Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0021 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.013 | 0.7399 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.013 | 0.7399 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1954 | 0.2641 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0893 | 0.0893 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0021 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1954 | 0.2641 |
Brugia malayi | RNA binding protein | 0.013 | 0.7399 | 1 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 | |
Echinococcus multilocularis | tar DNA binding protein | 0.013 | 0.7399 | 0.7399 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0893 | 0.1206 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0168 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.013 | 0.7399 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.013 | 0.7399 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.7399 | 0.7399 |
Echinococcus granulosus | tar DNA binding protein | 0.013 | 0.7399 | 0.7399 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.7399 | 0.7399 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0893 | 0.1206 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.7399 | 0.7399 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.7399 | 0.7399 |
Loa Loa (eye worm) | RNA binding protein | 0.013 | 0.7399 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1954 | 0.2641 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.7399 | 0.7399 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1954 | 0.2641 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 20 uM | Antiplasmodial activity against Plasmodium falciparum W2 | ChEMBL. | 21376591 |
Inhibition (functional) | Antitubercular activity against Mycobacterium tuberculosis H37Rv at 1 ug/ml by BACTEC radiometric susceptibility assay | ChEMBL. | 21376591 | |
Inhibition (functional) | Antitubercular activity against Mycobacterium tuberculosis H37Rv at 10 ug/ml by BACTEC radiometric susceptibility assay | ChEMBL. | 21376591 | |
MIC (functional) | Antitubercular activity against Mycobacterium tuberculosis H37Rv by LORA assay | ChEMBL. | 21376591 | |
MIC (functional) | > 128 uM | Antitubercular activity against Mycobacterium tuberculosis H37Rv by microplate alamar blue assay | ChEMBL. | 21376591 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.