Detailed information for compound 1520429

Basic information

Technical information
  • TDR Targets ID: 1520429
  • Name: 2-(2-fluorophenoxy)-N-(4-pyridin-2-yl-1,3-thi azol-2-yl)acetamide
  • MW: 329.349 | Formula: C16H12FN3O2S
  • H donors: 1 H acceptors: 3 LogP: 2.89 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1scc(n1)c1ccccn1)COc1ccccc1F
  • InChi: 1S/C16H12FN3O2S/c17-11-5-1-2-7-14(11)22-9-15(21)20-16-19-13(10-23-16)12-6-3-4-8-18-12/h1-8,10H,9H2,(H,19,20,21)
  • InChiKey: VHXHHYPHXNWUOP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(2-fluorophenoxy)-N-[4-(2-pyridyl)thiazol-2-yl]acetamide
  • 2-(2-fluorophenoxy)-N-[4-(2-pyridyl)-2-thiazolyl]acetamide
  • 2-(2-fluorophenoxy)-N-(4-pyridin-2-yl-1,3-thiazol-2-yl)ethanamide
  • T5404398

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens phosphatidylinositol-5-phosphate 4-kinase, type II, alpha Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II Get druggable targets OG5_131617 All targets in OG5_131617
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 Get druggable targets OG5_131617 All targets in OG5_131617
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) pip kinase 2 Get druggable targets OG5_131617 All targets in OG5_131617
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131617 All targets in OG5_131617
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Get druggable targets OG5_131617 All targets in OG5_131617
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K00889 1-phosphatidylinositol-4-phosphate 5-kinase [EC2.7.1.68], putative Get druggable targets OG5_131617 All targets in OG5_131617
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Pip kinase protein 2 Get druggable targets OG5_131617 All targets in OG5_131617
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II Get druggable targets OG5_131617 All targets in OG5_131617
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 Get druggable targets OG5_131617 All targets in OG5_131617
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 406 aa 341 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0016 0.0508 0.0129
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0397 0.0205
Echinococcus multilocularis dna polymerase kappa 0.0047 0.213 0.1973
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.5677 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.5677 0.5591
Loa Loa (eye worm) hypothetical protein 0.0012 0.0308 0.0115
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0016 0.0508 0.0318
Leishmania major DNA polymerase eta, putative 0.0077 0.3747 0.6316
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.8624 0.8597
Brugia malayi hypothetical protein 0.003 0.128 0.1106
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.213 0.3227
Giardia lamblia Hypothetical protein 0.0016 0.0508 0.0371
Giardia lamblia DNA damage repair protein 0.0014 0.044 0.0245
Giardia lamblia Kinase, PLK 0.0114 0.5677 1
Leishmania major DNA polymerase eta, putative 0.0045 0.2057 0.3088
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.128 0.1604
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0196 1 1
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.216 0.3449
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0308 0.0115
Trypanosoma brucei unspecified product 0.0032 0.1369 0.1775
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0494 0.0102
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0016 0.0508 0.2128
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.5677 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.128 0.1604
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0508 0.0129
Loa Loa (eye worm) pip kinase 2 0.0196 1 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0397 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.1369 0.1775
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.071 0.1388
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.213 0.3157
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0698 0.2925
Loa Loa (eye worm) hypothetical protein 0.0196 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.1369 0.1775
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0016 0.0508 0.0027
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0016 0.0508 0.0318
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0016 0.0508 0.0129
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.216 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.213 0.3157
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0494 0.0102
Schistosoma mansoni DNA polymerase eta 0.0077 0.3747 0.3623
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.213 0.3227
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.726 0.7205
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.8882 0.886
Leishmania major hypothetical protein, conserved 0.003 0.128 0.1604
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.5677 1
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0016 0.0508 0.0318
Giardia lamblia Phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0508 0.0371
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.213 0.1973
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0014 0.044 0.1844
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.1204 0.1028
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0308 0.1293
Onchocerca volvulus 0.0196 1 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0883 0.0701
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.2386 1
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0016 0.0508 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.213 0.3227
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.216 0.3805
Loa Loa (eye worm) hypothetical protein 0.0146 0.7352 0.7299
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.213 0.1973
Plasmodium falciparum DNA repair protein REV1, putative 0.0014 0.044 0.071
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0016 0.0508 0.2128
Giardia lamblia DINP protein human, muc B family 0.0047 0.213 0.3393
Echinococcus granulosus dna polymerase eta 0.0077 0.3747 0.3623
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0308 0.0115
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0016 0.0508 0.0129
Schistosoma mansoni DNA helicase recq1 0.0012 0.0308 0.0115
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.5677 1
Trypanosoma brucei unspecified product 0.0032 0.1369 0.1775
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0016 0.0508 0.0129
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0016 0.0508 0.0318
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0016 0.0508 0.0318
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.5677 1
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0016 0.0508 0.2128
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0308 0.0115
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0047 0.213 0.1973
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.213 0.3227
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0047 0.213 0.5
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.1018 0.3834
Loa Loa (eye worm) RecQ helicase 0.0029 0.1204 0.1028
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.213 0.3227
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0016 0.0508 0.0129
Brugia malayi Pip kinase protein 1 0.0016 0.0508 0.0318
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.2386 1
Trypanosoma brucei unspecified product 0.0047 0.213 0.3227
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.213 1
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.1204 0.137
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.1369 0.1775
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.5677 0.5591
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.5677 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.213 0.3227
Loa Loa (eye worm) acetyltransferase 0.0175 0.8882 0.886
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.213 0.3227
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.213 0.1973
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0308 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.213 0.3227
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0014 0.044 0.1844
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0016 0.0508 0.0129
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.128 0.5245
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.5677 1
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0508 0.0129
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0494 0.0869
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.5677 1
Brugia malayi hypothetical protein 0.002 0.0713 0.0527
Brugia malayi MH2 domain containing protein 0.0144 0.726 0.7205
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.3747 0.6316
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.213 0.3227
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0016 0.0508 0.1076
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0196 1 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.2386 0.365
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.5677 0.5591
Echinococcus granulosus dna polymerase kappa 0.0047 0.213 0.1973
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0016 0.0508 0.0318
Schistosoma mansoni hypothetical protein 0.0014 0.0397 0.0205
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.5677 0.5591
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.128 0.5364
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.213 0.1973
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.5677 1
Loa Loa (eye worm) FYVE zinc finger family protein 0.0016 0.0508 0.0318
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0196 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.213 0.3227
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0508 0.0129
Echinococcus multilocularis bloom syndrome protein 0.0029 0.1204 0.1028
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0508 0.0348
Schistosoma mansoni kinase 0.0058 0.2728 0.2582
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.1204 0.137
Loa Loa (eye worm) pip kinase 1 0.0016 0.0508 0.0318
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.2057 0.3088
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.2057 0.8624
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.2648 0.4157
Schistosoma mansoni DNA polymerase IV / kappa 0.0014 0.044 0.0249
Loa Loa (eye worm) hypothetical protein 0.0077 0.3747 0.3623
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0016 0.0508 0.0129
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0308 0.0115
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.213 0.3227
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0508 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.213 0.3227
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.128 0.4316
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.5677 0.5591
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0508 0.0348
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.213 0.3227
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0508 0.0129
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0016 0.0508 0.0318
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.213 0.3227
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.2386 1
Echinococcus multilocularis dna polymerase eta 0.0077 0.3747 0.3623
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.213 0.3752
Loa Loa (eye worm) hypothetical protein 0.003 0.128 0.1106
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.213 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0308 0.0115
Schistosoma mansoni DNA helicase recq5 0.0012 0.0308 0.0115
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.5677 1
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.128 0.1604
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0016 0.0508 0.0129
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0508 0.0894
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.2386 0.2234
Echinococcus granulosus bloom syndrome protein 0.0029 0.1204 0.1028
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.726 0.7205
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0016 0.0508 0.0318
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0016 0.0508 0.0318
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0308 0.0115
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.8882 0.886
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0016 0.0508 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.213 0.3227
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.213 0.3227
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0196 1 1
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0016 0.0508 0.0129
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.5677 1
Brugia malayi polk-prov protein 0.0014 0.044 0.0249
Trypanosoma brucei polo-like protein kinase 0.0114 0.5677 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.213 0.3227
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0308 0.1293
Leishmania major DNA polymerase kappa, putative 0.0047 0.213 0.3227
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.3747 0.6316
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.213 0.3227
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.213 0.5
Entamoeba histolytica phosphoinositide kinase, putative 0.0016 0.0508 0.0894
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0016 0.0508 0.0129
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.8882 0.886
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.3747 0.3623
Loa Loa (eye worm) hypothetical protein 0.0014 0.044 0.0249
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.128 0.5245
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0016 0.0508 0.0318
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.2648 0.4157
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.213 0.1973
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0494 0.0102
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.2386 0.365

Activities

Activity type Activity value Assay description Source Reference
AbsAC1000_uM (functional) = 5.517 uM PUBCHEM_BIOASSAY: In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504552] ChEMBL. No reference
AbsAC35 (functional) = 10.45 uM PubChem BioAssay. Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (3D7 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-05_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
AbsAC35 (functional) = 12.03 uM PubChem BioAssay. Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (HB3 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-06_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.5849 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.9173 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.9173 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Inhibitors of PI5P4K: Confirmation in Primary Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 25.9185 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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