Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | hypothetical protein, conserved | 0.0026 | 0.1138 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.2941 | 0.4395 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0.205 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0054 | 0.5219 | 0.5094 |
Plasmodium falciparum | phd finger protein, putative | 0.0026 | 0.1138 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.205 | 0.2778 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0036 | 0.2664 | 0.2472 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0.205 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3921 | 0.5859 |
Echinococcus granulosus | peregrin | 0.0028 | 0.1455 | 0.1231 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0032 | 0.1958 | 0.1747 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0054 | 0.5219 | 0.5094 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0033 | 0.2213 | 0.2009 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0026 | 0.1138 | 0.1701 |
Brugia malayi | jmjC domain containing protein | 0.0033 | 0.2213 | 0.1741 |
Brugia malayi | PHD-finger family protein | 0.0026 | 0.1138 | 0.0601 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0033 | 0.2213 | 0.3307 |
Schistosoma mansoni | hypothetical protein | 0.0026 | 0.1138 | 0.1543 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0032 | 0.2044 | 0.1835 |
Onchocerca volvulus | Alhambra homolog | 0.0026 | 0.1138 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0067 | 0.7263 | 0.7097 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0026 | 0.1138 | 0.0906 |
Schistosoma mansoni | bromodomain containing protein | 0.0057 | 0.5698 | 0.7722 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0045 | 0.3903 | 0.5833 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0026 | 0.1138 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0086 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0045 | 0.3903 | 0.3534 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0032 | 0.205 | 0.1842 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.2686 | 0.4014 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0045 | 0.3903 | 0.3534 |
Brugia malayi | Bromodomain containing protein | 0.0028 | 0.1455 | 0.0937 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1796 | 0.2434 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0033 | 0.2213 | 0.2999 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0026 | 0.1138 | 0.0906 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0054 | 0.5286 | 0.7899 |
Schistosoma mansoni | jumonji domain containing protein | 0.0068 | 0.7378 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.002 | 0.0255 | 0.0346 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0032 | 0.205 | 0.2778 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1138 | 0.1701 |
Brugia malayi | Bromodomain containing protein | 0.0034 | 0.236 | 0.1897 |
Giardia lamblia | PHD finger protein 15 | 0.0026 | 0.1138 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0086 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1796 | 0.2684 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.237 | 0.3541 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0033 | 0.2213 | 0.2999 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0032 | 0.205 | 0.1842 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0031 | 0.1796 | 0.1299 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0.205 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3903 | 0.5833 |
Echinococcus multilocularis | peregrin | 0.0028 | 0.1455 | 0.1231 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0032 | 0.2044 | 0.1835 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.6692 | 1 |
Brugia malayi | hypothetical protein | 0.0032 | 0.205 | 0.1568 |
Echinococcus granulosus | jumonji domain containing protein | 0.0036 | 0.2664 | 0.2472 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0026 | 0.1138 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0.205 | 0.5 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0026 | 0.1138 | 0.1543 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.