Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0513 | 1 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0513 | 1 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0318 | 0.604 | 0.6003 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0513 | 1 | 0.5 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0513 | 1 | 1 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0513 | 1 | 0.5 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0232 | 0.431 | 0.4256 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0513 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0041 | 0.044 | 0.035 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0513 | 1 | 0.5 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0513 | 1 | 0.5 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0513 | 1 | 1 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0513 | 1 | 0.5 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0513 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0318 | 0.604 | 0.6003 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0044 | 0.0507 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0829 | 0.0829 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0513 | 1 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0513 | 1 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.0829 | 0.0407 |
Loa Loa (eye worm) | glutamate receptor | 0.0049 | 0.06 | 0.06 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0318 | 0.604 | 0.6003 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0513 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0513 | 1 | 0.5 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0232 | 0.431 | 0.431 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0513 | 1 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.0829 | 0.0407 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.06 | 0.0512 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0513 | 1 | 0.5 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0513 | 1 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0318 | 0.604 | 0.6003 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.0736 | 0.0649 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.09 nM | Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization | ChEMBL. | 21546249 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.