Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | dopamine receptor D3 | 400 aa | 392 aa | 19.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lamin | 0.0031 | 0.6517 | 0.6517 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 1 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0015 | 0.1124 | 0.1124 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1124 | 0.1725 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.6517 | 0.6517 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 1 | 0.5 |
Schistosoma mansoni | lamin | 0.0031 | 0.6517 | 0.6517 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.1678 | 0.1678 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.6517 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0933 | 0.1432 |
Echinococcus granulosus | lamin | 0.0031 | 0.6517 | 0.6517 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.6517 | 0.6517 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.6327 | 0.9707 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 1 | 0.5 |
Echinococcus multilocularis | musashi | 0.0031 | 0.6517 | 0.6517 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.6517 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.6517 | 0.6517 |
Schistosoma mansoni | lamin | 0.0031 | 0.6517 | 0.6517 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.6517 | 0.6517 |
Onchocerca volvulus | 0.0031 | 0.6517 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.0042 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 1 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.1678 | 0.2574 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.6517 | 0.6517 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.6517 | 0.6517 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.6517 | 1 |
Onchocerca volvulus | 0.0031 | 0.6517 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0042 | 1 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0015 | 0.1124 | 0.1124 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0933 | 0.1432 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2.7 nM | Displacement of [3H]spiperone from wild type human dopamine D3 receptor expressed in HEK293 cells after 60 mins | ChEMBL. | 21388142 |
Ki (binding) | = 250 nM | Displacement of [3H]spiperone from human dopamine D3 receptor V2.61F mutant expressed in HEK293 cells after 60 mins | ChEMBL. | 21388142 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.