Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.5 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0195 | 0.5 | 0.5 | |
Loa Loa (eye worm) | thymidylate synthase | 0.0195 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0195 | 0.5 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.5 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0195 | 0.5 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0195 | 0.5 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0195 | 0.5 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.5 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0195 | 0.5 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.5 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.5 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0195 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 1.4 uM | Compound was evaluated for the inhibition of human Thymidylate Synthase | ChEMBL. | 1895294 |
I50 (functional) | > 50 uM | Compound was evaluated for inhibition of tumor cell growth in SW/480 cell line | ChEMBL. | 1895294 |
I50 (functional) | > 600 uM | Compound was evaluated for inhibition of tumor cell growth in Manca human lymphoma cell line | ChEMBL. | 1895294 |
IC50 (binding) | = 1.4 uM | Compound was evaluated for the inhibition of human Thymidylate Synthase | ChEMBL. | 1895294 |
IC50 (functional) | > 50 uM | Compound was evaluated for inhibition of tumor cell growth in SW/480 cell line | ChEMBL. | 1895294 |
IC50 (functional) | > 600 uM | Compound was evaluated for inhibition of tumor cell growth in Manca human lymphoma cell line | ChEMBL. | 1895294 |
Km (binding) | > 200 uM | Apparent kinetic constant of substrate activity for Hog liver Folyl-polyglutamate synthase | ChEMBL. | 1895294 |
Km (binding) | > 200 uM | Apparent kinetic constant of substrate activity for Hog liver Folyl-polyglutamate synthase | ChEMBL. | 1895294 |
Vmax (binding) | = 1.8 % | Relative maximum velocity of substrate activity for Hog liver Folyl-polyglutamate synthase (relative to control of 50 microM aminopterin) | ChEMBL. | 1895294 |
Vmax (binding) | = 1.8 % | Relative maximum velocity of substrate activity for Hog liver Folyl-polyglutamate synthase (relative to control of 50 microM aminopterin) | ChEMBL. | 1895294 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.