Detailed information for compound 1519861

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 414.518 | Formula: C22H26N2O4S
  • H donors: 1 H acceptors: 3 LogP: 2.52 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)S(=O)(=O)NCCC(=O)N1CCC(=CC1)c1ccccc1
  • InChi: 1S/C22H26N2O4S/c1-2-28-20-8-10-21(11-9-20)29(26,27)23-15-12-22(25)24-16-13-19(14-17-24)18-6-4-3-5-7-18/h3-11,13,23H,2,12,14-17H2,1H3
  • InChiKey: ZAMJNSVRNXQEKW-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0053 0.058 0.1241
Brugia malayi Smad1 0.001 0.0022 0.0128
Trypanosoma brucei oxidoreductase-like protein 0.0053 0.058 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0103
Loa Loa (eye worm) Smad1 0.001 0.0022 0.0048
Schistosoma mansoni importin beta-1 0.0035 0.0344 0.0735
Echinococcus granulosus snurportin 1 0.0372 0.4677 1
Echinococcus granulosus importin subunit beta 1 0.0035 0.0344 0.0735
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0053 0.058 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0455 0.0972
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0387 0.0387
Echinococcus multilocularis snurportin 1 0.0372 0.4677 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0053 0.058 1
Plasmodium falciparum importin beta, putative 0.0035 0.0344 0.0121
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0344 0.3333
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0053 0.058 0.3316
Loa Loa (eye worm) hypothetical protein 0.0118 0.1418 0.3032
Brugia malayi hypothetical protein 0.0043 0.0455 0.2598
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0344 0.0735
Onchocerca volvulus Huntingtin homolog 0.0118 0.1418 1
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0786 1 1
Plasmodium vivax importin-beta 2, putative 0.0035 0.0344 0.0121
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0344 0.3333
Plasmodium falciparum enoyl-acyl carrier reductase 0.0786 1 1
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0344 0.0121
Leishmania major pteridine reductase 1 0.0053 0.058 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0352 0.0753
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0022 0.0048
Loa Loa (eye worm) hypothetical protein 0.0035 0.0344 0.0735
Schistosoma mansoni dihydropteridine reductase 0.0053 0.058 0.1241
Echinococcus granulosus smad 0.001 0.0022 0.0048
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0259 0.0259
Loa Loa (eye worm) retinol dehydrogenase 12 0.0053 0.058 0.1241
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0022 0.0048
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.047 0.1005
Trypanosoma brucei pteridine reductase 1 0.0053 0.058 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0455 0.0972
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0259 0.0259
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0053 0.058 0.1241
Echinococcus granulosus voltage gated potassium channel 0.0012 0.0048 0.0103
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.175 0.3742
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0259 0.0946
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0053 0.058 1
Leishmania major oxidoreductase-like protein 0.0053 0.058 1
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0786 1 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0022 0.0048
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0226 0.5
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0022 0.0048
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0053 0.058 0.0363
Leishmania major importin beta-1 subunit, putative 0.0028 0.0259 0.0946
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0387 0.0387
Brugia malayi MH1 domain containing protein 0.001 0.0022 0.0128
Schistosoma mansoni hypothetical protein 0.0372 0.4677 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.058 0.1241
Entamoeba histolytica hypothetical protein 0.0043 0.0455 0.6461
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0226 0.1289
Entamoeba histolytica hypothetical protein 0.0043 0.0455 0.6461
Schistosoma mansoni Smad4 0.001 0.0022 0.0048
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0053 0.058 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0012 0.0048 0.0103
Schistosoma mansoni smad 0.001 0.0022 0.0048
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0422 0.0902
Toxoplasma gondii cytochrome p450 superfamily protein 0.0734 0.9337 0.9322
Brugia malayi MH2 domain containing protein 0.0144 0.175 1
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0048 0.0103
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0022 0.0048
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0053 0.058 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0226 0.0482
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0053 0.058 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0422 0.0902
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0226 0.0482
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0022 0.0048
Entamoeba histolytica hypothetical protein 0.0043 0.0455 0.6461
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0053 0.058 0.0363
Echinococcus multilocularis Smad4 0.001 0.0022 0.0048
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0053 0.058 0.1241
Onchocerca volvulus Huntingtin homolog 0.0118 0.1418 1
Echinococcus multilocularis voltage gated potassium channel 0.0012 0.0048 0.0103
Brugia malayi MH2 domain containing protein 0.001 0.0022 0.0128
Schistosoma mansoni smad1 5 8 and 0.001 0.0022 0.0048
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0012 0.0048 0.0103
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0786 1 1
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0786 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0048 0.0103
Schistosoma mansoni smad1 5 8 and 0.001 0.0022 0.0048
Trichomonas vaginalis hypothetical protein 0.0786 1 1
Schistosoma mansoni ran 0.0026 0.0226 0.0482
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0455 0.0972
Loa Loa (eye worm) oxidoreductase 0.0053 0.058 0.1241
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0422 0.0902
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0786 1 1
Brugia malayi Importin beta-1 subunit 0.0035 0.0344 0.1964
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.058 0.1241
Trichomonas vaginalis ran, putative 0.0026 0.0226 0.0226
Brugia malayi MH2 domain containing protein 0.001 0.0022 0.0128
Brugia malayi RNA, U transporter 1 0.0099 0.1169 0.6682
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.047 0.1005
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0786 1 1
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0053 0.058 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0226 0.0482
Schistosoma mansoni ran 0.0026 0.0226 0.0482
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0053 0.058 0.0363
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0022 0.0048
Loa Loa (eye worm) hypothetical protein 0.0118 0.1418 0.3032
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0422 0.2409
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0012 0.0048 0.0276
Echinococcus multilocularis smad 0.001 0.0022 0.0048
Schistosoma mansoni hypothetical protein 0.0043 0.0455 0.0972
Brugia malayi hypothetical protein 0.0118 0.1418 0.8103
Brugia malayi MH1 domain containing protein 0.001 0.0022 0.0128
Entamoeba histolytica hypothetical protein 0.0028 0.0259 0.0946
Entamoeba histolytica hypothetical protein 0.0043 0.0455 0.6461
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0259 0.0259
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4677 1
Echinococcus granulosus Smad4 0.001 0.0022 0.0048
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0053 0.058 1
Schistosoma mansoni smad1 5 8 and 0.001 0.0022 0.0048
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.175 0.3742
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0053 0.058 0.0363
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0053 0.058 0.0363
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0053 0.058 0.3316

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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