TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 438.423 | Formula: C19H17F3N4O3S
H donors: 1 H acceptors: 4 LogP: 2.82 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: NC(=O)c1nccc(c1)CN1C(=O)N(C(=O)C1(C)C)c1ccc(cc1)SC(F)(F)F
InChi: 1S/C19H17F3N4O3S/c1-18(2)16(28)26(12-3-5-13(6-4-12)30-19(20,21)22)17(29)25(18)10-11-7-8-24-14(9-11)15(23)27/h3-9H,10H2,1-2H3,(H2,23,27)
InChiKey: JLIDRJHOEBMXLP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	insulin-like growth factor 1 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Insulin-like peptide receptor precursor, putative	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus granulosus	insulin growth factor 1 receptor beta	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus granulosus	insulin receptor	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	ko:K04527 insulin receptor, putative	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129857	All targets in OG5_129857
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	IPR008957,Fibronectin, type III-like fold,domain-containing	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	ko:K08252 receptor protein-tyrosine kinase [EC2.7.10.1], putative	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_129857	All targets in OG5_129857
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	Insulin-like peptide receptor precursor, putative	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus multilocularis	insulin growth factor 1 receptor beta	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129857	All targets in OG5_129857
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus multilocularis	insulin receptor	Get druggable targets OG5_129857	All targets in OG5_129857
Loa Loa (eye worm)	TK/INSR protein kinase	Get druggable targets OG5_129857	All targets in OG5_129857

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0097	0.0998	0.2719
Entamoeba histolytica	cysteine proteinase, putative	0.0025	0.0054	0.0231
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0292	0.3526	1
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.0438	0.4293
Echinococcus multilocularis	cathepsin L cysteine protease	0.0054	0.0438	0.0438
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0054	0.0438	0.1163
Echinococcus multilocularis	cathepsin L	0.0025	0.0054	0.0054
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0054	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0054	0.0062
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0054	0.0231
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0438	0.3581
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0158	0.1786	0.1786
Schistosoma mansoni	hypothetical protein	0.004	0.0247	0.0558
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0072	0.0666	0.1816
Schistosoma mansoni	hypothetical protein	0.004	0.0247	0.0558
Echinococcus multilocularis	insulin receptor	0.0158	0.1786	0.1786
Loa Loa (eye worm)	hypothetical protein	0.003	0.0116	0.0241
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0032	0.5
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0054	0.0438	0.1107
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0267	0.0267
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0438	0.4293
Loa Loa (eye worm)	ctsf protein	0.0054	0.0438	0.1163
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0534	0.1383
Loa Loa (eye worm)	hypothetical protein	0.003	0.0116	0.0241
Echinococcus multilocularis	epidermal growth factor receptor	0.0072	0.0666	0.0666
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0025	0.0054	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0054	0.0062
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0072	0.0666	0.1765
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0438	0.1163
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0054	0.0438	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0096	0.0978	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0054	0.0438	0.1107
Plasmodium vivax	vivapain-2	0.0054	0.0438	1
Leishmania major	cathepsin L-like protease	0.0054	0.0438	0.3709
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0438	0.3581
Brugia malayi	Niemann-Pick C1 protein precursor	0.0096	0.0978	0.2709
Schistosoma mansoni	hypothetical protein	0.004	0.0247	0.0558
Trypanosoma cruzi	cysteine proteinase, putative	0.0054	0.0438	0.1107
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0438	0.3581
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0054	0.0062
Schistosoma mansoni	tyrosine kinase	0.0071	0.065	0.1717
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0054	0.0438	0.1163
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0438	0.4293
Toxoplasma gondii	cathepsin B	0.0107	0.1127	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0032	0.5
Brugia malayi	Papain family cysteine protease containing protein	0.0054	0.0438	0.1163
Brugia malayi	cathepsin L-like cysteine proteinase	0.0025	0.0054	0.0062
Schistosoma mansoni	hypothetical protein	0.004	0.0247	0.0558
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0438	0.3581
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0267	0.1983
Leishmania major	cathepsin L-like protease	0.0054	0.0438	0.3709
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0032	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0534	0.1383
Brugia malayi	cathepsin L-like precursor	0.0025	0.0054	0.0062
Leishmania major	cathepsin L-like protease	0.0054	0.0438	0.3709
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0025	0.0054	0.0062
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0438	0.4293
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0025	0.0054	0.0231
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0438	0.3581
Onchocerca volvulus		0.0054	0.0438	1
Giardia lamblia	Cathepsin B precursor	0.0107	0.1127	1
Plasmodium vivax	unspecified product	0.0054	0.0438	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0096	0.0978	0.0978
Loa Loa (eye worm)	hypothetical protein	0.003	0.0116	0.0241
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0032	0.5
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0054	0.0438	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0054	0.0438	0.1107
Schistosoma mansoni	tyrosine kinase	0.0158	0.1786	0.4991
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0032	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0438	0.3581
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.0054	0.0062
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.0438	0.4293
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0025	0.0054	0.0062
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0158	0.1786	0.4991
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0054	0.0438	0.0438
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0054	0.0062
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0534	0.1437
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0054	0.0062
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.0438	0.1107
Loa Loa (eye worm)	hypothetical protein	0.0292	0.3526	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0438	0.3581
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0438	0.4293
Onchocerca volvulus	Cathepsin F homolog	0.0054	0.0438	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0438	0.3581
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0534	0.1383
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0438	0.3581
Brugia malayi	cathepsin F-like cysteine proteinase	0.0025	0.0054	0.0062
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0438	0.3581
Echinococcus granulosus	cathepsin L cysteine protease	0.0054	0.0438	0.1107
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.003	0.0116	0.0241
Loa Loa (eye worm)	TK/INSR protein kinase	0.0158	0.1786	0.5022
Schistosoma mansoni	tyrosine kinase	0.0072	0.0666	0.1765
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0438	0.3581
Schistosoma mansoni	tyrosine kinase	0.0071	0.065	0.1717
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.0438	0.4293
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0054	0.0438	1
Echinococcus multilocularis	cathepsin b	0.0292	0.3526	0.3526
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0054	0.0438	0.1107
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0025	0.0054	0.0062
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0438	0.1163
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0438	0.3581
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0438	0.3581
Onchocerca volvulus		0.0054	0.0438	1
Onchocerca volvulus		0.0025	0.0054	0.0537
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0534	0.1383
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0292	0.3526	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0107	0.1127	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0025	0.0054	0.0231
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0054	0.0062
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.0438	0.4293
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0438	0.1163
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0032	0.5
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0438	0.4293
Plasmodium vivax	vivapain-2	0.0054	0.0438	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0025	0.0054	0.0062
Echinococcus multilocularis	expressed conserved protein	0.009	0.0903	0.0903
Brugia malayi	TAR-binding protein	0.0062	0.0534	0.1437
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0054	0.0231
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0342	0.0342
Echinococcus granulosus	Niemann Pick C1 protein	0.0137	0.1513	0.4204
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0438	0.4293
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0025	0.0054	0.0062
Leishmania major	cathepsin L-like protease	0.0054	0.0438	0.3709
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.003	0.0116	0.0241
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0107	0.1127	1
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0438	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0054	0.0062
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0438	0.3581
Loa Loa (eye worm)	hypothetical protein	0.005	0.0387	0.1016
Leishmania major	cysteine peptidase A (CPA)	0.0054	0.0438	0.3709
Echinococcus granulosus	cathepsin b	0.0292	0.3526	1
Onchocerca volvulus		0.0054	0.0438	1
Trypanosoma cruzi	cysteine protease, putative	0.0054	0.0438	0.1107
Onchocerca volvulus	Cathepsin L homolog	0.0054	0.0438	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0072	0.0666	0.0666
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0054	0.0438	0.3581
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0054	0.0062
Echinococcus granulosus	cathepsin l1	0.0054	0.0438	0.1107
Onchocerca volvulus		0.0054	0.0438	1
Trypanosoma cruzi	cysteine peptidase, putative	0.003	0.0116	0.018
Brugia malayi	cathepsin L precursor	0.0025	0.0054	0.0062
Loa Loa (eye worm)	cathepsin B	0.0107	0.1127	0.3136
Plasmodium vivax	vivapain-3	0.0054	0.0438	1
Schistosoma mansoni	tyrosine kinase	0.0158	0.1786	0.4991
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0438	0.3581
Loa Loa (eye worm)	cysteine protease	0.0054	0.0438	0.1163
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0054	0.0438	0.1107
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0107	0.1127	0.3093
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0438	0.4293
Giardia lamblia	Cathepsin B precursor	0.0107	0.1127	1
Brugia malayi	Papain family cysteine protease containing protein	0.0054	0.0438	0.1163
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0534	0.0534
Onchocerca volvulus		0.0054	0.0438	1
Trypanosoma cruzi	cruzipain precursor, putative	0.003	0.0116	0.018
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0438	0.3581
Brugia malayi	Protein kinase domain containing protein	0.0158	0.1786	0.5022
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0054	0.0062
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0438	0.4293
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0438	0.4293
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0438	0.4293
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0438	0.3581
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0054	0.0438	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0032	0.5
Schistosoma mansoni	tyrosine kinase	0.0072	0.0666	0.1765
Echinococcus granulosus	expressed conserved protein	0.009	0.0903	0.2445
Echinococcus multilocularis	cathepsin L cysteine protease	0.0054	0.0438	0.0438
Leishmania major	cathepsin L-like protease	0.0054	0.0438	0.3709
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0438	0.1163
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.0054	0.0062
Brugia malayi	cathepsin F-like cysteine proteinase	0.003	0.0116	0.0241
Onchocerca volvulus		0.0054	0.0438	1
Schistosoma mansoni	cathepsin s	0.003	0.0116	0.018
Giardia lamblia	Cathepsin B precursor	0.0107	0.1127	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0137	0.1513	0.1513
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0438	0.3581
Plasmodium vivax	vivapain-1	0.0054	0.0438	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0054	0.0438	0.3581
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0054	0.0231
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0438	0.4293
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.0438	0.1107
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0438	0.3581
Echinococcus granulosus	epidermal growth factor receptor	0.0072	0.0666	0.1765
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0054	0.0231
Schistosoma mansoni	cathepsin F (C01 family)	0.0054	0.0438	0.1107
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0978	0.2709
Trypanosoma cruzi	cruzipain precursor, putative	0.0054	0.0438	0.1107
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0534	0.1437
Loa Loa (eye worm)	fibroinase	0.0054	0.0438	0.1163
Entamoeba histolytica	cysteine proteinase 1, putative	0.0054	0.0438	0.4293
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.0438	0.4293
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0292	0.3526	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0438	0.3581
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0438	0.3581
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0032	0.5
Onchocerca volvulus	Cathepsin L homolog	0.0054	0.0438	1
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0438	0.4293
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0054	0.0231
Schistosoma mansoni	tyrosine kinase	0.0072	0.0666	0.1765
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0032	0.5
Onchocerca volvulus		0.0025	0.0054	0.0537
Echinococcus multilocularis	cathepsin L	0.0054	0.0438	0.0438
Schistosoma mansoni	patched 1	0.0041	0.0267	0.0613
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0534	0.1383
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0438	0.3581
Echinococcus multilocularis	cathepsin b	0.0292	0.3526	0.3526
Brugia malayi	Protein kinase domain containing protein	0.0087	0.0868	0.2394
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0267	0.0672
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.0438	0.1107
Echinococcus granulosus	cathepsin b	0.0292	0.3526	1
Echinococcus granulosus	epidermal growth factor receptor	0.0072	0.0666	0.1765
Echinococcus granulosus	insulin receptor	0.0158	0.1786	0.4991
Onchocerca volvulus		0.0054	0.0438	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0438	0.3581
Brugia malayi	Furin-like cysteine rich region family protein	0.0072	0.0666	0.1816
Leishmania major	cathepsin L-like protease	0.0054	0.0438	0.3709
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0267	0.0613
Toxoplasma gondii	cathepsin CPL	0.0054	0.0438	0.3581
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.0438	0.1107
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0054	0.0438	0.0438
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0534	0.1383
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0267	0.0613
Brugia malayi	Papain family cysteine protease containing protein	0.0054	0.0438	0.1163
Schistosoma mansoni	tyrosine kinase	0.0071	0.065	0.1717
Brugia malayi	Cathepsin L-like precursor	0.003	0.0116	0.0241
Entamoeba histolytica	cysteine proteinase 2	0.0054	0.0438	0.4293
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0852	0.2347
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.0054	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0054	0.0062
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0292	0.3526	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0107	0.1127	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0292	0.3526	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0054	0.0438	0.1107
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0438	0.4293
Brugia malayi	cathepsin B-like cysteine proteinase	0.0292	0.3526	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0032	0.5
Echinococcus granulosus	cathepsin L	0.0054	0.0438	0.1107
Echinococcus multilocularis	cysteine protease	0.0054	0.0438	0.0438
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.0438	0.1107
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0438	0.3581
Leishmania major	cathepsin L-like protease	0.0054	0.0438	0.3709
Onchocerca volvulus	Cathepsin L homolog	0.0025	0.0054	0.0537
Leishmania major	cathepsin L-like protease	0.0054	0.0438	0.3709
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0438	0.1163
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0534	0.1437
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0107	0.1127	0.3093
Schistosoma mansoni	cathepsin F (C01 family)	0.0054	0.0438	0.1107
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0025	0.0054	0.0062
Echinococcus multilocularis	cysteine protease	0.0054	0.0438	0.0438
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0438	0.3581
Brugia malayi	fibroinase precursor	0.0025	0.0054	0.0062
Echinococcus granulosus	Niemann Pick C1 protein	0.0096	0.0978	0.2663
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0438	0.1163
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0438	0.1163
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0534	0.1437
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.0438	0.4293
Brugia malayi	RNA binding protein	0.0062	0.0534	0.1437
Entamoeba histolytica	hypothetical protein	0.0025	0.0054	0.0231
Echinococcus granulosus	cysteine protease	0.0054	0.0438	0.1107
Plasmodium vivax	unspecified product	0.003	0.0116	0.1625
Trypanosoma cruzi	cysteine proteinase, putative	0.0054	0.0438	0.1107
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0267	0.0672
Echinococcus multilocularis	protein patched	0.0041	0.0267	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0054	0.0062
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0032	0.5
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0032	0.5
Brugia malayi	CHE-14 protein	0.0041	0.0267	0.0672

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2950 nM	Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay	ChEMBL.	21441024

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1762164

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1522356