Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | prostaglandin-endoperoxide synthase 2 | Starlite/ChEMBL | References |
Mus musculus | nitric oxide synthase 2, inducible | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.967 | 0.9572 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0032 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0032 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.967 | 0.9572 |
Schistosoma mansoni | peroxidasin | 0.0032 | 0.967 | 0.967 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.967 | 0.9572 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0032 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.967 | 0.9572 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0032 | 0.967 | 0.9572 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.967 | 0.9572 |
Onchocerca volvulus | 0.0032 | 0.967 | 0.5 | |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0032 | 1 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0032 | 0.967 | 0.5 |
Onchocerca volvulus | 0.0032 | 0.967 | 0.5 | |
Trypanosoma cruzi | p450 reductase, putative | 0.0032 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0032 | 0.967 | 0.9572 |
Onchocerca volvulus | Peroxidasin homolog | 0.0032 | 0.967 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0029 | 0.7709 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.967 | 0.9572 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.002 | 0.2291 | 0.2291 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.967 | 0.9572 |
Onchocerca volvulus | Peroxidasin homolog | 0.0032 | 0.967 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0032 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.967 | 0.9572 |
Brugia malayi | FAD binding domain containing protein | 0.0032 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0032 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.967 | 0.9572 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.967 | 0.9572 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0032 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.967 | 0.9572 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.967 | 0.9572 |
Onchocerca volvulus | Dual oxidase homolog | 0.0032 | 0.967 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.967 | 0.9572 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.967 | 0.9572 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0032 | 1 | 0.5 |
Brugia malayi | Peroxidasin | 0.0032 | 0.967 | 0.9572 |
Echinococcus granulosus | peroxidasin | 0.0032 | 0.967 | 0.9572 |
Brugia malayi | hypothetical protein | 0.0032 | 0.967 | 0.9572 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0032 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0032 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.967 | 0.9572 |
Chlamydia trachomatis | sulfite reductase | 0.002 | 0.2291 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0032 | 0.967 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.967 | 0.9572 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.967 | 0.9572 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.967 | 0.9572 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.967 | 0.9572 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.967 | 0.9572 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0032 | 1 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0032 | 0.967 | 0.9572 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0032 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0029 | 0.7709 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.967 | 0.9572 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0032 | 1 | 0.5 |
Onchocerca volvulus | 0.0032 | 0.967 | 0.5 | |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0032 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0032 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.967 | 0.9572 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.967 | 0.9572 |
Onchocerca volvulus | Peroxidase homolog | 0.0032 | 0.967 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0032 | 0.967 | 0.967 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.12 uM | Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW 264.7 cells after 24 hrs by ELISA | ChEMBL. | 21381754 |
IC50 (binding) | = 13.92 uM | Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells treated 2 hrs before LPS challenge measured after 18 hrs by Griess reaction method | ChEMBL. | 21381754 |
IC50 (binding) | = 34.08 uM | Inhibition of iNOS in LPS-stimulated mouse RAW 264.7 cells after 2 hrs by fluorescence plate reader analysis | ChEMBL. | 21381754 |
IC50 (ADMET) | > 100 uM | Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay | ChEMBL. | 21381754 |
IC50 (ADMET) | > 100 uM | Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay | ChEMBL. | 21381754 |
Inhibition (binding) | = 83.9 % | Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW 264.7 cells treated 2 hrs before LPS challenge measured after 18 hrs by Griess reaction method relative to control | ChEMBL. | 21381754 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.