Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0026 | 0.0475 | 0.0141 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0252 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0026 | 0.0475 | 1 |
Schistosoma mansoni | disulfide oxidoreductase | 0.0023 | 0.0339 | 0.0339 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0087 | 0.3047 | 0.2803 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0475 | 0.0475 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0026 | 0.0475 | 0.0475 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0475 | 0.0475 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0252 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0252 | 1 | 1 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0087 | 0.3047 | 0.2803 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0077 | 0.2609 | 0.2609 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0087 | 0.3047 | 0.2803 |
Brugia malayi | Thioredoxin reductase | 0.0252 | 1 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0087 | 0.3047 | 0.3047 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0087 | 0.3047 | 0.2803 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0087 | 0.3047 | 0.2803 |
Schistosoma mansoni | nuclear hormone receptor | 0.0026 | 0.0475 | 0.0475 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0087 | 0.3047 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0026 | 0.0475 | 0.0141 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0087 | 0.3047 | 0.2803 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0087 | 0.3047 | 0.2803 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0077 | 0.2609 | 0.2609 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0947 | 0.0947 |
Schistosoma mansoni | thyroid hormone receptor | 0.0026 | 0.0475 | 0.0475 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0026 | 0.0475 | 0.0141 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0026 | 0.0475 | 0.0141 |
Brugia malayi | nuclear hormone receptor | 0.0026 | 0.0475 | 0.0141 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0023 | 0.0339 | 0.0339 |
Onchocerca volvulus | 0.0026 | 0.0475 | 1 | |
Schistosoma mansoni | coup transcription factor | 0.0026 | 0.0475 | 0.0475 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0087 | 0.3047 | 0.2803 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0339 | 0.0339 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0475 | 0.0475 |
Trypanosoma brucei | trypanothione reductase | 0.0252 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0087 | 0.3047 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0252 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0026 | 0.0475 | 0.0475 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0252 | 1 | 1 |
Echinococcus granulosus | NADPH:adrenodoxin oxidoreductase | 0.0023 | 0.0339 | 0.0339 |
Schistosoma mansoni | sulfide quinone reductase | 0.0023 | 0.0339 | 0.0339 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0026 | 0.0475 | 0.0475 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0475 | 0.0475 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0026 | 0.0475 | 0.0475 |
Echinococcus multilocularis | glutamate synthase | 0.0023 | 0.0339 | 0.0339 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0087 | 0.3047 | 0.2803 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0026 | 0.0475 | 0.0475 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0947 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0026 | 0.0475 | 0.0141 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0026 | 0.0475 | 0.0475 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0026 | 0.0475 | 0.0141 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0947 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0026 | 0.0475 | 0.0475 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0947 | 0.0947 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0026 | 0.0475 | 0.0475 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0252 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0252 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0026 | 0.0475 | 0.0475 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0023 | 0.0339 | 0.0339 |
Schistosoma mansoni | glutamate synthase | 0.0023 | 0.0339 | 0.0339 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0026 | 0.0475 | 0.0475 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0087 | 0.3047 | 0.2803 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0087 | 0.3047 | 0.2803 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0026 | 0.0475 | 0.0141 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0026 | 0.0475 | 0.0141 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0087 | 0.3047 | 0.2803 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0026 | 0.0475 | 0.0475 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0026 | 0.0475 | 0.0475 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0087 | 0.3047 | 0.3047 |
Schistosoma mansoni | thyroid hormone receptor | 0.0026 | 0.0475 | 0.0475 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0026 | 0.0475 | 0.0475 |
Brugia malayi | ecdysteroid receptor | 0.0026 | 0.0475 | 0.0141 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0064 | 0.2069 | 0.179 |
Loa Loa (eye worm) | programmed cell death 8 | 0.0023 | 0.0339 | 0.0339 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0087 | 0.3047 | 0.2803 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0026 | 0.0475 | 0.0475 |
Loa Loa (eye worm) | glutathione reductase | 0.0252 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0947 | 1 |
Echinococcus granulosus | apoptosis inducing factor 1 mitochondrial | 0.0023 | 0.0339 | 0.0339 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0023 | 0.0339 | 0.0339 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0026 | 0.0475 | 0.0475 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0087 | 0.3047 | 0.2803 |
Treponema pallidum | NADH oxidase | 0.0087 | 0.3047 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0087 | 0.3047 | 0.2803 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0087 | 0.3047 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0087 | 0.3047 | 1 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0087 | 0.3047 | 0.2803 |
Plasmodium falciparum | glutathione reductase | 0.0252 | 1 | 1 |
Echinococcus multilocularis | apoptosis inducing factor 1 mitochondrial | 0.0023 | 0.0339 | 0.0339 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0026 | 0.0475 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0087 | 0.3047 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0026 | 0.0475 | 0.0141 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0087 | 0.3047 | 0.2803 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0252 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0026 | 0.0475 | 0.0475 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0087 | 0.3047 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0064 | 0.2069 | 0.179 |
Echinococcus granulosus | sulfide:quinone oxidoreductase | 0.0023 | 0.0339 | 0.0339 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0026 | 0.0475 | 0.0475 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0026 | 0.0475 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0087 | 0.3047 | 0.2803 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0026 | 0.0475 | 0.0475 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0026 | 0.0475 | 0.0475 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0087 | 0.3047 | 0.2803 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0026 | 0.0475 | 0.0475 |
Echinococcus granulosus | FTZ F1 alpha | 0.0026 | 0.0475 | 0.0475 |
Loa Loa (eye worm) | pyridine nucleotide-disufhide oxidoreductase | 0.0023 | 0.0339 | 0.0339 |
Plasmodium falciparum | glutathione reductase | 0.0087 | 0.3047 | 0.2803 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0087 | 0.3047 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0026 | 0.0475 | 0.0141 |
Toxoplasma gondii | thioredoxin reductase | 0.0252 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0339 | 0.0339 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0026 | 0.0475 | 0.0475 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0087 | 0.3047 | 0.2803 |
Plasmodium vivax | glutathione reductase, putative | 0.0252 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0026 | 0.0475 | 0.0475 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0087 | 0.3047 | 0.2803 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0087 | 0.3047 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0026 | 0.0475 | 0.0475 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0026 | 0.0475 | 0.0475 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0947 | 0.0947 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0026 | 0.0475 | 0.0141 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0026 | 0.0475 | 0.0141 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0023 | 0.0339 | 0.0339 |
Echinococcus multilocularis | sulfide:quinone oxidoreductase | 0.0023 | 0.0339 | 0.0339 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0087 | 0.3047 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0026 | 0.0475 | 0.0141 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0026 | 0.0475 | 0.0475 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0475 | 0.0475 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0087 | 0.3047 | 0.2803 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0475 | 0.0475 |
Echinococcus multilocularis | pyridine nucleotide disulfide oxidoreductase | 0.0023 | 0.0339 | 0.0339 |
Schistosoma mansoni | glutamate synthase | 0.0023 | 0.0339 | 0.0339 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0087 | 0.3047 | 0.2803 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0026 | 0.0475 | 0.0475 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0087 | 0.3047 | 0.2803 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0026 | 0.0475 | 0.0141 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0026 | 0.0475 | 0.0475 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0475 | 0.0475 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0947 | 0.0947 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0026 | 0.0475 | 0.0141 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0026 | 0.0475 | 0.0475 |
Echinococcus multilocularis | NADPH:adrenodoxin oxidoreductase | 0.0023 | 0.0339 | 0.0339 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0026 | 0.0475 | 0.0475 |
Echinococcus granulosus | pyridine nucleotide disulfide oxidoreductase | 0.0023 | 0.0339 | 0.0339 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0026 | 0.0475 | 0.0475 |
Schistosoma mansoni | glutamate synthase | 0.0023 | 0.0339 | 0.0339 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0026 | 0.0475 | 0.0475 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0087 | 0.3047 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0026 | 0.0475 | 0.0475 |
Schistosoma mansoni | sulfide quinone reductase | 0.0023 | 0.0339 | 0.0339 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0947 | 0.063 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0087 | 0.3047 | 0.2803 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0947 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0087 | 0.3047 | 0.2803 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0087 | 0.3047 | 0.3047 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0475 | 0.0475 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0026 | 0.0475 | 0.0141 |
Echinococcus granulosus | glutamate synthase | 0.0023 | 0.0339 | 0.0339 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0087 | 0.3047 | 0.2803 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0026 | 0.0475 | 0.0475 |
Brugia malayi | steroid hormone receptor | 0.0026 | 0.0475 | 0.0141 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0026 | 0.0475 | 0.0475 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0026 | 0.0475 | 0.0141 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0087 | 0.3047 | 0.2803 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0087 | 0.3047 | 0.2803 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 0.075 uM | Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay | ChEMBL. | 21615090 |
GI50 (functional) | = 0.1 uM | Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay | ChEMBL. | 21615090 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.