Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.1004 | 0.1004 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.1904 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.1004 | 0.3047 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.1004 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.1004 | 0.1904 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 0.3293 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1004 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.1904 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0054 | 0.3293 | 0.3293 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.1904 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.1004 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 0.3293 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.1004 | 0.3047 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.1904 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 0.3293 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.1004 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.1004 | 0.3047 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.1904 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.2097 | 0.4775 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.1004 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.2097 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.1904 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.1004 | 0.5 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.1004 | 0.3047 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 0.3293 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.3293 | 0.3293 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.1004 | 0.3047 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.1004 | 0.3047 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1004 | 0.1904 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.2097 | 0.4775 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.1004 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.1904 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1004 | 0.1904 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.1004 | 0.1004 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.1004 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 0.3293 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.1904 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 0.3293 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.1004 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1004 | 0.1904 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.