC)Cl
InChi: 1S/C21H22ClNO7S/c1-28-14-6-13(22)11(5-17-23-7-16(31-17)10-2-3-29-9-10)4-12(14)21-20(27)19(26)18(25)15(8-24)30-21/h2-4,6-7,9,15,18-21,24-27H,5,8H2,1H3/t15-,18-,19+,20-,21+/m1/s1
InChiKey: OQDKIDRKHVAQOH-GRARQNNCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	solute carrier family 5 (sodium/glucose cotransporter), member 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	inositol transporter	Get druggable targets OG5_127197	All targets in OG5_127197
Echinococcus multilocularis	solute carrier family 5	Get druggable targets OG5_127197	All targets in OG5_127197
Schistosoma mansoni	inositol transporter	Get druggable targets OG5_127197	All targets in OG5_127197
Schistosoma japonicum	ko:K03307 solute:Na+ symporter, SSS family, putative	Get druggable targets OG5_127197	All targets in OG5_127197
Echinococcus multilocularis	sodium:glucose cotransporter 2	Get druggable targets OG5_127197	All targets in OG5_127197
Echinococcus granulosus	sodium:myo inositol cotransporter	Get druggable targets OG5_127197	All targets in OG5_127197
Schistosoma japonicum	Sodium/myo-inositol cotransporter, putative	Get druggable targets OG5_127197	All targets in OG5_127197
Echinococcus granulosus	sodium:glucose cotransporter	Get druggable targets OG5_127197	All targets in OG5_127197
Echinococcus multilocularis	sodium:myo inositol cotransporter	Get druggable targets OG5_127197	All targets in OG5_127197
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127197	All targets in OG5_127197
Echinococcus granulosus	sodium:glucose cotransporter 2	Get druggable targets OG5_127197	All targets in OG5_127197
Echinococcus granulosus	solute carrier family 5	Get druggable targets OG5_127197	All targets in OG5_127197

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.005	0.0532	0.0532
Echinococcus multilocularis	ecdysone induced protein 78C	0.005	0.0532	0.1879
Trichomonas vaginalis	DNA polymerase eta, putative	0.002	0	0.5
Brugia malayi	ecdysteroid receptor	0.005	0.0532	0.0532
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0026	0.0118	0.0417
Brugia malayi	hypothetical protein	0.0026	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0118	0.0118
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0299	0.1055
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0024	0.0068	0.0242
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0024	0.0068	0.0242
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0	0.5
Brugia malayi	GH02984p	0.0046	0.0465	0.0465
Brugia malayi	hypothetical protein	0.0067	0.0835	0.0835
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0024	0.0068	0.0242
Entamoeba histolytica	hypothetical protein	0.0037	0.0299	1
Echinococcus multilocularis	jun protein	0.0086	0.1158	0.409
Schistosoma mansoni	nuclear hormone receptor	0.0024	0.0068	0.0242
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.005	0.0532	0.0532
Brugia malayi	hypothetical protein	0.0024	0.0068	0.0068
Brugia malayi	photoreceptor-specific nuclear receptor	0.005	0.0532	0.0532
Loa Loa (eye worm)	hypothetical protein	0.005	0.0532	0.0532
Schistosoma mansoni	nuclear hormone receptor	0.005	0.0532	0.1879
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0124	0.1834	0.6475
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0026	0.0118	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0591	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0	0.5
Entamoeba histolytica	hypothetical protein	0.0037	0.0299	1
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0046	0.0465	0.1643
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0118	0.0118
Brugia malayi	hypothetical protein	0.0037	0.0299	0.0299
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.005	0.0532	0.1879
Schistosoma mansoni	sodium/solute symporter	0.0046	0.0465	0.1643
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0068	0.0068
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0	0.5
Brugia malayi	MH2 domain containing protein	0.0122	0.1793	0.1793
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0	0.5
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0026	0.0118	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0068	0.0068
Schistosoma mansoni	jun-related protein	0.007	0.0877	0.3095
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0068	0.0068
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.005	0.0532	0.1879
Schistosoma mansoni	hypothetical protein	0.0037	0.0299	0.1055
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0465	0.0465
Schistosoma mansoni	hypothetical protein	0.007	0.0877	0.3095
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0	0.5
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0024	0.0068	0.0242
Brugia malayi	Nuclear hormone receptor E75	0.0024	0.0068	0.0068
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0	0.5
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0024	0.0068	0.0242
Loa Loa (eye worm)	hypothetical protein	0.005	0.0532	0.0532
Brugia malayi	Nuclear hormone receptor-like 1	0.005	0.0532	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0465	0.0465
Trypanosoma cruzi	DNA polymerase eta, putative	0.002	0	0.5
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.005	0.0532	0.1879
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.005	0.0532	0.1879
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.005	0.0532	0.0532
Echinococcus multilocularis	FTZ F1 alpha	0.005	0.0532	0.1879
Schistosoma mansoni	inositol transporter	0.0181	0.2833	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0068	0.0068
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0	0.5
Brugia malayi	nuclear hormone receptor family member odr-7	0.0024	0.0068	0.0068
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0151	0.2298	0.8112
Loa Loa (eye worm)	hypothetical protein	0.0084	0.1117	0.1117
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0179	0.2787	0.9839
Echinococcus multilocularis	high affinity choline transporter 1	0.0046	0.0465	0.1643
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0068	0.0068
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0	0.5
Onchocerca volvulus		0.005	0.0532	0.6047
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0	0.5
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0086	0.1158	0.409
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0024	0.0068	0.0242
Echinococcus granulosus	jun protein	0.0086	0.1158	0.409
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.005	0.0532	0.0532
Echinococcus granulosus	solute carrier family 5	0.0181	0.2833	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0026	0.0118	0.0417
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0024	0.0068	0.0242
Brugia malayi	ecdysone receptor	0.0024	0.0068	0.0068
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.005	0.0532	0.1879
Loa Loa (eye worm)	nuclear hormone receptor	0.0024	0.0068	0.0068
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0024	0.0068	0.0242
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.005	0.0532	0.0532
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0046	0.0465	0.1643
Loa Loa (eye worm)	hypothetical protein	0.005	0.0532	0.0532
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0129	0.1909	0.674
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0024	0.0068	0.0242
Brugia malayi	orphan nuclear receptor NR2E1	0.0024	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0068	0.0068
Schistosoma mansoni	nuclear receptor	0.0024	0.0068	0.0242
Loa Loa (eye worm)	steroid hormone receptor	0.005	0.0532	0.0532
Brugia malayi	hypothetical protein	0.0024	0.0068	0.0068
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0026	0.0118	0.0118
Brugia malayi	nuclear receptor RXR	0.0024	0.0068	0.0068
Brugia malayi	hypothetical protein	0.0026	0.0118	0.0118
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0299	0.1055
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0075	0.0973	0.3436
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.005	0.0532	0.0532
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.005	0.0532	0.1879
Brugia malayi	nuclear hormone receptor	0.005	0.0532	0.0532
Brugia malayi	nuclear receptor RXR	0.0026	0.0118	0.0118
Schistosoma mansoni	RAR-like nuclear receptor	0.005	0.0532	0.1879
Leishmania major	DNA polymerase kappa, putative	0.002	0	0.5
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.005	0.0532	0.1879
Brugia malayi	Sodium:solute symporter family protein	0.0046	0.0465	0.0465
Trypanosoma brucei	unspecified product	0.002	0	0.5
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0181	0.2833	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.005	0.0532	0.1879
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0129	0.1909	0.674
Schistosoma mansoni	thyroid hormone receptor	0.0179	0.2787	0.9839
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0024	0.0068	0.0068
Brugia malayi	Steroid receptor seven-up type 2	0.005	0.0532	0.0532
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0118	0.0118
Onchocerca volvulus		0.0067	0.0835	1
Brugia malayi	nuclear hormone receptor	0.0024	0.0068	0.0068
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0	0.5
Schistosoma mansoni	zinc finger protein	0.0024	0.0068	0.0242
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.005	0.0532	0.1879
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0	0.5
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0024	0.0068	0.0242
Brugia malayi	Nuclear hormone receptor-like 1	0.0026	0.0118	0.0118
Loa Loa (eye worm)	DR-78	0.0024	0.0068	0.0068
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0075	0.0973	0.3436
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.005	0.0532	0.0532
Schistosoma mansoni	inositol transporter	0.0181	0.2833	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0532	0.0532
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0	0.5
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0181	0.2833	1
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0181	0.2833	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.005	0.0532	0.1879
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.005	0.0532	0.0532
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.005	0.0532	0.0532
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.005	0.0532	0.0532
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.005	0.0532	0.0532
Onchocerca volvulus	Bile acid receptor homolog	0.005	0.0532	0.6047
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.005	0.0532	0.0532
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.005	0.0532	0.1879
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.005	0.0532	0.0532
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.005	0.0532	0.1879
Schistosoma mansoni	nuclear hormone receptor	0.0024	0.0068	0.0242
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0	0.5
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.005	0.0532	0.0532
Loa Loa (eye worm)	hypothetical protein	0.005	0.0532	0.0532
Onchocerca volvulus		0.0046	0.0465	0.5175
Echinococcus multilocularis	nuclear receptor nhr 48	0.0024	0.0068	0.0242
Echinococcus granulosus	ecdysone induced protein 78C	0.005	0.0532	0.1879
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.005	0.0532	0.0532
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.005	0.0532	0.0532
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0024	0.0068	0.0068
Brugia malayi	Nuclear hormone receptor-like 1	0.0026	0.0118	0.0118
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.005	0.0532	0.1879
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.005	0.0532	0.0532
Echinococcus granulosus	thyroid hormone receptor alpha	0.0024	0.0068	0.0242
Onchocerca volvulus	Protein ultraspiracle homolog	0.005	0.0532	0.6047
Entamoeba histolytica	hypothetical protein	0.0037	0.0299	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0024	0.0068	0.0242
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.005	0.0532	0.1879
Echinococcus granulosus	high affinity choline transporter 1	0.0046	0.0465	0.1643
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0068	0.0068
Brugia malayi	Nuclear hormone receptor E75	0.0024	0.0068	0.0068
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0	0.5
Schistosoma mansoni	high-affinity choline transporter	0.0046	0.0465	0.1643
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0118	0.0118
Schistosoma mansoni	nuclear receptor nhr-48	0.0024	0.0068	0.0242
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.005	0.0532	0.1879
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.005	0.0532	0.0532
Schistosoma mansoni	hypothetical protein	0.0129	0.1909	0.674
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.005	0.0532	0.0532
Brugia malayi	tailless protein	0.0024	0.0068	0.0068
Schistosoma mansoni	retinoic acid receptor RXR	0.0151	0.2298	0.8112
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0068	0.0068
Leishmania major	DNA polymerase eta, putative	0.002	0	0.5
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0024	0.0068	0.0068
Schistosoma mansoni	coup transcription factor	0.005	0.0532	0.1879
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.005	0.0532	0.0532
Brugia malayi	conserved hypotetical protein	0.0024	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0068	0.0068
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.005	0.0532	0.1879
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0	0.5
Brugia malayi	steroid hormone receptor	0.005	0.0532	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0068	0.0068
Mycobacterium ulcerans	DNA polymerase IV	0.002	0	0.5
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.005	0.0532	0.1879
Echinococcus multilocularis	solute carrier family 5	0.0181	0.2833	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.1793	0.1793
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0181	0.2833	1
Echinococcus granulosus	FTZ F1 alpha	0.005	0.0532	0.1879
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.005	0.0532	0.6047
Echinococcus granulosus	sodium:glucose cotransporter	0.0181	0.2833	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0024	0.0068	0.0068
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.005	0.0532	0.0532
Giardia lamblia	DINP protein human, muc B family	0.002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.0532	0.0532
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.005	0.0532	0.0532
Brugia malayi	nuclear receptor NHR-67	0.0024	0.0068	0.0068
Schistosoma mansoni	thyroid hormone receptor	0.0179	0.2787	0.9839
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0118	0.0118
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.0046	0.0465	0.5
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.1793	0.1793
Brugia malayi	nuclear receptor NHR-88	0.005	0.0532	0.0532
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0299	0.1055
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0	0.5
Mycobacterium ulcerans	DNA polymerase IV	0.002	0	0.5
Entamoeba histolytica	hypothetical protein	0.0037	0.0299	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.005	0.0532	0.1879
Brugia malayi	nuclear receptor NHR-88	0.0024	0.0068	0.0068
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.005	0.0532	0.1879
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0	0.5
Brugia malayi	bZIP transcription factor family protein	0.0086	0.1158	0.1158
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0086	0.1158	0.409
Schistosoma mansoni	nuclear receptor	0.0024	0.0068	0.0242

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 7.37 nM	Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter	ChEMBL.	21514014

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1784274

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1519847