Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Steroid receptor seven-up type 2 | 0.005 | 0.0613 | 0.0532 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0024 | 0.0153 | 0.0538 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0153 | 0.0153 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0024 | 0.0153 | 0.0068 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0.0153 | 0.0538 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0613 | 0.0613 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0153 | 0.0153 |
Onchocerca volvulus | 0.005 | 0.0613 | 0.6047 | |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.005 | 0.0613 | 0.0532 |
Brugia malayi | steroid hormone receptor | 0.005 | 0.0613 | 0.0532 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.005 | 0.0613 | 0.6047 |
Echinococcus multilocularis | jun protein | 0.0086 | 0.1234 | 0.4331 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.015 | 0.2364 | 0.8245 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0613 | 0.0613 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0024 | 0.0153 | 0.0538 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0085 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.005 | 0.0613 | 0.191 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.005 | 0.0613 | 0.0613 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0024 | 0.0153 | 0.0648 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.1863 | 0.1863 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0026 | 0.0202 | 0.0856 |
Echinococcus granulosus | dna polymerase kappa | 0.002 | 0.0085 | 0.0361 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0024 | 0.0153 | 0.0246 |
Echinococcus multilocularis | dna polymerase kappa | 0.002 | 0.0085 | 0.0299 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.005 | 0.0613 | 0.0532 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.002 | 0.0085 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.005 | 0.0613 | 0.0532 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0085 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0178 | 0.2849 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0153 | 0.0153 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0381 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0026 | 0.0202 | 0.0202 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.005 | 0.0613 | 0.2593 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0085 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0153 | 0.0153 |
Brugia malayi | bZIP transcription factor family protein | 0.0086 | 0.1234 | 0.1158 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0085 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0085 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.002 | 0.0085 | 0.0361 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.005 | 0.0613 | 0.2593 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.015 | 0.2364 | 1 |
Brugia malayi | ecdysteroid receptor | 0.005 | 0.0613 | 0.0532 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0613 | 0.0613 |
Schistosoma mansoni | nuclear hormone receptor | 0.0024 | 0.0153 | 0.0246 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0.0085 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.005 | 0.0613 | 0.191 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.005 | 0.0613 | 0.2593 |
Echinococcus multilocularis | dna polymerase eta | 0.002 | 0.0085 | 0.0299 |
Echinococcus granulosus | jun protein | 0.0086 | 0.1234 | 0.522 |
Brugia malayi | ecdysone receptor | 0.0024 | 0.0153 | 0.0068 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.0085 | 0.5 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0026 | 0.0202 | 0.071 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0024 | 0.0153 | 0.0648 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.005 | 0.0613 | 0.0532 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.0085 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.005 | 0.0613 | 0.191 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.1863 | 0.1793 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0954 | 0.3145 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0024 | 0.0153 | 0.0068 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0.0085 | 0.5 |
Onchocerca volvulus | 0.0067 | 0.0914 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.005 | 0.0613 | 0.0532 |
Brugia malayi | nuclear receptor NHR-67 | 0.0024 | 0.0153 | 0.0068 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0024 | 0.0153 | 0.0648 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0085 | 0.0085 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0.0085 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.002 | 0.0085 | 0.5 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0381 | 0.0299 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0202 | 0.0202 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0381 | 1 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0075 | 0.105 | 0.4443 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.0085 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0153 | 0.0153 |
Brugia malayi | nuclear receptor RXR | 0.0026 | 0.0202 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0153 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0613 | 0.0613 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0153 | 0.0246 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.005 | 0.0613 | 0.2593 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.0085 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.1193 | 0.1193 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.005 | 0.0613 | 0.191 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0153 | 0.0153 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0085 | 0.0299 |
Loa Loa (eye worm) | hypothetical protein | 0.0589 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0024 | 0.0153 | 0.0538 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0153 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0202 | 0.0202 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.005 | 0.0613 | 0.0613 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0202 | 0.0202 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0085 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0153 | 0.0153 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0024 | 0.0153 | 0.0538 |
Schistosoma mansoni | nuclear hormone receptor | 0.005 | 0.0613 | 0.191 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0085 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0026 | 0.0202 | 0.0118 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0381 | 0.1614 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0085 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.002 | 0.0085 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.005 | 0.0613 | 0.191 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.005 | 0.0613 | 0.2152 |
Echinococcus multilocularis | FTZ F1 alpha | 0.005 | 0.0613 | 0.2152 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.005 | 0.0613 | 0.0532 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.005 | 0.0613 | 0.2152 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.005 | 0.0613 | 0.0532 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0024 | 0.0153 | 0.0068 |
Loa Loa (eye worm) | DR-78 | 0.0024 | 0.0153 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0153 | 0.0153 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.0085 | 0.5 |
Leishmania major | DNA polymerase kappa, putative | 0.002 | 0.0085 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0026 | 0.0202 | 0.0118 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0024 | 0.0153 | 0.0068 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0026 | 0.0202 | 0.0424 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0153 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0613 | 0.0613 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0024 | 0.0153 | 0.0068 |
Schistosoma mansoni | coup transcription factor | 0.005 | 0.0613 | 0.191 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.005 | 0.0613 | 0.0613 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0914 | 0.0835 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0153 | 0.0153 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0085 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.005 | 0.0613 | 0.0532 |
Schistosoma mansoni | hypothetical protein | 0.0128 | 0.1978 | 0.685 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.005 | 0.0613 | 0.191 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.005 | 0.0613 | 0.0532 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.005 | 0.0613 | 0.2152 |
Trypanosoma brucei | unspecified product | 0.002 | 0.0085 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.1863 | 0.1863 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0024 | 0.0153 | 0.0153 |
Schistosoma mansoni | nuclear hormone receptor | 0.0024 | 0.0153 | 0.0246 |
Schistosoma mansoni | jun-related protein | 0.007 | 0.0954 | 0.3145 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0024 | 0.0153 | 0.0153 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.005 | 0.0613 | 0.0532 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0202 | 0.0118 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.005 | 0.0613 | 0.2593 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.005 | 0.0613 | 0.2152 |
Brugia malayi | nuclear receptor NHR-88 | 0.0024 | 0.0153 | 0.0068 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0.0153 | 0.0648 |
Schistosoma mansoni | thyroid hormone receptor | 0.0178 | 0.2849 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.005 | 0.0613 | 0.2593 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0075 | 0.105 | 0.3687 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0128 | 0.1978 | 0.8369 |
Onchocerca volvulus | Bile acid receptor homolog | 0.005 | 0.0613 | 0.6047 |
Brugia malayi | nuclear receptor NHR-88 | 0.005 | 0.0613 | 0.0532 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.005 | 0.0613 | 0.6047 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0086 | 0.1234 | 0.522 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0024 | 0.0153 | 0.0648 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0085 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0086 | 0.1234 | 0.4331 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0381 | 0.1072 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0153 | 0.0068 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.005 | 0.0613 | 0.0613 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.005 | 0.0613 | 0.2152 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0024 | 0.0153 | 0.0068 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0085 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0085 | 0.5 |
Schistosoma mansoni | nuclear receptor | 0.0024 | 0.0153 | 0.0246 |
Brugia malayi | nuclear hormone receptor | 0.005 | 0.0613 | 0.0532 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.005 | 0.0613 | 0.0613 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0085 | 0.5 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0202 | 0.0118 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0024 | 0.0153 | 0.0648 |
Brugia malayi | tailless protein | 0.0024 | 0.0153 | 0.0068 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0024 | 0.0153 | 0.0246 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.005 | 0.0613 | 0.0532 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0026 | 0.0202 | 0.0424 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0153 | 0.0153 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0085 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0202 | 0.0202 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0085 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.005 | 0.0613 | 0.2593 |
Echinococcus granulosus | FTZ F1 alpha | 0.005 | 0.0613 | 0.2593 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.002 | 0.0085 | 0.5 |
Brugia malayi | conserved hypotetical protein | 0.0024 | 0.0153 | 0.0068 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.005 | 0.0613 | 0.0532 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0202 | 0.0202 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0381 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.005 | 0.0613 | 0.191 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0024 | 0.0153 | 0.0153 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0024 | 0.0153 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0613 | 0.0613 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.005 | 0.0613 | 0.0532 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0124 | 0.1904 | 0.6683 |
Loa Loa (eye worm) | steroid hormone receptor | 0.005 | 0.0613 | 0.0613 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0178 | 0.2849 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0613 | 0.0613 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0381 | 0.1339 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.005 | 0.0613 | 0.0613 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.005 | 0.0613 | 0.2152 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0381 | 0.1072 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.005 | 0.0613 | 0.0532 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.005 | 0.0613 | 0.0532 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.005 | 0.0613 | 0.0613 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.005 | 0.0613 | 0.2152 |
Schistosoma mansoni | nuclear receptor | 0.0024 | 0.0153 | 0.0246 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0085 | 0.0361 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0085 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0085 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0613 | 0.0613 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0381 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0128 | 0.1978 | 0.6944 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0153 | 0.0153 |
Brugia malayi | nuclear hormone receptor | 0.0024 | 0.0153 | 0.0068 |
Brugia malayi | nuclear receptor RXR | 0.0024 | 0.0153 | 0.0068 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.005 | 0.0613 | 0.191 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.