TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 387.393 | Formula: C17H21N7O4
H donors: 4 H acceptors: 6 LogP: -1.18 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CNc1nc2c(n1[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COCc1cccnc1)ncnc2N
InChi: 1S/C17H21N7O4/c1-19-17-23-11-14(18)21-8-22-15(11)24(17)16-13(26)12(25)10(28-16)7-27-6-9-3-2-4-20-5-9/h2-5,8,10,12-13,16,25-26H,6-7H2,1H3,(H,19,23)(H2,18,21,22)/t10-,12-,13-,16-/m1/s1
InChiKey: YFNVDWQSHZOXMH-XNIJJKJLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 71 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium yoelii	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock 70 kDa protein 1A:1B	Get druggable targets OG5_126588	All targets in OG5_126588
Onchocerca volvulus		Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock 70 kda protein 1a	Get druggable targets OG5_126588	All targets in OG5_126588
Toxoplasma gondii	heat shock protein HSP70	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania donovani	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat Shock protein family member (hsp 3)	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70 related	Get druggable targets OG5_126588	All targets in OG5_126588
Loa Loa (eye worm)	heat shock 70kDa protein 5	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium falciparum	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium berghei	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium yoelii	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	similar to Heat shock 70 kDa protein cognate 4, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Brugia malayi	heat shock 70 kDa protein C precursor	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	Cytoplasmic chaperone	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat Shock protein family member hsp 3	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein kDa heat shock kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 71 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania donovani	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	ko:K09490 heat shock 70kDa protein 5, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania mexicana	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Cryptosporidium hominis	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein kDa	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	similar to Heat shock 70 kDa protein homolog, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania braziliensis	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	microsomal stress 70 protein ATPase core precursor, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium berghei	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei gambiense	glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium falciparum	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock 70 kDa protein 1	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock kda protein	Get druggable targets OG5_126588	All targets in OG5_126588
Cryptosporidium parvum	heat shock 70 (HSP70) protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Babesia bovis	heat shock protein 70 precursor, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Toxoplasma gondii	chaperonin protein BiP	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium knowlesi	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70 related	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	3'partial\|5'partial\|heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	Cytoplasmic chaperone	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Babesia bovis	dnaK protein	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania braziliensis	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania braziliensis	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania major	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei gambiense	glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Neospora caninum	Heat shock protein 70, related	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	heat shock protein 70 (hsp70), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania major	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma mansoni	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania donovani	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma cruzi	heat shock protein 70 (hsp70), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania mexicana	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania mexicana	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania mexicana	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein kDa heat shock kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70 family	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium knowlesi	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Giardia lamblia	Bip	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma cruzi	heat shock protein 70 (hsp70), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Giardia lamblia	Cytosolic HSP70	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis		Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70 related	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei gambiense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma brucei	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Brugia malayi	heat shock 70 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania major	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70kD, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock protein 70 (HSP70)	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Cryptosporidium parvum	heat shock protein, Hsp70	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70kD, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 71 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70 related	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis		Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania donovani	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat shock protein 70-related protein	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium falciparum	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania major	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70b	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	HSP70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Leishmania infantum	heat-shock protein hsp70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma mansoni	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70b	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	luminal binding protein 1 (BiP), putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium vivax	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Theileria parva	heat shock protein 70, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis		Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	70 kDa heat shock protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Cryptosporidium hominis	heat shock protein 70 precursor	Get druggable targets OG5_126588	All targets in OG5_126588
Plasmodium vivax	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Neospora caninum	Heat shock protein 70 (Precursor), related	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma congolense	heat shock 70 kDa protein, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	HSP70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	Heat shock 70 kDa protein 4	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Schistosoma mansoni	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock kda protein	Get druggable targets OG5_126588	All targets in OG5_126588
Candida albicans	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus granulosus	heat shock protein 71 kDa protein	Get druggable targets OG5_126588	All targets in OG5_126588
Trypanosoma cruzi	glucose-regulated protein 78, putative	Get druggable targets OG5_126588	All targets in OG5_126588
Echinococcus multilocularis	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588
Entamoeba histolytica	heat shock protein 70 family	Get druggable targets OG5_126588	All targets in OG5_126588
Theileria parva	heat shock protein 70	Get druggable targets OG5_126588	All targets in OG5_126588

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	heat shock protein 70	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	654 aa	613 aa	51.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	ecdysone receptor	0.001	0.4254	0.4254
Leishmania major	heat-shock protein hsp70, putative	0.0002	0	0.5
Leishmania major	glucose-regulated protein 78, putative	0.0002	0	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	1	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.4254	0.4254
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0022	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	1	1
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	0.0002	0	0.5
Entamoeba histolytica	hypothetical protein	0.0002	0	0.5
Trichomonas vaginalis	heat shock protein, putative	0.0002	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0022	1	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.001	0.4254	0.4254
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0012	0.4869	0.4869
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0012	0.4869	0.4869
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	1	1
Loa Loa (eye worm)	DR-78	0.001	0.4254	0.4254
Brugia malayi	nuclear receptor NHR-88	0.001	0.4254	0.4254
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	1	1
Echinococcus granulosus	FTZ F1 alpha	0.0022	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	1	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.4869	0.4869
Loa Loa (eye worm)	hypothetical protein	0.0022	1	1
Brugia malayi	orphan nuclear receptor NR2E1	0.001	0.4254	0.4254
Schistosoma mansoni	nuclear receptor	0.001	0.4254	0.4254
Onchocerca volvulus		0.0022	1	1
Loa Loa (eye worm)	nuclear hormone receptor	0.001	0.4254	0.4254
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0012	0.4869	0.4869
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.001	0.4254	0.4254
Trypanosoma brucei	luminal binding protein 1 (BiP), putative	0.0002	0	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	1	1
Trichomonas vaginalis	heat shock protein, putative	0.0002	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0022	1	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.001	0.4254	0.4254
Echinococcus granulosus	Nuclear hormone receptor HR96	0.001	0.4254	0.4254
Plasmodium falciparum	heat shock protein 70	0.0002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.4869	0.4869
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.001	0.4254	0.4254
Leishmania major	heat shock protein 70-related protein	0.0002	0	0.5
Schistosoma mansoni	zinc finger protein	0.001	0.4254	0.4254
Loa Loa (eye worm)	hypothetical protein	0.001	0.4254	0.4254
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	0.0002	0	0.5
Brugia malayi	nuclear receptor NHR-67	0.001	0.4254	0.4254
Trichomonas vaginalis	heat shock protein, putative	0.0002	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0022	1	1
Entamoeba histolytica	70 kDa heat shock protein, putative	0.0002	0	0.5
Plasmodium vivax	heat shock 70 kDa protein, putative	0.0002	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	1	1
Plasmodium vivax	heat shock protein 70, putative	0.0002	0	0.5
Brugia malayi	photoreceptor-specific nuclear receptor	0.0022	1	1
Brugia malayi	hypothetical protein	0.001	0.4254	0.4254
Entamoeba histolytica	heat shock protein 70 family	0.0002	0	0.5
Echinococcus multilocularis	nuclear receptor nhr 48	0.001	0.4254	0.4254
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	1	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	1	1
Trichomonas vaginalis	microsomal stress 70 protein ATPase core precursor, putative	0.0002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.4869	0.4869
Loa Loa (eye worm)	nuclear receptor NHR-67	0.001	0.4254	0.4254
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	1	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	1	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	1	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	1	1
Brugia malayi	nuclear hormone receptor	0.0022	1	1
Trichomonas vaginalis	heat shock protein, putative	0.0002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	1	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.4254	0.4254
Trypanosoma brucei	heat shock 70 kDa protein, putative	0.0002	0	0.5
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.001	0.4254	0.4254
Schistosoma mansoni	retinoic acid receptor RXR	0.0022	1	1
Brugia malayi	hypothetical protein	0.001	0.4254	0.4254
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0012	0.4869	0.4869
Trichomonas vaginalis	heat shock protein 70kD, putative	0.0002	0	0.5
Schistosoma mansoni	coup transcription factor	0.0022	1	1
Brugia malayi	conserved hypotetical protein	0.001	0.4254	0.4254
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	1	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0022	1	1
Brugia malayi	nuclear receptor RXR	0.0012	0.4869	0.4869
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	1	1
Entamoeba histolytica	heat shock protein 70, putative	0.0002	0	0.5
Trypanosoma brucei	heat shock protein 70 (hsp70), putative	0.0002	0	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0022	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	1	1
Leishmania major	heat-shock protein hsp70, putative	0.0002	0	0.5
Brugia malayi	Steroid receptor seven-up type 2	0.0022	1	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	1	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.001	0.4254	0.4254
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.001	0.4254	0.4254
Loa Loa (eye worm)	hypothetical protein	0.001	0.4254	0.4254
Trichomonas vaginalis	heat shock protein, putative	0.0002	0	0.5
Plasmodium falciparum	heat shock protein 70	0.0002	0	0.5
Brugia malayi	nuclear receptor RXR	0.001	0.4254	0.4254
Schistosoma mansoni	nuclear hormone receptor	0.001	0.4254	0.4254
Brugia malayi	nuclear hormone receptor family member nhr-6	0.001	0.4254	0.4254
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0022	1	1
Brugia malayi	hypothetical protein	0.0012	0.4869	0.4869
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0022	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.4869	0.4869
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.001	0.4254	0.4254
Loa Loa (eye worm)	hypothetical protein	0.0022	1	1
Entamoeba histolytica	heat shock protein 70, putative	0.0002	0	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.4254	0.4254
Entamoeba histolytica	heat shock protein 70 family	0.0002	0	0.5
Brugia malayi	Nuclear hormone receptor E75	0.001	0.4254	0.4254
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	1	1
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	0.0002	0	0.5
Brugia malayi	nuclear hormone receptor	0.001	0.4254	0.4254
Echinococcus granulosus	thyroid hormone receptor alpha	0.001	0.4254	0.4254
Brugia malayi	nuclear hormone receptor family member odr-7	0.001	0.4254	0.4254
Loa Loa (eye worm)	hypothetical protein	0.0022	1	1
Entamoeba histolytica	heat shock protein 70, putative	0.0002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.001	0.4254	0.4254
Echinococcus granulosus	nuclear receptor nhr 48	0.001	0.4254	0.4254
Onchocerca volvulus		0.001	0.4254	0.4254
Schistosoma mansoni	nuclear hormone receptor	0.0022	1	1
Schistosoma mansoni	nuclear receptor	0.001	0.4254	0.4254
Onchocerca volvulus	Protein ultraspiracle homolog	0.0022	1	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	1	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0022	1	1
Brugia malayi	Nuclear hormone receptor E75	0.001	0.4254	0.4254
Plasmodium falciparum	heat shock protein 70	0.0002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	1	1
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	0.0002	0	0.5
Brugia malayi	tailless protein	0.001	0.4254	0.4254
Loa Loa (eye worm)	hypothetical protein	0.001	0.4254	0.4254
Schistosoma mansoni	thyroid hormone receptor	0.0022	1	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.4254	0.4254
Loa Loa (eye worm)	hypothetical protein	0.001	0.4254	0.4254
Loa Loa (eye worm)	hypothetical protein	0.001	0.4254	0.4254
Trichomonas vaginalis	heat shock protein 70kD, putative	0.0002	0	0.5
Trichomonas vaginalis	heat shock protein, putative	0.0002	0	0.5
Trypanosoma brucei	luminal binding protein 1 (BiP), putative	0.0002	0	0.5
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	1	1
Trypanosoma cruzi	heat shock protein 70 (hsp70), putative	0.0002	0	0.5
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	1	1
Toxoplasma gondii	chaperonin protein BiP	0.0002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.001	0.4254	0.4254
Brugia malayi	hypothetical protein	0.0012	0.4869	0.4869
Giardia lamblia	Bip	0.0002	0	0.5
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	1	1
Trypanosoma brucei	heat shock protein 70	0.0002	0	0.5
Onchocerca volvulus	Bile acid receptor homolog	0.0022	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	1	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	1	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.4254	0.4254
Loa Loa (eye worm)	hypothetical protein	0.0012	0.4869	0.4869
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.4254	0.4254
Loa Loa (eye worm)	hypothetical protein	0.0022	1	1
Giardia lamblia	Cytosolic HSP70	0.0002	0	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	1	1
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	0.0002	0	0.5
Trichomonas vaginalis	heat shock protein, putative	0.0002	0	0.5
Trichomonas vaginalis	heat shock protein, putative	0.0002	0	0.5
Entamoeba histolytica	heat shock protein70, hsp70A2, putative	0.0002	0	0.5
Onchocerca volvulus		0.001	0.4254	0.4254
Loa Loa (eye worm)	hypothetical protein	0.001	0.4254	0.4254
Brugia malayi	nuclear receptor NHR-88	0.0022	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	1	1
Schistosoma mansoni	nuclear receptor nhr-48	0.001	0.4254	0.4254
Trichomonas vaginalis	heat shock protein 70 (HSP70)-4, putative	0.0002	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0022	1	1
Trypanosoma cruzi	heat shock protein 70 (hsp70), putative	0.0002	0	0.5
Entamoeba histolytica	heat shock protein 70, putative	0.0002	0	0.5
Trichomonas vaginalis	heat shock protein, putative	0.0002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.001	0.4254	0.4254
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	1	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	1	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0022	1	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	1	1
Echinococcus multilocularis	FTZ F1 alpha	0.0022	1	1
Loa Loa (eye worm)	steroid hormone receptor	0.0022	1	1
Trypanosoma cruzi	glucose-regulated protein 78, putative	0.0002	0	0.5
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.001	0.4254	0.4254
Loa Loa (eye worm)	hypothetical protein	0.0012	0.4869	0.4869
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.4869	0.4869
Brugia malayi	steroid hormone receptor	0.0022	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.4869	0.4869
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.001	0.4254	0.4254
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	1	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.001	0.4254	0.4254
Echinococcus granulosus	Nuclear hormone receptor HR96	0.001	0.4254	0.4254
Toxoplasma gondii	heat shock protein HSP70	0.0002	0	0.5
Schistosoma mansoni	nuclear hormone receptor	0.001	0.4254	0.4254
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (binding)	= 2.71 uM	Binding affinity to histidine-tagged Grp78 by surface plasmon resonance analysis	ChEMBL.	21526763

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1784884

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1520631