Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0199 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0199 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.4357 | 0.4709 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3186 | 0.4188 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0199 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0199 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0199 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3194 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0518 | 0.0411 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.1264 | 0.1086 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0333 | 0.0188 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0199 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0199 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0851 | 0.0914 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.0199 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.3194 | 0.3861 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.0199 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.3194 | 0.4199 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.0199 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.9254 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0199 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3194 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7332 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3186 | 0.4188 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0518 | 0.0559 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0851 | 0.0914 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0199 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0333 | 0.0188 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0333 | 0.0173 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3194 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0851 | 0.084 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3611 | 0.3902 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.3194 | 0.4199 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.7956 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0199 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.4024 | 0.4348 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3194 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7332 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0199 | 0.0215 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.3599 | 0.3469 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.3194 | 0.3861 |
Brugia malayi | hypothetical protein | 0.0043 | 0.3194 | 0.3056 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0199 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.92 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.