Detailed information for compound 1521715

Basic information

Technical information
  • TDR Targets ID: 1521715
  • Name: 3-[(E)-2-(4-methoxyphenyl)ethenyl]-5-(trifluo romethyl)-1,2-oxazole
  • MW: 269.219 | Formula: C13H10F3NO2
  • H donors: 0 H acceptors: 1 LogP: 3.57 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)/C=C/c1noc(c1)C(F)(F)F
  • InChi: 1S/C13H10F3NO2/c1-18-11-6-3-9(4-7-11)2-5-10-8-12(19-17-10)13(14,15)16/h2-8H,1H3/b5-2+
  • InChiKey: OKAOCLGRSWDJRC-GORDUTHDSA-N  


Substructure search Similarity search

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Synonyms

  • 3-[2-(4-methoxyphenyl)ethenyl]-5-(trifluoromethyl)-1,2-oxazole
  • 3-[(E)-2-(4-methoxyphenyl)vinyl]-5-(trifluoromethyl)isoxazole
  • 3-[2-(4-methoxyphenyl)vinyl]-5-(trifluoromethyl)isoxazole
  • MLS001029895
  • SMR000426848
  • 3-[(E)-2-(4-Methoxy-phenyl)-vinyl]-5-trifluoromethyl-isoxazole
  • ST034300
  • ZINC04008561

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0147 0.0507
Toxoplasma gondii hypothetical protein 0.0017 0.009 0.6106
Mycobacterium tuberculosis Possible lysophospholipase 0.0291 0.2909 1
Leishmania major hypothetical protein, conserved 0.0017 0.009 0.0309
Plasmodium vivax lysophospholipase, putative 0.0017 0.009 0.0309
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0208 0.0213
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0017 0.009 0.009
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0208 0.0716
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0115 0.1103 0.3791
Leishmania major monoglyceride lipase, putative 0.0291 0.2909 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.009 0.0309
Schistosoma mansoni amidase 0.0957 0.9772 1
Plasmodium vivax lysophospholipase, putative 0.0017 0.009 0.0309
Echinococcus multilocularis abhydrolase domain containing 3 0.0017 0.009 0.009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0122 0.0419
Trypanosoma cruzi serine peptidase, putative 0.0017 0.009 0.0309
Loa Loa (eye worm) hypothetical protein 0.0021 0.0134 0.0137
Plasmodium falciparum epoxide hydrolase 2 0.0017 0.009 0.0309
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0208 0.0716
Mycobacterium ulcerans amidase 0.0115 0.1103 0.3791
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0208 0.0716
Brugia malayi putative amidase 0.0115 0.1103 0.1128
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0017 0.009 0.0309
Plasmodium falciparum alpha/beta hydrolase, putative 0.0017 0.009 0.0309
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0291 0.2909 1
Echinococcus granulosus abhydrolase domain containing 3 0.0017 0.009 0.0092
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0208 0.0716
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0291 0.2909 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.009 0.0309
Plasmodium vivax PST-A protein 0.0017 0.009 0.0309
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0017 0.009 0.0309
Brugia malayi Amidase family protein 0.0115 0.1103 0.1128
Toxoplasma gondii phospholipase 0.0017 0.009 0.6106
Mycobacterium ulcerans hydrolase 0.0017 0.009 0.0309
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0017 0.009 0.0309
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0115 0.1103 1
Entamoeba histolytica ;Alias 0.0017 0.009 0.0309
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0122 0.0419
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.009 0.0309
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0115 0.1103 0.1103
Mycobacterium ulcerans hypothetical protein 0.0291 0.2909 1
Plasmodium falciparum lysophospholipase, putative 0.0291 0.2909 1
Toxoplasma gondii hypothetical protein 0.0017 0.009 0.6106
Plasmodium falciparum lysophospholipase, putative 0.0017 0.009 0.0309
Entamoeba histolytica hypothetical protein 0.0017 0.009 0.0309
Mycobacterium ulcerans amidase 0.0115 0.1103 0.3791
Trypanosoma cruzi serine peptidase, putative 0.0017 0.009 0.0309
Plasmodium vivax PST-A protein 0.0017 0.009 0.0309
Trypanosoma cruzi amidase, putative 0.0115 0.1103 0.3791
Leishmania major hypothetical protein, conserved 0.0017 0.009 0.0309
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0208 0.0716
Plasmodium falciparum esterase, putative 0.0017 0.009 0.0309
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0115 0.1103 0.3791
Loa Loa (eye worm) hypothetical protein 0.0021 0.0134 0.0137
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0291 0.2909 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0208 0.0716
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0147 0.0507
Schistosoma mansoni ap endonuclease 0.0023 0.0147 0.0151
Schistosoma mansoni ap endonuclease 0.0023 0.0147 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0291 0.2909 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0092
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0017 0.009 0.0309
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0208 0.0716
Plasmodium falciparum exported lipase 2 0.0017 0.009 0.0309
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0017 0.009 0.6106
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.009 0.0309
Plasmodium vivax PST-A protein 0.0291 0.2909 1
Plasmodium vivax lysophospholipase, putative 0.0017 0.009 0.0309
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0147 0.0507
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0208 0.0716
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0115 0.1103 0.3791
Trypanosoma cruzi monoglyceride lipase, putative 0.0291 0.2909 1
Schistosoma mansoni fatty-acid amide hydrolase 0.0115 0.1103 0.1128
Schistosoma mansoni peptidase 0.0017 0.009 0.0092
Echinococcus granulosus fatty acid amide hydrolase 1 0.0115 0.1103 0.1128
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0208 0.0716
Plasmodium vivax hypothetical protein, conserved 0.0017 0.009 0.0309
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0291 0.2909 1
Mycobacterium ulcerans amidase 0.0115 0.1103 0.3791
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.009 0.0309
Mycobacterium ulcerans amidase 0.0115 0.1103 0.3791
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0092
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0017 0.009 0.0309
Plasmodium vivax hypothetical protein, conserved 0.0017 0.009 0.0309
Toxoplasma gondii protein c14orf29, putative 0.0017 0.009 0.6106
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0115 0.1103 0.1103
Plasmodium vivax PST-A protein 0.0017 0.009 0.0309
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0147 1
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0115 0.1103 0.3791
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0208 0.0716
Brugia malayi Protein C20orf22 0.0017 0.009 0.0092
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0017 0.009 0.0092
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0122 0.0419
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0134 0.046
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0147 0.0507
Echinococcus granulosus abhydrolase domain containing protein 13 0.0017 0.009 0.0092
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0017 0.009 0.0309
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0017 0.009 0.0309
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0115 0.1103 0.3791
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0147 0.0147
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0134 0.046
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.009 0.0309
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0134 0.046
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0147 0.0507
Echinococcus granulosus Phospholipase carboxylesterase 0.0017 0.009 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.009 0.0309
Plasmodium vivax hypothetical protein, conserved 0.0017 0.009 0.0309
Plasmodium falciparum alpha/beta hydrolase, putative 0.0017 0.009 0.0309
Echinococcus multilocularis Phospholipase carboxylesterase 0.0017 0.009 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.009 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0291 0.2909 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0147 0.0507
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0134 0.046
Plasmodium falciparum lysophospholipase, putative 0.0291 0.2909 1
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0115 0.1103 1
Mycobacterium ulcerans lysophospholipase 0.0291 0.2909 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0208 0.0716
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0017 0.009 0.0309
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0291 0.2909 1
Toxoplasma gondii peptidase S15, putative 0.0017 0.009 0.6106
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0208 0.0213
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0017 0.009 0.0309
Plasmodium vivax PST-A protein 0.0017 0.009 0.0309
Plasmodium falciparum prodrug activation and resistance esterase 0.0017 0.009 0.0309
Echinococcus granulosus fatty acid amide hydrolase 1 0.0957 0.9772 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0092
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0017 0.009 0.0309
Plasmodium vivax PST-A protein 0.0017 0.009 0.0309
Mycobacterium ulcerans peptide amidase, GatA 0.0115 0.1103 0.3791
Plasmodium vivax alpha/beta hydrolase, putative 0.0017 0.009 0.0309
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0115 0.1103 0.3791
Mycobacterium ulcerans amidase 0.0115 0.1103 0.3791
Brugia malayi Amidase family protein 0.0115 0.1103 0.1128
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0147 0.0151
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0017 0.009 0.0309
Toxoplasma gondii hypothetical protein 0.0017 0.009 0.6106
Schistosoma mansoni fatty-acid amide hydrolase 0.0957 0.9772 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0147 0.0151
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0115 0.1103 0.1128
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0092
Loa Loa (eye worm) hypothetical protein 0.0957 0.9772 1
Echinococcus granulosus fatty acid amide hydrolase 1 0.0957 0.9772 1
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0115 0.1103 0.1128
Toxoplasma gondii phospholipase/carboxylesterase 0.0017 0.009 0.6106
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0147 0.0507
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0208 0.0213
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0208 0.0716
Plasmodium falciparum alpha/beta hydrolase, putative 0.0017 0.009 0.0309
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0017 0.009 0.0092
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0017 0.009 0.0309
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0291 0.2909 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0134 0.0433
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0147 0.0507
Plasmodium falciparum esterase, putative 0.0017 0.009 0.0309
Plasmodium falciparum lysophospholipase, putative 0.0017 0.009 0.0309
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0147 0.0507
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0017 0.009 0.0309
Plasmodium falciparum alpha/beta hydrolase, putative 0.0017 0.009 0.0309
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0017 0.009 0.0309
Entamoeba histolytica hypothetical protein 0.0017 0.009 0.0309
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0213
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0115 0.1103 0.3791
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0115 0.1103 0.3791
Onchocerca volvulus 0.0029 0.0208 1
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0017 0.009 0.0309
Mycobacterium ulcerans hypothetical protein 0.0017 0.009 0.0309
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0017 0.009 0.0309
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0213
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0957 0.9772 0.9772
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0147 0.0507
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0208 0.0716
Loa Loa (eye worm) hypothetical protein 0.0021 0.0134 0.0137
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0291 0.2909 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0208 0.0716
Loa Loa (eye worm) amidase 0.0115 0.1103 0.1128
Plasmodium falciparum esterase, putative 0.0291 0.2909 1
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0017 0.009 0.0309
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0208 0.0716
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.009 0.0309
Plasmodium falciparum alpha/beta hydrolase, putative 0.0017 0.009 0.0309
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0092
Toxoplasma gondii exonuclease III APE 0.0023 0.0147 1
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0017 0.009 0.0309
Plasmodium vivax unspecified product 0.0017 0.009 0.0309
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0115 0.1103 0.3791
Brugia malayi amidase 0.0957 0.9772 1
Loa Loa (eye worm) amidase 0.0115 0.1103 0.1128
Trypanosoma cruzi amidase, putative 0.0115 0.1103 0.3791
Brugia malayi MGC83647 protein 0.0017 0.009 0.0092
Toxoplasma gondii hypothetical protein 0.0017 0.009 0.6106
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0017 0.009 0.0309
Leishmania major hypothetical protein, conserved 0.0115 0.1103 0.3791
Mycobacterium ulcerans hypothetical protein 0.0029 0.0208 0.0716
Plasmodium falciparum BEM46-like protein, putative 0.0017 0.009 0.0309
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0115 0.1103 0.3791
Loa Loa (eye worm) hypothetical protein 0.0021 0.0134 0.0137
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0213
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0208 0.0716
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0957 0.9772 0.9772
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0147 0.0507
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0017 0.009 0.0092
Plasmodium falciparum exported lipase 1 0.0017 0.009 0.0309
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0291 0.2909 1
Plasmodium vivax alpha/beta hydrolase, putative 0.0017 0.009 0.0309
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0017 0.009 0.6106
Trypanosoma brucei monoglyceride lipase, putative 0.0291 0.2909 1
Plasmodium falciparum lysophospholipase, putative 0.0291 0.2909 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0291 0.2909 1
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0147 0.0151
Mycobacterium ulcerans hypothetical protein 0.0017 0.009 0.0309
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0017 0.009 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.009 0.0309
Brugia malayi MGC79044 protein 0.0017 0.009 0.0092
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0122 0.0419
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0017 0.009 0.0309
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0017 0.009 0.6106
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0208 0.0716
Trypanosoma brucei monoglyceride lipase, putative 0.0291 0.2909 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0134 0.0137
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0115 0.1103 1
Plasmodium vivax unspecified product 0.0017 0.009 0.0309
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0115 0.1103 0.3791

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) > 35 uM PUBCHEM_BIOASSAY: MITF: Counter assay: A375 proliferation Measured in Cell-Based System Using Plate Reader - 2084-03_Inhibitor_Dose_DryPowder_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
AC50 (functional) > 35 uM PUBCHEM_BIOASSAY: MITF: Counter assay: A375 proliferation Measured in Cell-Based System Using Plate Reader - 2084-03_Inhibitor_Dose_CherryPick_Activity_Set2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
Potency (functional) 0.5623 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.012 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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