Detailed information for compound 152036

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 384.048 | Formula: C7H8F3IN2O5
  • H donors: 3 H acceptors: 4 LogP: 0.78 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: ICC(=O)NCC(C(=O)O)NC(=O)OC(F)(F)F
  • InChi: 1S/C7H8F3IN2O5/c8-7(9,10)18-6(17)13-3(5(15)16)2-12-4(14)1-11/h3H,1-2H2,(H,12,14)(H,13,17)(H,15,16)
  • InChiKey: FMWKYWVDUJPCKZ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nAChR subunit 0.0012 0.0006 0.0005
Onchocerca volvulus 0.0007 0.0001 0.0004
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0007 0.0001 0.0001
Onchocerca volvulus 0.0012 0.0006 0.0028
Brugia malayi excitatory GABA receptor EXP-1A 0.0012 0.0006 0.0005
Brugia malayi MH2 domain containing protein 0.0008 0.0002 0.0002
Schistosoma mansoni smad 0.0008 0.0002 0.0002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0067 0.0067
Chlamydia trachomatis dihydrofolate reductase 1.2956 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0013 0.0139
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0055 0.0076
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0013 0.0012
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0002 0.0001
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0135 0.0101 0.009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0005
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0012 0.0006 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0067 0.0067
Brugia malayi CXXC zinc finger family protein 0.0028 0.0018 0.0017
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0012
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0013 0.0012
Onchocerca volvulus Putative nachr subunit 0.0012 0.0006 0.0028
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.2318 0.1786 0.1778
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.001 0.0012
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0012 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0077 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0005
Brugia malayi Cation transporter family protein 0.0012 0.0006 0.0005
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0013 0.0012
Loa Loa (eye worm) thymidylate synthase 0.2318 0.1786 0.1786
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0005
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0013 0.0012
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0013 0.0002
Loa Loa (eye worm) ACC-1 protein 0.0012 0.0006 0.0005
Plasmodium falciparum transporter, putative 0.0047 0.0032 0.0043
Echinococcus multilocularis glycine receptor subunit beta 0.0012 0.0006 0.0005
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0013 0.0012
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0012 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.001 0.0012
Trichomonas vaginalis protein disulfide isomerase, putative 0.0008 0.0002 0.0012
Brugia malayi thymidylate synthase 0.2318 0.1786 0.1786
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0001
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0037 0.0037
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.001 0.0012
Echinococcus multilocularis musashi 0.0057 0.004 0.004
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.9067 0.6997 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.0016
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0002 0.0002
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0047 0.0032 0.0032
Loa Loa (eye worm) solute carrier family 6 member 4 0.0275 0.0208 0.0208
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0007 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0082 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.001 0.0012
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0003 0.0002
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.001 0.0012
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.004 0.004
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0055 0.0055
Entamoeba histolytica hypothetical protein 0.0022 0.0013 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0135 0.0101 0.009
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0082 0.0059 0.0059
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.0006 0.0005
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0012 0.0006 0.0005
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0013 0.0012
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0013 0.0012
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0012 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0005
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0013 0.0469
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0013 0.0002
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.9067 0.6997 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0135 0.0101 0.0101
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.004 0.004
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0006 0.0005
Mycobacterium ulcerans dihydrofolate reductase DfrA 1.2956 1 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0047 0.0032 0.0032
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0012 0.0006 0.0005
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0013 0.0012
Plasmodium falciparum glutathione reductase 0.0018 0.001 0.0012
Schistosoma mansoni protein disulfide-isomerase er-60 precursor (erp60) 0.0008 0.0002 0.0002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0002 0.0001
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.001 0.0012
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.002 0.0019
Trichomonas vaginalis protein disulfide isomerase, putative 0.0008 0.0002 0.0012
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0002 0.0002
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0047 0.0032 0.0032
Schistosoma mansoni cpg binding protein 0.0028 0.0018 0.0017
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0013 0.0015
Leishmania major trypanothione reductase 0.0053 0.0037 0.005
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0013 0.0012
Echinococcus granulosus lamin 0.0057 0.004 0.004
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0012 0.0006 0.0005
Schistosoma mansoni sodium-dependent amino acid transporter 0.0047 0.0032 0.0032
Schistosoma mansoni nAChR subunit 0.0012 0.0006 0.0005
Onchocerca volvulus 0.0057 0.004 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0013 0.0139
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0037 0.005
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0013 0.0012
Loa Loa (eye worm) Pdia4 protein 0.0008 0.0002 0.0002
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0013 0.0012
Schistosoma mansoni smad1 5 8 and 0.0008 0.0002 0.0002
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0055 0.0045
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0006 0.0005
Loa Loa (eye worm) Smad1 0.0008 0.0002 0.0002
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0035 0.0034
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0055 0.0076
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.001 0.001
Echinococcus granulosus Smad4 0.0008 0.0002 0.0002
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0007 0.0001 0.0001
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0122 0.009 0.008
Brugia malayi MH2 domain containing protein 0.0117 0.0087 0.0086
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0047 0.0032 0.0032
Schistosoma mansoni smad1 5 8 and 0.0008 0.0002 0.0002
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.1103 0.0848 0.1209
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0017 0.0017
Schistosoma mansoni Probable protein disulfide-isomerase ER-60 precursor (ERP60) 0.0008 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0012
Echinococcus granulosus lamin dm0 0.0057 0.004 0.004
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0006 0.0005
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0012 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0047 0.0032 0.0032
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.0006 0.0005
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.001 0.0012
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0012 0.0006 0.0005
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0012
Echinococcus multilocularis nAChR subunit 0.0012 0.0006 0.0005
Brugia malayi PXA domain containing protein 0.0022 0.0013 0.0012
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0122 0.009 0.008
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.0006 0.0005
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0013 0.0012
Echinococcus multilocularis sodium and chloride dependent glycine 0.0047 0.0032 0.0032
Loa Loa (eye worm) GABA receptor subunit 0.0007 0.0001 0.0001
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0013 0.0012
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0013 0.0015
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0017 0.0017
Echinococcus multilocularis glycine receptor subunit beta 0.0012 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0017 0.0017
Echinococcus multilocularis serotonin transporter 0.0275 0.0208 0.0208
Echinococcus multilocularis dihydrofolate reductase 1.2956 1 1
Onchocerca volvulus 0.2318 0.1786 1
Loa Loa (eye worm) hypothetical protein 0.0275 0.0208 0.0208
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0017 0.0021
Leishmania major dihydrofolate reductase-thymidylate synthase 0.9067 0.6997 1
Plasmodium vivax amine transporter, putative 0.0047 0.0032 0.0043
Brugia malayi hypothetical protein 0.0022 0.0013 0.0012
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.001 0.0012
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0012 0.0006 0.0005
Loa Loa (eye worm) ACC-1 protein 0.0012 0.0006 0.0005
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0002 0.0002
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0013 0.0012
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0013 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0067 0.0067
Brugia malayi MH1 domain containing protein 0.0008 0.0002 0.0002
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0035 0.0025
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0032 0.0032
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.0006 0.0005
Onchocerca volvulus 0.0275 0.0208 0.1164
Schistosoma mansoni ap endonuclease 0.0021 0.0013 0.0012
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.2318 0.1786 0.1786
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0013 0.0012
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0047 0.0032 0.0022
Brugia malayi intermediate filament protein 0.0057 0.004 0.004
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0087 0.0086
Brugia malayi Cation transporter family protein 0.0012 0.0006 0.0005
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0002 0.0002
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0047 0.0032 0.0032
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.001 0.0012
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0013 0.0012
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0082 0.0059 0.0059
Schistosoma mansoni nAChR subunit 0.0012 0.0006 0.0005
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.001 0.0012
Onchocerca volvulus 0.0082 0.0059 0.0329
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0055 0.0055
Onchocerca volvulus 0.0057 0.004 0.0221
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0013 0.0012
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.001 0.0012
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.001 0.0012
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0012 0.0006 0.0005
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0002 0.0001
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0012 0.0006 0.0005
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.001 0.0012
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0012 0.0006 0.0005
Echinococcus granulosus glycine receptor subunit beta 0.0012 0.0006 0.0005
Brugia malayi PXA domain containing protein 0.0022 0.0013 0.0012
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0017 0.0021
Toxoplasma gondii thioredoxin reductase 0.0053 0.0037 0.005
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0032 0.0032
Schistosoma mansoni sodium/chloride dependent transporter 0.0047 0.0032 0.0032
Onchocerca volvulus 0.0012 0.0006 0.0028
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0013 0.0012
Echinococcus granulosus protein disulfide isomerase A3 0.0008 0.0002 0.0002
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0032 0.0032
Echinococcus granulosus nAChR subunit 0.0007 0.0001 0.0001
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0013 0.0012
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0067 0.0067
Entamoeba histolytica hypothetical protein 0.0022 0.0013 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.001 0.001
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0047 0.0032 0.0032
Echinococcus multilocularis cpg binding protein 0.003 0.0019 0.0019
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0275 0.0208 0.0208
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.001 0.011
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0013 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0007 0.0001 0.0001
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0122 0.009 0.008
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0013 0.0012
Trypanosoma brucei trypanothione reductase 0.0053 0.0037 0.005
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0005
Brugia malayi glutathione reductase 0.0053 0.0037 0.0037
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0006 0.0005
Loa Loa (eye worm) glutathione reductase 0.0053 0.0037 0.0037
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.001 0.001
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0013 0.0012
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0012 0.0006 0.0005
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0275 0.0208 0.0208
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0013 0.0135
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0087 0.0086
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0002 0.0001
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.2318 0.1786 0.1786
Brugia malayi Dihydrofolate reductase 1.2956 1 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0001
Echinococcus granulosus smad 0.0008 0.0002 0.0002
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0012 0.0006 0.0005
Schistosoma mansoni nAChR subunit 0.0012 0.0006 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0013 0.0139
Mycobacterium tuberculosis Probable dehydrogenase 0.0122 0.009 0.008
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0047 0.0032 0.0032
Toxoplasma gondii hypothetical protein 0.0047 0.0032 0.0043
Toxoplasma gondii exonuclease III APE 0.0021 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0005
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0032 0.0032
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.0006 0.0005
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0013 0.0012
Echinococcus multilocularis lamin dm0 0.0057 0.004 0.004
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.002 0.0019
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.9067 0.6997 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0001
Onchocerca volvulus 0.0047 0.0032 0.0177
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0005
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0013 0.0012
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0047 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0076 0.0055 0.0054
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0006 0.0005
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0002 0.0002
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0005
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0032 0.0043
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0013 0.0012
Mycobacterium tuberculosis Hypothetical protein 0.1103 0.0848 0.0838
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0012 0.0006 0.0005
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0013 0.0012
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0122 0.009 0.009
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0006 0.0005
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0012 0.0006 0.0005
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0013 0.0012
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0135 0.0101 0.009
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0037 0.0027
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0013 0.0012
Onchocerca volvulus 0.0007 0.0001 0.0004
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0055 0.0076
Schistosoma mansoni nAChR subunit 0.0012 0.0006 0.0005
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0013 0.0012
Schistosoma mansoni nAChR subunit 0.0012 0.0006 0.0005
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0032 0.0032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0067 0.0067
Echinococcus granulosus glycine receptor subunit beta 0.0012 0.0006 0.0005
Echinococcus multilocularis smad 0.0008 0.0002 0.0002
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0013 0.0012
Schistosoma mansoni cpg binding protein 0.003 0.0019 0.0019
Brugia malayi Cation transporter family protein 0.0082 0.0059 0.0059
Schistosoma mansoni dihydrofolate reductase 1.2956 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0013 0.0012
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0055 0.0055
Schistosoma mansoni lamin 0.0057 0.004 0.004
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0013 0.0012
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0012 0.0006 0.0005
Treponema pallidum sodium- and chloride- dependent transporter 0.0275 0.0208 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0067 0.0067
Brugia malayi probable protein disulfide-isomerase 0.0008 0.0002 0.0002
Echinococcus multilocularis protein disulfide isomerase A3 0.0008 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0012
Echinococcus granulosus dihydrofolate reductase 1.2956 1 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0013 0.0012
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0055 0.0045
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.001 0.0012
Onchocerca volvulus 0.0012 0.0006 0.0028
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0006 0.0005
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0012 0.0006 0.0005
Schistosoma mansoni nAChR subunit 0.0012 0.0006 0.0005
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0037 0.005
Echinococcus granulosus expressed protein 0.0421 0.0321 0.0321
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0013 0.0015
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0012 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0001
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0007 0.0006
Mycobacterium tuberculosis Probable reductase 0.0122 0.009 0.008
Loa Loa (eye worm) protein disulfide isomerase 0.0008 0.0002 0.0002
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0013 0.0012
Echinococcus multilocularis sodium and chloride dependent glycine 0.0047 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0047 0.0032 0.0032
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0012 0.0006 0.0005
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0055 0.0045
Echinococcus granulosus sodium and chloride dependent glycine 0.0047 0.0032 0.0032
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0001
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0001
Brugia malayi protein disulphide isomerase 0.0008 0.0002 0.0002
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0047 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0047 0.0032 0.0032
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0275 0.0208 0.0208
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0013 0.0012
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0012 0.0006 0.0005
Loa Loa (eye worm) intermediate filament protein 0.0057 0.004 0.004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.001 0.0012
Schistosoma mansoni sodium/chloride dependent transporter 0.0275 0.0208 0.0208
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0003 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0013 0.0139
Brugia malayi transglutaminase 0.0008 0.0002 0.0002
Onchocerca volvulus 0.0047 0.0032 0.0177
Schistosoma mansoni nAChR subunit 0.0012 0.0006 0.0005
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0055 0.0076
Echinococcus granulosus intermediate filament protein 0.0057 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.0016
Loa Loa (eye worm) transglutaminase 0.0008 0.0002 0.0002
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0013 0.0012
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0032 0.0043
Echinococcus multilocularis thymidylate synthase 0.2318 0.1786 0.1786
Entamoeba histolytica hypothetical protein 0.0022 0.0013 1
Brugia malayi MH1 domain containing protein 0.0008 0.0002 0.0002
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0002 0.0001
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0012 0.0006 0.0005
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0047 0.0032 0.0032
Brugia malayi Probable ClpP-like protease 0.0077 0.0055 0.0055
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0017 0.031
Trichomonas vaginalis conserved hypothetical protein 0.1103 0.0848 1
Trichomonas vaginalis protein disulfide isomerase, putative 0.0008 0.0002 0.0012
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.9067 0.6997 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.9067 0.6997 1
Plasmodium falciparum thioredoxin reductase 0.0018 0.001 0.0012
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0018 0.0017
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0012 0.0006 0.0005
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.001 0.7979
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 1.2956 1 1
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.0013 0.0139
Loa Loa (eye worm) hypothetical protein 0.0082 0.0059 0.0059
Brugia malayi hypothetical protein 0.0047 0.0032 0.0032
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0017 0.0017
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0122 0.009 0.008
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0012
Schistosoma mansoni intermediate filament proteins 0.0057 0.004 0.004
Plasmodium vivax glutathione reductase, putative 0.0053 0.0037 0.005
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0042 0.0042
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0012 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0001
Schistosoma mansoni protein disulfide-isomerase 0.0008 0.0002 0.0002
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0013 0.0106
Schistosoma mansoni smad1 5 8 and 0.0008 0.0002 0.0002
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0032 0.0043
Entamoeba histolytica thioredoxin, putative 0.0008 0.0002 0.074
Plasmodium falciparum amino acid transporter, putative 0.0047 0.0032 0.0043
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0013 0.0012
Loa Loa (eye worm) serotonin transporter b 0.0275 0.0208 0.0208
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0275 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0056 0.0039 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0013 0.0139
Brugia malayi Smad1 0.0008 0.0002 0.0002
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0013 0.0012
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0055 0.2271
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0006 0.0005
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0013 0.0012
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0012 0.0006 0.0005
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0035 0.0035
Schistosoma mansoni ap endonuclease 0.0021 0.0013 0.0012
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0055 0.0045
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0013 0.0135
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0067 0.0067
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0055 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0012 0.0006 0.0005
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.001 0.0012
Echinococcus multilocularis expressed protein 0.0421 0.0321 0.0321
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0035 0.0025
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0037 0.0037
Onchocerca volvulus 0.0028 0.0018 0.0097
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.001 0.011
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0047 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0047 0.0032 0.0032
Loa Loa (eye worm) LGC-31 protein 0.0012 0.0006 0.0005
Toxoplasma gondii hypothetical protein 0.0047 0.0032 0.0043
Echinococcus multilocularis nAChR subunit 0.0007 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0057 0.004 0.004
Schistosoma mansoni Smad4 0.0008 0.0002 0.0002
Onchocerca volvulus 0.0082 0.0059 0.0329
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0032 0.0043
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0005
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0047 0.0032 0.0032
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0012 0.0006 0.0005
Loa Loa (eye worm) dihydrofolate reductase 1.2956 1 1
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0035 0.0034
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0047 0.0032 0.0032
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.001 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0013 0.0139
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0013 0.9728
Echinococcus granulosus protein disulfide isomerase 0.0008 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0047 0.0032 0.0032
Schistosoma mansoni neurotransmitter gated ion channel 0.0007 0.0001 0.0001
Brugia malayi hypothetical protein 0.1103 0.0848 0.0847
Echinococcus granulosus cpg binding protein 0.003 0.0019 0.0019
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.0006 0.0005
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0013 0.0012
Plasmodium falciparum glutathione reductase 0.0053 0.0037 0.005
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0007 0.0001 0.0001
Echinococcus granulosus serotonin transporter 0.0275 0.0208 0.0208
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0032 0.0032
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0037 0.005
Brugia malayi MH2 domain containing protein 0.0008 0.0002 0.0002
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0013 0.0012
Echinococcus multilocularis Smad4 0.0008 0.0002 0.0002
Echinococcus multilocularis protein disulfide isomerase 0.0008 0.0002 0.0002
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0032 0.0032
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.001 0.0012
Onchocerca volvulus 0.0047 0.0032 0.0177
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.001 0.0012
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0012 0.0006 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0067 0.0067
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.0006 0.0005
Onchocerca volvulus 0.0082 0.0059 0.0329
Brugia malayi Thioredoxin reductase 0.0053 0.0037 0.0037
Schistosoma mansoni lamin 0.0057 0.004 0.004
Loa Loa (eye worm) norepinephrine transporter 0.0275 0.0208 0.0208
Schistosoma mansoni sodium/chloride dependent transporter 0.0047 0.0032 0.0032
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0007 0.0001 0.0001
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0003 0.0002
Trichomonas vaginalis protein disulfide isomerase, putative 0.0008 0.0002 0.0012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.001 0.0012
Toxoplasma gondii hypothetical protein 0.0026 0.0017 0.0021
Echinococcus granulosus thymidylate synthase 0.2318 0.1786 0.1786
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0013 0.0012
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0013 0.0012
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0005
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.001 0.0012
Echinococcus multilocularis lamin 0.0057 0.004 0.004
Schistosoma mansoni cpg binding protein 0.003 0.0019 0.0019
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0001
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0047 0.0032 0.0032
Echinococcus granulosus sodium and chloride dependent glycine 0.0047 0.0032 0.0032
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.001 0.0012
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0013 0.0012
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0002 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0013 0.0012
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0012 0.0006 0.0005
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0013 0.0012
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 1.2956 1 1
Plasmodium falciparum thioredoxin reductase 0.0053 0.0037 0.005
Brugia malayi hypothetical protein 0.0022 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0005
Echinococcus granulosus glycine receptor subunit alpha 1 0.0012 0.0006 0.0005
Mycobacterium ulcerans thymidylate synthase 0.2318 0.1786 0.1778
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0013 0.0012
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0007 0.0006

Activities

Activity type Activity value Assay description Source Reference
Cleavage rate (functional) = 27 uM min-1 g-1 Intracellular cleavage of the compound exhibited in Candida albicans ATCC 26278 ChEMBL. 2120441
Cleavage rate (functional) = 27 uM min-1 g-1 Intracellular cleavage of the compound exhibited in Candida albicans ATCC 26278 ChEMBL. 2120441
MIC (functional) = 2 ug ml-1 In vitro antimicrobial activity of the compound against Cornyebacterium sp. 239 ChEMBL. 2120441
MIC (functional) = 2 ug ml-1 In vitro antimicrobial activity of the compound against Bacillus pumilis CCM 1697 ChEMBL. 2120441
MIC (functional) = 4 ug ml-1 In vitro antimicrobial activity of the compound against Staphylococcus aureus 163J ChEMBL. 2120441
MIC (functional) = 10 ug ml-1 Invitro antifungal activity of the compound against Trychophyton nanum ChEMBL. 2120441
MIC (functional) = 15 ug ml-1 In vitro antifungal activity of the compound against Candida albicans 4477 ChEMBL. 2120441
MIC (functional) = 15 ug ml-1 In vitro antifungal activity of the compound against Candida tropicalis ChEMBL. 2120441
MIC (functional) = 15 ug ml-1 In vitro antifungal activity of the compound against Candida albicans 4477 ChEMBL. 2120441
MIC (functional) = 16 ug ml-1 In vitro antimicrobial activity of the compound against Staphylococcus epidermis 154J ChEMBL. 2120441
MIC (functional) = 16 ug ml-1 In vitro antimicrobial activity of the compound against Streptococcus beta-haemolyticus A 800 ChEMBL. 2120441
MIC (functional) = 17.5 ug ml-1 In vitro antifungal activity of the compound against Geotrichum candidum ChEMBL. 2120441
MIC (functional) = 32 ug ml-1 In vitro antimicrobial activity of the compound against Streptococcus faecalis CCM 1875 ChEMBL. 2120441
MIC (functional) = 32 ug ml-1 In vitro antimicrobial activity of the compound against Microsporum luteus NCTC 2665 ChEMBL. 2120441
MIC (functional) > 50 ug ml-1 In vitro antifungal activity of the compound against Rhizopus arrhizus ChEMBL. 2120441
MIC (functional) > 50 ug ml-1 In vitro antifungal activity of the compound against Aspergillus nidulans 590 ChEMBL. 2120441
Transport rate (functional) = 0.4 uM min-1 g-1 Rate of transport of compound in Candida albicans ATCC 26278 ChEMBL. 2120441
Transport rate (functional) = 0.4 uM min-1 g-1 Rate of transport of compound in Candida albicans ATCC 26278 ChEMBL. 2120441

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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