Detailed information for compound 152052

Basic information

Technical information
  • TDR Targets ID: 152052
  • Name: 5-Methoxy-1,2-Dimethyl-3-(Phenoxymethyl)Indol e-4,7-Dione
  • MW: 311.332 | Formula: C18H17NO4
  • H donors: 0 H acceptors: 2 LogP: 2.57 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC1=CC(=O)c2c(C1=O)c(COc1ccccc1)c(n2C)C
  • InChi: 1S/C18H17NO4/c1-11-13(10-23-12-7-5-4-6-8-12)16-17(19(11)2)14(20)9-15(22-3)18(16)21/h4-9H,10H2,1-3H3
  • InChiKey: JRPJCFILHCLEJI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-methoxy-1,2-dimethyl-3-(phenoxymethyl)indole-4,7-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum subtilisin-like protease 3 0.0025 0.0078 0.1056
Onchocerca volvulus 0.0035 0.0208 0.0584
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0285
Echinococcus multilocularis thyroid hormone receptor alpha 0.0148 0.165 0.1634
Brugia malayi G protein-coupled receptor F59B2.13 0.0026 0.009 0.0098
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0059 0.0041
Echinococcus granulosus 7tm_1 domain containing protein 0.0026 0.009 0.0079
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0059 0.0045
Echinococcus granulosus dna polymerase kappa 0.0041 0.0275 0.0282
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0026 0.009 0.0079
Echinococcus multilocularis neuropeptide FF receptor 2 0.0026 0.009 0.0072
Echinococcus granulosus cyclin B3 1 0.0032 0.0163 0.0159
Brugia malayi Serotonin receptor 0.0026 0.009 0.0098
Brugia malayi nuclear receptor NHR-88 0.0024 0.0059 0.0057
Trichomonas vaginalis cyclin D, putative 0.0032 0.0163 0.0335
Onchocerca volvulus 0.0026 0.009 0.022
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Echinococcus multilocularis cyclins 0.0032 0.0163 0.0145
Brugia malayi follicle stimulating hormone receptor 0.0026 0.009 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0059 0.0081
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Schistosoma mansoni neuropeptide f receptor 76f 0.0026 0.009 0.0079
Schistosoma mansoni neuropeptide receptor 0.0026 0.009 0.0079
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0026 0.009 0.0072
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.009 0.0079
Schistosoma mansoni opsin-like receptor 0.0026 0.009 0.0079
Entamoeba histolytica cyclin, putative 0.0051 0.0406 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0026 0.009 0.0098
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.002 0.0018 0.0025
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0275 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.009 0.0079
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0026 0.009 0.0079
Echinococcus granulosus neuropeptide receptor A26 0.0026 0.009 0.0079
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0032 0.0163 0.0145
Trichomonas vaginalis cyclin B, putative 0.0051 0.0406 0.09
Loa Loa (eye worm) hypothetical protein 0.0231 0.271 0.3719
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0025
Brugia malayi hypothetical protein 0.0026 0.009 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0059 0.0057
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Onchocerca volvulus 0.0035 0.0208 0.0584
Loa Loa (eye worm) hypothetical protein 0.0024 0.0059 0.0081
Echinococcus multilocularis C type lectin domian containing protein 0.0035 0.0208 0.019
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0025 0.0078 1
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1213 0.2769
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0139 0.1535 0.3515
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0275 0.0906
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.009 0.0079
Plasmodium falciparum SET domain protein, putative 0.0065 0.0587 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0059 0.0045
Echinococcus granulosus Furin 1 0.0139 0.1535 0.1665
Trichomonas vaginalis cyclin A, putative 0.0051 0.0406 0.09
Echinococcus multilocularis neuropeptide receptor 0.0026 0.009 0.0072
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0275 0.5997
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0275 0.0906
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Trichomonas vaginalis cyclins, putative 0.0051 0.0406 0.09
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0025 0.0078 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.009 0.0079
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.009 0.0079
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.009 0.0079
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Schistosoma mansoni hypothetical protein 0.0114 0.1213 0.1312
Onchocerca volvulus 0.0026 0.009 0.022
Brugia malayi nuclear hormone receptor 0.0024 0.0059 0.0057
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0026 0.009 0.0123
Brugia malayi Melatonin receptor type 1A 0.0026 0.009 0.0098
Schistosoma mansoni coup transcription factor 0.0024 0.0059 0.0045
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0026 0.009 0.0072
Brugia malayi RE15519p 0.0026 0.009 0.0098
Onchocerca volvulus 0.0026 0.009 0.022
Schistosoma mansoni growth hormone secretagogue receptor 0.0026 0.009 0.0079
Echinococcus granulosus neuropeptide receptor 0.0026 0.009 0.0079
Brugia malayi G-protein coupled receptor 0.0026 0.009 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0059 0.0081
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0025 0.0078 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.009 0.0079
Echinococcus multilocularis cyclins 0.0032 0.0163 0.0145
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0026 0.009 0.0098
Onchocerca volvulus 0.0035 0.0208 0.0584
Onchocerca volvulus 0.0026 0.009 0.022
Trichomonas vaginalis cyclin B3, putative 0.0032 0.0163 0.0335
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.009 0.0079
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0422 0.0556
Plasmodium vivax subtilisin-like protease 1 0.0025 0.0078 0.1056
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0285
Onchocerca volvulus 0.0026 0.009 0.022
Schistosoma mansoni furin-1 (S08 family) 0.0256 0.3032 0.3309
Onchocerca volvulus 0.0026 0.009 0.022
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0285
Echinococcus granulosus dro:myosuppressin receptor 0.0026 0.009 0.0079
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0059 0.0041
Brugia malayi hypothetical protein 0.0026 0.009 0.0098
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0931 0.1002
Echinococcus multilocularis neuropeptide receptor 0.0026 0.009 0.0072
Toxoplasma gondii rhoptry neck protein RON9 0.0035 0.0208 0.3334
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1213 0.2769
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.009 0.0079
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.1347 0.1331
Onchocerca volvulus 0.0035 0.0208 0.0584
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0078 0.0139
Brugia malayi hypothetical protein 0.0026 0.009 0.0098
Schistosoma mansoni amine GPCR 0.0026 0.009 0.0079
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0026 0.009 0.0072
Echinococcus multilocularis serotonin receptor 0.0026 0.009 0.0072
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0092 0.0931 0.1277
Brugia malayi Dopamine receptor protein 1 0.0026 0.009 0.0098
Onchocerca volvulus 0.0026 0.009 0.022
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.009 0.0079
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0285
Loa Loa (eye worm) hypothetical protein 0.0024 0.0059 0.0081
Echinococcus granulosus G protein coupled receptor 139 0.0026 0.009 0.0079
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0059 0.0057
Brugia malayi celfurPC protein 0.0475 0.5831 0.7996
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0026 0.009 0.0079
Echinococcus granulosus sex peptide receptor 0.0026 0.009 0.0079
Onchocerca volvulus 0.0035 0.0208 0.0584
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0078 0.0139
Schistosoma mansoni biogenic amine receptor 0.0026 0.009 0.0079
Brugia malayi ORL1-like opioid receptor 0.0026 0.009 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0078 0.0139
Toxoplasma gondii hypothetical protein 0.0024 0.0065 0.0819
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.009 0.0072
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Schistosoma mansoni biogenic amine receptor 0.0026 0.009 0.0079
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.009 0.0079
Brugia malayi ecdysteroid receptor 0.0024 0.0059 0.0057
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0035 0.0208 0.0285
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.009 0.0079
Echinococcus multilocularis protein will die slowly 0.0274 0.3266 0.3254
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0059 0.0057
Onchocerca volvulus 0.0026 0.009 0.022
Brugia malayi Dopamine receptor protein 2 0.0026 0.009 0.0098
Echinococcus multilocularis cyclin B3 1 0.0032 0.0163 0.0145
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0285
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0059 0.0045
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Loa Loa (eye worm) hypothetical protein 0.0024 0.0059 0.0081
Trichomonas vaginalis cyclin B, putative 0.0051 0.0406 0.09
Brugia malayi Cyclin, N-terminal domain containing protein 0.0032 0.0163 0.0199
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0025
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0026 0.009 0.0079
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Brugia malayi hypothetical protein 0.0035 0.0208 0.0261
Giardia lamblia Cyclin A 0.0032 0.0163 0.0554
Onchocerca volvulus 0.0026 0.009 0.022
Schistosoma mansoni hypothetical protein 0.0026 0.009 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0059 0.0081
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0026 0.009 0.0123
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0059 0.0057
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0139 0.1535 0.3515
Schistosoma mansoni amine GPCR 0.0026 0.009 0.0079
Loa Loa (eye worm) hypothetical protein 0.0051 0.0406 0.0558
Brugia malayi hypothetical protein 0.0026 0.009 0.0098
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Toxoplasma gondii subtilisin SUB5 0.0025 0.0078 0.1056
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0059 0.0057
Echinococcus granulosus somatostatin receptor 0.0026 0.009 0.0079
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0025 0.0078 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0059 0.0127
Brugia malayi Serotonin receptor 0.0026 0.009 0.0098
Echinococcus multilocularis G-protein coupled receptor, putative 0.0026 0.009 0.0072
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.009 0.0072
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.009 0.0079
Loa Loa (eye worm) hypothetical protein 0.0024 0.0059 0.0081
Trypanosoma cruzi cyclin, putative 0.0051 0.0406 1
Onchocerca volvulus 0.0026 0.009 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1213 0.2769
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0139 0.1535 0.3515
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.009 0.0072
Echinococcus multilocularis serotonin receptor 0.0026 0.009 0.0072
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.009 0.0123
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0025
Schistosoma mansoni thyroid hormone receptor 0.0148 0.165 0.1791
Echinococcus multilocularis cyclin b3 0.0032 0.0163 0.0145
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0732 0.9126 1
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0114 0.1213 0.2769
Brugia malayi GCC2 and GCC3 family protein 0.0035 0.0208 0.0261
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0025 0.0078 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0059 0.0041
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Echinococcus multilocularis beta adrenergic receptor kinase 0.0092 0.0931 0.0914
Brugia malayi neuroendocrine convertase 1 precursor 0.037 0.4489 0.615
Brugia malayi sulfakinin receptor protein 0.0026 0.009 0.0098
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.009 0.0123
Brugia malayi Tachykinin-like peptides receptor 99D 0.0026 0.009 0.0098
Schistosoma mansoni biogenic amine receptor 0.0026 0.009 0.0079
Echinococcus multilocularis cyclins 0.0032 0.0163 0.0145
Trypanosoma cruzi cyclin, putative 0.0051 0.0406 1
Echinococcus granulosus serotonin receptor 0.0026 0.009 0.0079
Echinococcus multilocularis fmrfamide receptor 0.0026 0.009 0.0072
Schistosoma mansoni opsin-like receptor 0.0026 0.009 0.0079
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.009 0.0079
Brugia malayi neuropeptide F receptor 0.0026 0.009 0.0098
Toxoplasma gondii subtilisin SUB7 0.0025 0.0078 0.1056
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.009 0.0123
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0082 0.0809 0.0792
Echinococcus multilocularis cyclins 0.0032 0.0163 0.0145
Entamoeba histolytica cyclin, putative 0.0032 0.0163 0.3725
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0025
Brugia malayi endoprotease bli-4 precursor 0.0588 0.7288 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.009 0.0079
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0059 0.0041
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0059 0.0127
Brugia malayi Cyclin, N-terminal domain containing protein 0.0051 0.0406 0.0534
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0026 0.009 0.0072
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0059 0.0045
Brugia malayi putative neuropeptide receptor 0.0026 0.009 0.0098
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0192 0.0607
Loa Loa (eye worm) TYRA-2 protein 0.0026 0.009 0.0123
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0025
Loa Loa (eye worm) CUTiclin family member 0.002 0.0018 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0275 0.0906
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0025
Echinococcus granulosus g protein coupled receptor 0.0026 0.009 0.0079
Entamoeba histolytica cyclin family protein 0.0032 0.0163 0.3725
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1213 0.2769
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1213 0.2769
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0025 0.0078 0.0083
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.009 0.0072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0285
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0025
Echinococcus multilocularis cyclin B 0.0051 0.0406 0.0389
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0285
Brugia malayi G-protein coupled receptor 0.0026 0.009 0.0098
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Onchocerca volvulus 0.0035 0.0208 0.0584
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1213 0.2769
Toxoplasma gondii subtilisin SUB1 0.0025 0.0078 0.1056
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0059 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0059 0.0057
Schistosoma mansoni cyclins 0.0032 0.0163 0.0159
Echinococcus granulosus membrane bound transcription factor site 1 0.0025 0.0078 0.0066
Schistosoma mansoni hypothetical protein 0.0026 0.009 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0059 0.0057
Echinococcus multilocularis G protein coupled receptor 139 0.0026 0.009 0.0072
Leishmania major subtilisin-like serine peptidase 0.0025 0.0078 0.1451
Toxoplasma gondii subtilisin SUB2 0.0025 0.0078 0.1056
Echinococcus granulosus allatostatin A receptor 0.0026 0.009 0.0079
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0026 0.009 0.022
Brugia malayi pregnancy-associated plasma protein-A 0.0035 0.0208 0.0261
Echinococcus granulosus G protein coupled receptor kinase 1 0.0082 0.0809 0.0868
Trypanosoma brucei subtilisin peptidase 0.0025 0.0078 0.02
Brugia malayi hypothetical protein 0.0026 0.009 0.0098
Plasmodium falciparum subtilisin-like protease 1 0.0025 0.0078 0.1056
Onchocerca volvulus 0.0274 0.3266 1
Echinococcus granulosus c4b binding protein beta chain 0.0035 0.0208 0.0208
Schistosoma mansoni cyclin B3 0.0032 0.0163 0.0159
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.009 0.0079
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.009 0.0072
Onchocerca volvulus 0.0026 0.009 0.022
Echinococcus multilocularis somatostatin receptor 0.0026 0.009 0.0072
Brugia malayi polk-prov protein 0.0031 0.0149 0.018
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0059 0.0045
Trypanosoma cruzi CYC2-like cyclin, putative 0.0051 0.0406 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0026 0.009 0.0079
Plasmodium vivax subtilisin-like protease 2, putative 0.0025 0.0078 0.1056
Echinococcus multilocularis cyclins 0.0032 0.0163 0.0145
Entamoeba histolytica cyclin family protein 0.0032 0.0163 0.3725
Trichomonas vaginalis cyclins, putative 0.0051 0.0406 0.09
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0059 0.0045
Schistosoma mansoni hypothetical protein 0.0026 0.009 0.0079
Schistosoma mansoni amine GPCR 0.0026 0.009 0.0079
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0059 0.0045
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0026 0.009 0.0123
Trichomonas vaginalis cyclins, putative 0.0032 0.0163 0.0335
Echinococcus granulosus cyclin b3 0.0032 0.0163 0.0159
Brugia malayi neuropeptide F receptor 0.0026 0.009 0.0098
Echinococcus granulosus protein will die slowly 0.0274 0.3266 0.3566
Loa Loa (eye worm) hypothetical protein 0.0025 0.0078 0.0107
Brugia malayi larval opioid receptor 0.0026 0.009 0.0098
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.009 0.0079
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0026 0.009 0.0079
Echinococcus granulosus cyclins 0.0032 0.0163 0.0159
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0275 0.0595
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.009 0.0079
Schistosoma mansoni hypothetical protein 0.0036 0.0211 0.0212
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1213 0.2769
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0026 0.009 0.0072
Echinococcus granulosus C type lectin domian containing protein 0.0035 0.0208 0.0208
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0059 0.0045
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0026 0.009 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0059 0.0057
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0059 0.0041
Treponema pallidum hypothetical protein 0.002 0.0018 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.009 0.0079
Loa Loa (eye worm) hypothetical protein 0.0051 0.0406 0.0558
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Echinococcus multilocularis sex peptide receptor 0.0026 0.009 0.0072
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0211 0.0266
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0059 0.0045
Plasmodium falciparum cyclin 0.0032 0.0163 0.2542
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0026 0.009 0.0072
Toxoplasma gondii subtilisin SUB10 0.0025 0.0078 0.1056
Onchocerca volvulus 0.0035 0.0208 0.0584
Onchocerca volvulus 0.0026 0.009 0.022
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0025 0.0078 0.006
Schistosoma mansoni opsin-like receptor 0.0026 0.009 0.0079
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0059 0.0045
Loa Loa (eye worm) subtilase 0.0025 0.0078 0.0107
Trichomonas vaginalis cyclins, putative 0.0051 0.0406 0.09
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Echinococcus granulosus cyclins 0.0032 0.0163 0.0159
Echinococcus multilocularis allatostatin A receptor 0.0026 0.009 0.0072
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.009 0.0079
Onchocerca volvulus 0.0026 0.009 0.022
Loa Loa (eye worm) proprotein convertase 2 0.0139 0.1535 0.2106
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.009 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0059 0.0057
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0051 0.0406 1
Mycobacterium leprae Possible secreted protease 0.0025 0.0078 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Brugia malayi hypothetical protein 0.0035 0.0208 0.0261
Schistosoma mansoni amine GPCR 0.0026 0.009 0.0079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.009 0.0072
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.009 0.0079
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0059 0.0045
Echinococcus granulosus alpha 1A adrenergic receptor 0.0026 0.009 0.0079
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0026 0.009 0.0098
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0422 0.0579
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0588 0.7288 0.7981
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.009 0.0072
Toxoplasma gondii subtilisin SUB4 0.0025 0.0078 0.1056
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Loa Loa (eye worm) hypothetical protein 0.0024 0.0059 0.0081
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0025 0.0078 0.0066
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0285
Echinococcus granulosus neuroendocrine convertase 2 0.037 0.4489 0.4909
Echinococcus granulosus orexin receptor type 2 0.0026 0.009 0.0079
Brugia malayi hypothetical protein 0.0035 0.0208 0.0261
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0059 0.0081
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0114 0.1213 0.2769
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1213 0.2769
Brugia malayi hypothetical protein 0.0035 0.0208 0.0261
Echinococcus multilocularis c4b binding protein beta chain 0.0035 0.0208 0.019
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.009 0.0072
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Echinococcus granulosus neuropeptide receptor 0.0026 0.009 0.0079
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0026 0.009 0.0079
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0026 0.009 0.0079
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0025 0.0078 0.0066
Brugia malayi Sushi domain 0.0035 0.0208 0.0261
Brugia malayi proprotein convertase 2 0.037 0.4489 0.615
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.009 0.0079
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Schistosoma mansoni adenoreceptor 0.0026 0.009 0.0079
Toxoplasma gondii histone lysine methyltransferase SET8 0.0065 0.0587 1
Brugia malayi Protein set-1 0.0065 0.0587 0.0783
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0422 0.0556
Loa Loa (eye worm) WD40 repeat protein 0.0274 0.3266 0.4481
Trichomonas vaginalis cyclin B, putative 0.0051 0.0406 0.09
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0139 0.1535 0.3515
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0275 0.0906
Trichomonas vaginalis cyclin D, putative 0.0032 0.0163 0.0335
Echinococcus granulosus 7TM GPCR rhodopsin 0.0026 0.009 0.0079
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0275 0.0906
Onchocerca volvulus Neuropeptide F receptor homolog 0.0026 0.009 0.022
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Schistosoma mansoni c4b-binding protein beta chain 0.0035 0.0208 0.0208
Schistosoma mansoni cyclin B 0.0051 0.0406 0.0426
Brugia malayi hypothetical protein 0.0026 0.009 0.0098
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0032 0.0163 0.0159
Loa Loa (eye worm) cyclin domain-containing protein 0.0032 0.0163 0.0223
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0059 0.0057
Toxoplasma gondii rhoptry neck protein RON1 0.0035 0.0208 0.3334
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Trichomonas vaginalis cyclin B, putative 0.0032 0.0163 0.0335
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.009 0.0072
Echinococcus multilocularis g protein coupled receptor 0.0026 0.009 0.0072
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0275 0.0595
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0275 0.0906
Echinococcus multilocularis fmrfamide receptor 0.0026 0.009 0.0072
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0025
Loa Loa (eye worm) hypothetical protein 0.0052 0.0422 0.0579
Brugia malayi hypothetical protein 0.0035 0.0208 0.0261
Giardia lamblia G2/mitotic-specific cyclin B 0.0051 0.0406 0.1516
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0059 0.0045
Echinococcus multilocularis orexin receptor type 2 0.0026 0.009 0.0072
Treponema pallidum 76K protein 0.002 0.0018 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.4334 1
Plasmodium vivax subtilisin-like serine protease, putative 0.0025 0.0078 0.1056
Loa Loa (eye worm) hypothetical protein 0.0031 0.0149 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0078 0.0139
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0025
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Schistosoma mansoni histone-lysine n-methyltransferase seto7 0.0065 0.0587 0.0625
Trypanosoma brucei RNA helicase, putative 0.0239 0.281 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0025
Plasmodium falciparum apical sushi protein 0.0035 0.0208 0.3334
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.002 0.0018 0.0025
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0026 0.009 0.0079
Toxoplasma gondii subtilisin SUB6 0.0025 0.0078 0.1056
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1213 0.2769
Brugia malayi hypothetical protein 0.0026 0.009 0.0098
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.009 0.0072
Giardia lamblia High cysteine membrane protein Group 2 0.0219 0.2555 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0059 0.0045
Echinococcus multilocularis membrane bound transcription factor site 1 0.0025 0.0078 0.006
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0059 0.0057
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0026 0.009 0.0098
Onchocerca volvulus 0.0035 0.0208 0.0584
Echinococcus multilocularis dro:myosuppressin receptor 0.0026 0.009 0.0072
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0059 0.0041
Echinococcus multilocularis cyclins 0.0032 0.0163 0.0145
Toxoplasma gondii subtilisin SUB11 0.0025 0.0078 0.1056
Loa Loa (eye worm) melatonin receptor type 1A 0.0026 0.009 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0149 0.0454
Plasmodium vivax apical sushi protein, putative 0.0035 0.0208 0.3334
Schistosoma mansoni hypothetical protein 0.0026 0.009 0.0079
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0026 0.009 0.0079
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.009 0.0079
Leishmania major cyclin 0.0051 0.0406 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0275 0.5997
Loa Loa (eye worm) hypothetical protein 0.0588 0.7288 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.009 0.0072
Echinococcus granulosus tachykinin peptides receptor 99D 0.0026 0.009 0.0079
Plasmodium falciparum subtilisin-like protease 2 0.0025 0.0078 0.1056
Echinococcus granulosus furin 0.0588 0.7288 0.7981
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0059 0.0045
Schistosoma mansoni neuropeptide receptor 0.0026 0.009 0.0079
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0026 0.009 0.0123
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0139 0.1535 0.3515
Onchocerca volvulus 0.0025 0.0078 0.0185
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.009 0.0079
Brugia malayi steroid hormone receptor 0.0024 0.0059 0.0057
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0025
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0114 0.1213 0.2769
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0275 0.5997
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.009 0.0079
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Onchocerca volvulus 0.0051 0.0406 0.1196
Schistosoma mansoni neuropeptide receptor 0.0026 0.009 0.0079
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0025 0.0078 0.0066
Echinococcus granulosus g protein coupled receptor 0.0026 0.009 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1213 0.2769
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0059 0.0045
Trypanosoma brucei unspecified product 0.0034 0.0192 0.0607
Brugia malayi Will die slowly protein 0.0274 0.3266 0.4468
Echinococcus granulosus peptide allatostatin:somatostatin 0.0026 0.009 0.0079
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0931 0.1002
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0275 0.0906
Trichomonas vaginalis WD repeat domain, putative 0.0274 0.3266 0.7526
Schistosoma mansoni histamine h1 receptor 0.0026 0.009 0.0079
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0059 0.0081
Brugia malayi GnHR receptor homolog 0.0026 0.009 0.0098
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0059 0.0045
Schistosoma mansoni site-1 peptidase (S08 family) 0.0025 0.0078 0.0066
Brugia malayi hypothetical protein 0.0026 0.009 0.0098
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0059 0.0081
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0059 0.0081
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0059 0.0045
Echinococcus multilocularis cyclins 0.0032 0.0163 0.0145
Loa Loa (eye worm) hypothetical protein 0.0024 0.0059 0.0081
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Echinococcus multilocularis neuropeptide s receptor 0.0026 0.009 0.0072
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.009 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0059 0.0081
Schistosoma mansoni myosin xvIII 0.0026 0.009 0.0079
Echinococcus granulosus fmrfamide receptor 0.0026 0.009 0.0079
Echinococcus granulosus g-protein coupled receptor 0.0026 0.009 0.0079
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0026 0.009 0.0123
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.009 0.0079
Echinococcus granulosus cyclin B 0.0051 0.0406 0.0426
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0275 0.0257
Trichomonas vaginalis cyclin B, putative 0.0051 0.0406 0.09
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0275 0.0906
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0025
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Toxoplasma gondii subtilisin SUB12 0.0025 0.0078 0.1056
Toxoplasma gondii subtilisin SUB8 0.0025 0.0078 0.1056
Schistosoma mansoni thyroid hormone receptor 0.0148 0.165 0.1791
Brugia malayi hypothetical protein 0.0026 0.009 0.0098
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Schistosoma mansoni hypothetical protein 0.0124 0.1347 0.1459
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0059 0.0045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.009 0.0079
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0025
Schistosoma mansoni amine GPCR 0.0026 0.009 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0059 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0059 0.0057
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Echinococcus granulosus beta-adrenergic receptor kinase 0.0092 0.0931 0.1002
Schistosoma mansoni neuropeptide receptor 0.0026 0.009 0.0079
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Loa Loa (eye worm) CUTiclin-Like family member 0.002 0.0018 0.0025
Echinococcus multilocularis histone lysine n methyltransferase setd8 0.0065 0.0587 0.057
Brugia malayi Subtilase family protein 0.0025 0.0078 0.0083
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.009 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1213 0.2769
Brugia malayi AKH receptor 0.0026 0.009 0.0098
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0732 0.9126 0.9125
Echinococcus granulosus g protein coupled receptor 0.0026 0.009 0.0079
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.009 0.0079
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.009 0.0123
Brugia malayi putative neuropeptide receptor NPR1 0.0026 0.009 0.0098
Echinococcus granulosus cyclins 0.0032 0.0163 0.0159
Echinococcus multilocularis g protein coupled receptor 0.0026 0.009 0.0072
Echinococcus multilocularis neuroendocrine convertase 2 0.037 0.4489 0.4479
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0026 0.009 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0275 0.0906
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0358 0.4334 0.4323
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.009 0.0072
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0025 0.0078 0.02
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0358 0.4334 0.4738
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0026 0.009 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0078 0.0139
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.1347 0.1459
Echinococcus multilocularis g-protein coupled receptor 0.0026 0.009 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0275 0.0906
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0059 0.0057
Trypanosoma brucei mitotic cyclin 6 0.0051 0.0406 0.1377
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Loa Loa (eye worm) hypothetical protein 0.0024 0.0059 0.0081
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.009 0.0079
Echinococcus granulosus neuropeptide s receptor 0.0026 0.009 0.0079
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.009 0.0079
Brugia malayi Dopamine receptor 0.0026 0.009 0.0098
Onchocerca volvulus 0.0035 0.0208 0.0584
Onchocerca volvulus 0.0026 0.009 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0275 0.0906
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0163 0.0335
Loa Loa (eye worm) hypothetical protein 0.0065 0.0587 0.0806
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0139 0.1535 0.3515
Giardia lamblia Furin precursor putative serine protease 0.0114 0.1213 0.4702
Onchocerca volvulus 0.0026 0.009 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0149 0.0454
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.0285
Trypanosoma cruzi cyclin 6, putative 0.0051 0.0406 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0358 0.4334 1
Echinococcus multilocularis 0.0475 0.5831 0.5823
Trichomonas vaginalis cyclins, putative 0.0051 0.0406 0.09
Brugia malayi hypothetical protein 0.0026 0.009 0.0098
Brugia malayi hypothetical protein 0.0035 0.0208 0.0261
Echinococcus granulosus histone lysine n methyltransferase setd8 0.0065 0.0587 0.0625
Loa Loa (eye worm) hypothetical protein 0.0024 0.0059 0.0081
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.009 0.0072
Trichomonas vaginalis cyclins, putative 0.0027 0.0098 0.0185
Echinococcus multilocularis Furin 1 0.0139 0.1535 0.152
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0025 0.0078 0.5
Giardia lamblia Hypothetical protein 0.0032 0.0163 0.0554
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0275 1
Onchocerca volvulus 0.0024 0.0059 0.0127
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.009 0.0072
Brugia malayi Cyclin, N-terminal domain containing protein 0.0051 0.0406 0.0534
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0139 0.1535 0.1665
Onchocerca volvulus 0.0035 0.0208 0.0584
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.009 0.0079
Schistosoma mansoni site-1 peptidase (S08 family) 0.0025 0.0078 0.0066
Plasmodium vivax SET domain protein, putative 0.0065 0.0587 1
Echinococcus granulosus cyclins 0.0032 0.0163 0.0159
Echinococcus granulosus hypothetical protein 0.0026 0.009 0.0079
Schistosoma mansoni alpha-1 adrenergic receptor 0.0026 0.009 0.0079
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0059 0.0057
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0732 0.9126 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0059 0.0127
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0025
Trichomonas vaginalis hypothetical protein 0.0114 0.1213 0.2769
Brugia malayi G protein-coupled receptor 0.0026 0.009 0.0098
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0059 0.0045
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0025 0.0078 0.0083
Schistosoma mansoni hypothetical protein 0.0274 0.3266 0.3566
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0275 0.5997
Onchocerca volvulus 0.0026 0.009 0.022
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.009 0.0072
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.009 0.0079
Brugia malayi hypothetical protein 0.0035 0.0208 0.0261
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.009 0.0079
Echinococcus multilocularis g protein coupled receptor 0.0026 0.009 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0059 0.0057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.009 0.0072
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0026 0.009 0.0079
Loa Loa (eye worm) hypothetical protein 0.0036 0.0211 0.029
Toxoplasma gondii subtilisin SUB9 0.0025 0.0078 0.1056
Echinococcus granulosus cyclins 0.0032 0.0163 0.0159
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123
Onchocerca volvulus 0.0026 0.009 0.022
Echinococcus multilocularis neuropeptide receptor A26 0.0026 0.009 0.0072
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0059 0.0041
Loa Loa (eye worm) endoprotease bli-4 0.0588 0.7288 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.009 0.0072
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0025 0.0078 0.0139
Schistosoma mansoni hypothetical protein 0.0239 0.281 0.3066
Loa Loa (eye worm) hypothetical protein 0.0026 0.009 0.0123

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 962 nM Cytotoxicity against human MIA PaCa2 cells after 72 hrs by MTT assay ChEMBL. 17944451
IC50 (functional) = 962 nM Cytotoxicity against human MIA PaCa2 cells after 72 hrs by MTT assay ChEMBL. 17944451
IC50 (functional) = 1385 nM Cytotoxicity against human MIA PaCa2 cells after 4 hrs by MTT assay ChEMBL. 17944451
IC50 (functional) = 1385 nM Cytotoxicity against human MIA PaCa2 cells after 4 hrs by MTT assay ChEMBL. 17944451
IC50 (functional) = 0.7 uM In vitro cytotoxicity against hypoxic V79-379A cells determined by MTT assay in the presence of nitrogen ChEMBL. 9667963
IC50 (functional) = 12 uM In vitro cytotoxicity against hypoxic V79-379A cells determined by MTT assay in the presence of air ChEMBL. 9667963
Inhibition (binding) Inhibition of human recombinant NQO1 expressed in MIA PaCa2 cells after 1 hrs ChEMBL. 17944451
Inhibition (binding) 0 Inhibition of human recombinant NQO1 expressed in MIA PaCa2 cells after 1 hrs ChEMBL. 17944451
Metabolism (functional) = 0.28 uM min-1mg-1 NADH oxidation is used as a measure of the compound metabolism since 1 mol of NADH is oxidized for each mole of compound that is reduced ChEMBL. 11563930
Metabolism (functional) = 0.28 uM min-1mg-1 NADH oxidation is used as a measure of the compound metabolism since 1 mol of NADH is oxidized for each mole of compound that is reduced ChEMBL. 11563930

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 17944451

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.