Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA binding protein | 0.0129 | 0.7399 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1954 | 0.264 |
Echinococcus multilocularis | geminin | 0.0167 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0129 | 0.7399 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0129 | 0.7399 | 0.7399 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0893 | 0.0893 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0893 | 0.1206 |
Loa Loa (eye worm) | TAR-binding protein | 0.0129 | 0.7399 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1954 | 0.264 |
Brugia malayi | TAR-binding protein | 0.0129 | 0.7399 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.7399 | 0.7399 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.7399 | 0.7399 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.7399 | 0.7399 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1954 | 0.264 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1954 | 0.264 |
Onchocerca volvulus | 0.0021 | 0 | 0.5 | |
Loa Loa (eye worm) | RNA binding protein | 0.0129 | 0.7399 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0129 | 0.7399 | 0.7399 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0893 | 0.1206 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.7399 | 0.7399 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0129 | 0.7399 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.7399 | 0.7399 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 65.8 uM | Cytotoxicity against human K562 cells after 48 hrs by MTT assay | ChEMBL. | 21295380 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.