Detailed information for compound 1522930

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 439.527 | Formula: C23H25N3O4S
  • H donors: 1 H acceptors: 5 LogP: 2.67 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C([C@@H](n1ccc(cc1=O)S(=O)(=O)C(C)C)Cc1ccccc1)Nc1ccc(cn1)C
  • InChi: 1S/C23H25N3O4S/c1-16(2)31(29,30)19-11-12-26(22(27)14-19)20(13-18-7-5-4-6-8-18)23(28)25-21-10-9-17(3)15-24-21/h4-12,14-16,20H,13H2,1-3H3,(H,24,25,28)/t20-/m0/s1
  • InChiKey: DQYQJMJXVJQDGG-FQEVSTJZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucokinase (hexokinase 4) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania mexicana hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Schistosoma mansoni hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania major hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Toxoplasma gondii hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Brugia malayi Hexokinase family protein Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma cruzi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Cryptosporidium parvum hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium yoelii hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Theileria parva hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Treponema pallidum hexokinase (hxk) Get druggable targets OG5_126743 All targets in OG5_126743
Entamoeba histolytica hexokinase 2 Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium vivax hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei gambiense hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania braziliensis hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania infantum hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium knowlesi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania infantum hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Babesia bovis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei gambiense hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase type 2 Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Brugia malayi hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Neospora caninum cDNA FLJ57348, highly similar to Homo sapiens hexokinase domain containing 1 (HKDC1), mRNA, related Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma congolense hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Theileria parva hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium berghei hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Cryptosporidium hominis hexokinase i Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase type 2 Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma cruzi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania major hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Schistosoma japonicum ko:K00844 hexokinase [EC2.7.1.1], putative Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium falciparum hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hexokinase type II Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania mexicana hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania donovani hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Entamoeba histolytica hexokinase 1 Get druggable targets OG5_126743 All targets in OG5_126743
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hexokinase family protein glucokinase (hexokinase 4) 465 aa 470 aa 30.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major beta tubulin 0.0267 1 1
Echinococcus multilocularis beta tubulin 0.0267 1 1
Entamoeba histolytica tubulin family protein 0.0267 1 1
Giardia lamblia Beta tubulin 0.0267 1 1
Loa Loa (eye worm) tubulin beta-4 chain 0.0267 1 1
Onchocerca volvulus 0.0096 0.152 1
Brugia malayi Tubulin alpha-2 chain 0.0193 0.6329 0.6053
Trichomonas vaginalis tubulin beta chain, putative 0.0193 0.6329 0.6053
Brugia malayi hexokinase 0.0096 0.152 0.0881
Leishmania major beta tubulin 0.0267 1 1
Echinococcus granulosus tubulin epsilon chain 0.0141 0.3741 0.2619
Schistosoma mansoni tubulin subunit alpha 0.0193 0.6329 0.5671
Leishmania major beta tubulin 0.0267 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0267 1 1
Trypanosoma brucei hexokinase, putative 0.0096 0.152 0.0881
Echinococcus granulosus alpha tubulin 0.0193 0.6329 0.5671
Trypanosoma brucei beta tubulin 0.0141 0.3741 0.3269
Leishmania major beta tubulin 0.0267 1 1
Echinococcus granulosus tubulin alpha chain 0.0193 0.6329 0.5671
Loa Loa (eye worm) tubulin gamma chain 0.0141 0.3741 0.3741
Schistosoma mansoni alpha tubulin 0.0193 0.6329 0.5671
Loa Loa (eye worm) BEN-1 protein 0.0267 1 1
Schistosoma mansoni tubulin subunit gamma 0.0141 0.3741 0.2619
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0193 0.6329 0.6053
Echinococcus multilocularis tubulin subunit TubB 0.0193 0.6329 0.5671
Trypanosoma brucei epsilon tubulin 0.0141 0.3741 0.3269
Echinococcus granulosus tubulin subunit beta 0.0267 1 1
Echinococcus granulosus beta tubulin 0.0267 1 1
Leishmania major beta tubulin 0.0267 1 1
Echinococcus multilocularis tubulin alpha chain 0.0193 0.6329 0.5671
Leishmania major beta tubulin 0.0267 1 1
Leishmania major alpha tubulin 0.0193 0.6329 0.5671
Loa Loa (eye worm) tubulin alpha-2 chain 0.0193 0.6329 0.6329
Trypanosoma brucei alpha tubulin 0.0193 0.6329 0.6053
Loa Loa (eye worm) tubulin beta chain 0.0267 1 1
Leishmania major alpha tubulin 0.0193 0.6329 0.5671
Echinococcus multilocularis hypothetical protein 0.0193 0.6329 0.5671
Loa Loa (eye worm) hexokinase type II 0.0096 0.152 0.152
Trichomonas vaginalis tubulin epsilon chain, putative 0.0267 1 1
Plasmodium vivax tubulin alpha chain, putative 0.0193 0.6329 0.5671
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0267 1 1
Schistosoma mansoni tubulin subunit beta 0.0267 1 1
Loa Loa (eye worm) BEN-1 protein 0.0267 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0141 0.3741 0.3269
Toxoplasma gondii beta-tubulin, putative 0.0267 1 1
Echinococcus granulosus tubulin alpha chain 0.0193 0.6329 0.5671
Echinococcus granulosus tubulin alpha chain 0.0193 0.6329 0.5671
Echinococcus multilocularis tubulin alpha 3 chain 0.0193 0.6329 0.5671
Entamoeba histolytica tubulin alpha chain, putative 0.0193 0.6329 0.5671
Trypanosoma brucei beta tubulin 0.0267 1 1
Loa Loa (eye worm) beta-tubulin 0.0267 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0193 0.6329 0.6053
Leishmania major beta tubulin 0.0267 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0267 1 1
Leishmania major beta tubulin 0.0267 1 1
Giardia lamblia Beta tubulin 0.0267 1 1
Brugia malayi beta-tubulin, identical 0.0267 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0193 0.6329 0.6053
Entamoeba histolytica tubulin family protein 0.0267 1 1
Giardia lamblia Alpha-tubulin 0.0193 0.6329 0.4135
Echinococcus granulosus Tubulin beta 2C chain 0.0267 1 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0193 0.6329 0.5671
Plasmodium vivax tubulin alpha chain, putative 0.0193 0.6329 0.5671
Toxoplasma gondii alpha tubulin TUBA1 0.0193 0.6329 0.5671
Trypanosoma brucei hexokinase 0.0096 0.152 0.0881
Leishmania major beta tubulin 0.0267 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0141 0.3741 0.3269
Loa Loa (eye worm) tubulin alpha 2 0.0132 0.3289 0.3289
Echinococcus granulosus Tubulin alpha 1 chain 0.0193 0.6329 0.5671
Trypanosoma brucei alpha tubulin 0.0193 0.6329 0.6053
Trypanosoma brucei tubulin gamma chain 0.0141 0.3741 0.3269
Trichomonas vaginalis tubulin beta chain, putative 0.0193 0.6329 0.6053
Echinococcus multilocularis tubulin alpha chain 0.0193 0.6329 0.5671
Echinococcus granulosus tubulin alpha 3 chain 0.0193 0.6329 0.5671
Loa Loa (eye worm) hypothetical protein 0.0193 0.6329 0.6329
Loa Loa (eye worm) alpha-tubulin 0.0193 0.6329 0.6329
Echinococcus granulosus tubulin alpha 0.0141 0.3741 0.2619
Echinococcus multilocularis tubulin alpha chain 0.0193 0.6329 0.5671
Plasmodium falciparum tubulin beta chain 0.0267 1 1
Trypanosoma cruzi tubulin gamma chain 0.0141 0.3741 0.2619
Trichomonas vaginalis tubulin beta chain, putative 0.0193 0.6329 0.6053
Echinococcus multilocularis Tubulin alpha 1 chain 0.0193 0.6329 0.5671
Schistosoma mansoni tubulin subunit beta 0.0267 1 1
Echinococcus granulosus tubulin alpha chain 0.0193 0.6329 0.5671
Loa Loa (eye worm) alpha-tubulin 0.0193 0.6329 0.6329
Loa Loa (eye worm) tubulin alpha chain 0.0193 0.6329 0.6329
Echinococcus granulosus Tubulin beta 2C chain 0.0267 1 1
Echinococcus multilocularis peroxisome assembly protein 26 0.0193 0.6329 0.5671
Echinococcus granulosus peroxisome assembly protein 26 0.0193 0.6329 0.5671
Loa Loa (eye worm) tubulin alpha chain 0.0193 0.6329 0.6329
Leishmania major beta tubulin 0.0267 1 1
Loa Loa (eye worm) hexokinase 0.0096 0.152 0.152
Leishmania major epsilon tubulin, putative 0.0141 0.3741 0.2619
Trypanosoma brucei beta tubulin 0.0267 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0267 1 1
Echinococcus multilocularis tubulin gamma 1 chain 0.0141 0.3741 0.2619
Onchocerca volvulus 0.0096 0.152 1
Echinococcus granulosus tubulin beta 4A class IVa 0.0267 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0113 0.2367 0.1792
Echinococcus granulosus Tubulin alpha 1 chain 0.0193 0.6329 0.5671
Leishmania major alpha tubulin 0.0193 0.6329 0.5671
Echinococcus multilocularis tubulin epsilon chain 0.0141 0.3741 0.2619
Echinococcus multilocularis beta tubulin 0.0267 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0267 1 1
Toxoplasma gondii alpha-tubulin I, putative 0.0193 0.6329 0.5671
Leishmania major beta tubulin 0.0267 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0132 0.3289 0.2783
Loa Loa (eye worm) tubulin alpha-3 chain 0.0113 0.2367 0.2367
Echinococcus granulosus tubulin alpha chain 0.0193 0.6329 0.5671
Leishmania major beta tubulin 0.0267 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0193 0.6329 0.6053
Toxoplasma gondii beta tubulin 0.0267 1 1
Trypanosoma brucei hexokinase 0.0096 0.152 0.0881
Trypanosoma brucei beta tubulin 0.0267 1 1
Leishmania major beta tubulin 0.0267 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0193 0.6329 0.6053
Leishmania major alpha tubulin 0.0193 0.6329 0.5671
Entamoeba histolytica tubulin alpha-1 chain 0.0193 0.6329 0.5671
Plasmodium vivax tubulin epsilon chain, putative 0.0141 0.3741 0.2619
Loa Loa (eye worm) hypothetical protein 0.0132 0.3289 0.3289
Brugia malayi Tubulin alpha chain 0.0193 0.6329 0.6053
Plasmodium falciparum tubulin epsilon chain, putative 0.0141 0.3741 0.2619
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0132 0.3289 0.3289
Echinococcus granulosus Tubulin beta 2C chain 0.0267 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0267 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0267 1 1
Echinococcus multilocularis tubulin alpha 0.0141 0.3741 0.2619
Echinococcus multilocularis tubulin alpha chain 0.0193 0.6329 0.5671
Onchocerca volvulus 0.0096 0.152 1
Schistosoma mansoni tubulin subunit beta 0.0267 1 1
Toxoplasma gondii beta-1 tubulin, putative 0.0267 1 1
Trypanosoma cruzi beta tubulin, putative 0.0267 1 1
Giardia lamblia Beta tubulin 0.0267 1 1
Brugia malayi Hexokinase family protein 0.0096 0.152 0.0881
Leishmania major alpha tubulin 0.0193 0.6329 0.5671
Echinococcus multilocularis tubulin alpha 1C chain 0.0193 0.6329 0.5671
Leishmania major alpha tubulin 0.0193 0.6329 0.5671
Trypanosoma brucei beta tubulin 0.0267 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0193 0.6329 0.5671
Echinococcus granulosus tubulin alpha 1C chain 0.0193 0.6329 0.5671
Loa Loa (eye worm) tubulin beta-1 chain 0.0267 1 1
Echinococcus granulosus tubulin beta 1 chain 0.0267 1 1
Echinococcus granulosus tubulin alpha 1C chain 0.0193 0.6329 0.5671
Schistosoma mansoni alpha tubulin 0.0193 0.6329 0.5671
Trypanosoma brucei alpha tubulin 0.0193 0.6329 0.6053
Leishmania major alpha tubulin 0.0193 0.6329 0.5671
Loa Loa (eye worm) tubulin alpha 2 0.0132 0.3289 0.3289
Schistosoma mansoni tubulin subunit beta 0.0267 1 1
Plasmodium falciparum tubulin gamma chain 0.0141 0.3741 0.2619
Echinococcus granulosus tubulin gamma 1 chain 0.0141 0.3741 0.2619
Plasmodium vivax tubulin gamma chain, putative 0.0141 0.3741 0.2619
Trypanosoma brucei epsilon tubulin 0.0141 0.3741 0.3269
Trichomonas vaginalis tubulin, putative 0.0267 1 1
Leishmania major beta tubulin 0.0267 1 1
Giardia lamblia Alpha-tubulin 0.0193 0.6329 0.4135
Plasmodium falciparum alpha tubulin 2 0.0193 0.6329 0.5671
Brugia malayi Tubulin gamma chain 0.0141 0.3741 0.3269
Echinococcus multilocularis tubulin alpha 3 chain 0.0193 0.6329 0.5671
Trichomonas vaginalis tubulin epsilon chain, putative 0.0267 1 1
Trypanosoma brucei epsilon tubulin 0.0141 0.3741 0.3269
Echinococcus multilocularis tubulin alpha chain 0.0193 0.6329 0.5671
Echinococcus multilocularis Tubulin beta 2C chain 0.0267 1 1
Trypanosoma cruzi epsilon tubulin, putative 0.0141 0.3741 0.2619
Leishmania major beta tubulin 0.0267 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0193 0.6329 0.6053
Leishmania major beta tubulin 0.0267 1 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0141 0.3741 0.2619
Echinococcus multilocularis Tubulin alpha 1 chain 0.0193 0.6329 0.5671
Echinococcus granulosus beta tubulin 0.0267 1 1
Schistosoma mansoni tubulin subunit epsilon 0.0141 0.3741 0.2619
Trypanosoma cruzi alpha tubulin, putative 0.0193 0.6329 0.5671
Leishmania major gamma-tubulin 0.0141 0.3741 0.2619
Plasmodium vivax tubulin beta chain, putative 0.0267 1 1
Leishmania major alpha tubulin 0.0193 0.6329 0.5671
Loa Loa (eye worm) hexokinase 0.0096 0.152 0.152
Brugia malayi Tubulin alpha-2 chain 0.0193 0.6329 0.6053
Trypanosoma cruzi epsilon tubulin, putative 0.0141 0.3741 0.2619
Brugia malayi tubulin alpha-2 chain 0.0193 0.6329 0.6053
Schistosoma mansoni tubulin subunit alpha 0.0193 0.6329 0.5671
Schistosoma mansoni tubulin subunit alpha 0.0193 0.6329 0.5671
Schistosoma mansoni alpha tubulin 0.0193 0.6329 0.5671
Echinococcus multilocularis tubulin beta 1 chain 0.0267 1 1
Leishmania major beta tubulin 0.0267 1 1
Leishmania major beta tubulin 0.0267 1 1
Leishmania major alpha tubulin 0.0193 0.6329 0.5671
Plasmodium falciparum alpha tubulin 1 0.0193 0.6329 0.5671
Schistosoma mansoni tubulin subunit beta 0.0267 1 1
Entamoeba histolytica tubulin gamma chain 0.0141 0.3741 0.2619
Brugia malayi tubulin alpha chain - mouse 0.0193 0.6329 0.6053
Echinococcus granulosus tubulin alpha 3 chain 0.0193 0.6329 0.5671
Echinococcus multilocularis Tubulin beta 2C chain 0.0267 1 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.2367 0.2367
Trichomonas vaginalis tubulin gamma chain, putative 0.0267 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0141 0.3741 0.3269
Loa Loa (eye worm) tubulin beta-2A chain 0.0267 1 1
Leishmania major alpha tubulin 0.0193 0.6329 0.5671
Leishmania major alpha tubulin 0.0193 0.6329 0.5671
Brugia malayi alpha-tubulin 0.0193 0.6329 0.6053
Echinococcus granulosus tubulin subunit TubB 0.0193 0.6329 0.5671
Echinococcus multilocularis Tubulin alpha 1 chain 0.0193 0.6329 0.5671
Leishmania major alpha tubulin 0.0193 0.6329 0.5671
Trypanosoma brucei alpha tubulin 0.0193 0.6329 0.6053
Trichomonas vaginalis tubulin beta chain, putative 0.0267 1 1
Treponema pallidum hexokinase (hxk) 0.0096 0.152 0.5
Echinococcus multilocularis tubulin subunit beta 0.0267 1 1
Schistosoma mansoni tubulin subunit beta 0.0267 1 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 3.3 uM Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometry ChEMBL. 19435665
Emax (binding) = 30 % Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometry relative to control ChEMBL. 19435665

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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