Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cathepsin L-like precursor | 0.0059 | 0.2067 | 0.2067 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0088 | 0.6495 | 0.6495 |
Leishmania major | cathepsin L-like protease | 0.0088 | 0.6495 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0088 | 0.6495 | 0.6495 |
Onchocerca volvulus | 0.0087 | 0.6314 | 0.5354 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0088 | 0.6495 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0059 | 0.2067 | 0.2067 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0059 | 0.2067 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0088 | 0.6495 | 0.5582 |
Onchocerca volvulus | Cathepsin F homolog | 0.0088 | 0.6495 | 0.5582 |
Onchocerca volvulus | 0.0088 | 0.6495 | 0.5582 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0088 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0088 | 0.6495 | 0.6495 |
Onchocerca volvulus | 0.0111 | 1 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Leishmania major | cathepsin L-like protease | 0.0088 | 0.6495 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0088 | 0.6495 | 0.5582 |
Entamoeba histolytica | cysteine protease, putative | 0.0088 | 0.6495 | 1 |
Leishmania major | cathepsin L-like protease | 0.0088 | 0.6495 | 0.5 |
Echinococcus granulosus | cathepsin l1 | 0.0059 | 0.2067 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0088 | 0.6495 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0088 | 0.6495 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0088 | 0.6495 | 0.6495 |
Brugia malayi | Cathepsin L-like precursor | 0.0088 | 0.6495 | 0.6495 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0088 | 0.6495 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0059 | 0.2067 | 0.2067 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0088 | 0.6495 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0088 | 0.6495 | 1 |
Onchocerca volvulus | 0.0088 | 0.6495 | 0.5582 | |
Leishmania major | cathepsin L-like protease | 0.0088 | 0.6495 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0111 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0059 | 0.2067 | 0.3182 |
Onchocerca volvulus | Cathepsin L homolog | 0.0088 | 0.6495 | 0.5582 |
Brugia malayi | Cathepsin L-like precursor | 0.0088 | 0.6495 | 0.6495 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0088 | 0.6495 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0088 | 0.6495 | 0.5582 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Onchocerca volvulus | 0.0088 | 0.6495 | 0.5582 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Onchocerca volvulus | 0.0088 | 0.6495 | 0.5582 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0088 | 0.6495 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0088 | 0.6495 | 0.5582 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0088 | 0.6495 | 0.6495 |
Echinococcus multilocularis | cysteine protease | 0.0088 | 0.6495 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0088 | 0.6495 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0088 | 0.6495 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0088 | 0.6495 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.6495 | 0.5582 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0088 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0088 | 0.6495 | 0.6495 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0088 | 0.6495 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Leishmania major | cathepsin L-like protease | 0.0088 | 0.6495 | 0.5 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0088 | 0.6495 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0088 | 0.6495 | 0.5582 |
Leishmania major | cathepsin L-like protease | 0.0088 | 0.6495 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0088 | 0.6495 | 1 |
Plasmodium vivax | vivapain-2 | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Leishmania major | cathepsin L-like protease | 0.0088 | 0.6495 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0059 | 0.2067 | 0.2067 |
Onchocerca volvulus | 0.0088 | 0.6495 | 0.5582 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0059 | 0.2067 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Plasmodium vivax | vivapain-2 | 0.0088 | 0.6495 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0088 | 0.6495 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0088 | 0.6495 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0088 | 0.6495 | 0.6495 |
Brugia malayi | Cathepsin L-like precursor | 0.0059 | 0.2067 | 0.2067 |
Onchocerca volvulus | 0.0088 | 0.6495 | 0.5582 | |
Leishmania major | cathepsin L-like protease | 0.0088 | 0.6495 | 0.5 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0088 | 0.6495 | 0.5582 |
Onchocerca volvulus | 0.0088 | 0.6495 | 0.5582 | |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0088 | 0.6495 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0088 | 0.6495 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0088 | 0.6495 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0059 | 0.2067 | 0.3182 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0088 | 0.6495 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0111 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0088 | 0.6495 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of HNF4alpha mRNA expression in human HepG2 cells after 24 hrs by RT-PCR analysis | ChEMBL. | 21190853 | |
Activity (binding) | Inhibition of HNF4alpha mRNA expression in human HepG2 cells after 24 hrs by Western blotting | ChEMBL. | 21190853 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.