Detailed information for compound 1521768

Basic information

Technical information
  • TDR Targets ID: 1521768
  • Name: 2-(4-methoxyphenyl)-N-(5-propan-2-yl-1,3,4-th iadiazol-2-yl)acetamide
  • MW: 291.369 | Formula: C14H17N3O2S
  • H donors: 1 H acceptors: 3 LogP: 2.6 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CC(=O)Nc1nnc(s1)C(C)C
  • InChi: 1S/C14H17N3O2S/c1-9(2)13-16-17-14(20-13)15-12(18)8-10-4-6-11(19-3)7-5-10/h4-7,9H,8H2,1-3H3,(H,15,17,18)
  • InChiKey: QYAJDSZPZOJCQH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(5-isopropyl-1,3,4-thiadiazol-2-yl)-2-(4-methoxyphenyl)acetamide
  • 2-(4-methoxyphenyl)-N-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)ethanamide
  • ST066119
  • MLS000706316
  • SMR000288368
  • Oprea1_360029
  • ZINC02821277
  • BAS 05276796
  • N-(5-Isopropyl-[1,3,4]thiadiazol-2-yl)-2-(4-methoxy-phenyl)-acetamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0067 0.6146 1
Echinococcus granulosus neuropeptide s receptor 0.0067 0.6146 1
Schistosoma mansoni biogenic amine receptor 0.0067 0.6146 1
Schistosoma mansoni biogenic amine receptor 0.0067 0.6146 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.6146 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.6146 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0067 0.6146 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0067 0.6146 1
Loa Loa (eye worm) G-protein coupled receptor 0.0067 0.6146 0.6146
Loa Loa (eye worm) cytochrome P450 family protein 0.0074 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0067 0.6146 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.6146 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0067 0.6146 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0067 0.6146 1
Onchocerca volvulus 0.0067 0.6146 0.5
Trypanosoma cruzi cytochrome P450, putative 0.0074 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Brugia malayi neuropeptide F receptor 0.0067 0.6146 0.6146
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Onchocerca volvulus 0.0067 0.6146 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0067 0.6146 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0067 0.6146 0.6146
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.6146 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0067 0.6146 1
Brugia malayi G-protein coupled receptor 0.0067 0.6146 0.6146
Brugia malayi Dopamine receptor protein 2 0.0067 0.6146 0.6146
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Onchocerca volvulus 0.0067 0.6146 0.5
Onchocerca volvulus 0.0067 0.6146 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Echinococcus multilocularis neuropeptides capa receptor 0.0067 0.6146 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0067 0.6146 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Schistosoma mansoni biogenic amine (5HT) receptor 0.0067 0.6146 1
Brugia malayi hypothetical protein 0.0067 0.6146 0.6146
Brugia malayi Dopamine receptor 0.0067 0.6146 0.6146
Brugia malayi hypothetical protein 0.0067 0.6146 0.6146
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0067 0.6146 0.6146
Echinococcus granulosus 7tm_1 domain containing protein 0.0067 0.6146 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0067 0.6146 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.6146 1
Echinococcus granulosus g protein coupled receptor 0.0067 0.6146 1
Brugia malayi putative neuropeptide receptor 0.0067 0.6146 0.6146
Schistosoma mansoni opsin-like receptor 0.0067 0.6146 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0067 0.6146 0.6146
Echinococcus multilocularis neuropeptide Y receptor 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Brugia malayi sulfakinin receptor protein 0.0067 0.6146 0.6146
Echinococcus multilocularis neuropeptide FF receptor 2 0.0067 0.6146 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.6146 1
Echinococcus multilocularis g protein coupled receptor 0.0067 0.6146 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.6146 1
Loa Loa (eye worm) CYP4Cod1 0.0074 1 1
Brugia malayi hypothetical protein 0.0067 0.6146 0.6146
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Brugia malayi hypothetical protein 0.0067 0.6146 0.6146
Brugia malayi G protein-coupled receptor F59B2.13 0.0067 0.6146 0.6146
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Onchocerca volvulus 0.0067 0.6146 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0067 0.6146 0.6146
Echinococcus granulosus neuropeptide Y receptor 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Echinococcus granulosus peptide allatostatin:somatostatin 0.0067 0.6146 1
Onchocerca volvulus 0.0067 0.6146 0.5
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Echinococcus granulosus serotonin receptor 0.0067 0.6146 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.6146 1
Schistosoma mansoni neuropeptide receptor 0.0067 0.6146 1
Echinococcus granulosus g-protein coupled receptor 0.0067 0.6146 1
Schistosoma mansoni amine GPCR 0.0067 0.6146 1
Brugia malayi Dopamine receptor protein 1 0.0067 0.6146 0.6146
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0067 0.6146 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0067 0.6146 1
Echinococcus multilocularis neuropeptide Y receptor 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Brugia malayi GnHR receptor homolog 0.0067 0.6146 0.6146
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0067 0.6146 0.6146
Brugia malayi neuropeptide F receptor 0.0067 0.6146 0.6146
Loa Loa (eye worm) G-protein coupled receptor 0.0067 0.6146 0.6146
Echinococcus multilocularis dro:myosuppressin receptor 0.0067 0.6146 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0067 0.6146 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Trypanosoma cruzi cytochrome P450, putative 0.0074 1 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0067 0.6146 1
Echinococcus multilocularis neuropeptide receptor 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Echinococcus multilocularis fmrfamide receptor 0.0067 0.6146 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0067 0.6146 1
Onchocerca volvulus 0.0067 0.6146 0.5
Brugia malayi follicle stimulating hormone receptor 0.0067 0.6146 0.6146
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Echinococcus multilocularis neuropeptide s receptor 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0067 0.6146 0.6146
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Schistosoma mansoni hypothetical protein 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Schistosoma mansoni adenoreceptor 0.0067 0.6146 1
Brugia malayi AKH receptor 0.0067 0.6146 0.6146
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0067 0.6146 1
Echinococcus granulosus G protein coupled receptor 139 0.0067 0.6146 1
Onchocerca volvulus 0.0067 0.6146 0.5
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Schistosoma mansoni amine GPCR 0.0067 0.6146 1
Echinococcus granulosus allatostatin A receptor 0.0067 0.6146 1
Echinococcus granulosus neuropeptides capa receptor 0.0067 0.6146 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0067 0.6146 0.6146
Echinococcus multilocularis fmrfamide receptor 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0067 0.6146 0.6146
Brugia malayi hypothetical protein 0.0067 0.6146 0.6146
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Schistosoma mansoni hypothetical protein 0.0067 0.6146 1
Brugia malayi ORL1-like opioid receptor 0.0067 0.6146 0.6146
Schistosoma mansoni neuropeptide F-like receptor 0.0067 0.6146 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0067 0.6146 1
Brugia malayi G-protein coupled receptor 0.0067 0.6146 0.6146
Echinococcus granulosus dro:myosuppressin receptor 0.0067 0.6146 1
Echinococcus granulosus neuropeptide receptor 0.0067 0.6146 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.6146 1
Echinococcus multilocularis somatostatin receptor 0.0067 0.6146 1
Brugia malayi RE15519p 0.0067 0.6146 0.6146
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.6146 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0067 0.6146 0.6146
Schistosoma mansoni hypothetical protein 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0067 0.6146 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.6146 1
Onchocerca volvulus 0.0067 0.6146 0.5
Onchocerca volvulus 0.0067 0.6146 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0067 0.6146 1
Onchocerca volvulus 0.0067 0.6146 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0067 0.6146 0.6146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.6146 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0067 0.6146 0.6146
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.6146 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.6146 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0067 0.6146 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.6146 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.6146 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0067 0.6146 1
Brugia malayi hypothetical protein 0.0067 0.6146 0.6146
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0067 0.6146 1
Echinococcus granulosus neuropeptide Y receptor 0.0067 0.6146 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0067 0.6146 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0067 0.6146 0.6146
Echinococcus multilocularis neuropeptide receptor 0.0067 0.6146 1
Brugia malayi hypothetical protein 0.0067 0.6146 0.6146
Schistosoma mansoni opsin-like receptor 0.0067 0.6146 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.6146 1
Brugia malayi Serotonin receptor 0.0067 0.6146 0.6146
Onchocerca volvulus 0.0067 0.6146 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0067 0.6146 1
Leishmania major cytochrome p450-like protein 0.0074 1 0.5
Echinococcus granulosus somatostatin receptor 0.0067 0.6146 1
Schistosoma mansoni biogenic amine receptor 0.0067 0.6146 1
Echinococcus multilocularis serotonin receptor 0.0067 0.6146 1
Loa Loa (eye worm) neuropeptide F receptor 0.0067 0.6146 0.6146
Brugia malayi hypothetical protein 0.0067 0.6146 0.6146
Echinococcus multilocularis G protein coupled receptor 139 0.0067 0.6146 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Schistosoma mansoni amine GPCR 0.0067 0.6146 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0067 0.6146 0.5
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0067 0.6146 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0067 0.6146 1
Schistosoma mansoni opsin-like receptor 0.0067 0.6146 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.6146 1
Echinococcus granulosus orexin receptor type 2 0.0067 0.6146 1
Echinococcus multilocularis orexin receptor type 2 0.0067 0.6146 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0067 0.6146 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0067 0.6146 0.5
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Loa Loa (eye worm) TYRA-2 protein 0.0067 0.6146 0.6146
Echinococcus granulosus sex peptide receptor 0.0067 0.6146 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0067 0.6146 1
Echinococcus granulosus hypothetical protein 0.0067 0.6146 1
Onchocerca volvulus 0.0067 0.6146 0.5
Echinococcus granulosus alpha 1A adrenergic receptor 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.6146 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Schistosoma mansoni alpha-1 adrenergic receptor 0.0067 0.6146 1
Echinococcus multilocularis allatostatin A receptor 0.0067 0.6146 1
Schistosoma mansoni neuropeptide receptor 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Echinococcus granulosus g protein coupled receptor 0.0067 0.6146 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0074 1 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0067 0.6146 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0067 0.6146 1
Echinococcus granulosus g protein coupled receptor 0.0067 0.6146 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Loa Loa (eye worm) neuropeptide F receptor 0.0067 0.6146 0.6146
Brugia malayi hypothetical protein 0.0067 0.6146 0.6146
Echinococcus multilocularis g protein coupled receptor 0.0067 0.6146 1
Schistosoma mansoni neuropeptide F-like receptor 0.0067 0.6146 1
Echinococcus granulosus fmrfamide receptor 0.0067 0.6146 1
Schistosoma mansoni neuropeptide receptor 0.0067 0.6146 1
Echinococcus granulosus tm gpcr rhodopsin 0.0067 0.6146 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0067 0.6146 1
Schistosoma mansoni amine GPCR 0.0067 0.6146 1
Echinococcus granulosus tm gpcr rhodopsin 0.0067 0.6146 1
Schistosoma mansoni myosin xvIII 0.0067 0.6146 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0067 0.6146 1
Onchocerca volvulus 0.0067 0.6146 0.5
Schistosoma mansoni hypothetical protein 0.0067 0.6146 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.6146 1
Brugia malayi larval opioid receptor 0.0067 0.6146 0.6146
Echinococcus multilocularis g-protein coupled receptor 0.0067 0.6146 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0067 0.6146 0.6146
Echinococcus multilocularis neuropeptides capa receptor 0.0067 0.6146 1
Onchocerca volvulus 0.0067 0.6146 0.5
Onchocerca volvulus 0.0067 0.6146 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.6146 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0067 0.6146 1
Echinococcus granulosus neuropeptide receptor 0.0067 0.6146 1
Echinococcus multilocularis serotonin receptor 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Loa Loa (eye worm) cytochrome P450 family protein 0.0074 1 1
Brugia malayi hypothetical protein 0.0067 0.6146 0.6146
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0067 0.6146 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0067 0.6146 1
Schistosoma mansoni histamine h1 receptor 0.0067 0.6146 1
Schistosoma mansoni neuropeptide receptor 0.0067 0.6146 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0067 0.6146 1
Brugia malayi Melatonin receptor type 1A 0.0067 0.6146 0.6146
Echinococcus multilocularis sex peptide receptor 0.0067 0.6146 1
Brugia malayi Serotonin receptor 0.0067 0.6146 0.6146
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.6146 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0067 0.6146 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Loa Loa (eye worm) hypothetical protein 0.0067 0.6146 0.6146
Onchocerca volvulus 0.0067 0.6146 0.5
Brugia malayi Cytochrome P450 family protein 0.0074 1 1
Trypanosoma brucei cytochrome P450, putative 0.0074 1 0.5
Brugia malayi G protein-coupled receptor 0.0067 0.6146 0.6146
Echinococcus multilocularis g protein coupled receptor 0.0067 0.6146 1
Schistosoma mansoni amine GPCR 0.0067 0.6146 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 50 uM PUBCHEM_BIOASSAY: Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID782] ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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