Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fructose-1,6-bisphosphatase 1 | Starlite/ChEMBL | References |
Mus musculus | fructose bisphosphatase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | fructose-bisphospatase I | fructose bisphosphatase 1 | 338 aa | 326 aa | 29.4 % |
Toxoplasma gondii | fructose-bisphospatase I | fructose-1,6-bisphosphatase 1 | 338 aa | 326 aa | 31.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0141 | 0.1294 | 0.3334 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0378 | 0.388 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0339 | 0.3452 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0217 | 0.0559 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0165 | 0.1565 | 0.5 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0141 | 0.1294 | 0.3334 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0339 | 0.3452 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0165 | 0.1565 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0339 | 0.3452 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0339 | 0.3452 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0339 | 0.3452 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0217 | 0.0559 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0378 | 0.388 | 0.388 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0 | 0.5 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0378 | 0.388 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0141 | 0.1294 | 0.3334 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0141 | 0.1294 | 0.3334 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0339 | 0.3452 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0217 | 0.0628 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0339 | 0.3452 | 1 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0141 | 0.1294 | 0.3334 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0378 | 0.388 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0378 | 0.388 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0378 | 0.388 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0339 | 0.3452 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0378 | 0.388 | 1 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0165 | 0.1565 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0378 | 0.388 | 1 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0217 | 0.0559 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0217 | 0.0628 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0217 | 0.0628 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0217 | 0.0559 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0339 | 0.3452 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0339 | 0.3452 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0217 | 0.0628 |
Leishmania major | 0.0378 | 0.388 | 1 | |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0339 | 0.3452 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0339 | 0.3452 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0217 | 0.0217 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0378 | 0.388 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 8 uM | Reduction of glucose production in mouse hepatocytes after 6 hrs by glucose oxidase assay | ChEMBL. | 21550236 |
IC50 (binding) | = 0.76 uM | Inhibition of human liver fructose-1,6-bisphosphatase | ChEMBL. | 21550236 |
IC50 (binding) | = 6 uM | Inhibition of mouse liver fructose-1,6-bisphosphatase | ChEMBL. | 21550236 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 21550236 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.