Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0171 | 0.0862 | 0.5 | |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0092 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0209 | 0.1276 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0862 | 0.0862 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0232 | 0.153 | 1 |
Onchocerca volvulus | 0.0171 | 0.0862 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.1011 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0171 | 0.0862 | 0.0862 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0171 | 0.0862 | 0.0862 |
Loa Loa (eye worm) | carboxylesterase | 0.0171 | 0.0862 | 0.0862 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0171 | 0.0862 | 0.5635 |
Brugia malayi | Carboxylesterase family protein | 0.0171 | 0.0862 | 0.0862 |
Echinococcus multilocularis | acetylcholinesterase | 0.1011 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1011 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0862 | 0.0862 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1011 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1011 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0092 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0232 | 0.153 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1011 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0862 | 0.0862 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0171 | 0.0862 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0171 | 0.0862 | 0.0862 |
Echinococcus multilocularis | acetylcholinesterase | 0.1011 | 1 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0209 | 0.1276 | 0.8342 |
Brugia malayi | hypothetical protein | 0.0171 | 0.0862 | 0.0862 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0171 | 0.0862 | 0.0862 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0862 | 0.0862 |
Loa Loa (eye worm) | carboxylesterase | 0.0171 | 0.0862 | 0.0862 |
Echinococcus granulosus | acetylcholinesterase | 0.1011 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1011 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0171 | 0.0862 | 0.0862 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0092 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0209 | 0.1276 | 0.8342 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0171 | 0.0862 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0092 | 0 | 0.5 |
Leishmania major | trypanothione reductase | 0.0092 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1011 | 1 | 1 |
Onchocerca volvulus | 0.0171 | 0.0862 | 0.5 | |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0232 | 0.153 | 1 |
Echinococcus multilocularis | neuroligin | 0.0171 | 0.0862 | 0.0862 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0232 | 0.153 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0171 | 0.0862 | 0.5635 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0171 | 0.0862 | 0.5635 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0209 | 0.1276 | 0.8342 |
Echinococcus granulosus | neuroligin | 0.0171 | 0.0862 | 0.0862 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0171 | 0.0862 | 0.0862 |
Toxoplasma gondii | thioredoxin reductase | 0.0092 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0171 | 0.0862 | 0.0862 |
Plasmodium falciparum | glutathione reductase | 0.0092 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0171 | 0.0862 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0092 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0209 | 0.1276 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0862 | 0.0862 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0862 | 0.0862 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0862 | 0.0862 |
Onchocerca volvulus | 0.0171 | 0.0862 | 0.5 | |
Onchocerca volvulus | 0.0171 | 0.0862 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1011 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0171 | 0.0862 | 0.0862 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1011 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0171 | 0.0862 | 0.0862 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0209 | 0.1276 | 0.8342 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | M | Evaluated for beta-receptor affinity, determined in rat brain membrane fraction with [3H]- dihydroalprenolol; NA means compound not tested | ChEMBL. | 2883317 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.